Appetite and body weight : integrative systems and the development of anti-obesity drugs
https://libcat.nshealth.ca/en/permalink/provcat27199
edited by Tim C. Kirkham and Steven J. Cooper.
--Burlington, MA:
Elsevier Academic Press
, c2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Kirkham, Tim C
- Other Authors
- Cooper, S. J
- Responsibility
- edited by Tim C. Kirkham and Steven J. Cooper
- Place of Publication
- Burlington, MA
- Publisher
- Elsevier Academic Press
- Date of Publication
- c2007
- Physical Description
- 371 p.
- ISBN
- 9786610728954
- Subjects (MeSH)
- Appetite
- Body Weight
- Obesity - physiopathology
- Anti-Obesity Agents
- Contents
- Cover -- APPETITE AND BODY WEIGHT -- Copyright page -- Table of Contents -- Contributors -- CHAPTER 1: Introduction and Overview -- CHAPTER 2: Cortical Systems Involved in Appetite and Food Consumption -- I. INTRODUCTION -- II. FOOD MOTIVATION -- III. CORTICAL REPRESENTATIONS OF SENSORY INPUTS -- IV. CONCLUSION -- Acknowledgments -- References -- CHAPTER 3: The Nucleus Accumbens Shell as a Model of Integrative Subcortical Forebrain Systems Regulating Food Intake -- I. INTRODUCTION -- II. THE REGULATION OF FEEDING BEHAVIOR BY THE NUCLEUS ACCUMBENS SHELL -- III. AFFERENT PROJECTIONS TO THE AcbSh THAT MAY BE INVOLVED IN REGULATING FOOD INTAKE -- IV. DOWNSTREAM COMPONENTS OF THE FUNCTIONAL AcbSh FEEDING CIRCUIT -- V. THE AcbSh FEEDING CIRCUIT AS A POTENTIAL SITE FOR PATHOLOGY AND THERAPEUTIC INTERVENTION IN THE TREATMENT OF EATING DISORDERS -- References -- CHAPTER 4: Hypothalamic Neuropeptides and Feeding Regulation -- I. INTRODUCTION -- II. NEUROPEPTIDE Y -- III. THE OREXINS -- IV. MELANIN-CONCENTRATING HORMONE -- V. CONCLUSION -- Acknowledgments -- References -- CHAPTER 5: Brainstem-Hypothalamic Neuropeptides and the Regulation of Feeding -- I. THE CONTROL OF FEEDING -- II. NEURAL INTEGRATION BY THE DORSAL VAGAL COMPLEX -- III. CONSIDERATIONS IN ASSESSING THE ROLE OF "NEUROPEPTIDES" -- IV. "HUMORAL" INTERACTIONS WITH THE DORSAL VAGAL COMPLEX -- V. INTRINSIC PEPTIDERGIC NEURONS OF THE DORSAL VAGAL COMPLEX -- VI. DESCENDING PEPTIDERGIC REGULATION OF BRAINSTEM FEEDING CIRCUITS -- VII. SUMMARY AND POTENTIAL FOR DRUG DEVELOPMENT -- References -- CHAPTER 6: The Gut-Brain Axis in the Control of Eating -- I. INTRODUCTION -- II. GASTRIC MECHANORECEPTION -- III. INTESTINAL CHOLECYSTOKININ (CCK) -- IV. AMYLIN -- V. GHRELIN -- VI. POTENTIALS AND PROBLEMS OF GUT-BRAIN AXIS SIGNALS IN THE TREATMENT OF OBESITY -- References -- CHAPTER 7: Integration of Peripheral Adiposity Signals and Psychological Controls of Appetite -- I. INTRODUCTION AND OVERVIEW -- II. MESOLIMBIC DOPAMINE CIRCUITRY AND ENERGY REGULATORY SIGNALS -- III. BRAIN OPIOID SYSTEMS AND ENERGY REGULATORY SIGNALS -- IV. ENDOCANNABINOIDS AND ENERGY REGULATORY SIGNALS -- V. LHA CIRCUITRY AND ENERGY REGULATORY SIGNALS -- VI. OTHER CNS SITES: TARGET FOR FUTURE STUDIES? -- VII. HUMAN AND CLINICAL STUDIES: AT THE FOREFRONT OF OUR KNOWLEDGE -- VIII. CONCLUDING REMARKS -- Acknowledgments -- References -- CHAPTER 8: Brain Reward Systems for Food Incentives and Hedonics in Normal Appetite and Eating Disorders -- I. INTRODUCTION -- II. POSSIBLE ROLES OF BRAIN REWARD SYSTEMS IN EATING DISORDERS -- III. UNDERSTANDING BRAIN REWARD SYSTEMS FOR FOOD "LIKING" AND "WANTING" -- IV. "WANTING" WITHOUT "LIKING" -- V. A BRIEF HISTORY OF APPETITE: FOOD INCENTIVES, NOT HUNGER DRIVES -- VI. CONNECTING BRAIN REWARD AND REGULATORY SYSTEMS -- VII. CONCLUSION -- Acknowledgments -- References -- CHAPTER 9: Pharmacology of Food, Taste, and Learned Flavor Preferences -- I. INTRODUCTION -- II. PHARMACOLOGY OF FOOD PREFERENCE -- III. PHARMACOLOGY OF UNLEARNED TASTE PREFERENCE AND REACTIVITY -- IV. PHARMACOLOGY OF LEARNED FLAVOR PREFERENCE -- V. CONCLUDING REMARKS
- Format
- e-Book
- Location
- Online
Handbook of obesity : etiology and pathophysiology
https://libcat.nshealth.ca/en/permalink/provcat21663
Bray, George A.
(2nd ed.)
--New York, NY:
Marcel Dekker
, 2004.
- Call Number
- WD 210 H236 2004
- Location
- Halifax Infirmary
- Call Number
- WD 210 H236 2004
- Author
- Bray, George A
- Other Authors
- Bouchard, Claude
- Edition
- 2nd ed.
- Place of Publication
- New York, NY
- Publisher
- Marcel Dekker
- Date of Publication
- 2004
- Physical Description
- 1046 p.
- ISBN
- 0824709691
- Subjects (MeSH)
- Obesity - etiology
- Obesity - physiopathology
- Format
- Book
- Location
- Halifax Infirmary
- Loan Period
- 3 weeks
Nutrition and diabetes : pathophysiology and management
https://libcat.nshealth.ca/en/permalink/provcat23037
Opara, Emmanuel.
--Boca Raton, FL:
CRC Press
, 2006.
- Call Number
- WK 835 N976 2006
- Location
- Dickson Building
- Call Number
- WK 835 N976 2006
- Author
- Opara, Emmanuel
- Place of Publication
- Boca Raton, FL
- Publisher
- CRC Press
- Date of Publication
- 2006
- Physical Description
- 476 p.
- ISBN
- 084932307X
- Subjects (MeSH)
- Obesity - physiopathology
- Diabetes Mellitus - physiopathology
- Obesity - therapy
- Diabetes Mellitus - therapy
- Nutritional Physiological Phenomena
- Diabetes Complications
- Oxidative Stress
- Format
- Book
- Location
- Dickson Building
- Loan Period
- 3 weeks
Obesity and Diabetes
https://libcat.nshealth.ca/en/permalink/provcat30228
edited by Christos S. Mantzoros.
--Totowa, NJ:
Humana Press
, c2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Mantzoros, Christos S
- Responsibility
- edited by Christos S. Mantzoros
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2006
- Series Title
- Contemporary diabetes
- ISBN
- 9781592599851
- Subjects (MeSH)
- Diabetes Complications
- Diabetes Mellitus - physiopathology
- Obesity - complications
- Obesity - physiopathology
- Subjects (LCSH)
- Diabetes
- Format
- e-Book
- Location
- Online
Obesity : Pathogenesis, Diagnosis, and Treatment
https://libcat.nshealth.ca/en/permalink/provcat44065
Paolo Sbraccia, Nicholas Finer, editors.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book presents the latest advances in our understanding of the pathophysiologic basis that induces the chronic positive energy balance necessary to progressively store excessive amounts of fat mass. It highlights the clinical complications of obesity, while also focusing on the major scientific advances that have highlighted the role of genetics, adipose tissue endocrinology and the environment in the mechanisms and causes of obesity. Particular attention is given to the consequences of obe…
- Available Online
- View e-Book
- Other Authors
- Sbraccia, Paolo
- Finer, Nicholas
- Responsibility
- Paolo Sbraccia, Nicholas Finer, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xv, 440 p.) : 66 illus., 49 illus. in color
- Series
- Endocrinology
- Series Title
- Springer reference
- Endocrinology
- ISBN
- 9783319469331
- 9783319469324 (Print ed.)
- ISSN
- 2510-1927
- Subjects (MeSH)
- Obesity - physiopathology
- Obesity - complications
- Obesity - therapy
- Specialty
- Bariatric Medicine
- Notes
- "eReference".
- Abstract
- This book presents the latest advances in our understanding of the pathophysiologic basis that induces the chronic positive energy balance necessary to progressively store excessive amounts of fat mass. It highlights the clinical complications of obesity, while also focusing on the major scientific advances that have highlighted the role of genetics, adipose tissue endocrinology and the environment in the mechanisms and causes of obesity. Particular attention is given to the consequences of obesity, including an ever-increasing number of other diseases such as type 2 diabetes, cardiovascular diseases and cancer, as well as conditions such as arthropathy, asthma, non-alcoholic liver disease, and dementia. Increasingly recognized uniting causes highlight the role of systemic, local and paracrine actions of adipocytokines in causing inflammation. As we come to better understand how hypothalamic control of energy balance is influenced by endocrine signaling from the gut and adipose tissue, it paves the way for new therapeutic targets and a resurgence of pharmacological and surgical approaches to treatment. Written by respected experts in the field, this volume is intended as a major reference source for endocrinologists, nutritionists, basic and clinical scientists alike.
- Contents
- 1. Epidemiology of Obesity -- 2. Neuroendocrinology of Energy Balance -- 3. The Adipose Organ -- 4. Roles of Gut Hormones in the Regulation of Food Intake and Body Weight -- 5. Obesity Pathogenesis -- 6. The Microbiota and Energy Balance -- 7. Eating Disorders -- 8. Clinical Assessment of the Patient with Overweight or Obesity -- 9. Obesity and NAFLD -- 10. Obesity and Type 2 Diabetes -- 11. Obesity, Hypertension, and Dyslipidemia -- 12. Obesity and Obstructive Sleep Apnea Syndrome -- 13. Impact of Obesity on Cardiovascular Disease -- 14. Obesity in Children and Adolescents -- 15. Exercise in the Treatment of Obesity -- 16. Psychological Approaches in the Treatment of Obesity -- 17. Surgical Approaches in the Treatment of Obesity -- 18. Medications Indicated for Chronic Weight Management -- 19. An Integrated View of Treatment Options Available for Obesity.
- Format
- e-Book
- Location
- Online
Obesity : Pathogenesis, Diagnosis, and Treatment
https://libcat.nshealth.ca/en/permalink/provcat44573
edited by Paolo Sbraccia, Nicholas Finer.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book presents the latest advances in our understanding of the pathophysiologic basis that induces the chronic positive energy balance necessary to progressively store excessive amounts of fat mass. It highlights the clinical complications of obesity, while also focusing on the major scientific advances that have highlighted the role of genetics, adipose tissue endocrinology and the environment in the mechanisms and causes of obesity. Particular attention is given to the consequences of obe…
- Available Online
- View e-Book
- Other Authors
- Sbraccia, Paolo
- Finer, Nicholas
- Responsibility
- edited by Paolo Sbraccia, Nicholas Finer
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (x, 352 p.)
- Series Title
- Springer reference
- Endocrinology
- ISBN
- 9783319476858
- ISSN
- 2510-1927
- Subjects (MeSH)
- Obesity - complications
- Obesity - physiopathology
- Specialty
- Bariatric Medicine
- Notes
- "Living reference work."
- Abstract
- This book presents the latest advances in our understanding of the pathophysiologic basis that induces the chronic positive energy balance necessary to progressively store excessive amounts of fat mass. It highlights the clinical complications of obesity, while also focusing on the major scientific advances that have highlighted the role of genetics, adipose tissue endocrinology and the environment in the mechanisms and causes of obesity. Particular attention is given to the consequences of obesity, including an ever -increasing number of other diseases such as type 2 diabetes, cardiovascular diseases and cancer, as well as conditions such as arthropathy, asthma, non-alcoholic liver disease, and dementia. Increasingly recognized uniting causes highlight the role of systemic, local and paracrine actions of adipocytokines in causing inflammation. As we come to better understand how hypothalamic control of energy balance is influenced by endocrine signaling from the gut and adipose tissue, it paves the way for new therapeutic targets and a resurgence of pharmacological and surgical approaches to treatment. Written by respected experts in the field, this volume is intended as a major reference source for endocrinologists, nutritionists, basic and clinical scientists alike.
- Contents
- An Integrated View of Treatment Options Available for Obesity -- Clinical Assessment of the Patient with Overweight or Obesity -- Eating Disorders -- Epidemiology of Obesity -- Exercise in the Treatment of Obesity -- Impact of Obesity on Cardiovascular Disease -- Medications Indicated for Chronic Weight Management -- Neuroendocrinology of Energy Balance -- Obesity and NAFLD -- Obesity and Obstructive Sleep Apnea Syndrome -- Obesity and Type 2 Diabetes -- Obesity in Children and Adolescents -- Obesity Pathogenesis -- Obesity, Hypertension, and Dyslipidemia -- Psychological Approaches in the Treatment of Obesity -- Roles of Gut Hormones in the Regulation of Food Intake and Body Weight -- Surgical Approaches in the Treatment of Obesity -- The Adipose Organ -- The Microbiota and Energy Balance.
- Format
- e-Book
- Location
- Online
Physiology and physiopathology of adipose tissue
https://libcat.nshealth.ca/en/permalink/provcat32475
Jean-Philippe Bastard, Bruno Fève, editors.
--Paris:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines…
- Available Online
- View e-Book
- Other Authors
- Bastard, Jean-Philippe
- Fève, Bruno
- Responsibility
- Jean-Philippe Bastard, Bruno Fève, editors
- Place of Publication
- Paris
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xix, 437 p. : 51 ill. in color)
- ISBN
- 9782817803432
- Subjects (MeSH)
- Adipose Tissue - physiology
- Adipose Tissue - physiopathology
- Obesity - physiopathology
- Subjects (LCSH)
- Endocrinology
- Metabolic diseases
- Lipids
- Abstract
- The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.
- Contents
- Foreword -- Part I: Adipose tissue development -- 1. Development of adipose cells -- 2. Emerging roles of cell cycle regulators in adipocyte metabolism -- 3. Angiogenesis in adipose tissue -- 4. Prospects for using adipose tissue in regenerative medicine -- 5. Brown adipose tissue: function and development -- 6. Histology of adipose tissue -- Part II: Adipose tissue metabolic functions -- 7. Glucose transport in white adipocyte -- 8. Mechanism of storage and synthesis of fatty acids and triglycerides in white adipocytes -- 9. Adipocyte lipid droplet physiology -- 10. Adipose tissue lipolysis -- 11. The adipose tissue: storage, source and target of pollutants -- Part III: Endocrine functions of adipocyte -- 12. Chatting between the brain and white adipose tissues -- 13. Adiponectin: an adipokine with multiple faces -- 14. Apelin metabolic functions -- 15. Up-to-date on novel "adipocrines" -- Part IV: Pathology of adipose tissue -- 16. Obesity: an evolving process -- 17. Obesity phenotypes : Measures to assess adipose tissue mass in humans -- 18. Animal models of obesity -- 19. Contribution of "omics" approaches to understand the pathophysiology of obesity -- 20. Adipose tissue inflammation in obesity -- 21. Impact of proinflammatory cytokines on adipocyte insulin signaling -- 22. Adaptive changes in human adipose tissue during weight gain -- 23. Differences between subcutaneous and visceral adipose tissues -- 24. Genetics of human obesities -- 25. Genetic and acquired lipodystrophic syndromes -- 26. Is adipose tissue a relevant therapeutic target of obesity? -- Index.
- Format
- e-Book
- Location
- Online
Treatment of the obese patient
https://libcat.nshealth.ca/en/permalink/provcat33273
Robert F. Kushner, Daniel H. Bessesen, editors.
(Second edition)
--New York:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
This is a timely and informative updated volume for all health care providers challenged with helping patients manage weight. Similar to the well-reviewed first edition, Treatment of the Obese Patient, Second Edition is directed toward individuals who wish to read further about targeted topics, rather than find an introduction to the field. This second edition again provides insights into recent scientific advances in obesity research and provides the most up-to-date instruction about current t…
- Available Online
- View e-Book
- Other Authors
- Kushner, Robert F
- Bessesen, Daniel H
- Responsibility
- Robert F. Kushner, Daniel H. Bessesen, editors
- Edition
- Second edition
- Place of Publication
- New York
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xii, 336 pages)
- ISBN
- 9781493912032 (electronic bk.)
- 9781493912025
- Subjects (MeSH)
- Bariatrics
- Obesity - physiopathology
- Obesity - therapy
- Subjects (LCSH)
- Obesity
- Abstract
- This is a timely and informative updated volume for all health care providers challenged with helping patients manage weight. Similar to the well-reviewed first edition, Treatment of the Obese Patient, Second Edition is directed toward individuals who wish to read further about targeted topics, rather than find an introduction to the field. This second edition again provides insights into recent scientific advances in obesity research and provides the most up-to-date instruction about current treatment issues and strategies for both adults and children. An essential, practical text that sorts, synthesizes, and interprets the latest information on obesity-related topics, Treatment of the Obese Patient, Second Edition, is an essential resource for clinical endocrinologists and other health care providers across a broad spectrum of specialties.
- Contents
- Part I. Physiology and Pathophysiology -- 1. Neuroregulation of Appetite -- 2. Reward, Reinforcement, and Impulsivity in Obesity -- 3. Gut Peptides -- 4. Critical Importance of the Perinatal Period in the Development of Obesity -- 5. Gut Microbiome and Obesity -- 6. Browning of Adipose Organ -- 7. Adaptive Responses to Weight Loss -- 8. Shortened Sleep Time and Obesity -- 9. Obesity and the Pathogenesis of Nonalcoholic Fatty Liver Disease -- 10. Mechanisms of Bariatric Surgery -- Part II. Clinical Management -- 11. Recent Developments in the Epidemiology of Obesity -- 12. Assessment of the Obese -- 13. Behavioral Strategies in Weight Management -- 14. Dietary Modifi cation as a Weight Management Strategy -- 15. Physical Activity as a Weight Management Strategy -- 16. Drugs for Weight Loss and Maintenance: Present and Future -- 17. Surgical Approaches and Outcome in the Treatment of the Obese Patients -- 18. Managing Micronutrient Defi ciencies in the Bariatric Surgical Patient -- 19. Evaluation and Treatment of Obesity in Primary Care -- 20. Assessment of the Obese Child or Adolescent -- 21. Treatment of the Obese Child or Adolescent -- Index.
- Format
- e-Book
- Location
- Online
