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Advancing Healthcare Through Personalized Medicine

https://libcat.nshealth.ca/en/permalink/provcat47114
Priya Hays. (Second edition) Springer , 2021.
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Online
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Responsibility
Priya Hays
Edition
Second edition
Publisher
Springer
Date of Publication
2021
Physical Description
1 online resource (xxv, 745 pages) : illustrations
ISBN
9783030801007
Specialty
Precision Medicine
Internal Medicine
Format
e-Book
Location
Online
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An Information Technology Framework for Predictive, Preventive and Personalised Medicine : A Use-Case with Hepatocellular Carcinoma

https://libcat.nshealth.ca/en/permalink/provcat39137
Leonard Berliner, Heinz U. Lemke, editors. --Cham: Springer , c2015.
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This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for hepatocellular carcinoma (HCC). The subject was approached with four interrelated tasks: (1) review of clinical practices relating to HCC; (2) propose an IT system relating to HCC, including clinical decision support and research needs; (3) determine how a clinical liver cancer center can contribute; and, (4) examine the enhancements and impact tha…
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Other Authors
Berliner, Leonard
Lemke, Heinz U
Responsibility
Leonard Berliner, Heinz U. Lemke, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xx, 130 p. : 23 illus., 15 illus. in color)
Series Vol.
v. 8
Series Title
Advances in predictive, preventive and personalised medicine
ISBN
9783319121666
9783319121659 (print ed.)
ISSN
2211-3495
Subjects (MeSH)
Carcinoma, Hepatocellular - therapy
Medical Informatics - methods
Precision Medicine - methods
Preventive Medicine - methods
Abstract
This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for hepatocellular carcinoma (HCC). The subject was approached with four interrelated tasks: (1) review of clinical practices relating to HCC; (2) propose an IT system relating to HCC, including clinical decision support and research needs; (3) determine how a clinical liver cancer center can contribute; and, (4) examine the enhancements and impact that the first three tasks will have on the management of HCC. An IT System for Personalized Medicine (ITS-PM) for HCC will provide the means to identify and determine the relative value of the wide number of variables, including clinical assessment of the patient -- functional status, liver function, degree of cirrhosis, and comorbidities; tumor biology, at a molecular, genetic and anatomic level; tumor burden and individual patient response; medical and operative treatments and their outcomes.
Contents
Preface -- Introduction -- The Digital Patient Model and Model Guided Therapy -- Hepatocellular Carcinoma and Patient Assessment -- Imaging in Hepatocellular Carcinoma: Radiologic Assessment -- Imaging in Hepatocellular Carcinoma: PET/CT -- Personalized Chemotherapy for Hepatocellular Carcinoma -- Surgical Treatment for Hepatocellular Carcinoma -- Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Technologies -- Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Therapies -- Minimally Invasive Therapies for Hepatocellular Cancer: Catheter-Directed Therapies -- Radiation Oncology in the Treatment of Hepatocellular Carcinoma -- Design of an IT System for Hepatocellular Carcinoma -- Outlook and Expert Recommendations for Predictive, Preventive and Personalized Medicine and Hepatocellular Carcinoma.
Format
e-Book
Location
Online
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The Art and Science of Personalising Care with Older People with Diabetes

https://libcat.nshealth.ca/en/permalink/provcat42636
Trisha Dunning, editor. --Cham: Springer , c2018.
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This unique book is intended for all health professionals caring for older people with diabetes such as specialist and general nurses, doctors, primary care practioners and dieteticians. Although there is an increasing body of work about personalised care, no publications were identified that encompass the focus and scope of the proposed book. The global population is ageing and increasing age is a key risk factor for diabetes. Older people with diabetes are often vulnerable, have complex care …
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Other Authors
Dunning, Trisha
Responsibility
Trisha Dunning, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xiii, 187 p.) : 8 illus. in color
ISBN
9783319743608
9783319743592 (print ed.)
9783319743615 (print ed.)
Subjects (MeSH)
Aged
Diabetes Mellitus - therapy
Precision Medicine
Specialty
Diabetes Mellitus
Geriatrics
Patient Care
Abstract
This unique book is intended for all health professionals caring for older people with diabetes such as specialist and general nurses, doctors, primary care practioners and dieteticians. Although there is an increasing body of work about personalised care, no publications were identified that encompass the focus and scope of the proposed book. The global population is ageing and increasing age is a key risk factor for diabetes. Older people with diabetes are often vulnerable, have complex care needs and often have cognitive changes, which makes personalising care challenging for health professionals. Thus, this is an internationally relevant book filling a gap in the current literature. This is a practical and updated book that will use an engaging and easy to read narrative style. It challenges readers to reflect in and on their practice. It encompasses people with diabetes' and authors' stories, which are known to have a special interest to readers, make it easier to apply the information to practice, enhance learning, and hence the relevance and value of the book. It is relevant to advocacy organisations as well as managers and service planners. Researchers and scientists may find relevant information on grant and ethics applications, research protocols, plain language statements for potential participants and operationalising research protocols.
Contents
1. Overview of Older People, Ageing and Diabetes, the Disease -- 2. The Art of Shared Decision-Making and Personalising Care with Older People with Diabetes -- 3. Health Professionals: What Do They Need to Cogenerate Holistic Personalised Care? -- 4. From Research to Evidence to Context: Implementing and Using Guidelines as Decision Aids to Personalise Care -- 5. Nutrition and Exercise: A Personalised Approach -- 6. Medicines and Older People with Diabetes: Beliefs, Benefits and Risks -- 7. Older People with Diabetes and Life Transitions -- 8. Personalising Care with Older People Who Have Cognitive Changes or Dementia -- 9. The Art of Using Technology to Personalise Care with Older People with Diabetes -- 10. Personalised Care and Research.
Format
e-Book
Location
Online
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Asthma : Targeted Biological Therapies

https://libcat.nshealth.ca/en/permalink/provcat41552
Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli. --Cham: Springer , 2017.
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This book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody oma…
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Author
Pelaia, Girolamo
Other Authors
Vatrella, Alessandro
Maselli, Rosario
Responsibility
Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (vi, 99 pages) : 11 illus. in color
ISBN
9783319460079
9783319460055 (print ed.)
Subjects (MeSH)
Asthma - drug therapy
Biological Therapy
Precision Medicine
Abstract
This book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody omalizumab, widely approved as add-on treatment for inadequately controlled disease, through to emerging biologics for which evidence supportive of efficacy is accumulating, including anti-IL-5, anti-IL-4, and anti-IL-13 therapies. One aspect to emerge is the variability in individual response, which suggests a need for characterization of different asthma subtypes to permit the effective implementation of phenotype-targeted treatments. This book will be of interest for pulmonologists, clinical immunologists, and physicians seeking sound information on these therapies, but also for scientists and pharmacologists wishing to enhance their knowledge of the therapeutic implications of the cellular and molecular mechanisms that underlie severe, uncontrolled asthma.
Contents
1. Introduction -- 2. Inflammatory Cellular Patterns in Asthma -- 3. Airway Remodelling in Asthma -- 4. Anti-IgE Therapy -- 5. IL-5-Targeted Antibodies -- 6. Anti-IL-4/IL-13 Biologics -- 7. Anti-TNF-a Therapies -- 8. Biologic Treatments Targeted to Innate Cytokines -- 9. Other Biologic Drugs -- 10. Conclusions and Future Perspectives.
Format
e-Book
Location
Online
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Clinical Relevance of Genetic Factors in Pulmonary Diseases

https://libcat.nshealth.ca/en/permalink/provcat43400
Takeshi Kaneko, editor. --Singapore: Springer , c2018.
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This book describes the underlying genetic basis of common pulmonary diseases and discusses their pathogenesis and pathophysiology. These insights provide the basis for understanding different subtypes and phonotypes, and will promote better treatment strategies and individualized medicine. The book provides new and valuable information for the development of the areas of study, as well as practical guidelines for clinicians engaged in treating pulmonary diseases. This volume of the Respiratory…
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Kaneko, Takeshi
Responsibility
Takeshi Kaneko, editor
Place of Publication
Singapore
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (ix, 344 p.) : 55 illus., 36 illus. in color
Series
Respiratory Disease Series: Diagnostic Tools and Disease Managements
Series Title
Respiratory disease series
ISBN
9789811081446
9789811081439 (print ed.)
9789811081453 (print ed.)
ISSN
2509-5552
Subjects (MeSH)
Genetic Predisposition to Disease
Lung Diseases - diagnosis
Lung Diseases - genetics
Lung Diseases - physiopathology
Precision Medicine
Risk Factors
Specialty
Genetics, Medical
Pulmonary Medicine
Abstract
This book describes the underlying genetic basis of common pulmonary diseases and discusses their pathogenesis and pathophysiology. These insights provide the basis for understanding different subtypes and phonotypes, and will promote better treatment strategies and individualized medicine. The book provides new and valuable information for the development of the areas of study, as well as practical guidelines for clinicians engaged in treating pulmonary diseases. This volume of the Respiratory Disease Series : Diagnostic Tools and Disease Managements will broaden the understanding of beginning and experienced researchers and clinicians who treat pulmonary diseases. Moreover, residents and clinicians engaged in medical oncology will find it a valuable guide to support them in their day-to-day work.
Contents
Part I. Introduction -- 1. Clinical development of genomic medicine in pulmonary diseases: Are genetic factors enough to determine the phenotype and inheritance of pulmonary diseases? -- 2. Statistical approaches and strategies for complex diseases - Overview - : What is the rationale for the genome-wide approach to understand complex diseases - its application and limitations -- Part II. Genetic Disorders in Pulmonary Disease -- 3. Bronchial asthma: Is asthma inherited? -- 4. COPD - Hereditary (A1-AT) and Non-hereditary: What are the roles of genetic factors in the pathogenesis of COPD? -- 5. Smoking behavior and cessation (nicotine addiction): Are genetic factors involved in smoking behavior? -- 6. Cystic fibrosis, Primary ciliary dyskinesia and Diffuse panbronchiolitis - Hereditary and Non-Hereditary: What are the roles of genetic factors in the pathogenesis of these diseases? -- 7. Pulmonary Fibrosis -Hereditary and Nonhereditary: What are the role of genetic factors in the pathogenesis of pulmonary fibrosis? -- 8. Other diffuse lung diseases - Diffuse cystic lung diseases (LAM, TSC, BHD), Sarcoidosis, Pulmonary alveolar proteinosis, and Pulmonary alveolar microlithiasis: What are the roles of genetic factors in the pathogenesis of these diseases? -- 9. Pulmonary vascular diseases. Pulmonary hypertension and HHT: What are the roles of genetic factors in the pathogenesis of pulmonary vascular diseases? -- 10. Mycobacterial infection—TB and NTM: What are the roles of genetic factors in the pathogenesis of mycobacterial infection? -- 11. Pulmonary malignancies (1). Lung cancer: What are the roles of genetic factors in lung cancer pathogenesis? -- 12. Pulmonary malignancies (2). Mesothelioma: What are the Roles of Genetic Factors in the Pathogenesis of Mesothelioma? -- 13. Genetic Factors in Sleep Disorders: What are the roles of genetic factors in the pathogenesis of sleep disorders? -- 14. Pharmacokinetics, pharmacodynamics, and toxicities: What should we know about genetic factors that affect the pharmacotherapy of pulmonary diseases? -- Part III. Oncogenic Driver Mutation (Somatic Mutations) in Lung Cancer -- 15. EGFR: How important is EGFR mutation status in the management of lung cancer? -- 16. ALK, and others: How important are ALK, and other mutations in the management of lung cancer? -- Part IV. Current Topics -- 17. Application of high-throughput technologies in personal genomics: How is the progress in personal genome service? -- 18. Nucleic acid amplification-based diagnostics for pulmonary diseases : What is the current state and perspectives of nucleic acid amplification technologies used in diagnostics associated with pulmonary diseases?
Format
e-Book
Location
Online
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Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors

https://libcat.nshealth.ca/en/permalink/provcat41555
Karel Pacak, David Taïeb, editors. --Cham: Humana Press , 2017.
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Based on the most novel approaches and cutting-edge clinical and scientific information regarding radionuclide imaging and therapies for neuroendocrine tumors, this clinical guidebook represents a unique collaborative effort between endocrinologists, nuclear physicians, oncologists, surgeons, physicists, radio-pharmacists and geneticists. It begins with the embryology, classification and molecular genetics of gastroenteropancreatic neuroendocrine tumors and carcinoids, chromaffin cell tumors, a…
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Other Authors
Pacak, Karel
Taïeb, David
Responsibility
Karel Pacak, David Taïeb, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
2017
Physical Description
1 online resource (xiv, 484 pages) : 104 illus., 79 illus. in color
Series Title
Contemporary endocrinology
ISBN
9783319460383
9783319460369 (print ed.)
ISSN
2523-3785
2523-3793 (e)
Subjects (MeSH)
Neuroendocrine Tumors - diagnostic imaging
Neuroendocrine Tumors - radiotherapy
Precision Medicine
Abstract
Based on the most novel approaches and cutting-edge clinical and scientific information regarding radionuclide imaging and therapies for neuroendocrine tumors, this clinical guidebook represents a unique collaborative effort between endocrinologists, nuclear physicians, oncologists, surgeons, physicists, radio-pharmacists and geneticists. It begins with the embryology, classification and molecular genetics of gastroenteropancreatic neuroendocrine tumors and carcinoids, chromaffin cell tumors, and MEN1- and MEN2-related tumors. Following a chapter on radiopharmaceuticals in neuroendocrine imaging, it turns to the physics and technology of current and cutting-edge radiology, including SPECT/CT and PET/CT and PET/MR. Discussing of radionuclide imaging covers the tumors mentioned above, as well as pulmonary and thymic neuroendocrine tumors and medullary thyroid carcinoma. A presentation of radionuclide therapies follows, including 131I-MIBG therapy, somatostatin receptor-based therapy, and alpha radionuclide therapy, as well as the role of nanoparticles. Comprehensive and up-to-date, Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors will assist and guide physicians who encounter patients with these conditions, either from a diagnostic or therapeutic standpoint, and particularly emphasizes the current and emerging medical devices and imaging and therapeutic options.
Contents
Classification of neuroendocrine tumors -- Molecular genetics of Pheochromocytoma and paraganglioma -- Molecular Genetics of MEN1-related Neuroendocrine Tumors -- Molecular genetics of MEN2-related neuroendocrine tumors -- Molecular genetics of Neuroblastoma -- Molecular Genetics of Gastroenteropancreatic Neuroendocrine Tumors -- Current and future radiopharmaceuticals in neuroendocrine tumors imaging -- SPECT/CT, PET/CT and PET/MR: Principles -- Internal dosimetry: Principles and Applications to NET -- Principles and Application of Molecular Imaging for Personalised Medicine and Guiding Interventions in Neuroendocrine Tumors -- Tumor metabolism and metabolomics of pheochromocytomas and paragangliomas -- Radionuclide imaging of pheochromocytoma and paraganglioma in the era of multi-omics -- Radionuclide imaging of Head and neck PGLs -- Radionuclide imaging of Chromaffin cell tumors -- Radionuclide imaging of Gastrointestinal neuroendocrine tumors -- Radionuclide imaging of Pancreatic neuroendocrine tumors -- Radionuclide imaging of Pulmonary, thymic neuroendocrine tumors and other neuroendocrine tumors -- Radionuclide imaging of Medullary thyroid carcinoma -- 131I-MIBG therapy for pheochromocytoma/paraganglioma and neuroblastoma -- Somatostatin receptors-based radionuclide therapy -- Alpha radionuclide therapy: Principles and Applications to NET -- Nanoparticles for Radionuclide Imaging and Therapy: Principles.
Format
e-Book
Location
Online
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Digital Health Approach for Predictive, Preventive, Personalised and Participatory Medicine

https://libcat.nshealth.ca/en/permalink/provcat44509
Lotfi Chaari, editor. --Cham: Springer , c2019.
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Online
This collection, entitled «Digital Health for Predictive, Preventive, Personalized and Participatory Medicine» contains the proceedings of the first International conference on digital health technologies (ICDHT 2018). Ten recent contributions in the fields of Artificial Intelligence (AI) and machine learning, Internet of Things (IoT) and data analysis, all applied to digital health. This collection enables researchers to learn about recent advances in the above mentioned fields. It brings a te…
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Other Authors
Chaari, Lotfi
Responsibility
Lotfi Chaari, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xvi, 88 p.) : 35 illus., 23 illus. in color
Series Vol.
v. 10
Series Title
Advances in predictive, preventive and personalised medicine
ISBN
9783030118006
9783030117993 (Print ed.)
9783030118013 (Print ed.)
ISSN
2211-3495
Subjects (MeSH)
Medical Informatics Applications
Precision Medicine
Specialty
Medical Informatics
Telemedicine
Abstract
This collection, entitled «Digital Health for Predictive, Preventive, Personalized and Participatory Medicine» contains the proceedings of the first International conference on digital health technologies (ICDHT 2018). Ten recent contributions in the fields of Artificial Intelligence (AI) and machine learning, Internet of Things (IoT) and data analysis, all applied to digital health. This collection enables researchers to learn about recent advances in the above mentioned fields. It brings a technological viewpoint of P4 medicine. Readers will discover how advanced Information Technology (IT) tools can be used for healthcare. For instance, the use of connected objects to monitor physiological parameters is discussed. Moreover, even if compressed sensing is nowadays a common acquisition technique, its use for IoT is presented in this collection through one of the pioneer works in the field. In addition, the use of AI for epileptic seizure detection is also discussed as being one of the major concerns of predictive medicine both in industrialized and low-income countries. This work is edited by Prof. Lotfi Chaari, professor at the University of Sfax, and previously at the University of Toulouse. This work comes after more than ten years of expertise in the biomedical signal and image processing field.
Contents
Seizure Onset Detection in EEG Signals Based on Entropy from Generalized Gaussian PDF Modeling and Ensemble Bagging Classifier -- Artificial Neuroplasticity with Deep Learning Reconstruction Signals to Reconnect Motion Signals for the Spinal Cord -- Improved Massive MIMO Cylindrical Adaptive Antenna Array -- Mulitifractal Analysis with Lacunarity for Microcalcification Segmentation -- Consolidated Clinical Document Architecture: Analysis and Evaluation to Support the Interoperability of Tunisian Health Systems - Bayesian Compressed Sensing for IoT: Application to EEG Recording -- Patients Stratification in Imbalanced Datasets: A Roadmap -- Real-Time Driver Fatigue Monitoring with a Dynamic Bayesian Network Model -- Epileptic Seizure Detection Using a Convolutional Neural Network.
Format
e-Book
Publication Type
Congress
Location
Online
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Flammer Syndrome : From Phenotype to Associated Pathologies, Prediction, Prevention and Personalisation

https://libcat.nshealth.ca/en/permalink/provcat44651
Olga Golubnitschaja, editor. --Cham: Springer , c2019.
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Unmet healthcare needs of young populations and individuals in suboptimal health conditions are the key issue of currently observed epidemics of non-communicable disorders. Moreover, an unprecedented decrease in the average age of onset of these disorders is recorded. The majority of non-communicable disorders carry a chronic character by progressing over a couple of years from a reversible suboptimal health condition to irreversible pathology with collateral complications. The time-frame betwe…
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Other Authors
Golubnitschaja, Olga
Responsibility
Olga Golubnitschaja, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xii, 376 p.) : 47 illus., 40 illus. in color
Series Vol.
v. 11
Series Title
Advances in predictive, preventive and personalised medicine
ISBN
9783030135508
9783030135492 (Print ed.)
9783030135515 (Print ed.)
9783030135522 (Print ed.)
ISSN
2211-3495
Subjects (MeSH)
Adolescent
Precision Medicine
Syndrome
Vascular Diseases - complications
Vascular Diseases - physiopathology
Specialty
Cardiology
Abstract
Unmet healthcare needs of young populations and individuals in suboptimal health conditions are the key issue of currently observed epidemics of non-communicable disorders. Moreover, an unprecedented decrease in the average age of onset of these disorders is recorded. The majority of non-communicable disorders carry a chronic character by progressing over a couple of years from a reversible suboptimal health condition to irreversible pathology with collateral complications. The time-frame between both conditions is the operational area for predictive diagnosis and identification of persons at risk by innovative screening programmes followed by the most cost-effective personalised treatment possible, namely primary prevention tailored to the person. The book propagates the paradigm change from delayed, costly but frequently ineffective medical services to the holistic approach by predictive, preventive and personalised medicine clearly demonstrating multifaceted benefits to the individual, healthcare sector and society as a whole. The book is focused on the needs of young people: teenagers, adolescents and young adults; regardless of the age, individuals in suboptimal health conditions, who are interested in remaining healthy by optimising their modifiable risk factors – both endogenous and exogenous ones; several patient cohorts demonstrating similar phenotype of Flammer syndrome. The book is based on the multi-professional expertise, scientific excellence and practical experiences of the world-acknowledged experts in Flammer syndrome, predictive diagnostics, targeted prevention and personalised medicine, amongst others. The topic of this book is particularly relevant to general practitioners, experts in non-communicable diseases, phenotyping, genotyping, multilevel diagnostics, targeted prevention, personalised medicine, as well as the readers interested in advancing their health literacy.
Contents
Flammer Syndrome in the Global Context – The “U-Shape” of Health Risks -- General Lessons Learned from Flammer Syndrome -- Flammer Syndrome-Affected Individuals May Be Predisposed to Associated Pathologies Early in Life: Psychological and Psychiatric Aspects -- Flammer Syndrome: Psychological Causes and Consequences of Visual Impairment -- Multiomic Signature of Glaucoma Predisposition in Flammer Syndrome Affected Individuals – Innovative Predictive, Preventive and Personalised Strategies in Disease Management -- Interrelation Between Dry Mouth and Flammer Syndromes: Neglected Risks in Youth and New Concepts of Personalised Prevention -- Specific Symptoms of Flammer Syndrome in Women Suffering from Vaginal Dryness: Individualised Patient Profiles, Risks and Mitigating Measures -- Relevance of Flammer Syndrome to the “Sleep-Wake” Rhythm: Possible Mechanisms, Risks and Preventive Strategies -- Flammer Syndrome and Autoimmune Inflammatory Conditions of the Central Nervous System: Multifactorial Interrelations -- “Young Stroke” Risks Potentially Linked to the Flammer Syndrome Phenotype: Facts and Hypotheses -- Flammer and Sjögren Syndromes: What and Why Is in Common? -- Flammer Syndrome in the Context of Healing Impairments – Facts and Hypotheses for Multi-professional Consideration -- Feeling Cold and Other Underestimated Symptoms of Flammer Syndrome in Breast Cancer Diagnostics: Is Innovative Screening on the Horizon? -- Relevance of Flammer Syndrome Phenotype to Metastatic Breast Cancer: Risks by Pre-metastatic Systemic Hypoxic Environment -- Individualised Patient Profile: Risk Assessment by the Patient’s Self-Report and Potential Clinical Utility of Flammer Syndrome Phenotype -- Triple-Negative Breast Cancer with Pronounced Flammer Syndrome Phenotype – Case Report -- Suboptimal Health Status and Cardiovascular Deficits -- Flammer Syndrome, Disordered Eating and Microbiome: Interrelations, Complexity of Risks and Individual Outcomes -- Nutritional Approach to the Common Symptoms of Flammer Syndrome -- Positive Effects of Acupuncture Benefiting Individuals with Flammer Syndrome and Patients with Associated Pathologies.
Format
e-Book
Location
Online
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Gastric Cancer In The Precision Medicine Era : Diagnosis and Therapy

https://libcat.nshealth.ca/en/permalink/provcat44285
Vincenzo Canzonieri, Antonio Giordano, editors. --Cham: Humana Press , 2019.
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Online
This book provides a comprehensive, state-of-the art review and serves as an overview of the different aspects of gastric cancer. The first section aims to clarify the main aspects of tumorigenesis, such as the role of inflammation linked to the presence of H. Pylori infection, and the genetic and epigenetic mechanisms so far known. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspective will be illustrated. The second section in…
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Other Authors
Canzonieri, Vincenzo
Giordano, Antonio
Responsibility
Vincenzo Canzonieri, Antonio Giordano, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
2019
Physical Description
1 online resource (xv, 256 p.: 47 illus. in color
Series
Current Clinical Pathology
Series Title
Current clinical pathology
ISBN
9783030048617
9783030048600 (Print ed.)
9783030048624 (Print ed.)
ISSN
2197-781X
Subjects (MeSH)
Biomarkers
Precision Medicine
Stomach Neoplasms - diagnosis
Stomach Neoplasms - therapy
Specialty
Gastroenterology
Medical Oncology
Precision Medicine
Abstract
This book provides a comprehensive, state-of-the art review and serves as an overview of the different aspects of gastric cancer. The first section aims to clarify the main aspects of tumorigenesis, such as the role of inflammation linked to the presence of H. Pylori infection, and the genetic and epigenetic mechanisms so far known. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspective will be illustrated. The second section includes the pathological and clinical features and contains information regarding the most recent tissue and serological biomarkers in these neoplasms. The three successive sections are intended to provide the “state of art” of multimodal treatment approaches to gastric cancer, i.e. standard and novel surgical aspects, common and innovative chemo and radio protocols and modern targeted therapies. Novel molecular classifications are under consideration to improve diagnostic and prognostic definitions and to prospect future treatments based on the use of immunotherapies and innovative molecules such as non-coding RNA and nanoparticles. Gastric Cancer in the Precision Medicine Era serves as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It provides a concise yet comprehensive summary of the current status of the field that helps guide patient management and stimulates investigative efforts. All chapters are written by experts in their fields and includes the most up to date scientific and clinical information.
Contents
Part I. Gastric Tumorigenesis -- Gastric Tumorigenesis: Role of Inflammation and Helicobacter Pylori -- Genetic and Epigenetic Mechanisms in Gastric Cancer -- Part II. Clinical and Pathological Characteristics -- Diagnosis and Surveillance: Endoscopic Hallmarks -- Pathological Diagnosis And Classification Of Gastric Epithelial Tumors -- Diagnostic, Prognostic, Predictive and Therapeutic Tissue Biomarkers in Gastric Cancer -- Serum Biomarkers in Gastric Cancer -- Part III. Gastric Cancer Therapy: Multimodal Treatment Approach -- New Agents in the Treatment of Advanced Gastric Cancer: Targeted Therapy and Immunotherapy -- Combined-Modality Treatment for Locally Advanced Gastric Cancer: Current Evidences and New Perspectives -- Surgical Strategies in Gastric Cancer -- Part IV. Evolving Treatment Landscape in Gastric Cancer -- From Molecular Classification to Targeted Therapy for Gastric Cancer in the Precision Medicine Era -- Part V. Future Medicine in Gastric Cancer -- Non-Coding RNA in Gastric Cancer with Potential Prognostic and Predictive Role -- Immunomodulation and Immunotherapy for Gastric Cancer -- Nanomedicine in Gastric Cancer.
Format
e-Book
Location
Online
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Gene Therapy in Reconstructive and Regenerative Surgery

https://libcat.nshealth.ca/en/permalink/provcat42577
Giorgio Giatsidis, editor. --Cham: Springer , c2018.
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Online
This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscle…
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Other Authors
Giatsidis, Giorgio
Responsibility
Giorgio Giatsidis, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (vii, 113 p.) : 8 illus., 7 illus. in color
ISBN
9783319789576
9783319789569 (print ed.)
9783319789583 (print ed.)
Subjects (MeSH)
Genetic Therapy - methods
Precision Medicine
Reconstructive Surgical Procedures
Regenerative Medicine
Wound Healing - genetics
Specialty
Precision Medicine
Regenerative Medicine
Abstract
This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided. Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants. Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.
Contents
Principles of Gene Therapy in Reconstructive and Regenerative Surgery -- Gene Therapy in Skin and Wound Healing -- Gene Therapy in Pathologic Scars -- Gene Therapy in Skeletal Muscle Repair and Regeneration -- Gene Therapy in Cartilage Repair and Regeneration -- Gene Therapy in Tendon Repair and Regeneration -- Gene Therapy and Free Flaps for Therapeutic Reconstructive Surgery -- Developing a Gene Therapy Clinical Trial: Tips and Tricks -- Future Directions in Reconstructive and Regenerative Surgery.
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e-Book
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Genomic and precision medicine : cardiovascular disease

https://libcat.nshealth.ca/en/permalink/provcat41104
edited by Geoffrey S. Ginsburg, Huntington F. Willard. (3rd ed.) --London, UK: Elsevier , c2018.
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Genomic and Precision Medicine: Cardiovascular Disease, Third Edition, focuses on the applications of genome discovery on the broad spectrum of cardiovascular disorders. Each chapter is organized for the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.
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Other Authors
Ginsburg, Geoffrey S
Responsibility
edited by Geoffrey S. Ginsburg, Huntington F. Willard
Edition
3rd ed.
Place of Publication
London, UK
Publisher
Elsevier
Date of Publication
c2018
Physical Description
1 online resource, 336 p.
ISBN
9780128018125
Subjects (MeSH)
Genetics, medical - methods
Precision Medicine - methods
Proteomics - methods
Specialty
Cardiology
Genetics, Medical
Precision Medicine
Abstract
Genomic and Precision Medicine: Cardiovascular Disease, Third Edition, focuses on the applications of genome discovery on the broad spectrum of cardiovascular disorders. Each chapter is organized for the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.
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Genomic and precision medicine : foundations, translation, and implementation

https://libcat.nshealth.ca/en/permalink/provcat41031
edited by Geoffrey S. Ginsburg, Huntington F. Willard. (3rd ed.) --London, UK: Elsevier , c2017.
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Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care.
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Other Authors
Ginsburg, Geoffrey S
Responsibility
edited by Geoffrey S. Ginsburg, Huntington F. Willard
Edition
3rd ed.
Place of Publication
London, UK
Publisher
Elsevier
Date of Publication
c2017
Physical Description
1 online resource, 398 p.
ISBN
9780128006818
Subjects (MeSH)
Genetics, medical - methods
Precision Medicine - methods
Proteomics - methods
Abstract
Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care.
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Genomic and precision medicine : foundations, translation, and implementation

https://libcat.nshealth.ca/en/permalink/provcat50741
Ginsburg, Geoffrey. (3rd ed.) --Philadelphia, PA: Elsevier , 2017.
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Author
Ginsburg, Geoffrey
Edition
3rd ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
2017
ISBN
9780128006818
Subjects (MeSH)
Genetics, Medical - methods
Precision Medicine - methods
Proteomics - methods
Notes
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
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e-Book
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Genomic and precision medicine : infectious and inflammatory disease

https://libcat.nshealth.ca/en/permalink/provcat43986
edited by Geoffrey S. Ginsburg, Huntington F. Willard. (3rd ed.) --London, UK: Academic Press , c2019.
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Genomic and Precision Medicine: Inflammation and Metabolic Disorders, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precisi…
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View e-Book
Other Authors
Ginsburg, Geoffrey S.
Responsibility
edited by Geoffrey S. Ginsburg, Huntington F. Willard
Edition
3rd ed.
Place of Publication
London, UK
Publisher
Academic Press
Date of Publication
c2019
Physical Description
1 online resource
ISBN
9780128014967
Subjects (MeSH)
Genetics, Medical - methods
Precision Medicine - methods
Proteomics - methods
Specialty
Genetics, Medical
Precision Medicine
Abstract
Genomic and Precision Medicine: Inflammation and Metabolic Disorders, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.
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Genomic and precision medicine : infectious and inflammatory disease

https://libcat.nshealth.ca/en/permalink/provcat50739
Ginsburg, Geoffrey S. (3rd ed.) --London, England: Academic Press , 2019.
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Online
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Author
Ginsburg, Geoffrey S.
Other Authors
Willard, Huntington F.
Tsalik, Ephraim L.
Woods, Christopher W.
Edition
3rd ed.
Place of Publication
London, England
Publisher
Academic Press
Date of Publication
2019
ISBN
9780128014967
Subjects (MeSH)
Genetics, Medical - methods
Precision Medicine - methods
Proteomics - methods
Notes
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
Format
e-Book
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Genomic and precision medicine : primary care

https://libcat.nshealth.ca/en/permalink/provcat41032
edited by Sean P. David. (3rd ed.) --London, UK: Elsevier , c2017.
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Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care.
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Other Authors
David, Sean P
Responsibility
edited by Sean P. David
Edition
3rd ed.
Place of Publication
London, UK
Publisher
Elsevier
Date of Publication
c2017
Physical Description
1 online resource, 370 p.
ISBN
9780128006856
Subjects (MeSH)
Genetics, medical - methods
Precision Medicine - methods
Proteomics - methods
Abstract
Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care.
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Genomic and precision medicine : primary care

https://libcat.nshealth.ca/en/permalink/provcat50742
David, Sean. (3rd ed.) --Philadelphia, PA: Elsevier , 2017.
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Author
David, Sean
Edition
3rd ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
2017
ISBN
9780128006856
Subjects (MeSH)
Genetics, Medical - methods
Precision Medicine - methods
Primary Health Care
Notes
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
Format
e-Book
Location
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Genomic Medicine : A Practical Guide

https://libcat.nshealth.ca/en/permalink/provcat44958
Laura J. Tafe, Maria E. Arcila, editors. --Cham: Springer , c2020.
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The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest…
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Other Authors
Tafe, Laura J.
Arcila, Maria E.
Responsibility
Laura J. Tafe, Maria E. Arcila, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (x, 325 p.) : 21 illus., 20 illus. in color
ISBN
9783030229221
9783030229214 (Print ed.)
9783030229238 (Print ed.)
Subjects (MeSH)
Biomarkers, Tumor
Molecular Diagnostic Techniques
Pathology, Molecular
Precision Medicine - methods
Specialty
Genetics, Medical
Abstract
The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest in molecular pathology and biomarkers. The book covers many aspects of molecular diagnostics, from techniques to applications and comprehensive summaries of the current molecular biomarkers of critical importance in solid and liquid tumors. Attention is also specifi cally devoted to bioinformatics and next generation sequencing, as well as pre-analytical issues that must be considered for accurate interpretation of molecular results in the context of overall patient care. This text focuses on clinical utility and validity and serves as an “owner’s manual” in Genomic Diagnostics for the practicing pathologist, pathology fellows and residents and other health care providers. Physicians will find this book invaluable as a quick reference for current molecular testing modalities and guidelines, tumor board preparation, deciding which test to order and interpreting genomic laboratory results. In addition, it is an accessible for trainees as a board review preparation reference.
Contents
Part I. General Concepts -- Pre-Analytics, Current Testing Technologies, and Limitations of Testing -- Next Generation Sequencing -- Cell-Free DNA Testing -- Role of Bioinformatics in Molecular Medicine -- Interpreting Genomic Reports -- Part II. Applications in Solid Tumors -- Lung Carcinoma -- GI including GIST -- Breast -- Genitourinary Tumors -- Gynecologic Malignancies -- Sarcomas -- Salivary Gland Carcinomas -- Sinonasal Carcinomas -- Part III. Applications in Hematopathology -- Acute Myeloid Neoplasms -- Chronic Myeloid Neoplasms -- Lymphomas.
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e-Book
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Hepatocellular Carcinoma : Translational Precision Medicine Approaches

https://libcat.nshealth.ca/en/permalink/provcat44371
Yujin Hoshida, editor. --Cham: Humana Press , c2019.
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This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment opti…
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Other Authors
Hoshida, Yujin
Responsibility
Yujin Hoshida, editor
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2019
Physical Description
1 online resource (xv, 364 p.) : 56 illus., 37 illus. in color
Series Title
Molecular and translational medicine
ISBN
9783030215408
9783030215392 (Print ed.)
9783030215415 (Print ed.)
9783030215422 (Print ed.)
ISSN
2197-7852
Subjects (MeSH)
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - therapy
Precision Medicine
Translational Medical Research
Specialty
Gastroenterology
Medical Oncology
Precision Medicine
Abstract
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
Contents
Part I: Clinical Demographics and Management -- 1. Risk Factors of Hepatocellular Carcinoma for Precision Personalized Care -- 2. Hepatocellular Carcinoma Surveillance and Staging -- 3. Changing Epidemiology of Hepatocellular Carcinoma and Role of Surveillance -- Part II: Diagnosis and Prognostication -- 4. Radiological Diagnosis and Characterization of HCC -- 5. Analysis of Hepatocellular Carcinoma Tissue for Biomarker and Therapeutic Target Discovery -- 6. Molecular Subtypes and Genomic Signatures of Hepatocellular Carcinoma for Prognostication and Therapeutic Decision Making -- 7. Liquid Biopsy in Hepatocellular Carcinoma -- Part III: Treatment -- 8. Surgical Therapies in Hepatocellular Carcinoma -- 9. Interventional Radiologic Therapies for Hepatocellular Carcinoma: From Where We Began To Where We Are Going -- 10. Precision Locoregional Therapies for Hepatocellular Carcinoma: Percutaneous Ablation and Radiotherapy -- 11. Molecular-targeted Therapies in Hepatocellular Carcinoma -- 12. Immune Therapies -- 13. Prevention Strategies for Hepatocellular Carcinoma -- Part IV: Molecular Pathogenesis and Therapeutic Discovery -- 14. Molecular Alterations and Heterogeneity in Hepatocellular Carcinoma -- 15. Stromal and Immune Drivers of Hepatocarcinogenesis -- 16. Experimental Models for Preclinical Research in Hepatocellular Carcinoma.
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e-Book
Location
Online
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Individualized Medicine : Ethical, Economical and Historical Perspectives

https://libcat.nshealth.ca/en/permalink/provcat39130
Tobias Fischer, Martin Langanke, Paul Marschall, Susanne Michl, editors. --Cham: Springer , c2015.
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In 2009 the University Medicine Greifswald launched the "Greifswald Approach to Individualized Medicine" (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes--next to clinical examples illustrating how the integrated analysis of …
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Other Authors
Fischer, Tobias
Langanke, Martin
Marschall, Paul
Michl, Susanne
Responsibility
Tobias Fischer, Martin Langanke, Paul Marschall, Susanne Michl, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xvi, 323 p. : 24 illus., 18 illus. in color)
Series Vol.
v. 7
Series Title
Advances in predictive, preventive and personalised medicine
ISBN
9783319117195
9783319117188 (print ed.)
ISSN
2211-3495
Subjects (MeSH)
Precision Medicine
Abstract
In 2009 the University Medicine Greifswald launched the "Greifswald Approach to Individualized Medicine" (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes--next to clinical examples illustrating how the integrated analysis of biomarkers leads to significant improvement of therapeutic outcomes for a subgroup of patients--chapters about the definition, history and epistemology of IM. Additionally there is a focus on conceptual philosophical questions as well as challenges for applied research ethics (informed consent process, the IT-based consent management and the handling of incidental findings). Finally it pays attention to health economic aspects. The possibilities of IM to initiate a paradigm shift in the German health care provision are investigated. Furthermore, it is asked whether the G-DRG system is ready for the implementation of such approaches into clinical routine.
Contents
1. Introduction -- Part I. Definition and Concept of Individualized Medicine -- 2. The Meaning of “Individualized Medicine”: A Terminological Adjustment of a Perplexing Term -- 3. Individualized Medicine Within the GANI_MED Project -- Part II. Perspectives of Socio-Cultural and Historical Studies 4. Inventing Traditions, Raising Expectations. Recent Debates on “Personalized Medicine" -- 5. The Epistemics of “Personalized Medicine”. Rebranding Pharmacogenetics -- Part III. Medical Perspectives -- 6. Use of Biomarkers for the Prediction of Treatment Response: Immunoadsorption in Dilated Cardiomyopathy as a Clinical Example -- 7. The Role of Pharmacogenomics in Individualized Medicine -- Part IV. Concept-Based Ethical Questions -- 8. On a Philosophy of Individualized Medicine: Conceptual and Ethical Questions -- 9. The Concept of Disease in the Era of Prediction -- Part V. Applied Research Ethics -- 10. Informed Consent in GANI_MED—A Sectional Design for Clinical Epidemiological Studies Within Individualized Medicine -- 11. Ethics Meets IT: Aspects and Elements of Computer-based Informed Consent Processing -- 12. Handling Incidental Findings from Imaging Within IM Related Research—Results from an Empirical-Ethical Study -- Part VI. Health Economic Assessment of Individualized Medicine -- 13 Individualized Medicine: From Potential to Macro-Innovation -- 14. Assessing Individualized Medicine—The Example of Immunoadsorption -- 15. How Individualized is Medicine Today? -- 16. Conclusions and Recommendations.
Format
e-Book
Location
Online
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