Asymptomatic Atherosclerosis : Pathophysiology, Detection and Treatment
https://libcat.nshealth.ca/en/permalink/provcat28741
edited by Morteza Naghavi.
--New York, NY:
Humana Press
, c2010.
- Available Online
- View e-Book
- Location
- Online
Despite recent advances in the diagnosis and treatment of symptomatic atherosclerosis, available traditional screening methods for early detection and treatment of asymptomatic coronary artery disease are grossly insufficient and fail to identify the majority of victims prior to the onset of a life-threatening event. In Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment, Dr. Morteza Naghavi and leading authorities from the Society for Heart Attack Prevention and Eradication …
- Available Online
- View e-Book
- Author
- Naghavi, Morteza
- Responsibility
- edited by Morteza Naghavi
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2010
- Physical Description
- 1 online resource (xxii, 737 p. : ill.)
- Series Title
- Contemporary cardiology (Totowa, N.J. : Unnumbered)
- ISBN
- 9781603271790
- 9781603271783 (print ed.)
- Subjects (MeSH)
- Atherosclerosis - diagnosis
- Atherosclerosis - physiopathology
- Atherosclerosis - therapy
- Plaque, Atherosclerotic
- Subjects (LCSH)
- Cardiology
- Abstract
- Despite recent advances in the diagnosis and treatment of symptomatic atherosclerosis, available traditional screening methods for early detection and treatment of asymptomatic coronary artery disease are grossly insufficient and fail to identify the majority of victims prior to the onset of a life-threatening event. In Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment, Dr. Morteza Naghavi and leading authorities from the Society for Heart Attack Prevention and Eradication (SHAPE) present a new paradigm for the screening and primary prevention of asymptomatic atherosclerosis. The text focuses on accurate, yet underutilized, measures of subclinical atherosclerosis, notably coronary artery calcium scanning and carotid intima-media thickness measurement. The authors introduce a comprehensive approach to identifying the vulnerable patients (asymptomatic individuals at risk of a near future adverse event). Additional chapters discuss future directions towards containing the epidemic of atherosclerotic cardiovascular disease using innovative solutions such as preemptive interventional therapies (bioabsorbable stents) for stabilization of vulnerable atherosclerotic plaques, mass unconditional Polypill therapy for population-based risk reduction, and ultimately vaccination strategies to prevent the development of atherosclerosis. Up-to-date and authoritative, Asymptomatic Atherosclerosis: Pathophysiology, Detection, and Treatment is a must-have for any cardiologist or primary care physician who wishes to practice modern preventive cardiology and manage the increasing number of asymptomatic atherosclerotic patients. Outlines more accurate measures of risk (coronary artery calcium and carotid intima-media thickness) than traditional risk factors (total cholesterol, LDL cholesterol, HDL cholesterol). Presents new multipronged strategies to aid in the early detection and treatment of high risk asymptomatic patients.
- Contents
- 1. Preventive Cardiology: The SHAPE of the Future -- 2. From Vulnerable Plaque to Vulnerable Patient -- 3. Pathology of Vulnerability Caused by High-Risk (Vulnerable) Arteries and Plaques -- 4. Pathophysiology of Vulnerability Caused by Thrombogenic (Vulnerable) Blood -- 5. Vulnerability Caused by Arrhythmogenic Vulnerable Myocardium -- 6. Approach to Atherosclerosis as a Disease: Primary Prevention Based on the Detection and Treatment of Asymptomatic Atherosclerosis -- Section I. Risk Factors and Circulating Markers of Asymptomatic Atherosclerotic Cardiovascular Disease -- 7. History of the Evolution of Cardiovascular Risk Factors and the Predictive Value of Traditional Risk-Factor-Based Risk -- 8. Comprehensive Lipid Profiling Beyond LDL -- 9. New Blood Biomarkers of Inflammation and Atherosclerosis -- 10. Genomics and Proteomics: The Role of Contemporary Biomolecular Analysis in Advancing the Knowledge of Atherosclerotic Coronary Artery Disease -- 11. Circulating Endothelial Progenitor Cells: Mechanisms and Measurements -- 12. Family History: An Index of Genetic and Environmental Predisposition to Coronary Artery Disease -- 13. Endothelial Activation Markers in Sub-clinical Atherosclerosis: Insights from Mechanism-Based Paradigms -- Section II. Non Invasive, Non Imaging, Assessment of Asymptomatic Atherosclerotic Cardiovascular Disease -- 14. Exercise Stress Testing in Asymptomatic Individuals and Its Relation to Subclinical Atherosclerotic Cardiovascular Disease -- 15. The Ankle Brachial Index -- 16. Arterial Elasticity/Stiffness -- 17. Assessment of Endothelial Function in Clinical Practice -- 18. Digital (Fingertip) Thermal Monitoring of Vascular Function: A Novel, Noninvasive, Nonimaging Test to Improve Traditional Cardiovascular Risk Assessment and Monitoring of Response to Treatments -- 19. Assessment of Macro- and Microvascular Function and Reactivity -- Section III. Non Invasive Structural Imaging of Asymptomatic Atherosclerotic Cardiovascular Disease -- 20. Coronary Artery Calcium Imaging -- 21. Noninvasive Ultrasound Imaging of Carotid Intima Thickness -- 22. Carotid Intima-Media Thickness: Clinical Implementation in Individual Cardiovascular Risk Assessment -- 23. Computed Tomographic Angiography -- 24. Role of Noninvasive Imaging using CT for Detection and Quantitation of Coronary Atherosclerosis -- 25. Noninvasive Coronary Plaque Characterization: CT Versus MRI -- 26. Magnetic Resonance Imaging -- 27. The Role of MRI in Examining Subclinical Carotid Plaque -- 28. Comprehensive Non-contrast CT Imaging of the Vulnerable Patient -- Section IV. Non Invasive Functional Imaging of Asymptomatic Atherosclerotic Cardiovascular Disease -- 29. Ultrasound Assessment of Brachial Artery Reactivity -- 30. Cardiac Imaging for Ischemia in Asymptomatic Patients: Use of Coronary Artery Calcium Scanning to Improve Patient Selection: Lessons from the EISNER Study -- 31. Targeted MRI of Molecular Components in Atherosclerotic Plaque -- 32. Noninvasive Imaging of the Vulnerable Myocardium: Cardiac MRI and CT Based -- Section V. Invasive (Intravascular) Risk Stratification for Detection of Vulnerable (High-Risk) Asymptomatic Atherosclerotic Plaques -- 33. Angiography for Detection of Complex and Vulnerable Atherosclerotic Plaque -- 34. Intravascular Characterization of Vulnerable Coronary Plaque -- 35. Detecting Vulnerable Plaque Using Invasive Methods -- 36. Assessment of Plaque Burden and Plaque Composition Using Intravascular Ultrasound -- 37. Vulnerable Anatomy; The Role of Coronary Anatomy and Endothelial Shear Stress in the Progression and Vulnerability of Coronary Artery Lesions: Is Anatomy Destiny? -- 38. Vasa Vasorum Imaging -- Section VI. Screening for Risk Assessment of Asymptomatic At-Risk Population and Identification of the Vulnerable Patient – The SHAPE Paradigm - 39. From Vulnerable Plaque to Vulnerable Patient – Part III. -- 40. Cost Effectiveness of Screening Atherosclerosis -- 41. Monitoring of Subclinical Atherosclerotic Disease -- 42. Implications of SHAPE Guideline for Improving Patient Compliance -- 43. The SHAPE Guideline: Why Primary Care Physicians Should Embrace It -- 44. Should We Treat According to the SHAPE Guidelines? -- 45. Duty-Bound: Rational Foundations of Clinical Strategies for Prevention of Cardiovascular Events -- 46. A Time to Live: Dynamic Changes in Risk as the Basis for Therapeutic Triage -- Section VII. Treatment of Asymptomatic Atherosclerotic Cardiovascular Disease and the Vulnerable Patients: Systemic Therapies -- 47. LDL Targeted Therapies -- 48. Antioxidants as Targeted Therapy: A Special Protective Role for Pomegranate and Paraoxonases (PONs -- 49. The Multiconstituent Cardiovascular Pill (MCCP): Challenges and Promises of Population Based Prophylactic Drug Therapy for Heart Attack Prevention and Eradication -- 50. Vaccine for Atherosclerosis: An Emerging New Paradigm -- Section VIII. Local and Focal Therapies for Stabilization of Vulnerable Arteries and Plaques -- 51. Drug-Eluting Stents: A Potential Preemptive Treatment Choice for Vulnerable Coronary Plaques -- 52. Intrapericardial Approach for Pancoronary Stabilization of the Vulnerable Arteries and Myocardium -- Section IX. Educations, Life Style Modifications and Non-Pharmacologic Treatments for Primary Prevention and Saving the Vulnerable -- 53. Dietary Management for Coronary Atherosclerosis Prevention and Treatment -- 54. Management of Preconditioning Physical Activity in a Vulnerable Patient: Getting in SHAPE -- 55. Last Chance for Prevention (Acute Prevention): Identification of Prodromal Symptoms and Early Heart Attack Care.
- Format
- e-Book
- Location
- Online
