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Genomic Applications in Pathology

https://libcat.nshealth.ca/en/permalink/provcat38933
George Jabboure Netto, Iris Schrijver, editors. --New York, NY: Springer , c2015.
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Genomic Applications in Pathology provides a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays are discussed together with issues related to reporting, including the pathologist's role…
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Other Authors
Netto, George Jabboure
Schrijver, Iris
Responsibility
George Jabboure Netto, Iris Schrijver, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xv, 622 p. : 85 illus., 79 illus. in color)
ISBN
9781493907274
9781493907267 (print ed.)
Subjects (MeSH)
Genomics - methods
Neoplasms - genetics
Pathology, Molecular - methods
Abstract
Genomic Applications in Pathology provides a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays are discussed together with issues related to reporting, including the pathologist's role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms are detailed, as well as genomic applications in pharmacogenomics, inherited genetic diseases, and infectious diseases. The latest iteration of practice recommendations and guidelines in genomic testing, put forth by stakeholder professional organizations such as the Association for Molecular Pathology and the College of American Pathologists, are also discussed in the volume, as well as regulatory issues and laboratory accreditation related to genomic testing. Written by experts in the field, Genomic Applications in Pathology provides a comprehensive resource that is of great value to practicing molecular pathologists, hematopathologists, other subspecialized pathologists, general pathologists, pathology trainees, oncologists, and geneticists.
Contents
Part I. Genomic Technologies -- Current Massively Parallel Sequencing Technologies: Platforms and Reporting Considerations -- Emerging Next Generation Sequencing Technologies -- Transcriptome Sequencing (RNA-Seq) -- miRNA Expression Assays -- Circulating Tumor Cells: Enrichment and Genomic Applications -- Circulating Cell-free DNA for Molecular Diagnostics and Therapeutic Monitoring -- Part II. Practice Related Aspects of Clinical Genomics -- Genomic Pathology: Training for New Technology -- Implementation of Genomic Sequencing Assays -- Regulatory and Reimbursement Issues in Genomic Testing -- Patents and Proprietary Assays -- Ethical Issues in Clinical Genetics and Genomics -- Part III. Clinical Implementation of Diagnostic Genomics -- Transitioning Discoveries from Cancer Genomics Research Laboratories into Pathology Practice -- Bioinformatics Tools in Clinical Genomics -- Next Generation Sequencing for Single Gene Analysis -- Next Generation Sequencing for Gene Panels -- Implementation of Exome Sequencing Assays -- Implementation of Genome Sequencing Assays -- Clinical Information Systems in the Era of Personalized Medicine -- Reporting Clinical Genomic Assay Results and the Role of the Pathologist -- Part IV. Genomic Applications in Oncology -- Genomic Applications in Hematologic Oncology -- Genomic Applications in Brain Tumors -- Genomic Applications in Head and Neck Cancers -- Genomic Applications in Breast Carcinoma -- Genomic Applications in Pulmonary Malignancies -- Genomic Applications in Colorectal and Pancreatic Tumors -- Molecular Pathology of Genitourinary Cancers: Translating the Cancer Genome to the Clinic -- Genomic Applications in Gynecologic Malignancies -- Genomic Applications in Epithelial Ovarian Malignancies -- Genomic Applications in Soft Tissue Sarcomas -- Part V. Genomic Applications of Inherited and Infectious Diseases -- Genomic Applications in Inherited Genetic Disorders -- Genomic Applications in Pharmacogenomics -- Sequencing Cell Free DNA in the Maternal Circulation to Screen for Down Syndrome and Other Common Aneuploidies -- Genomic Applications in the Clinical Management of Infectious Diseases.
Format
e-Book
Location
Online
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Gestational Trophoblastic Disease : Diagnostic and Molecular Genetic Pathology

https://libcat.nshealth.ca/en/permalink/provcat31010
Pei Hui, editor. --New York, NY: Springer , c2012.
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In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentati…
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Other Authors
Hui, Pei
Responsibility
Pei Hui, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xiii, 205 p. : 104 ill., 96 ill. in color)
Series Title
Current clinical pathology
ISBN
9781617793943
Subjects (MeSH)
Gestational Trophoblastic Disease - pathology
Molecular Diagnostic Techniques
Pathology, Molecular - methods
Subjects (LCSH)
Pathology
Gynecology
Oncology
Abstract
In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations. Descriptions of the pathology are supported by numerous excellent photomicrographs. Recent advances in our understanding of the genetics of gestational trophoblastic diseases are stressed. Introductory chapters cover the developmental biology of the placenta and the genetic basis of gestational trophoblastic disease, and one chapter is devoted to the molecular diagnosis of gestational trophoblastic disease. This chapter includes a review of the use of short tandem repeat (STR) genotyping which is of particular value in the diagnosis of hydatidiform moles. The final chapter covers clinical aspects of gestational trophoblastic disease, including treatment. The text throughout is current and thoroughly referenced. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students.
Contents
Gestational trophoblastic disease: general aspects -- Developmental biology of the placenta -- Genetic basis of gestational trophoblastic disease -- Complete hydatidiform mole -- Partial hydatidiform mole -- Placental site trophoblastic tumor -- Epithelioid trophoblastic tumor -- Gestational choriocarcinoma -- Persistent trophoblastic neoplasia -- Tumor-like trophoblastic conditions -- Molecular diagnosis of gestational trophoblastic disease -- Clinical aspects of gestational trophoblastic disease.
Format
e-Book
Location
Online
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Molecular Cytopathology

https://libcat.nshealth.ca/en/permalink/provcat40177
Bin Yang, Jianyu Rao, editors. --Cham: Springer , c2016.
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This book reviews the current application of molecular tools in cytopathology and serves as a concise handbook for those who provide care in this era of personalized medicine. Specifically, the text provides a comprehensive and concise review of the emerging molecular tests available clinically in different organ systems. It reviews the current data of molecular testing already applied in cytopathology, discusses some of the biomarkers with potential utility in cytopathology in the near future …
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Other Authors
Yang, Bin
Rao, Jianyu
Responsibility
Bin Yang, Jianyu Rao, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xi, 293 p. : 37 illus. in color)
Series
Essentials in cytopathology
Series Vol.
26
Series Title
Essentials in cytopathology series
ISBN
9783319307411
9783319307398 (print ed.)
ISSN
1574-9053
Subjects (MeSH)
Cytodiagnosis - methods
Molecular Diagnostic Techniques - methods
Pathology, Molecular - methods
Abstract
This book reviews the current application of molecular tools in cytopathology and serves as a concise handbook for those who provide care in this era of personalized medicine. Specifically, the text provides a comprehensive and concise review of the emerging molecular tests available clinically in different organ systems. It reviews the current data of molecular testing already applied in cytopathology, discusses some of the biomarkers with potential utility in cytopathology in the near future and reviews the technical challenges in applying and validating molecular tools in various cytologic materials. Molecular Cytopathology will serve as a valuable resource for cytopathologists, cytotechnologists, pathology trainees, and clinicians with an interest in molecular applications in cytopathology.
Contents
1. Development and Validation of Molecular Testing on Cytologic Specimens -- 2. Molecular Techniques and Methods Applied in Cytology -- 3. Potential of Next-Generation Sequencing in Cytology -- 4. HPV Testing and Molecular Biomarkers in Cervical Cytology -- 5. Molecular Diagnostics in Thyroid Cytopathology -- 6. Molecular Markers in Head and Neck Cytology -- 7. Molecular Biomarkers in Pulmonary Cytology -- 8. Molecular Analysis of Breast Cancer in Cytology Samples -- 9. Molecular Pathology of Urine Cytology -- 10. Molecular Biomarkers of Pancreatobiliary and Gastrointestinal Tract Neoplasms -- 11. Molecular Biomarkers in Hematopoietic Neoplasms -- 12. Molecular Markers in Soft Tissue and Bone Tumors -- 13. Molecular Biomarkers in Body Fluid Cytology -- 14. Molecular Biomarkers in Prognostication of Uveal Melanoma -- 15. Current Status of Microfluidics-Assisted Cytology: The Application in Molecular Cytology.
Format
e-Book
Location
Online
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Molecular genetic pathology

https://libcat.nshealth.ca/en/permalink/provcat32564
Liang Cheng, David Y. Zhang, John N. Eble, editors. (2nd ed.) --New York, NY: Springer , c2013.
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Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high …
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Other Authors
Cheng, Liang
Zhang, David Y
Eble, John N
Responsibility
Liang Cheng, David Y. Zhang, John N. Eble, editors
Edition
2nd ed.
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xxi, 1136 p. : 442 ill., 347 ill. in color)
Series Title
Springer reference
ISBN
9781461448006
Subjects (MeSH)
Molecular Diagnostic Techniques
Pathology, Clinical - methods
Pathology, Molecular - methods
Abstract
Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.
Contents
Principles of Clinical Molecular Biology -- Principles of Clinical Cytogenetics -- Conceptual Evolution in Cancer Biology -- Genetic Inheritance and Population Genetics -- Clonality Analysis and Tumor of Unknown Primary: Applications in Modern Oncology and Surgical Pathology -- Modern Immunohistochemistry in Targeted Therapy -- Systems Pathology -- Diagnostic Methodology and Technology -- Clinical Flow Cytometry -- Clinical Genomics in Oncology -- Clinical Proteomics -- Nanotechnology in Molecular Diagnostics -- Gene Therapy: Vector Technology and Clinical Applications -- Instrumentation for Molecular Testing -- Tissue Microarrays and Biomarker Validation -- Laser Capture Microdissection -- Human Tissue Biorepository -- Pathology Informatics -- Prenatal Cytogenetic and Cytogenomic Diagnosis -- Molecular Medical Genetics -- Biochemical Genetics and Inborn Errors of Metabolism -- Molecular Genetics of Congenital Heart Disease -- Familial Cancer Syndromes -- Genetic Counseling -- Molecular Virology -- Molecular Bacteriology and Mycobacteriology -- Molecular Parasitology and Mycology -- Molecular Microbiology in Transplantation -- Molecular Microbiology Epidemiology -- Principle of Immunoglobulin and T Cell Receptor Gene Rearrangement -- Molecular Diagnostics of Lymphoblastic Leukemia and Lymphoma -- Molecular Diagnostics of Myeloid Neoplasms -- Molecular Diagnostics of Lymphoid Malignancies -- Molecular Diagnostics of Myeloproliferative Neoplasms and Myelodysplastic Syndromes -- Molecular Diagnostics of Lymphoproliferative Disorders -- Molecular Testing for Coagulation Abnormalities -- Molecular Hemoglobinopathies -- The HLA System and Transfusion Medicine: Molecular Approach -- Clinical Pharmacogenomics -- Molecular Forensic Pathology -- Specimen Identification and Bone Marrow Engraftment Analysis -- Circulating Tumor Cells: The Liquid Biopsy for Molecular Pathology -- Ethical and Legal Issues in Molecular Testing -- Regulatory Issues in Molecular Testing -- Molecular Pathology Reporting -- Quality Assurance and Laboratory Inspection.
Format
e-Book
Location
Online
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Molecular pathology and diagnostics of cancer

https://libcat.nshealth.ca/en/permalink/provcat33803
Domenico Coppola, editor. --Dordrecht: Springer , c2014.
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Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and …
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Other Authors
Coppola, Domenico
Responsibility
Domenico Coppola, editor
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (viii, 601 pages)
Series Vol.
v. 16
Series Title
Cancer growth and progression
ISBN
9789400771925 (electronic bk.)
9789400771918
Subjects (MeSH)
Neoplasms - diagnosis
Pathology, Molecular - methods
Subjects (LCSH)
Cancer - Molecular aspects
Cancer - Molecular diagnosis
Oncology
Pathology
Abstract
Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.
Contents
Molecular Pathology and Diagnostics of Gliomas -- Molecular Pathology and Diagnostics of Thyroid and Parathyroid Malignancies -- Molecular Pathology and Diagnostics of Breast Cancer -- Molecular Pathology and Diagnostics of Non-Small Cell Lung Carcinoma -- Molecular Pathology and Diagnostics of Colorectal Cancer -- Molecular Pathology and Diagnostics in Esophago-Gastric Cancer -- Molecular-Genetic Testing in Hepatocellular Carcinoma and Its Premalignant Conditions -- Molecular Diagnostics of Pancreatic Cancer -- Molecular Pathology and Diagnostics of Prostate Cancer -- Molecular Diagnosis of Bladder and Kidney Cancer -- Molecular-Genetic Testing in Penile, Scrotal, and Testicular Cancer -- Molecular Pathology and Diagnostics of Gynecologic Malignancies -- Molecular Pathology of Bone and Soft Tissue Neoplasms and Potential Targets for Novel Therapy -- Molecular Pathology and Diagnostics of Pancreatic Endocrine Neoplasms -- Molecular Pathology and Diagnostics of Childhood Tumors -- Molecular Pathology and Diagnostics of Cutaneous Malignancy -- Molecular Diagnostics of Lymphoid Neoplasms -- Molecular Diagnostics of Myeloid Neoplasms.
Format
e-Book
Location
Online
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Molecular pathology : a practical guide for the surgical pathologist and cytopathologist

https://libcat.nshealth.ca/en/permalink/provcat34800
edited by John M.S. Bartlett, Abeer Shaaban, Fernando Schmitt. --Cambridge, UK: Cambridge University Press , 2015.
Call Number
QZ 50 M718 2015
Location
Dickson Building
"This practical manual provides a comprehensive yet concise guide to state-of-the-art molecular techniques and their applications. It starts with an overview of the essential principles of molecular techniques, followed by separate chapters detailing the use of these techniques in particular tissues and organs, and describing recommended treatment plans. Each chapter covers the tests available, their advantages, limitations, and use as diagnostic and prognostic tools, with key learning points a…
Call Number
QZ 50 M718 2015
Other Authors
Bartlett, John M.S.
Shaaban, Abeer
Schmitt, Fernando
Responsibility
edited by John M.S. Bartlett, Abeer Shaaban, Fernando Schmitt
Place of Publication
Cambridge, UK
Publisher
Cambridge University Press
Date of Publication
2015
Physical Description
xix, 396 pages
Series
Cambridge medicine
Series Title
Cambridge medicine (Series)
ISBN
9781107443464
Subjects (MeSH)
Pathology, Molecular - methods
Molecular Diagnostic Techniques - methods
Abstract
"This practical manual provides a comprehensive yet concise guide to state-of-the-art molecular techniques and their applications. It starts with an overview of the essential principles of molecular techniques, followed by separate chapters detailing the use of these techniques in particular tissues and organs, and describing recommended treatment plans. Each chapter covers the tests available, their advantages, limitations, and use as diagnostic and prognostic tools, with key learning points at the end of each topic. Using both histologic and cytologic samples, it discusses how to interpret test results in a pathologic context and enables trainees and practising pathologists to gain an in-depth understanding of molecular diagnostic techniques and how to incorporate them into routine diagnostic practice. Aiding the daily practice of refining diagnosis, as well as offering a didactic approach, this book is an essential reference for practising pathologists and cytopathologists as well as trainees in pathology"--Provided by publisher.
Contents
Preface -- 1. An introduction to molecular pathology / John M. S. Bartlett -- 2. Molecular regulation of cellular function / Marsela Braunstein and John M. S. Bartlett -- 3. Practical application of molecular techniques in diagnostic histopathology and cytopathology and clinical management / Abeer Shaaban and Fernando Schmitt -- 4. Fluorescent and non-fluorescent in situ hybridization / Jane Bayani and John M. S. Bartlett -- 5. Clinical applications of the polymerase chain reaction for molecular pathology / Angela B. Y. Hui, Annette D. Wong and Carlo V. Hojilla -- 6. Are microarrays ready for prime time? / Jane Bayani and John M. S. Bartlett -- 7. Tissue microarrays / Luigi Tornillo -- 8. Sequencing / Andrew M. K. Brown, Philipe C. Zuzarte and Paul M. Krzyzanowski -- 9. Microsatellite instability in colorectal cancer / Maria Sofia Fernandes, Raquel Seruca and Se;rgia Velho -- 10. Mutational analysis / Aaron R. Hansen, Mahadeo A. Sukhai, Hal K. Berman, Suzanne Kamel-Reid and Philippe L. Bedard -- 11. Tumors of the breast / Cathy B. Moelans, Petra van der Groep, Robert Kornegoor, Jelle Wesseling and Paul J. van Diest -- 12. Tumors of the female genital system / Adhemar Longatto Filho, Sigurd F. Lax and Bin Yang -- 13. Tumours of the male urogenital system / Kirsten D. Mertz and Lukas Bubendorf -- 14. Tumors of the gastrointestinal system / Manuel Salto-Tellez, Benedict Yan, Roseann I. Wu and Martha Bishop Pitman -- 15. Soft tissue, bone and skin tumours / Stamatios Theocharis and Jerzy Klijanienko -- 16. Cardio-thoracic tumors / Umberto Malapelle, Claudio Bellevicine, Elena Vigliar and Giancarlo Troncone -- 17. Tumors of the endocrine system / Sylvia L. Asa and Ozgur Mete -- 18. Haematological malignancies of the lymph nodes / Sarah E. Coupland and Pedro Farinha -- 19. Pediatric tumors / Paul Roberts, Susan Picton and Jens Stahlschmidt -- 20. Serous effusions / Ben Davidson -- 21. Academic applications and future of molecular pathology / Manuel Salto-Tellez and Benedict Yan -- Index.
Format
Book
Location
Dickson Building
Copies
1
Loan Period
3 weeks
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Molecular Pathology in Clinical Practice

https://libcat.nshealth.ca/en/permalink/provcat39809
Debra G.B. Leonard, editor. (Second edition) --Cham: Springer , c2016.
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Location
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This authoritative textbook offers in-depth coverage of all aspects of molecular pathology practice and embodies the current standard in molecular testing. Since the successful first edition, new sections have been added on pharmacogenetics and genomics, while other sections have been revised and updated to reflect the rapid advances in the field. The result is a superb reference that encompasses molecular biology basics, genetics, inherited cancers, solid tumors, neoplastic hematopathology, in…
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Other Authors
Leonard, Debra G.B
Responsibility
Debra G.B. Leonard, editor
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xix, 1001 p. : 219 illus., 132 illus. in color)
ISBN
9783319196749
9783319196732 (print ed.)
Subjects (MeSH)
Genetic Testing - methods
Molecular Diagnostic Techniques
Pathology, Molecular - methods
Abstract
This authoritative textbook offers in-depth coverage of all aspects of molecular pathology practice and embodies the current standard in molecular testing. Since the successful first edition, new sections have been added on pharmacogenetics and genomics, while other sections have been revised and updated to reflect the rapid advances in the field. The result is a superb reference that encompasses molecular biology basics, genetics, inherited cancers, solid tumors, neoplastic hematopathology, infectious diseases, identity testing, HLA typing, laboratory management, genomics, and proteomics. Throughout the text, emphasis is placed on the molecular variations being detected, the clinical usefulness of the tests, and important clinical and laboratory issues. The second edition of Molecular Pathology in Clinical Practice will be an invaluable source of information for all practicing molecular pathologists and will also be of utility for other pathologists, clinical colleagues, and trainees.
Contents
I. Genetics -- II. Inherited Cancers -- III. Solid Tumors -- IV. Neoplastic Hematopathology -- V. Infectious Diseases -- VI. Identity Testing -- VII. HLA Typing -- VIII. Evolving Clinical Molecular Technologies -- IX. Laboratory Management.
Format
e-Book
Location
Online
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Molecular Pathology of Gynecologic Cancer

https://libcat.nshealth.ca/en/permalink/provcat30336
edited by Antonio Giordano, Alessandro Bovicelli, Robert J. Kurman. --Totowa, NJ: Humana Press , c2007.
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Location
Online
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Author
Giordano, Antonio
Other Authors
Bovicelli, Alessandro
Kurman, Robert J
Responsibility
edited by Antonio Giordano, Alessandro Bovicelli, Robert J. Kurman
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2007
Series Title
Current clinical oncology
ISBN
9781597453462
Subjects (MeSH)
Genital Neoplasms, Female - etiology
Genital Neoplasms, Female - genetics
Genital Neoplasms, Female - physiopathology
Pathology, Molecular - methods
Subjects (LCSH)
Oncology
Gynecology
Pathology
Format
e-Book
Location
Online
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Molecular Pathology of Lung Cancer

https://libcat.nshealth.ca/en/permalink/provcat30969
Philip T. Cagle ... [et al.], editors. --New York, NY: Springer , c2012.
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Location
Online
As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, …
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Other Authors
Cagle, Philip T
Responsibility
Philip T. Cagle ... [et al.], editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xi, 216 p. : 46 ill. in color)
Series Vol.
v. 6
Series Title
Molecular pathology library
ISBN
9781461431978
Subjects (MeSH)
Lung Neoplasms - pathology
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Subjects (LCSH)
Oncology
Pathology
Thoracic surgery
Abstract
As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
Contents
Part I. Molecular Pathology of Lung Cancer: General Principles -- Approach to Personalized Care of the Lung Cancer Patient -- Etiology of Lung Cancer -- Genetic Susceptibility to Lung Cancer -- Lung Cancer Stem Cells -- The Classification of Pre-Invasive Lesions -- Molecular Pathology of Precursor and Pre-Invasive Lesions -- Revised Classification for Adenocarcinoma -- Molecular Basis for the Current Lung Cancer Classification -- Molecular Diagnosis of Lung Cancer -- Molecular Targeted Therapy of Lung Cancer -- Molecular Prognostic Markers of Lung Cancer -- New Techniques for Optical and Molecular Visualization of Lung Cancer -- Part II. Molecular Pathology of Lung Cancer: Specific Histologic Types -- Adenocarcinoma -- Squamous Cell Carcinoma -- Molecular Pathology of Large Cell Carcinoma -- Molecular Pathology of Small Cell Carcinomas -- Molecular Biopsy of Neuroendocrine Carcinomas Other Than Small Cell Carcinoma -- Molecular Pathology of Uncommon Carcinomas -- Biology of Lung Cancer Metastases.
Format
e-Book
Location
Online
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Pediatric Neoplasia : Advances in Molecular Pathology and Translational Medicine

https://libcat.nshealth.ca/en/permalink/provcat31030
Alexander Craig Mackinnon, Jr., editor. --New York, NY: Humana Press , c2012.
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Location
Online
Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts …
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Other Authors
Mackinnon, Alexander Craig
Responsibility
Alexander Craig Mackinnon, Jr., editor
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2012
Physical Description
1 online resource (ix, 267 p. : 76 ill., 73 ill. in color)
Series Title
Molecular and translational medicine
ISBN
9781627031165
Subjects (MeSH)
Neoplasms - pathology
Pathology, Molecular - methods
Pediatrics
Translational Medical Research - methods
Subjects (LCSH)
Oncology
Pathology
Pediatrics
Abstract
Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts in their field with subspecialty training and extensive clinical experience. Each chapter describes a variable number of tumors and includes an overview of the classification system and clinicopathological characteristics of each tumor. This is followed by a discussion of the molecular pathology relevant to a specific tumor, including specific molecular markers of the tumors, methods used for diagnosis or clinical management, clinical significance of the markers, and if appropriate, a description or discussion of current activities in translational research or issues that need to be addressed in the future. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine will be of great value to pathologists, oncologists, hematologists, internal medicine and pediatric specialists, as well as pharmaceutical professionals and translational and clinical researchers.
Contents
1. Towards Personalized Medicine in Pediatric Cancer: Genome-Wide Strategies to Investigate Cancer Risk and Response to Therapy -- 2. Acute Leukemia -- 3. Molecular Techniques Used in Evaluation of Pediatric Acute Leukemia -- 4. Myelodysplasia and Myeloid Proliferations -- 5. Childhood Lymphoma -- 6. Children are Not Small Adults: Importance of Molecular Analysis for Diagnosis, Prognosis, and Treatment of Pediatric CNS Tumors -- 7. Pediatric Bone Tumors -- 8. Soft Tissue "Small Round Blue Cell Tumors" of Childhood -- 9. Fibroblastic and Myofibroblastic Pediatric Soft Tissue Tumors -- 10. Molecular Analysis in Pediatric Renal Tumors -- 11. Hepatoblastoma: New Insights into the Biology of Embryonal Tumors of the Liver.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Bladder Cancer

https://libcat.nshealth.ca/en/permalink/provcat42915
edited by Donna E. Hansel, Seth P. Lerner. --Cham, Switzerland: Springer , c2018.
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Location
Online
This succinct yet comprehensive volume describes current and emerging concepts in molecular pathology of bladder cancer. Divided into two distinct sections, the first part focuses on the general principles of molecular findings in bladder cancer, while the second part focuses on the molecular changes associated with specific histologic subtypes. The volume also addresses such topics as molecular alterations in non-invasive and invasive disease, including bladder cancer variants as appropriate, …
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Other Authors
Hansel, Donna E.
Lerner, Seth P.
Responsibility
edited by Donna E. Hansel, Seth P. Lerner
Place of Publication
Cham, Switzerland
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (ix, 243 p.) : 40 illus., 38 illus. in color
Series Title
Molecular pathology library
ISBN
9783319647692
9783319647678 (print ed.)
9783319647685 (print ed.)
9783319878676 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Pathology, Molecular - methods
Precision Medicine - methods
Urinary Bladder Neoplasms
Specialty
Medical Oncology
Molecular Medicine
Pathology
Precision Medicine
Urology
Abstract
This succinct yet comprehensive volume describes current and emerging concepts in molecular pathology of bladder cancer. Divided into two distinct sections, the first part focuses on the general principles of molecular findings in bladder cancer, while the second part focuses on the molecular changes associated with specific histologic subtypes. The volume also addresses such topics as molecular alterations in non-invasive and invasive disease, including bladder cancer variants as appropriate, emerging molecular classifiers of bladder cancer, and molecular associations to outcome and treatment. Written by experts in the field, Precision Molecular Pathology of Bladder Cancer is a valuable resource for those in the urologic community, including urologic pathologists, urologists, urologic oncologists and radiation oncologists, who treat and manage bladder cancer.
Contents
1. Risk Factors and Molecular Features Associated with Bladder Cancer Development -- 2. Grading, Staging, and Morphologic Risk Stratification of Bladder Cancer -- 3. Genomic Assessment of Muscle-Invasive Bladder Cancer: Insights from The Cancer Genome Atlas (TCGA) Project -- 4. Molecular Alterations in the Pathogenesis of Bladder Cancer Subtypes and Urothelial Carcinoma Variants -- 5. Treatment Paradigms in Bladder Cancer: Clinical Implications of Histological and Molecular Analysis -- 6. Requisite for Collection and Distribution of Tissue and Fluid Specimens for Molecular Diagnostics and Discovery in Bladder Cancer -- 7. Diagnostic, Prognostic and Predictive Biomarkers on Bladder Tissue and Blood -- 8. Urine Cytology and Existing Urinary Biomarkers for Bladder Cancer -- 9. Molecular Targeted Therapy of Bladder Cancer -- 10. Response to Immunotherapy: Application of Molecular Pathology to Predict Successful Response -- 11. Emerging Molecular Approaches in the Analysis of Urine in Bladder Cancer Diagnosis -- 12. Stromal Contributions to Tumor Progression in Urothelial Carcinoma of the Bladder -- 13. Modeling Bladder Cancer with Genetic Engineering: Fidelity of Human-to-laboratory Models.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Breast Cancer

https://libcat.nshealth.ca/en/permalink/provcat39035
Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil, editors. (1st ed.) --New York, NY: Springer , c2015.
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This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters pre…
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Other Authors
Khan, Ashraf
Ellis, Ian O
Hanby, Andrew M
Cosar, Ediz F
Rakha, Emad A
Kandil, Dina
Responsibility
Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil, editors
Edition
1st ed.
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (x, 338 p. : 29 illus., 28 illus. in color)
Series Vol.
10
Series Title
Molecular pathology library
ISBN
9781493928866
9781493928859 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Breast neoplasms - pathology
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Abstract
This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2. Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.
Contents
Molecular basis of breast cancer imaging -- Familial Breast Cancer and Genetic Predisposition in Breast Cancer -- Modelling the Molecular Pathology of Breast Cancer Initiation -- Molecular Pathology of Precancerous Lesions of the Breast -- Breast Cancer Stem Cells: Role in Tumor Initiation, Progression and Targeted Therapy -- Molecular Pathology of Pre-Invasive Ductal Carcinoma -- Molecular Pathology of Lobular Carcinoma -- Molecular Pathology of Hormone Regulation in Breast Cancer: Hormone Receptor Evaluation and Therapeutic Implications -- Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2 Evaluation and Role in Targeted Therapy -- Molecular Classification of Breast Cancer -- Triple-Negative Breast Cancer: Subtypes with Clinical Implications -- Molecular-based Diagnostic, Prognostic and Predictive Tests in Breast Cancer -- Role of MicroRNAs in Breast Cancer -- Molecular Pathology of Fibroepithelial Neoplasms of the Breast -- Molecular Features of Mesenchymal Tumors of the Breast -- Molecular Pathology of Breast Cancer Metastasis -- The molecular pathology of chemoresistance during the therapeutic response in breast cancer -- The Molecular Pathology of Male Breast Cancer -- Specimens for Molecular Testing in Breast Cancer.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Dermatologic Diseases

https://libcat.nshealth.ca/en/permalink/provcat39034
Victor G. Prieto, editor. --New York, NY: Springer , c2015.
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This volume is a concise yet comprehensive resource for physicians dealing with, and interested in, the field of molecular pathology in dermatopathology. The book includes descriptions of the techniques and their application to cutaneous diseases and describes possible future techniques and their use in dermatopathology. Special emphasis is also given to the practical application of these techniques to particular situations illustrated by demonstrative cases. Written by experts in their fields,…
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Other Authors
Prieto, Victor G
Responsibility
Victor G. Prieto, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (viii, 136 p. : 40 illus., 39 illus. in color)
Series Title
Molecular pathology library
ISBN
9781493928613
9781493928606 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Molecular Diagnostic Techniques - methods
Pathology, Molecular - methods
Skin Diseases - pathology
Abstract
This volume is a concise yet comprehensive resource for physicians dealing with, and interested in, the field of molecular pathology in dermatopathology. The book includes descriptions of the techniques and their application to cutaneous diseases and describes possible future techniques and their use in dermatopathology. Special emphasis is also given to the practical application of these techniques to particular situations illustrated by demonstrative cases. Written by experts in their fields, Precision Molecular Pathology of Dermatologic Diseases is of great value to pathologists, dermatologists, residents and fellows, internists, and general practitioners who deal with dermatologic diseases.
Contents
Introduction -- Hematolymphoid Proliferations of the Skin -- Molecular Testing in Cutaneous Mesenchymal Tumors -- Molecular Pathology of Cutaneous Adnexal Tumors -- Infectious diseases of the skin -- Application of Molecular Pathology to Cutaneous Melanocytic Lesions -- Application of Molecular Pathology to Tissue Identification in Cutaneous Pathology.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Hodgkin Lymphoma

https://libcat.nshealth.ca/en/permalink/provcat43258
S. David Hudnall, Ralf Küppers, editors. --Cham: Springer , c2018.
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This text provides a comprehensive and up-to-date overview of Hodgkin lymphoma. The volume reviews every facet of the cancer in great detail, including pathology, pathobiology, molecular genetics, microenvironment, epidemiology, treatment, and new therapeutic advances. The specific role of the lymphoma microenvironment is addressed, and the relationship of Hodgkin lymphoma to related non-Hodgkin lymphomas is covered as well. Written by experts in the field, Precision Molecular Pathology of Hodg…
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Other Authors
Hudnall, S. David
Küppers, Ralf
Responsibility
S. David Hudnall, Ralf Küppers, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (x, 236 p.) : 47 illus. in color
Series Vol.
16
Series Title
Molecular pathology library
ISBN
9783319680941
9783319680934 (print ed.)
9783319680958 (print ed.)
9783319885476 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Hodgkin Disease - physiopathology
Hodgkin Disease - therapy
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Precision Medicine - methods
Specialty
Medical Oncology
Molecular Medicine
Pathology
Precision Medicine
Abstract
This text provides a comprehensive and up-to-date overview of Hodgkin lymphoma. The volume reviews every facet of the cancer in great detail, including pathology, pathobiology, molecular genetics, microenvironment, epidemiology, treatment, and new therapeutic advances. The specific role of the lymphoma microenvironment is addressed, and the relationship of Hodgkin lymphoma to related non-Hodgkin lymphomas is covered as well. Written by experts in the field, Precision Molecular Pathology of Hodgkin Lymphoma is a valuable resource for oncologists, surgeons, pathologists, clinical trainees, and investigators engaged in the diagnosis, treatment, and research studies of this lymphoid neoplasm.
Contents
1. Clinical Features of Hodgkin Lymphoma -- 2. Pathology of Hodgkin Lymphoma -- 3. Pathogenesis and Molecular Genetics of Hodgkin Lymphoma -- 4. Targeting the Microenvironment in Hodgkin Lymphoma: Opportunities and Challenges -- 5. Role of EBV in Classical Hodgkin Lymphoma -- 6. Pathobiology of Nodular Lymphocyte Predominant Hodgkin Lymphoma -- 7. Composite Lymphomas and the Relationship of Hodgkin Lymphoma to Non-Hodgkin Lymphomas -- 8. The Epidemiology of Hodgkin Lymphoma -- 9. Treatment and Prognosis -- 10. Novel Targeted Therapies in Hodgkin Lymphoma.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Liver Cancer

https://libcat.nshealth.ca/en/permalink/provcat43315
Chen Liu, editor. --Cham: Springer , c2018.
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This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available kno…
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Other Authors
Liu, Chen
Responsibility
Chen Liu, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xi, 271 p.) : 30 illus., 22 illus. in color
Series Vol.
14
Series Title
Molecular pathology library
ISBN
9783319680828
9783319680804 (print ed.)
9783319680811 (print ed.)
9783319885438 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Precision Medicine - methods
Specialty
Gastroenterology
Medical Oncology
Molecular Medicine
Pathology
Precision Medicine
Abstract
This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available knowledge, the book also discusses the future development of a precision and personalized medicine approach for HCC. Written by experts in the field, Precision Molecular Pathology of Liver Cancer is a concise yet comprehensive resource for practitioners who treat patients with hepatocellular carcinoma.
Contents
1. Etiology and Pathogenesis of Hepatocellular Carcinoma -- 2. Histologic Classification of Hepatocellular Carcinoma and Its Clinical Implications -- 3. Molecular Classification of Hepatocellular Carcinoma and Precision Medicine -- 4. Genomics Studies in Hepatocellular Carcinoma via Next-Generation Sequencing -- 5. Epigenetic Regulations in the Pathogenesis of HCC and the Clinical Application -- 6. Biomarker Discovery and Validation in HCC Diagnosis, Prognosis, and Therapy -- 7. Imaging of Hepatocellular Carcinoma -- 8. Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma -- 9. Hepatocellular Carcinoma Metastasis and Circulating Tumor Cells -- 10. Immune Regulation in HCC and the Prospect of Immunotherapy -- 11. Liver Cell Dysplasia and the Development of HCC -- 12. Locoregional Therapies for Hepatocellular Carcinoma -- 13. The Future Prospect of Targeted Therapy in Hepatocellular Carcinoma.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Lung Cancer

https://libcat.nshealth.ca/en/permalink/provcat43227
Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier, Eric H. Bernicker, editors. (Second edition) --Cham: Springer , c2018.
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This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, …
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Other Authors
Cagle, Philip T.
Responsibility
Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier, Eric H. Bernicker, editors
Edition
Second edition
Former Title
Molecular pathology of lung cancer
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 296 p.) : 57 illus., 55 illus. in color
Series Vol.
13
Series Title
Molecular pathology library
ISBN
9783319629414
9783319629407 (print ed.)
9783319629421 (print ed.)
9783319874340 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Lung Neoplasms - pathology
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Precision Medicine - methods
Specialty
Medical Oncology
Molecular Medicine
Pathology
Pulmonary Medicine
Precision Medicine
Notes
Preceded by: Molecular pathology of lung cancer / Philip T. Cagle ... [et al.], editors. c2012.
Abstract
This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and precursor and preinvasive lesions. Authored by experts in the field, Precision Molecular Pathology of Lung Cancer, Second Edition remains one of the few books that comprehensively covers the new molecular pathology of lung cancer and is a valuable resource for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, and thoracic radiologists.
Contents
Part I. Background -- 1. Precision Medicine of Lung Cancer: Introduction -- 2. Lung Cancer Epidemiology and Demographics -- 3. Genetic Susceptibility to Lung Cancer -- 4. Lung Cancer Stem Cells -- 5. The 2015 World Health Organization Classification of Lung Cancer: Overview -- Part II. Testing Methods -- 6. Preanalytic Considerations -- 7. Mutation Testing of Lung Cancer Biomarkers -- 8. Translocation Testing of Lung Cancer Biomarkers -- 9. Immunohistochemistry of Lung Cancer Biomarkers -- 10. Next Generation and Third Generation Sequencing of lung cancer biomarkers -- Part III. Molecular Pathology of Specific Cell Types -- 11. Mutations as Predictive Biomarkers for Adenocarcinoma -- 12. Translocations as Predictive Biomarkers for Adenocarcinoma -- 13. Predictive Biomarkers for Squamous Cell Carcinoma -- 14. Molecular Pathology of Small Cell Carcinoma -- 15. Molecular Pathology of Uncommon Carcinomas -- 16. Molecular Pathology of Lung Cancer Metastases -- 17. Molecular Pathology of Precursor and Preinvasive Lesions -- Part IV. General and Emerging Fields in Molecular Pathology of Lung Cancer -- 18. Prognostic Biomarkers in Lung Cancer -- 19. Biomarkers and Differing Therapy Modalities -- 20. Immuno-oncology of Lung Cancer -- 21. Liquid Biopsy.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Myeloid Neoplasms

https://libcat.nshealth.ca/en/permalink/provcat43385
Chung-Che (Jeff) Chang, Robert S. Ohgami, editors. --Cham: Springer , c2018.
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This volume provides a comprehensive, state-of-the art review of myeloid neoplasms. The book presents updated information on epidemiology, clinical presentation, morphologic findings, molecular genomic abnormalities, pathogenesis, and target therapies. The text helps to guide accurate diagnosis, the administration of appropriate ancillary molecular tests, patient management, and investigative efforts. Written by experts in the field, Precision Molecular Pathology of Myeloid Neoplasms serves as …
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Other Authors
Chang, Chung-Che (Jeff)
Ohgami, Robert S.
Responsibility
Chung-Che (Jeff) Chang, Robert S. Ohgami, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xi, 427 p.) : 84 illus., 66 illus. in color
Series Vol.
12
Series Title
Molecular pathology library
ISBN
9783319621463
9783319621449 (print ed.)
9783319621456 (print ed.)
9783319872414 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Bone Marrow Neoplasms - pathology
Leukemia, Myeloid - pathology
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Precision Medicine - methods
Specialty
Hematology
Medical Oncology
Molecular Medicine
Pathology
Precision Medicine
Abstract
This volume provides a comprehensive, state-of-the art review of myeloid neoplasms. The book presents updated information on epidemiology, clinical presentation, morphologic findings, molecular genomic abnormalities, pathogenesis, and target therapies. The text helps to guide accurate diagnosis, the administration of appropriate ancillary molecular tests, patient management, and investigative efforts. Written by experts in the field, Precision Molecular Pathology of Myeloid Neoplasms serves as a valuable resource for pathologists, hematologists/oncologists, fellows, and researchers in understanding the molecular pathology of myeloid neoplasms.
Contents
1. Acute Myeloid Leukemia with Recurrent Genetic Abnormalities, Part I: Cytogenetic Abnormalities -- 2. Acute Myeloid Leukemia with Recurrent Genetic Abnormalities, Part II: Mutations Involving CEBPA, NPM1, and RUNX1 -- 3. Acute Myeloid Leukemia with Myelodysplasia-Related Changes, Therapy-Related Myeloid Neoplasms, and Acute Myeloid Leukemia, Not Otherwise Specified -- 4. Myelodysplastic Syndrome -- 5. Chronic Myeloid Leukemia, BCR-ABL1 Positive -- 6. Updates in Polycythemia Vera -- 7. Essential Thrombocythemia -- 8. Primary Myelofibrosis -- 9. Mastocytosis -- 10. Chronic Myeloproliferative Neoplasm, Rare Types -- 11. Atypical Chronic Myeloid Leukemia, BCR/ABL1 Negative -- 12. Chronic Myelomonocytic Leukemia: Clinical and Pathologic Features -- 13. Juvenile Myelomonocytic Leukemia -- 14. Down Syndrome-Associated Hematologic Disorders and Leukemia -- 15. Inherited and Acquired Myeloid Neoplasms of Childhood -- 16. Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, FGFR1, or t(8;9)(p22;p24.1);PCM1-JAK2 -- 17. Mixed Phenotype Acute Leukemia -- 18. Blastic Plasmacytoid Dendritic Cell Neoplasm -- 19. Existing and Emerging Molecular Technologies in Myeloid Neoplasms.
Format
e-Book
Location
Online
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Precision Molecular Pathology of Neoplastic Pediatric Diseases

https://libcat.nshealth.ca/en/permalink/provcat42616
Larissa V. Furtado, Aliya N. Husain, editors. --Cham: Springer , c2018.
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This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their mole…
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Other Authors
Furtado, Larissa V.
Husain, Aliya N.
Responsibility
Larissa V. Furtado, Aliya N. Husain, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 360 p.) : 64 illus., 63 illus. in color
Series Title
Molecular pathology library
ISBN
9783319896267
9783319896250 (print ed.)
9783319896274 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Child
Neoplasms - pathology
Pathology, Molecular - methods
Precision Medicine - methods
Specialty
Medical Oncology
Molecular Medicine
Pathology
Pediatrics
Precision Medicine
Abstract
This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care. Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.
Contents
Part I. Molecular Pathology of Pediatric Neoplasms: General Principles -- 1. Principles of Molecular Biology and Oncogenesis -- 2. Molecular Methods in Oncology: Targeted Mutational Analysis -- 3. Molecular Methods in Oncology: Genomic Analysis -- 4. Molecular Testing in Pediatric Oncology Practice -- 5. Molecular Targeted Therapy of Pediatric Neoplasms -- Part II. Molecular Pathology of Specific Pediatric Neoplasms -- 6. Hematolymphoid System -- 7. Pediatric Brain Tumors -- 8. Neuroblastoma and Neuroblastic Tumors -- 9. Soft Tissue and Bone Neoplasms -- 10. Skin, Melanocytic Neoplasms -- 11. Salivary Gland, Thyroid, and Parathyroid Neoplasms: Molecular Features -- 12. Cardiovascular and Respiratory Systems -- 13. Gastrointestinal Tract -- 14. Liver and Pancreas -- 15. Molecular Pathology of Pediatric Renal Tumors.
Format
e-Book
Location
Online
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