Atlas of Thyroid and Neuroendocrine Tumor Markers
https://libcat.nshealth.ca/en/permalink/provcat43325
Luca Giovanella, editor.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is es…
- Available Online
- View e-Book
- Other Authors
- Giovanella, Luca
- Responsibility
- Luca Giovanella, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xii, 249 p.) : 41 illus., 30 illus. in color
- ISBN
- 9783319625065
- 9783319625058 (print ed.)
- 9783319625072 (print ed.)
- 9783319873305 (print ed.)
- Subjects (MeSH)
- Biomarkers, Tumor
- Neuroendocrine Tumors - diagnosis
- Neuroendocrine Tumors - therapy
- Thyroid Neoplasms - diagnosis
- Thyroid Neoplasms - therapy
- Specialty
- Endocrinology
- Medical Oncology
- Abstract
- This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances. In this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and clinical topics. Analytical problems such as interferences, false-negative and false-positive results are discussed in depth, and flow-charts offer insights into identifying and avoiding them. Illustrated clinical cases detail the clinical role and limitations of different tumor markers. Lastly, it explores health technology assessment and economic issues. This is a valuable resource for endocrinologists, oncologists, nuclear medicine physicians, scientists and technologists who want to keep abreast of the latest developments.
- Contents
- Part I. Pathology and Pathobiology -- 1. Pathology and Immunohistochemistry in Thyroid Tumors -- 2. Pathology of Neuroendocrine Neoplasms: Morphological, Immunophenotypical, and Circulating Molecular Markers -- 3. Circulating Biomarkers: Biological Basis, Methods, and Interpretation Criteria -- Part II. Differentiated Thyroid Cancer -- 4. Differentiated Thyroid Cancer: Diagnosis, Therapy, and Follow-Up -- 5. Thyroglobulin and Thyroglobulin Antibodies -- 6. Circulating Molecular Biomarkers in Thyroid Cancer -- 7. Circulating Epithelial Tumor Cells in Thyroid Carcinoma -- Part III. Medullary Thyroid Carcinoma -- 8. Medullary Thyroid Carcinoma (MTC): Diagnosis, Treatment and Follow-Up -- 9. Calcitonin and Carcinoembryonic Antigen for the Diagnosis and Management of Medullary Thyroid Carcinoma -- 10. Procalcitonin: Are We Ready for Clinical Use? -- Part IV. Aggressive and Rare Thyroid Carcinoma -- 11. Aggressive Variants of Thyroid Carcinoma -- 12. Circulating Mucins and Cytokeratins in Aggressive Thyroid Cancers -- Part V. Thyroid Biomarkers on Fine-Needle Washouts -- 13. Measurement of Thyroid Tumor Markers on Fine-Needle Washouts -- Part VI. Neuroendocrine Tumors -- 14. Neuroendocrine Tumours: Diagnosis, Therapy and Follow-up -- 15. Circulating Markers in Neuroendocrine Tumors -- 16. Neuroendocrine Gene Transcripts: The Role of Molecular Biomarkers in Diagnosis and Management.
- Format
- e-Book
- Publication Type
- Atlas
- Location
- Online
Management of Pancreatic Neuroendocrine Tumors
https://libcat.nshealth.ca/en/permalink/provcat38978
Joseph R. Pisegna, editor.
--New York, NY:
Springer
, c2015.
- Available Online
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- Location
- Online
This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. …
- Available Online
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- Other Authors
- Pisegna, Joseph R
- Responsibility
- Joseph R. Pisegna, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (x, 167 p. : 28 illus., 20 illus. in color)
- ISBN
- 9781493917983
- 9781493917976 (print ed.)
- Subjects (MeSH)
- Neuroendocrine Tumors - diagnosis
- Neuroendocrine Tumors - therapy
- Pancreatic Neoplasms - diagnosis
- Pancreatic Neoplasms - therapy
- Abstract
- This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. The volume reviews the pathological grading and staging systems providing useful clinical information for the treating clinician as well as a useful reference for pathologists. The clinical management of neuroendocrine tumors is reviewed enabling the treating physician to understand the diagnostic approaches to differentiating the various types of neuroendocrine tumors. In addition, the treatments are reviewed in great detail and include novel radiological, surgical, and chemotherapeutic approaches. The reader will utilize this book as both a comprehensive and quick reference guide through the use of diagnostic and treatment algorithms. Written by international experts in their particular field of study, Management of Pancreatic Neuroendocrine Tumors will be of great value to medical oncologists, endocrinologists, gastroenterologists, pathologists, surgeons, and diagnostic and interventional radiologists.
- Contents
- Pathology of Pancreatic Neuroendocrine Tumors -- Inherited and Somatic Genetics of Pancreatic Neuroendocrine Tumors -- Laboratory Assessment of NETS -- Zollinger-Ellison Syndrome: Diagnosis and Management -- Clinical Manifestations of Multiple Endocrine Neoplasia, Type 1 -- Gastric Carcinoids: Classification and Diagnosis -- Endoscopic Approaches for Diagnosis of Pancreatic Neuroendocrine Tumors -- Endoscopic Approaches to Treatment of Pancreatic Neuroendocrine Neoplasms -- Surgical Approaches to Pancreatic Neuroendocrine Tumors -- Radiotherapy and Radiopharmaceuticals for the Treatment of Pancreatic Neuroendocrine Tumors -- Nuclear Medicine Approaches to Treatment of Neuroendocrine Tumors -- Novel Targets for Future Medical Treatments.
- Format
- e-Book
- Location
- Online
Neuroendocrine Tumors in Real Life : From Practice to Knowledge
https://libcat.nshealth.ca/en/permalink/provcat43276
Annamaria Colao, Antongiulio Faggiano, Wouter de Herder, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book on neuroendocrine tumors (NETs) aims to present, in a clear and innovative manner, a broad topic that is still unevenly and in some respects poorly delineated. The novel feature is the nature of the focus on the principles of prognosis, diagnosis, and therapy, which are outlined on the basis of well-defined clinical scenarios described with the aid of high-quality images and illustrations. The salient observations to emerge from the reported clinical cases are clearly summarized, taki…
- Available Online
- View e-Book
- Other Authors
- Colao, Annamaria
- Faggiano, Antongiulio
- de Herder, Wouter
- Responsibility
- Annamaria Colao, Antongiulio Faggiano, Wouter de Herder, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xvii, 349 p.) : 74 illus., 62 illus. in color
- ISBN
- 9783319590240
- 9783319590226 (print ed.)
- 9783319590233 (print ed.)
- 9783319865348 (print ed.)
- Subjects (MeSH)
- Neuroendocrine Tumors - diagnosis
- Neuroendocrine Tumors - therapy
- Specialty
- Endocrinology
- Medical Oncology
- Neurology
- Abstract
- This book on neuroendocrine tumors (NETs) aims to present, in a clear and innovative manner, a broad topic that is still unevenly and in some respects poorly delineated. The novel feature is the nature of the focus on the principles of prognosis, diagnosis, and therapy, which are outlined on the basis of well-defined clinical scenarios described with the aid of high-quality images and illustrations. The salient observations to emerge from the reported clinical cases are clearly summarized, taking into account evidence from the literature and the available guidelines. All of the significant prognostic factors—histopathological, molecular, and imaging--and current diagnostic and therapeutic strategies for the major NETs (stomach, pancreas, ileum, appendix, bronchus) are covered. In addition, in the introductory part of the book the reader will find information on basic aspects including epidemiology, classification, and underlying biological mechanisms. Neuroendocrine Tumors in Real Life will be of interest to all specialists involved in the management of NETs; it will provide the experienced with important updates and equip trainees and students with a firm understanding of key concepts.
- Contents
- I. General Remarks -- 1. Epidemiology of Neuroendocrine Tumours: By Site of Tumour and by Geographical Area -- 2. Pathological Classification: GEP, TNET, and Rare Forms -- 3. The Molecular Biology of NET: Current Status and Evaluation of Biomarkers for Prediction and Prognosis -- 4. Tumor Staging TNM -- II. Clinical Cases and Their Implications (From Clinical Practice to Guidelines) -- 5. Prognostic Factors: Grading (Ki-67 Index) -- 6. Prognostic Factors: Molecular Pathway – Somatostatin Receptors -- 7. Prognostic Factors: Molecular Pathway – Oncogene (mTOR) -- 8. Prognostic Factors: Molecular Pathway – Tumour Suppressor Gene (MEN1) -- 9. Prognostic Factors: Nuclear Medicine Imaging (FDG PET–Octreoscan/Gallium PET) -- 10. Tumour Detection in Syndromic NET: Carcinoid Syndrome -- 11. Tumor Detection in Syndromic NET: Zollinger-Ellison Syndrome -- 12. Tumor Detection in Syndromic NET: Hypoglycemic Hyperinsulinemic Syndrome -- 13. Tumor Staging: Bronchi -- 14. Tumour Staging: Ileum -- 15. Tumor Staging: Pancreas -- 16. Therapy for Locoregional Disease: Stomach/Duodenum, Colon/Rectum -- 17. Therapy for Locoregional Disease: Pancreas -- 18. Therapy for Locoregional Disease: Ileum -- 19. Therapy for Locoregional Disease: Bronchi -- 20. Therapy for Metastatic Disease: Stomach/Duodenum, Colon/Rectum -- 21. Therapy for Metastatic Disease: Pancreas -- 22. Therapy for Metastatic Disease: Ileum -- 23. Therapy for Metastatic Disease: Bronchi -- 24. Therapy for Metastatic Disease with Unknown Primary Tumor -- Supplementary Information.
- Format
- e-Book
- Location
- Online
Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances
https://libcat.nshealth.ca/en/permalink/provcat39719
Aejaz Nasir, Domenico Coppola, editors.
--New York, NY:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This comprehensive subspecialty reference book on NeuroEndocrine Tumor (NET) pathology brings together the diagnostic and clinical expertise of an outstanding team of practicing neuroendocrine pathologists and oncologists. In addition to in-depth coverage of clinico-pathologic aspects of NETs of the various organ systems, the recent histological grading and staging schemes proposed by the North American and European NeuroEndocrine Tumor Societies (NANETS, ENETS), the World Health Organization (…
- Available Online
- View e-Book
- Other Authors
- Nasir, Aejaz
- Coppola, Domenico
- Responsibility
- Aejaz Nasir, Domenico Coppola, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xiii, 543 p. : 136 illus., 130 illus. in color)
- ISBN
- 9781493934263
- 9781493934249 (print ed.)
- Subjects (MeSH)
- Neuroendocrine Tumors - metabolism
- Neuroendocrine Tumors - pathology
- Neuroendocrine Tumors - therapy
- Abstract
- This comprehensive subspecialty reference book on NeuroEndocrine Tumor (NET) pathology brings together the diagnostic and clinical expertise of an outstanding team of practicing neuroendocrine pathologists and oncologists. In addition to in-depth coverage of clinico-pathologic aspects of NETs of the various organ systems, the recent histological grading and staging schemes proposed by the North American and European NeuroEndocrine Tumor Societies (NANETS, ENETS), the World Health Organization (WHO) and the American Joint Committee on Cancer (AJCC), this book also focuses on the recent molecular and therapeutic advances in the field of NET pathology and oncology. Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances will be an essential reference book for anatomic pathology (histopathology) residents, fellows, surgical pathologists, researchers, oncologists, surgeons and other medical professionals practicing advanced NET Pathology and Oncology in academia, community, private practice and research settings.
- Contents
- Part I. General Topics in Neuroendocrine Tumor Pathology -- 1. Current Grading of the Neuroendocrine Neoplasms -- 2. Current Staging of the Neuroendocrine Neoplasms -- 3. Differential Diagnosis of the Neuroendocrine Neoplasms -- 4. Immunohistochemistry of the Neuroendocrine Neoplasms -- 5. Poorly-Differentiated Neuroendocrine Carcinoma -- Part II. Systemic Aspects of Neuroendocrine Tumor Pathology -- 6. Neuroendocrine Carcinoma of the Brain -- 7. Medullary Carcinoma of the Thyroid -- 8. Neuroendocrine Carcinoma of the Thymus -- 9. Neuroendocrine Neoplasm of the Lung -- 10. Neuroendocrine Carcinoma of the Breast -- 11. Neuroendocrine Neoplasms of the Esophagus -- 12. Neuroendocrine Neoplasms of the Stomach -- 13. Neuroendocrine Neoplasms of the Pancreas -- 14. Neuroendocrine Neoplasms of the Small Intestine -- 15. Neuroendocrine Neoplasms of the Appendix -- 16. Neuroendocrine Neoplasms of the Colon -- 17. Neuroendocrine Tumors of the Adrenal Gland -- 18. Neuroendocrine Carcinoma of the Bladder -- 19. Neuroendocrine Carcinoma of the Prostate -- 20. Neuroendocrine Tumors of the Female Reproductive System -- 21. Neuroendocrine Tumors of the Skin -- 22 . Extraskeletal Ewing's Sarcoma-Primitive Neuroectodermal Tumor -- Part III. Molecular & Therapeutic Advances in Neuroendocrine Tumor Pathology -- 23. Molecular Pathology of Neuroendocrine Tumors in the Era of Targeted Therapeutics -- 24. Somatostatin Receptors in Neuroendocrine Tumors -- 25. Pathologic Angiogenesis in Neuroendocrine Tumors -- 26. Molecular Targets in Neuroendocrine Tumor Pathology -- 27. Molecular Biomarkers in Neuroendocrine Tumor Pathology -- 28. Targeted Therapies for Neuroendocrine Neoplasms -- 29. Future Directions in Neuroendocrine Tumor Pathology.
- Format
- e-Book
- Location
- Online
Neuroendocrine Tumours : Diagnosis and Management
https://libcat.nshealth.ca/en/permalink/provcat39439
Suayib Yalcin, Kjell Öberg, editors.
--Berlin, Heidelberg:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This book is a timely textbook that covers all aspects of neuroendocrine tumors (NET) from epidemiology, pathological classification and evaluation, and molecular biology through to diagnostic imaging methods and therapeutic options, including the latest targeted therapies. The various types of NET are individually discussed, including carcinoid tumors, insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, PPomas, medullary thyroid carcinomas, adrenocortical cancer, pheochromocytom…
- Available Online
- View e-Book
- Other Authors
- Yalcin, Suayib
- Öberg, Kjell
- Responsibility
- Suayib Yalcin, Kjell Öberg, editors
- Alternate Title
- Neuroendocrine tumors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (vii, 578 p. : 83 illus., 44 illus. in color)
- ISBN
- 9783662452158
- 9783662452141 (print ed.)
- Subjects (MeSH)
- Neuroendocrine Tumors - diagnosis
- Neuroendocrine Tumors - therapy
- Abstract
- This book is a timely textbook that covers all aspects of neuroendocrine tumors (NET) from epidemiology, pathological classification and evaluation, and molecular biology through to diagnostic imaging methods and therapeutic options, including the latest targeted therapies. The various types of NET are individually discussed, including carcinoid tumors, insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, PPomas, medullary thyroid carcinomas, adrenocortical cancer, pheochromocytomas, paragangliomas, and non-functioning pancreatic NETs. The contributing authors are internationally recognized experts who bring a wealth of experience to the subject. This book will be an invaluable source of information for practicing medical oncologists, surgeons, endocrinologists, gastroenterologists, and pathologists and also trainees.
- Contents
- [publisher supplied] Introduction -- Historical Background -- Epidemiology -- Pathological Classification -- Carcinoid Syndrome -- Molecular Biology -- ‘nsulinoma -- Gastrinoma -- Vipoma -- Glucagonoma -- Pathological Evaluation -- Radiological Imaging -- Nuclear Imaging -- Geneticá Syndromes Associated with NET -- Surgical Approach -- Locoregional treatment (RFA) -- Embolization (Chemo/radio) -- PRRT -- Management of Hormonal symptoms -- Chemotherapy -- Somatostatin Analogues -- Targeted Therapies -- Guidelines -- Societies and Guidelines -- Biomarkers -- Medullary Thyroid Cancer -- Adrenocortical Cancer -- Paraganglioma, feokromositoma -- Nonfonksiyone pNET -- Somatostatinoma -- Poorly differentiated NET -- Management of MEN -- Ppoma.
- Format
- e-Book
- Location
- Online
The Spectrum of Neuroendocrine Neoplasia : A Practical Approach to Diagnosis, Classification and Therapy
https://libcat.nshealth.ca/en/permalink/provcat46483
Sylvia L. Asa, Stefano La Rosa, Ozgur Mete, editors.
--Cham:
Springer
, c2021.
- Available Online
- View e-Book
- Access
- NEW Springer 2021
- Location
- Online
Neuroendocrine neoplasms comprise a large family of proliferative lesions that involve almost every part of the body. Our understanding of their cells of origin as well as the pathology, pathophysiology and genetics of these neoplasms has made tremendous advances in the last few decades. While they are often discussed as separate entities in textbooks of gastroenteropancreatic pathology and pulmonary pathology, their scope is much broader. The book conveys the similarities and differences of th…
- Available Online
- View e-Book
- Other Authors
- Asa, Sylvia L.
- La Rosa, Stefano
- Mete, Ozgur
- Responsibility
- Sylvia L. Asa, Stefano La Rosa, Ozgur Mete, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2021
- Physical Description
- 1 online resource (xi, 478 p.)
- ISBN
- 9783030543914
- 9783030543907 (Print ed.)
- 9783030543921 (Print ed.)
- 9783030543938 (Print ed.)
- Subjects (MeSH)
- Neuroendocrine Tumors - diagnosis
- Neuroendocrine Tumors - therapy
- Specialty
- Endocrinology
- Medical Oncology
- Neurology
- Abstract
- Neuroendocrine neoplasms comprise a large family of proliferative lesions that involve almost every part of the body. Our understanding of their cells of origin as well as the pathology, pathophysiology and genetics of these neoplasms has made tremendous advances in the last few decades. While they are often discussed as separate entities in textbooks of gastroenteropancreatic pathology and pulmonary pathology, their scope is much broader. The book conveys the similarities and differences of these fascinating tumors that may be found from the hypothalamus and pituitary to the rectum, and in soft tissue as well as in many organs. Written by experts in the field, the authors emphasize their structural, functional, predictive and prognostic features and attempt to provide the clinical context that allows improved diagnosis and therapy while building on the genetics that clarifies patterns of inheritance and predisposition to tumor development through precursor lesions. The Spectrum of Neuroendocrine Neoplasia provides a broad overview of neuroendocrine neoplasms using a practical approach to diagnosis, histological classification and therapy, and presents the most important and significant developments of the technologies used to diagnose, classify and treat them.
- Contents
- 1. Neuroendocrine Neoplasms: Historical Background and Terminologies -- 2. The Diagnosis of Neuroendocrine Neoplasms -- 3. Functional and Radiological Imaging of Neuroendocrine Neoplasms -- 4. Pituitary Neuroendocrine Neoplasms -- 5. Hypothalamic Neuroendocrine Neoplasms -- 6. Neuroendocrine Neoplasms of the Upper Aerodigestive Tract, Ear, and Salivary Glands -- 7. Thyroid Neuroendocrine Neoplasms -- 8. Parathyroid Neuroendocrine Neoplasms -- 9. Thoracic (Lung/Thymus) Neuroendocrine Neoplasms -- 10. Neuroendocrine Neoplasms of the Gut -- 11. Pancreatic Neuroendocrine Neoplasms -- 12. Paragangliomas and Pheochromocytomas -- 13. Neuroendocrine Neoplasms of the Breast -- 14. Genitourinary Neuroendocrine Neoplasms -- 15. Skin Neuroendocrine Neoplasms -- 16. Metastatic Neuroendocrine Neoplasms of Unknown Primary Site -- 17. Cytology of Neuroendocrine Neoplasms -- 18. Inherited Neuroendocrine Neoplasms -- 19. The Management of Neuro-Endocrine Neoplasms.
- Access
- NEW Springer 2021
- Format
- e-Book
- Location
- Online
