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70 Years of Levothyroxine

https://libcat.nshealth.ca/en/permalink/provcat46285
George J. Kahaly, editor. --Cham: Springer , c2021.
Available Online
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Access
Open access
Location
Online
Available Online
View e-Book
Other Authors
Kahaly, George J.
Responsibility
George J. Kahaly, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2021
Physical Description
1 online resource (xvii, 129 pages)
ISBN
9783030632779
Subjects (MeSH)
Thyroid Diseases - drug therapy
Thyroxine - therapeutic use
Specialty
Endocrinology
Pharmacology
Access
Open access
Format
e-Book
Location
Online
Less detail

ACEi and ARBS in Hypertension and Heart Failure

https://libcat.nshealth.ca/en/permalink/provcat39106
Pasquale Perrone Filardi, editor. --Cham: Springer International Publishing : Imprint: Springer ; ISCP , c2015.
Available Online
View e-Book
Location
Online
This book summarizes how the renin angiotensin system is implicated in the progression of atherosclerotic disease as well as of left ventricular dysfunction and reviews the action of angiotensin converting enzyme inhibitors and AT1 receptor antagonists on reducing morbidity and mortality in patients with left ventricular dysfunction or in those at high cardiovascular risk with preserved ventricular function. ACEi and ARBS in Hypertension and Heart Failure is a highly practical reference reviewi…
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Other Authors
Perrone Filardi, Pasquale
Other Authors
International Society of Cardiovascular Pharmacotherapy
Responsibility
Pasquale Perrone Filardi, editor
Alternate Title
Angiotensin converting enzyme inhibitors and angiotensin II receptor blockers in hypertension and heart failure
Place of Publication
Cham
Publisher
Springer International Publishing : Imprint: Springer ; ISCP
Date of Publication
c2015
Physical Description
1 online resource (x, 150 p. : 19 illus., 13 illus. in color)
Series Title
Current cardiovascular therapy
ISBN
9783319097886
9783319097879 (print ed.)
Subjects (MeSH)
Angiotensin II Type 1 Receptor Blockers
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Heart Failure - drug therapy
Hypertension - drug therapy
Renin-Angiotensin System
Abstract
This book summarizes how the renin angiotensin system is implicated in the progression of atherosclerotic disease as well as of left ventricular dysfunction and reviews the action of angiotensin converting enzyme inhibitors and AT1 receptor antagonists on reducing morbidity and mortality in patients with left ventricular dysfunction or in those at high cardiovascular risk with preserved ventricular function. ACEi and ARBS in Hypertension and Heart Failure is a highly practical reference reviewing the evidence and providing a rationale for the appropriate use of RAS antagonists in cardiovascular diseases. It is written in an easy-to-follow format and with many illustrations to aid clarity and the assimilation of information. Each chapter is written by established authorities in their fields who are also experienced in explaining often complex concepts. The result is a unique book which is not only comprehensive but also clear and useful for the busy medical practitioner.
Contents
1. Angiotensin Converting Enzyme Inhibitors and AT1 Antagonists for Treatment of Hypertension -- 2. ACE Inhibitor and Renin–Angiotensin System the Cornerstone of Therapy for Systolic Heart Failure -- 3. Impact of Chronic Kidney Disease and Diabetes Mellitus on Choice of Renin Angiotensin System: Inhibitors in Patients with Hypertension and Heart Failure -- 4. Target Organ Damage and RAAS Blockade.
Format
e-Book
Location
Online
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Advances in Psoriasis : A Multisystemic Guide

https://libcat.nshealth.ca/en/permalink/provcat46447
Jeffrey M. Weinberg, Mark Lebwohl, editors. (Second edition) --Cham: Springer , c2021.
Available Online
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Access
NEW Springer 2021
Location
Online
This extensively revised second edition provides an up-to-date and highly informative textbook on psoriasis. The understanding of the mechanisms behind the disease and the available treatment options have continued to develop rapidly in recent times, with this vital resource covering the latest in these management options, including targeted T-cell therapy, the use of immunomodulators, systemic therapies, and ultraviolet and laser therapy. In addition, it provides a detailed overview of the pat…
Available Online
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Other Authors
Weinberg, Jeffrey M.
Lebwohl, Mark
Responsibility
Jeffrey M. Weinberg, Mark Lebwohl, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2021
Physical Description
1 online resource (vi, 423 p.) : 54 illus., 45 illus. in color
ISBN
9783030548599
9783030548582 (Print ed.)
9783030548605 (Print ed.)
9783030548612 (Print ed.)
Subjects (MeSH)
Psoriasis - drug therapy
Psoriasis - physiopathology
Specialty
Dermatology
Pharmacology
Abstract
This extensively revised second edition provides an up-to-date and highly informative textbook on psoriasis. The understanding of the mechanisms behind the disease and the available treatment options have continued to develop rapidly in recent times, with this vital resource covering the latest in these management options, including targeted T-cell therapy, the use of immunomodulators, systemic therapies, and ultraviolet and laser therapy. In addition, it provides a detailed overview of the pathophysiology, comorbidities, epidemiology and triggers of the disease. Advances in Psoriasis: A Multisystemic Guide extensively details the scientific basis and practice management of psoriasis. It is therefore a vital resource for practicing and trainee dermatologists looking to develop their clinical knowledge of how to manage and treat these patients.
Contents
Introduction to and History of Psoriasis and Psoriasis Therapy -- Pathophysiology of Psoriasis/Novel Pathways -- Psoriasis: Clinical Review and Update -- Psoriasis: Epidemiology, Potential Triggers, Disease Course -- Topical Therapy I: Corticosteroids and Vitamin D Analogues -- Topical Therapy II: Retinoids, Immunomodulators, and Others -- Topical Therapy II: Retinoids, Immunomuodulators, and Others/ Ultraviolet Therapy for Psoriasis -- Laser Therapy for Psoriasis -- Traditional Systemic Therapy I: Methotrexate and Cyclosporine -- Traditional Systemic Therapy II: Retinoids and Others -- Apremilast -- Etanercept -- Adalimumab -- Infliximab, Golimumab , and Certolizumab Pegol -- Ustekinumab -- Guselkumab -- Tidrakizumab -- Risankizumab -- Secukinumab -- Ixekizumab -- Brodalumab -- Biosimilars for Psoriasis -- Research Pipeline I: Oral Therapeutics for Psoriasis -- Research Pipeline II: Upcoming Biologic Therapies -- Pediatric Psoriasis -- Challenges in Psoriasis Treatment: Nail, Scalp, and Palmoplantar Involvement -- Psoriasis and Comorbidities -- Summary of Published Treatment Guidelines.
Access
NEW Springer 2021
Format
e-Book
Location
Online
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American journal of pharmaceutical education

https://libcat.nshealth.ca/en/permalink/provcat43427
American Association of Colleges of Pharmacy
Available Online
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Holdings
Vol 68, 2004 -
Location
Online
Available Online
View e-Journal
Publisher
American Association of Colleges of Pharmacy
Holdings
Vol 68, 2004 -
Publication Frequency
Quarterly
ISSN
1553-6467
Specialty
Pharmacology
Format
e-Journal
Location
Online
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American Psychiatric Association Publishing textbook of psychopharmacology, The

https://libcat.nshealth.ca/en/permalink/provcat50338
Schatzberg, Alan F. (5th ed.) --Arlington, VA: American Psychiatric Association Publishing , 2017.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Schatzberg, Alan F.
Other Authors
Nemeroff, Charles B.
Edition
5th ed.
Place of Publication
Arlington, VA
Publisher
American Psychiatric Association Publishing
Date of Publication
2017
ISBN
9781615371624
Subjects (MeSH)
Psychotropic Drugs - pharmacology
Psychotropic Drugs - therapeutic use
Mental Disorders - drug therapy
Psychopharmacology
Notes
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
Format
e-Book
Location
Online
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The American Psychiatric Publishing textbook of psychopharmacology

https://libcat.nshealth.ca/en/permalink/provcat33188
edited by Alan F. Schatzberg, Charles B. Nemeroff. (5th ed.) --Arlington, VA: American Psychiatric Association Publishing , c2017.
Available Online
View e-Book
Location
Online
The American Psychiatric Association Publishing Textbook of Psychopharmacology boasts a long and unassailable reputation as a classic, providing a clearly written, meticulously cross-referenced, and user-friendly guide to this swiftly evolving field. This new 5th Edition has been thoroughly updated in the context of the latest research and reflects the introduction of DSM-5. The chapter authors were carefully selected for their expertise, and the editors have ensured that the resulting text is …
Available Online
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Other Authors
Schatzberg, Alan F.
Nemeroff, Charles B.
Responsibility
edited by Alan F. Schatzberg, Charles B. Nemeroff
Edition
5th ed.
Alternate Title
Textbook of psychopharmacology
Place of Publication
Arlington, VA
Publisher
American Psychiatric Association Publishing
Date of Publication
c2017
Physical Description
[1823 p.]
ISBN
9781615371228
Subjects (MeSH)
Mental Disorders - drug therapy
Psychopharmacology
Psychotropic Drugs - pharmacology
Psychotropic Drugs - therapeutic use
Abstract
The American Psychiatric Association Publishing Textbook of Psychopharmacology boasts a long and unassailable reputation as a classic, providing a clearly written, meticulously cross-referenced, and user-friendly guide to this swiftly evolving field. This new 5th Edition has been thoroughly updated in the context of the latest research and reflects the introduction of DSM-5. The chapter authors were carefully selected for their expertise, and the editors have ensured that the resulting text is consistent in style and approach across topics and sections. The journey -- beginning with the core principles of molecular biology, genetics and genomics, and pharmacokinetics, continuing with the myriad classes of psychopharmacological agents, and ultimately arriving at the treatment of major psychiatric disorders as well as of specific age groups and circumstances -- is logical, easy to follow, and authoritative. Both physicians still in training and clinicians who regularly prescribe psychotropic medications will find the up-to-date and specific guidance on drug selection invaluable. The American Psychiatric Association Publishing Textbook of Psychopharmacology remains an essential, and trusted, companion.
Format
e-Book
Location
Online
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The annals of pharmacotherapy

https://libcat.nshealth.ca/en/permalink/provcat15359
Harvey Whitney Books
Holdings
Halifax Infirmary: v. 26, 1992 - v. 37, 2003.
Location
Halifax Infirmary
Continues
DICP
Publisher
Harvey Whitney Books
Holdings
Halifax Infirmary: v. 26, 1992 - v. 37, 2003.
ISSN
1060-0280
Specialty
Pharmacology
Format
Journal
Location
Halifax Infirmary
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Antiarrhythmic Drugs

https://libcat.nshealth.ca/en/permalink/provcat44884
Antoni Martínez-Rubio, Juan Tamargo, Gheorghe- Andrei Dan, editors. --Cham: Springer , c2020.
Available Online
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Location
Online
This volume reviews current and potential future therapies for arrhythmias. It is a highly practical guide for the use of pharmaceuticals in the management of the discipline, and has been written in a simple quick-access format. Antiarrhythmic Drugs builds on the current understanding of pathophysiological mechanisms and insights gained from previous studies of therapeutic interventions. It is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know…
Available Online
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Other Authors
Martínez-Rubio, Antoni
Tamargo, Juan
Dan, Gheorghe- Andrei
Responsibility
Antoni Martínez-Rubio, Juan Tamargo, Gheorghe- Andrei Dan, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (viii, 428 p.) : 35 illus., 29 illus. in color
Series Title
Current cardiovascular therapy
ISBN
9783030348939
9783030348915 (Print ed.)
9783030348922 (Print ed.)
Subjects (MeSH)
Arrhythmias, Cardiac - drug therapy
Anti-Arrhythmia Agents - therapeutic use
Specialty
Cardiology
Pharmacology
Abstract
This volume reviews current and potential future therapies for arrhythmias. It is a highly practical guide for the use of pharmaceuticals in the management of the discipline, and has been written in a simple quick-access format. Antiarrhythmic Drugs builds on the current understanding of pathophysiological mechanisms and insights gained from previous studies of therapeutic interventions. It is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know on a day-to-day basis.
Contents
1. Mechanisms of Cardiac Arrhythmias -- 2. Class I Antiarrhythmic Drugs: Na+ Channel Blockers -- 3. Class III Antiarrhythmic Drugs -- 4. Beta-blockers as Antiarrhythmic Agents -- 5. Modulation of Calcium Handling: Calcium-Channel Modulators -- 6. Other Antiarrhythmic Drugs -- 7. Antiarrhythmic Properties of Non-Antiarrhythmic Drugs in Atrial Fibrillation: Upstream Therapy -- 8. Clinical Significance and Management of Arrhythmias.
Format
e-Book
Location
Online
Less detail

Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill

https://libcat.nshealth.ca/en/permalink/provcat43083
Andrew A. Udy, Jason A. Roberts, Jeffrey Lipman, editors. --Singapore: Adis , c2018.
Available Online
View e-Book
Location
Online
This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of e…
Available Online
View e-Book
Other Authors
Udy, Andrew A.
Roberts, Jason A.
Lipman, Jeffrey
Responsibility
Andrew A. Udy, Jason A. Roberts, Jeffrey Lipman, editors
Place of Publication
Singapore
Publisher
Adis
Date of Publication
c2018
Physical Description
1 online resource (x, 275 p.) : 22 illus., 9 illus. in color
ISBN
9789811053368
9789811053351 (print ed.)
9789811053375 (print ed.)
Subjects (MeSH)
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Comparative Effectiveness Research
Critical Illness - therapy
Treatment Outcome
Specialty
Critical Care
Pharmacology
Abstract
This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also toáavoid encouraging drug resistance.
Contents
1. Basic Pharmacokinetic Principles -- 2. Antibiotic Pharmacodynamics -- 3. Physiological Manifestations of Critical Illness -- 4. Dosing in Obese Critically Ill Patients -- 5. Hypoalbuminemia and Altered Protein Binding -- 6. Antibacterial Pharmacokinetic/Pharmacodynamic Considerations in the Critically ill -- 7. Augmented Renal Clearance -- 8. Antibiotic Dosing During Extracorporeal Membrane Oxygenation -- 9. Therapeutic Drug Monitoring: More than Avoiding Toxicity -- 10. Generic and Optimised Antibacterial Dosing Strategies in the Critically Ill -- 11. Antifungal PK/PD in the Critically Ill -- 12. Antibiotic Dosing in Pediatric Critically Ill Patients -- 13. Antibiotic Stewardship in the Intensive Care Unit.
Format
e-Book
Location
Online
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Antimicrobial Drug Resistance. Vol. 1, Mechanisms of Drug Resistance

https://libcat.nshealth.ca/en/permalink/provcat28266
edited by Douglas L. Mayers. --Totowa, NJ: Humana Press , c2009.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Mayers, Douglas L
Responsibility
edited by Douglas L. Mayers
Alternate Title
Mechanisms of drug resistance
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2009
Series Title
Infectious disease
ISBN
9781597451802
Subjects (MeSH)
Drug Resistance, Microbial
Anti-Infective Agents - pharmacology
Format
e-Book
Location
Online
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Antimicrobial Drug Resistance. Vol. 2, Clinical and Epidemiological Aspects

https://libcat.nshealth.ca/en/permalink/provcat29585
edited by Douglas L. Mayers. --Totowa, NJ: Humana Press , c2009.
Available Online
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Location
Online
Available Online
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Author
Mayers, Douglas L
Responsibility
edited by Douglas L. Mayers
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2009
Series Title
Infectious disease
ISBN
9781603275958
Subjects (MeSH)
Drug Resistance, Microbial
Anti-Infective Agents - pharmacology
Format
e-Book
Location
Online
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Antimicrobial Resistance in the 21st Century

https://libcat.nshealth.ca/en/permalink/provcat42795
I.W. Fong, David Shlaes, Karl Drlica, editors. (Second edition) --Cham: Springer , c2018.
Available Online
View e-Book
Location
Online
Antimicrobial resistance is now a general problem. Many of us have elderly relatives who died from a drug-resistant infection, and some of us have suffered from a resistant urinary infection that likely came from intestinal bacteria following antibiotic consumption. Antimicrobial Resistance in the 21st Century provides a broad introduction to the subject in which the situation with problematic pathogens is detailed, the biology of resistance is described, and gaining approval for new antibiotic…
Available Online
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Other Authors
Fong, I.W. (Ignatius W.)
Shlaes, David
Drlica, Karl
Responsibility
I.W. Fong, David Shlaes, Karl Drlica, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xviii, 775 p.) : 106 illus., 74 illus. in color
Series Title
Emerging infectious diseases of the 21st century
ISBN
9783319785387
9783319785370 (print ed.)
9783319785394 (print ed.)
Subjects (MeSH)
Communicable Diseases - epidemiology
Communicable Diseases, Emerging
Drug Resistance, Microbial
Specialty
Infectious Disease Medicine
Pharmacology
Abstract
Antimicrobial resistance is now a general problem. Many of us have elderly relatives who died from a drug-resistant infection, and some of us have suffered from a resistant urinary infection that likely came from intestinal bacteria following antibiotic consumption. Antimicrobial Resistance in the 21st Century provides a broad introduction to the subject in which the situation with problematic pathogens is detailed, the biology of resistance is described, and gaining approval for new antibiotics is discussed. Some topics are immediately practical, such as watching for resistant pathogen sub-populations in cultures taken from patients; other topics point to future research efforts that may lead to new antimicrobials and ways to stimulate the action of existing ones. Overall, Antimicrobial Resistance in the 21st Century provides an update for physicians, serves as a starting point for graduate students interested in solving the resistance problem, and may serve as a text for a course on resistance. Lay readers familiar with microbiology will gain an appreciation for a medical issue that promises to be one of the most important of our time.
Contents
1. Introduction: Coordinated Global Action is Needed to Combat Antimicrobial Resistance -- Part I: Examples of Resistance -- 2. Antimicrobial Resistance Among Streptococcus pneumoniae -- 3. Emergence of MRSA in the Community -- 4. Resistance of Gram-negative Bacilli to Antimicrobials -- 5. Drug Resistance in Tuberculosis -- 6. Anaerobic Bacteria: Antimicrobial Susceptibility Testing and Resistance Patterns -- 7. Clinical Significance and Biologic Basis of HIV Drug Resistance -- 8. Resistance of Herpesviruses to Antiviral Agents -- 9. Heteroresistance: A Harbinger of Future Resistance -- Part II: Biology of Resistance -- 10. Epidemiology of Bacterial Resistance -- 11. Transmissible Antibiotic Resistance -- 12. Antibiotics and Resistance in the Environment -- 13. Phenotypic Tolerance and Bacterial Persistence -- 14. Staphylococcus aureus Adaptation During Infection -- 15. Bacterial Signal Transduction Systems in Antimicrobial Resistance -- 16. Fluoroquinolone Interactions with Bacterial Type II Topoisomerases and Target-mediated Drug Resistance -- Part III: Finding New Antimicrobials -- 17. Natural Products in Antibiotic Discovery -- 18. The New vs. Old Target Debate For Drug Discovery -- 19. Non-quinolone Topoisomerase Inhibitors -- 20. Antimicrobial-Mediated Bacterial Suicide -- 21. PK/PD-based Prediction of "Anti-mutant" Antibiotic Exposures Using In Vitro Dynamic Models -- Part IV: Bringing Compounds to Market -- 22. The Role of Pharmacometrics in the Development of Antimicrobial Agents -- 23. New Regulatory Pathways for Antibacterial Drugs -- 24. Economic Incentives for Antibacterial Drug Development: Alternative Market Structures to Promote Innovation.
Format
e-Book
Location
Online
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Antioxidants in Andrology

https://libcat.nshealth.ca/en/permalink/provcat41396
Giancarlo Balercia, Loredana Gandini, Andrea Lenzi, Francesco, editors Lombardo, editors. --Cham: Springer , 2017.
Available Online
View e-Book
Location
Online
This book focuses on the use of various molecules with antioxidant properties in the treatment of major male genital tract disorders, especially male infertility, erectile dysfunction, and accessory gland infection. The coverage also includes discussion of pathophysiology, the molecular basis of male infertility, and the rationale for use of antioxidants, with particular attention to coenzyme Q10 and carnitine. Oxidative stress occurs when the production of reactive oxygen species, including fr…
Available Online
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Other Authors
Balercia, Giancarlo
Gandini, Loredana
Lenzi, Andrea
Lombardo, Francesco
Other Authors
Società Italiana di Andrologia e Medicina della Sessualità
Responsibility
Giancarlo Balercia, Loredana Gandini, Andrea Lenzi, Francesco, editors Lombardo, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (vii, 79 pages) : 7 illus. in color
Series Title
Trends in andrology and sexual medicine
ISBN
9783319417493
9783319417479 (print ed.)
ISSN
2367-0088
Subjects (MeSH)
Andrology
Antioxidants - pharmacology
Antioxidants - therapeutic use
Genital Diseases, Male - drug therapy
Infertility, Male - drug therapy
Oxidative Stress - physiology
Sexual Dysfunction, Physiological - drug therapy
Carnitine - physiology
Ubiquinone - analogs & derivatives
Abstract
This book focuses on the use of various molecules with antioxidant properties in the treatment of major male genital tract disorders, especially male infertility, erectile dysfunction, and accessory gland infection. The coverage also includes discussion of pathophysiology, the molecular basis of male infertility, and the rationale for use of antioxidants, with particular attention to coenzyme Q10 and carnitine. Oxidative stress occurs when the production of reactive oxygen species, including free radicals, exceeds the body's natural antioxidant defences, leading to cellular damage. Oxidative stress is present in about half of all infertile men, and reactive oxygen species can produce infertility both by damaging the sperm membrane, with consequences for sperm motility, and by altering the sperm DNA. There is consequently a clear rationale for the use of antioxidant treatments within andrology, and various in vitro and in vivo studies have indicated that many antioxidants indeed have beneficial impacts. In providing a detailed and up-to-date overview of the subject, this book will be of interest to both practitioners and researchers in andrology, endocrinology, and urology.
Contents
1. Free Radicals in Andrology -- 2. Biochemistry of Coenzyme Q10 -- 3. Carnitine in Male Infertility -- 4. Coenzyme Q10 in Male Infertility -- 5. Antioxidants in Male Accessory Gland Infection -- 6. Antioxidants in Male Sexual Dysfunctions.
Format
e-Book
Location
Online
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Application of peptide-based prodrug chemistry in drug development

https://libcat.nshealth.ca/en/permalink/provcat32406
Arnab De, author ; with special thanks to Richard DiMarchi and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University ; with foreword by Jean Martinez. --New York, NY: Springer , c2013.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
De, Arnab
Responsibility
Arnab De, author ; with special thanks to Richard DiMarchi and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University ; with foreword by Jean Martinez
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Series Title
SpringerBriefs in pharmaceutical science & drug development
ISBN
9781461448754
Subjects (MeSH)
Drug Design
Peptides - pharmacology
Prodrugs
Subjects (LCSH)
Toxicology
Pharmaceutical technology
Diabetes
Contents
Introduction -- Application of prodrug chemistry to GLP-1 -- Experimental procedures -- Characterization of prodrugs -- Conclusion -- Appendix I: Schematic Synthesis of Longer Acting Prodrugs -- Appendix II: Structure of Peptides in Table A.1 -- Appendix III: Structure of Peptides in Table A.2 -- Appendix IV: Structure of Peptides in Table A.3 -- Appendix V: Structure of Peptides in Table A.4 -- Appendix VI: Structure of Peptides in Table A.5 -- Appendix VII: Structure of Peptides in Table A.6 -- Appendix VIII: Acylation of HO-His7, GLP(8–37) -- Appendix IX: A Note on Nomenclature.
Format
e-Book
Location
Online
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Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents

https://libcat.nshealth.ca/en/permalink/provcat40067
Michael W. Jann, Scott R. Penzak, Lawrence J. Cohen, editors. (1st ed.) --Cham: Springer International Publishing : Imprint: Adis , c2016.
Available Online
View e-Book
Location
Online
This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information for clinicians, students, researchers, and members of the pharmaceutical industry alike. The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous…
Available Online
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Other Authors
Jann, Michael W
Penzak, Scott R
Cohen, Lawrence J
Responsibility
Michael W. Jann, Scott R. Penzak, Lawrence J. Cohen, editors
Edition
1st ed.
Place of Publication
Cham
Publisher
Springer International Publishing : Imprint: Adis
Date of Publication
c2016
Physical Description
1 online resource (xiv, 601 p. : 100 illus., 50 illus. in color)
ISBN
9783319278834
9783319278810 (print ed.)
Subjects (MeSH)
Drug Interactions
Psychotropic Drugs - pharmacokinetics
Psychotropic Drugs - pharmacology
Abstract
This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information for clinicians, students, researchers, and members of the pharmaceutical industry alike. The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories and with reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together, or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result. The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology. Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions, is frequently updated. However, with information presented on a host of different platforms, and in different formats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.
Contents
Section 1. General Pharmacokinetic and Pharmacodynamic Principles of Psychopharmacological Agents -- 1. Pharmacokinetic Properties -- 2. Pharmacodynamic Properties -- 3. PET Scan and Other Biomarkers -- 4. Population Pharmacokinetics -- 5. Drug Transporters (esp. Blood Brain Barrier) -- 6. Pharmacogenomics -- Section 2. Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Drug Classes -- 7. Antipsychotics: oral typical agents, oral atypical agents, and long-acting injectable (LAI) antipsychotics -- 8. Mood Stabilizers -- 9. Antidepressants: tricyclics, selective serotonergic reuptake inhibitors, serotonergic noradrenergic reuptake inhibitors, monoamine oxidase inhibitors, and other antidepressants -- 10. Benzodiazepines and Other Sedative Hypnotics/Anxiolytics -- 11. Opioid Analgesics -- 12. Stimulants and Other Non-Stimulants for ADHD -- 13. Cholinesterase Inhibitors and Other Antidementa Agents -- 14. Anti-Addiction Agents -- 15. Anesthetics -- Section 3. Clinically Significant Drug Interactions With Psychopharmacological Agents -- 16. Antipsychotics -- 17. Mood Stabilizers -- 18. Antidepressants -- 19. Benzodiazepines and Other Sedative Hypnotics/Anxiolytics -- 20. Opioid Analgesics -- 21. Stimulants and Other Non-Stimulants for ADHD -- 22. Cholinesterase Inhibitors and Other Antidementa Agents -- 23. Anti-Addiction Agents -- 24. Anesthetics.
Format
e-Book
Location
Online
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Archives of pharmacal research

https://libcat.nshealth.ca/en/permalink/provcat19288
Springer
Available Online
View e-Journal
Holdings
Vol 20, 1997 -
Location
Online
Available Online
View e-Journal
Publisher
Springer
Holdings
Vol 20, 1997 -
ISSN
1976-3786
Specialty
Pharmacology
Format
e-Journal
Location
Online
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Arrhythmia Induction in the EP Lab

https://libcat.nshealth.ca/en/permalink/provcat44060
Gabriel Cismaru, editor. --Cham: Springer , 2019.
Available Online
View e-Book
Location
Online
This book focuses on how to induce clinical arrhythmias in the electrophysiology (EP) laboratory, a procedure that is indispensable for analyzing the underlying mechanisms, and identifying the most effective treatment of the arrhythmia. In the main part of the book, the authors share their own experiences with 13 different medications that can be injected or infused for arrhythmia induction – ranging from isoprenaline and atropine to ephedrine – all of which can be easily found in any cardiolog…
Available Online
View e-Book
Other Authors
Cismaru, Gabriel
Responsibility
Gabriel Cismaru, editor
Alternate Title
Arrhythmia induction in the electrophysiology lab
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (ix, 228 p.) : 138 illus., 131 illus. in color
ISBN
9783319927299
9783319927282 (Print ed.)
9783319927305 (Print ed.)
Subjects (MeSH)
Arrhythmias, Cardiac - physiopathology
Heart Conduction System - drug effects
Pharmacologic Actions
Specialty
Cardiology
Pharmacology
Abstract
This book focuses on how to induce clinical arrhythmias in the electrophysiology (EP) laboratory, a procedure that is indispensable for analyzing the underlying mechanisms, and identifying the most effective treatment of the arrhythmia. In the main part of the book, the authors share their own experiences with 13 different medications that can be injected or infused for arrhythmia induction – ranging from isoprenaline and atropine to ephedrine – all of which can be easily found in any cardiology department. Each chapter begins with a description of the drug’s chemical structure and mechanism of actions, then illustrates the infusion preparation, dosage and side effects and lastly analyzes its electrophysiological properties and highlights the most important clinical studies on it. For each drug the authors list–in dedicated tables–administration protocols from their own hospital. This book is of interest to postgraduate students, cardiology residents, cardiologists and pediatric cardiologists with special interest in arrhythmias, as well as to trainees, technicians and nurses involved in the EP lab.
Contents
1. Introduction: Why Do We Need Arrhythmia Induction? -- 2. How to Induce Arrhythmias by Atrial and Ventricular Programmed Stimulation? -- 3. How to Induce Arrhythmias with Isoprenaline -- 4. How to Induce Arrhythmias with Orciprenaline -- 5. How to Induce Arrhythmias with Adrenaline -- 6. How to Induce Arrhythmias with Atropine -- 7. How to Induce Arrhythmias with Noradrenaline -- 8. How to Induce Arrhythmias with Dobutamine -- 9. How to Induce Arrhythmias with Dopamine -- 10. Adrenaline Versus Atropine for AVNRT Induction -- 11. Adrenaline Versus Isoprenaline for Arrhythmia Induction -- 12. How to Induce Arrhythmias with Salbutamol -- 13. How to Induce Arrhythmias with Caffeine? -- 14. How to Induce Arrhythmias with Adenosine? -- 15. How to Induce Arrhythmias with Aminophylline? -- 16. How to Induce Arrhythmias with Ephedrine? -- 17. Arrhythmias Induction and Energy Drinks -- 18. Ajmaline, Flecainide and Propafenone Can Induce Ventricular Fibrillation in Patients with Brugada Syndrome -- 19. Arrhythmia Induction in Children -- 20. Arrhythmia Induction During Transesophageal Electrophysiological Study -- 21. How to Induce Pacemaker-Mediated Tachycardia? -- 22. What to Do When Clinical Arrhythmia Is Uninducible?: Stepwise Approach.
Format
e-Book
Location
Online
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Basic clinical pharmacokinetics

https://libcat.nshealth.ca/en/permalink/provcat24582
Winter, Michael E. (5th ed.) --Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins , 2010.
Call Number
QV 38 W786b 2010
Location
Halifax Infirmary
Call Number
QV 38 W786b 2010
Author
Winter, Michael E
Edition
5th ed.
Place of Publication
Philadelphia, PA
Publisher
Wolters Kluwer Health/Lippincott Williams & Wilkins
Date of Publication
2010
Physical Description
548 p.
ISBN
9780781779036
Subjects (MeSH)
Pharmacokinetics
Pharmacology, Clinical
Format
Book
Location
Halifax Infirmary
Loan Period
3 weeks
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Basic & clinical pharmacology

https://libcat.nshealth.ca/en/permalink/provcat13200
edited by Bertram G. Katzung ; associate editors, Susan B. Masters, Anthony J. Trevor. (11th ed.) --New York, NY: McGraw-Hill Medical , 2009.
Call Number
QV 4 B3115 2009
Location
Cape Breton Regional
Call Number
QV 4 B3115 2009
Other Authors
Katzung, Bertram G.
Trevor, Anthony J.
Masters, Susan B.
Responsibility
edited by Bertram G. Katzung ; associate editors, Susan B. Masters, Anthony J. Trevor
Edition
11th ed.
Alternate Title
Basic and clinical pharmacology
Place of Publication
New York, NY
Publisher
McGraw-Hill Medical
Date of Publication
2009
Physical Description
xiii, 1218 p. : ill.
ISBN
9780071604055
0071604057
Subjects (MeSH)
Drug Therapy
Pharmacology, Clinical
Contents
Basic principles -- Autonomic drugs -- Cardiovascular-renal drugs -- Drugs with important actions on smooth muscle -- Drugs that act in the central nervous system -- Drugs used to treat diseases of the blood, inflammation, & gout -- Endocrine drugs -- Chemotherapeutic drugs -- Toxicology -- Special topics.
Format
Book
Location
Cape Breton Regional
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Benefits of the Mediterranean Diet in the Elderly Patient

https://libcat.nshealth.ca/en/permalink/provcat42575
Antonio Capurso, Gaetano Crepaldi, Cristiano Capurso. --Cham: Fondazione Dieta Mediterranea-ONLUS ; Springer , c2018.
Available Online
View e-Book
Location
Online
This book illustrates the role of Mediterranean diet in connection with well-being and particularly its impact on health and elderly care, as well as on the mechanisms of aging. Aging is a natural process of human life. The knowledge that a healthy dietary regimen like the Mediterranean diet can effectively prevent or delay many diseases typically affecting aging people may help to better manage the aging process. From this point of view, knowledge of the numerous benefits of the Mediterranean-…
Available Online
View e-Book
Author
Capurso, Antonio
Other Authors
Crepaldi, Gaetano
Capurso, Cristiano
Other Authors
Fondazione Dieta Mediterranea
Responsibility
Antonio Capurso, Gaetano Crepaldi, Cristiano Capurso
Place of Publication
Cham
Publisher
Fondazione Dieta Mediterranea-ONLUS ; Springer
Date of Publication
c2018
Physical Description
1 online resource (xvii, 439 p.) : 40 illus., 24 illus. in color
Series Title
Practical issues in geriatrics
ISBN
9783319780849
9783319780832 (print ed.)
9783319780856 (print ed.)
ISSN
2509-6060
Subjects (MeSH)
Aged
Diet, Mediterranean
Healthy Diet
Olive Oil - pharmacology
Specialty
Geriatrics
Nutritional Sciences
Abstract
This book illustrates the role of Mediterranean diet in connection with well-being and particularly its impact on health and elderly care, as well as on the mechanisms of aging. Aging is a natural process of human life. The knowledge that a healthy dietary regimen like the Mediterranean diet can effectively prevent or delay many diseases typically affecting aging people may help to better manage the aging process. From this point of view, knowledge of the numerous benefits of the Mediterranean-style diet may effectively promote better management of the burden of elderly care. As early as the 1950s, Ancel Keys pointed out the effectiveness of the Mediterranean diet in helping to control, and possibly avoid, myocardial infarction and/or cholesterol metabolism. Quite soon after the first studies were published, it became clear that the Mediterranean diet was beneficial not only in connection with cardiovascular disease but also many other diseases, from diabetes to hypertension, from cancer and thrombosis to neurodegenerative diseases, including dementia. Examining those benefits in detail, this book offers a valuable educational tool for young professionals and caregivers, as well as for students and trainees in Geriatrics and Nutrition.
Contents
1. The Historical Origins and Composition of Mediterranean Diet -- 2. Extra-Virgin Olive Oil (EVOO): History and Chemical Composition -- 3. Extra-Virgin Olive Oil and Cardiovascular Disease -- 4. Extra-Virgin Olive Oil and Type 2 Diabetes Mellitus -- 5. Extra-virgin Olive Oil, the Mediterranean Diet, and Neurodegenerative Diseases -- 6. Extra-virgin Olive Oil and Cancer -- 7. Epigenetics/Epigenomics of Olive Oil and the Mediterranean Diet -- 8. Cereals -- 9. Vegetables -- 10. Fresh Fruit -- 12. Legumes and Pulses -- 13. Fish -- 14. The Smells and Tastes of the Mediterranean Diet: Herbs -- 15. Red and White Wines -- 16. The Impact of the Mediterranean Diet on Aging, Frailty, and Longevity.
Format
e-Book
Location
Online
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