1. History of Tobacco -- 2. Epidemiology of Tobacco Dependence -- 3. Tobacco Constituents and Additives -- 4. Pharmacology and Pharmacokinetics of Nicotine -- 5. Smoking and Lung Disease -- 6. Cardiovascular Disease, Disturbances of Blood Coagulation and Fibrinolysis -- 7. Other Organ Systems -- 8. Smoking and Pregnancy -- 9. Passive Smoking -- 10. Non-Drug Treatments to Promote Smoking Cessation -- 11. Pharmacotherapy of Nicotine Dependence -- 12. Primary Prevention -- 13. Tobacco Industry, Advertising and Advertising Bans -- 14. Society, Politics and the Tobacco Industry -- 15. Appendix: Experiences from a Smoker Counselling Centre.