Herbal Drugs and Fingerprints : Evidence Based Herbal Drugs
https://libcat.nshealth.ca/en/permalink/provcat31211
Devi Datt Joshi.
--New Delhi:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Evidence based herbal drugs are on high-acceptance day by day due to health friendly nature compared to synthetic drugs. The active ingredients in herbal drugs are different chemical classes, e.g. alkaloids, coumarins, flavonoids, glycosides, phenols, steroids, terpenes etc., are identified at molecular level using current analytical practices, which are unique characteristic, as finger, so known as fingerprints. The fingerprints are used for assessment of quality consistency and stability by v…
- Available Online
- View e-Book
- Author
- Joshi, Devi Datt
- Responsibility
- Devi Datt Joshi
- Place of Publication
- New Delhi
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xvi, 252 p. : 108 ill., 42 ill. in color)
- ISBN
- 9788132208044
- Subjects (MeSH)
- Chemistry Techniques, Analytical - methods
- Plant Preparations - analysis
- Plant Preparations - pharmacology
- Subjects (LCSH)
- Chemistry
- Pharmacy
- Medical laboratories
- Abstract
- Evidence based herbal drugs are on high-acceptance day by day due to health friendly nature compared to synthetic drugs. The active ingredients in herbal drugs are different chemical classes, e.g. alkaloids, coumarins, flavonoids, glycosides, phenols, steroids, terpenes etc., are identified at molecular level using current analytical practices, which are unique characteristic, as finger, so known as fingerprints. The fingerprints are used for assessment of quality consistency and stability by visible observation and comparison of the standardized fingerprint pattern, have scientific potential to decipher the claims made on these drugs for authenticity and reliability of chemical constituents, with total traceability, which starts from the proper identification, season and area of collection, storage, their processing, stability during processing, and rationalizing the combinational in case of polyherbal drugs. These quality oriented documents have ample scientific logics so well accepted globally by regulatory authorities and industries, to determine intentional/ unintentional contamination, adulteration, pollutants, stability, quality, etc. parameters. Based on geo-climatic factors, a same plant species has different pharmacological properties due to different ingredients; such regional and morphological variations are identified by fingerprints, at the time of collection of the medicinal herb. The chromatographic (TLC, HPTLC, HPLC, GC,) and spectral (UV-Vis., FTIR, MNR, MS, LC-MS, GC-MS etc.) techniques have world-wide strong scientific approval as validated methods to generate the fingerprints of different chemical classes of active ingredients of herbal drugs. Presently there is a need for a book having all the fingerprinting techniques for herbal drugs at a place with theory, case studies and art to discover patentable forms. The present book is a milestone in the subject, to be utilized by Scientists, Medical Doctors, Technicians, Industrialists, Researchers, and Students both in PG and UG levels.
- Contents
- [Machine generated contents note] Pt. I. Herbal Drugs: A Review on Practices -- 1. Herbal Drugs: A Review on Practices -- Introduction -- Asian Continent and Traditional Herbal Drugs -- China and Japan -- Indian Subcontinent -- Traditional Herbal Drugs in Europe -- Traditional Herbal Drugs in America -- Traditional Herbal Drugs in Australia -- Traditional Herbal Drugs in Africa -- Industrialization of Herbal Drugs and Legislation -- Phytochemical Standardization -- Extraction of Therapeutics -- Analysis for Marker and Chromatographic Fingerprint -- Preparative HPLC to Isolate Therapeutic -- Biochemical Approach -- Reverse Pharmacology -- New Drug Development -- Synthetic Drug Development -- Modern Approach for Drug Development -- Fingerprints of Drugs: Needs and Values -- Multidisciplinary Strategy to Develop Fingerprints -- Modern Chemistry and Pharmacology -- Standardization of Fingerprints -- Pharmacokinetics of Standardized Form -- Case Study -- Commercial Manufacturing and Quality Control -- Regulatory Norms for Herbal Drugs -- Therapeutic Goods Act -- Drug Administration Law -- Ayush -- Ministry of Health and Welfare, Japan -- Ministry of Health, Saudi Arabia -- WHO Guidelines for Assessment of Herbal Drugs -- References -- Bibliography -- Pt. II. Herbal Drugs and Chromatographic Fingerprints -- 2. TLC: Herbal Drugs and Fingerprints -- Thin-Layer Chromatogram -- Preparation of TLC Plate in Laboratory -- Ready-Made TLC Plate -- Selection of Suitable Plate Size -- Spotting -- Preparation of Developing Chamber -- Chromoplate Generation -- Evaluation of TLC Plate -- Retention Factor -- Presentation of TLC Results -- Procedure to Determine R1 Value of Unknown -- Spot Development by Iodine Vapors -- Documentation of Fingerprints -- Two-Dimensional TLC -- TLC Bioautography -- Bioluminescence and TLC Analysis -- Detection of Colorless Compounds -- Combination of TLC with Other Techniques -- Criteria for Selectivity, Reproducibility and Robustness -- Special Hazards -- Troubleshooting in TLC Analysis -- Identification of Marker Compounds in Herbal Drugs -- TLC Analysis for Alkaloids -- TLC Analysis for Phenols -- TLC Analysis for Saponins -- TLC Analysis for Terpenoids -- TLC with DART-MS -- TLC Fingerprints for Batch to Batch Consistency -- References -- Bibliography -- 3. HPTLC: Herbal Drugs and Fingerprints -- Operational Summary of HPTLC -- HPTLC Pre-Coated Plates -- Detection and Visualization -- Nondestructive Techniques -- Nonreversible Reactions -- Destructive Techniques -- Common Visualizing Reagents -- Group-Specific Reaction -- Coupling of HPTLC with Spectrometry -- References -- Bibliography -- 4. HPLC: Herbal Drugs and Fingerprints -- Glance on HPLC Column -- Analytical Mobile Phases and HPLC -- Solvent Changeover in HPLC -- Buffers as Mobile Phase -- Selection of Buffer and Analytical Method Development -- Buffer Concentration -- Buffer Solubility -- Buffer and Its Impact on Detection -- Buffers as Mobile Phase in HPLC -- Detectors in HPLC: Detection, Quantification, and Fingerprints -- HPLC-UV -- HPLC-FD -- HPLC-CL -- HPLC-ECD -- HPLC Detection in Hyphenated System -- HPLC-RID -- HPLC-ELSD -- HPLC-CAD -- HPLC-FID -- HPLC-MS -- HPLC-NMR -- LC-Hyphenation for Online Structural Identification -- HPLC-DAD (Diode-Array Detector) -- HPLC-MS, MS-MS, and MSn -- HPLC-NMR (Nuclear Magnetic Resonance) -- HPLC Biochemical Detection -- HPTLC-HPLC for Quality Assurance -- Case Study -- Different Chemical Classes from Natural Products and LC Fingerprints -- Fingerprints for Flavonoids -- Fingerprints for Terpenoids -- Fingerprints for Alkaloids -- Fingerprints for Coumarins -- Fingerprints for Alkamides -- References -- Bibliography -- 5. GC: Herbal Drugs and Fingerprints -- Instrumentation -- GLC Columns -- Detectors in GLC -- Development of GC Fingerprints and Data Interpretation -- Sample Preparation -- Separation and Detection -- Analytical Results -- Utility of GC Fingerprints in Herbal Drugs -- Contamination/Adulteration -- Traceability -- Qualification and Quantification of Therapeutics -- Nutraceutical Discovery -- New Cosmeceuticals -- In Aromatherapy -- To Decipher Traditional Formulations -- References -- Bibliography -- Pt. III. Herbal Drugs and Spectral Fingerprints -- 6. UV-Vis. Spectroscopy: Herbal Drugs and Fingerprints -- Instrumentation -- UV-Vis. Spectrometry and Herbal Drugs -- To Study the Phenolics and Derivatives -- UV Spectrometry for Different Derivatives -- UV-Vis. Coupled Methods for Analysis -- Preparation of Sunscreens -- Evaluation of Vitamin C Content -- Preparation of Stock Solutions -- Green Synthesis of Nanoparticles -- SNPs from C. tamala Twigs -- Purification of Geometrical Isomers -- Analysis of Ultra-Diluted Drugs -- Identification of Powdered Medicinal Plants -- Biological Assay Using Hyphenated Techniques -- To Differentiate Various Species of a Genus -- References -- Bibliography -- 7. FTIR Spectroscopy: Herbal Drugs and Fingerprints -- Interpretation of IR Spectra -- Authentication of Herbal and Herbal Drugs -- Interpretation of Data -- Identification and Comparison of Biomolecules -- Authenticity of Herbal and Herbal Drugs -- To Distinguish Herb from Its Morphological Fakes -- Standardization of Metal-Based Herbal Drugs -- References -- Bibliography -- 8. Mass Spectroscopy: Herbal Drugs and Fingerprints -- Interpretation of Mass Spectra -- Techniques for Analysis of Ions in MS -- Detection and Recording of Fingerprints -- Electrospray MS for Herbal Fingerprints -- Matrix-Assisted Laser Desorption Ionization -- Hyphenated Techniques -- References -- Bibliography -- 9. NMR Spectroscopy: Herbal Drugs and Fingerprints -- Metabolic Fingerprints -- Case Study 1 -- 1H-NMR Detection -- 1H-NMR Spectra to Recognize Patterns and Find Discriminating Signals -- 2D-NMR Spectroscopy to Compare Metabolites -- Evaluation of Quality of High Therapeutic-Value Herbals -- Case Study 2 -- Materials and Chemicals -- Molecular Modeling -- Case Study 3 -- To Decipher the Herbal Constituents -- Case Study 4 -- Metabolic Fingerprints to Distinguish Plant Species -- Case Study 5 -- Quality Assurance of Traditional Medicines -- Case Study 6 -- Detection of Contaminations -- References -- Bibliography -- Pt. IV. Pollutants in Herbal Drugs and Fingerprints -- 10. Metals in Herbal Drugs and Fingerprints -- Atomic Absorption Spectroscopy -- Instrumentation in AAS -- Case Study 1 -- Case Study 2 -- Graphite Furnace Atomizer -- Inductively Coupled Plasma -- WDXRF Spectroscopy -- Heavy Metals -- Removal of Heavy Metals from Herbal Drugs -- Case Study 3 -- Bhasmas as Nanoherbal Drugs -- References -- Bibliography -- 11. Pesticide Residues in Herbals and Detection -- Regulatory Norms -- Analysis of Pesticide Residues -- Isolation and Purification Methods -- Hyphenated Techniques for Isolation and Purification -- Contemporary Trends in Pesticide Residue Analysis -- Degree of Uncertainty of Analysis -- Pesticides Residues in Natural Products -- Current Scenario of Pesticides Residues in Herbals -- Pesticide Residues in Dry Fruits -- TLC Fingerprints -- GC Fingerprints -- References -- Bibliography -- 12. Radiation Detection in Herbals -- Microorganisms in Herbals -- Safety and Effectiveness of Irradiation -- Irradiation of Spices and Dried Vegetable Seasonings -- Irradiation Dose for Essential Oils and Organoleptic Characters -- Radiation Quantity and Antioxidant Activity -- Detection of Irradiated Foods and Food Supplements -- Thermoluminescence -- Pulse Photo-Stimulated Luminescence -- Electron Paramagnetic Spin Resonance Spectroscopy -- References -- Bibliography -- Pt. V. DNA Techniques for Evidence-Based Herbals -- 13. Herbal Drugs and DNA Fingerprints -- Authentication of Traditional Formulations -- Experimental Details -- RAPD Reaction -- Identification of Chemotypes, Ecotypes, and Substitutes -- Case Study -- Identification of Adulterants -- DNA Fingerprint Techniques for Identification of Ingredients -- Polymerase Chain Reaction -- Simple Sequence Repeats -- Restriction Fragment Length Polymorphisms -- Amplified Fragment Length Polymorphism -- Random Amplified Polymorphism -- Single-Nucleotide Polymorphism -- Short Tandem Repeat -- DNA Barcode -- Genetic Markers -- Trouble Shooting in DNA Fingerprinting -- Commercial Utility of Genetic Markers in Herbal Technology -- Comparative Genetic Analysis -- Future Scope of Genetic Markers in Herbal Drug Research -- References -- Bibliography.
- Format
- e-Book
- Location
- Online
Naturally occurring bioactive compounds
https://libcat.nshealth.ca/en/permalink/provcat27186
Mahendra Rai and María Cecilia Carpinella.
(1st ed.)
--Amsterdam, Netherlands:
Elsevier
, 2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Rai, Mahendra
- Other Authors
- Carpinella, María Cecilia
- Responsibility
- Mahendra Rai and María Cecilia Carpinella
- Edition
- 1st ed.
- Place of Publication
- Amsterdam, Netherlands
- Publisher
- Elsevier
- Date of Publication
- 2006
- Series Vol.
- v. 3
- Series Title
- Advances in phytomedicine
- ISBN
- 661063680X (electronic bk.)
- Subjects (MeSH)
- Agrochemicals
- Plant Preparations - pharmacology
- Pharmacognosy
- Contents
- Cover -- Contents -- Preface to the series -- Preface -- Chapter 1. Natural compounds as antioxidant and molting inhibitors can play a role as a model for search of new botanical pesticides -- Introduction -- Insecticidal or IGR (insect growth regulator) activity -- Experimental part -- Discussion -- Concluding remarks -- Future perspectives -- Acknowledgments -- References -- Chapter 2. Pesticides based on plant essential oils: from traditional practice to commercialization -- Introduction -- Sources and chemistry of essential oils -- Biological activity -- Commercial products and uses -- Conclusion and future prospects -- Acknowledgment -- References -- Chapter 3. Natural substrates and inhibitors of multidrug resistant pumps (MDRs) redefine the plant antimicrobials -- Introduction -- The quest for natural substrates - rationale -- MDR inhibitors - proof of principle -- MDR mutants and inhibitors valuable tools for natural drug discovery -- A new series of promising plant antimicrobials -- Natural MDR inhibitors from plants -- an increasing body of evidence, 5' methoxyhydnocarpin and synergy in Berberis plants -- Inhibitors against MFS MDRs -- Inhibitors against ABC transporters -- Conclusions and future perspectives -- Acknowledgments -- References -- Chapter 4. New concept to search for alternate insect control agents from plants -- Introduction -- Tannins -- Saponins -- Acknowledgments -- References -- Chapter 5. Role of Melia azedarach L. (Meliaceae) for the control of insects and acari: present status and future prospects -- Introduction -- Phytochemistry -- Laboratory assays -- Conclusion and future prospects -- Acknowledgments -- References -- Chapter 6. Bioactivity of fabaceous plants against food-borne and plant pathogens: potentials and limitations -- Introduction -- Antimicrobial activities of some important fabaceous plants -- Antimicrobials for management of phytopathogens -- Future directions and conclusions -- References -- Chapter 7. Screening of plants against fungi affecting crops and stored foods -- Introduction -- Fungi as contaminants of crops and foods -- History of the use of antifungal compounds -- Interaction of plant products with fungi -- Plant synthesis of light-activated compounds -- Factors affecting plant synthesis of bioactive compounds -- Experimental -- Bioassays -- Plant analysis -- Cell culture analysis -- Isolated compounds -- Assay procedure -- Results and discussion -- Plant extracts -- Cell cultures -- Photoactivity -- Isolated compounds -- Conclusions and future perspectives -- Acknowledgments -- References -- Chapter 8. Opportunities and potentials of botanical extracts and products for management of insect pests in cruciferous vegetables -- Introduction -- Azadirachtin and related products from Azadirachta indica A. Juss -- Spiro enol ether analogues and extracts from Chrysanthemum coronarium L. -- Extracts from Daphne tangutica Maxim. -- Rotenoids and extracts from Derris spp. -- Rotenoids and
- Format
- e-Book
- Location
- Online
