Cancer Proteomics : From Bench to Bedside
https://libcat.nshealth.ca/en/permalink/provcat40631
edited by Sayed S. Daoud.
--Totowa, NJ:
Humana Press
, c2008.
- Available Online
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- Location
- Online
Over the past 20 years or so, there have been tremendous advances in our understanding of how normal cells transform to cancer and the importance of signaling pathways in cancer initiation and progression. Therefore, proteomics technologies must be improved for more global analysis of protein content of cells, tissues and body fluids as well as the posttranslational modifications to allow for proper detections and validation. In Cancer Proteomics, the authors collectively provide the current st…
- Available Online
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- Other Authors
- Daoud, Sayed S
- Responsibility
- edited by Sayed S. Daoud
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2008
- Physical Description
- 1 online resource (xii, 264 p. : 5 illus. in color)
- Series Title
- Cancer drug discovery and development
- ISBN
- 9781597451697
- 9781588298584 (print ed.)
- Subjects (MeSH)
- Antineoplastic Agents
- Biomarkers, Tumor
- Neoplasms
- Proteomics - methods
- Abstract
- Over the past 20 years or so, there have been tremendous advances in our understanding of how normal cells transform to cancer and the importance of signaling pathways in cancer initiation and progression. Therefore, proteomics technologies must be improved for more global analysis of protein content of cells, tissues and body fluids as well as the posttranslational modifications to allow for proper detections and validation. In Cancer Proteomics, the authors collectively provide the current status of proteomics in cancer therapy and offers the existing technologies used in proteomics that allow for protein profiling and for the identification of druggable targets in human samples. Mass spectrometry based protein characterization and protein microarrays hold great promise of predicting response to specific drugs in cancer therapy. Insightful to the reader with broad perspectives on topics related to the use of proteomic strategies in cancer therapy, Cancer Proteomics offers anticipated challenges that may arise from its application in daily practice.
- Contents
- Part I. Proteomics Technologies -- Current and Emerging Mass Spectrometry Instrumentation and Methods for Proteomic Analyses -- Part II. Cell Signaling Proteomics -- Integration of Genomics and Proteomics in Dissecting p53 Signaling -- Proteomic Profiling of Tyrosine Kinases as Pharmacological Endpoints for Targeted Cancer Therapy -- Part III. Tumor Proteomics -- Oncoproteomics for Personalized Management of Cancer -- Application of Serum and Tissue Proteomics to Understand and Detect Solid Tumors -- Insight on Renal Cell Carcinoma Proteome -- Proteomics in Lung Cancer -- Proteomic Strategies of Therapeutic Individualization and Target Discovery in Acute Myeloid Leukemia -- New Tumor Biomarkers: Practical Considerations Prior to Clinical Application -- Part IV. Bioinformatics and Regulatory Aspects of Proteomics -- Annotating the Human Proteome: From Establishing a Parts List to a Tool for Target Identification -- Regulatory Issues in the Co-Development of Oncology Drugs and Proteomic Tests: An Overview.
- Format
- e-Book
- Location
- Online
Genomic and precision medicine : cardiovascular disease
https://libcat.nshealth.ca/en/permalink/provcat41104
edited by Geoffrey S. Ginsburg, Huntington F. Willard.
(3rd ed.)
--London, UK:
Elsevier
, c2018.
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- Online
Genomic and Precision Medicine: Cardiovascular Disease, Third Edition, focuses on the applications of genome discovery on the broad spectrum of cardiovascular disorders. Each chapter is organized for the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.
- Available Online
- View e-Book
- Other Authors
- Ginsburg, Geoffrey S
- Responsibility
- edited by Geoffrey S. Ginsburg, Huntington F. Willard
- Edition
- 3rd ed.
- Place of Publication
- London, UK
- Publisher
- Elsevier
- Date of Publication
- c2018
- Physical Description
- 1 online resource, 336 p.
- ISBN
- 9780128018125
- Specialty
- Cardiology
- Genetics, Medical
- Precision Medicine
- Abstract
- Genomic and Precision Medicine: Cardiovascular Disease, Third Edition, focuses on the applications of genome discovery on the broad spectrum of cardiovascular disorders. Each chapter is organized for the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Genomic and precision medicine : cardiovascular disease
https://libcat.nshealth.ca/en/permalink/provcat50740
Ginsburg, Geoffrey S.
(3rd ed.)
--London, England:
Elsevier
, 2018.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Ginsburg, Geoffrey S.
- Other Authors
- Willard, Huntington F.
- Edition
- 3rd ed.
- Place of Publication
- London, England
- Publisher
- Elsevier
- Date of Publication
- 2018
- ISBN
- 9780128018125
- Subjects (MeSH)
- Genetics, Medical - methods
- Proteomics - methods
- Notes
- Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
- Format
- e-Book
- Location
- Online
Genomic and precision medicine : foundations, translation, and implementation
https://libcat.nshealth.ca/en/permalink/provcat41031
edited by Geoffrey S. Ginsburg, Huntington F. Willard.
(3rd ed.)
--London, UK:
Elsevier
, c2017.
- Available Online
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- Registration required for PDF access.
- Location
- Online
Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care.
- Available Online
- View e-Book
- Other Authors
- Ginsburg, Geoffrey S
- Responsibility
- edited by Geoffrey S. Ginsburg, Huntington F. Willard
- Edition
- 3rd ed.
- Place of Publication
- London, UK
- Publisher
- Elsevier
- Date of Publication
- c2017
- Physical Description
- 1 online resource, 398 p.
- ISBN
- 9780128006818
- Abstract
- Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Genomic and precision medicine : foundations, translation, and implementation
https://libcat.nshealth.ca/en/permalink/provcat50741
Ginsburg, Geoffrey.
(3rd ed.)
--Philadelphia, PA:
Elsevier
, 2017.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Ginsburg, Geoffrey
- Edition
- 3rd ed.
- Place of Publication
- Philadelphia, PA
- Publisher
- Elsevier
- Date of Publication
- 2017
- ISBN
- 9780128006818
- Notes
- Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
- Format
- e-Book
- Location
- Online
Genomic and precision medicine : infectious and inflammatory disease
https://libcat.nshealth.ca/en/permalink/provcat43986
edited by Geoffrey S. Ginsburg, Huntington F. Willard.
(3rd ed.)
--London, UK:
Academic Press
, c2019.
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- Location
- Online
Genomic and Precision Medicine: Inflammation and Metabolic Disorders, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precisi…
- Available Online
- View e-Book
- Other Authors
- Ginsburg, Geoffrey S.
- Responsibility
- edited by Geoffrey S. Ginsburg, Huntington F. Willard
- Edition
- 3rd ed.
- Place of Publication
- London, UK
- Publisher
- Academic Press
- Date of Publication
- c2019
- Physical Description
- 1 online resource
- ISBN
- 9780128014967
- Specialty
- Genetics, Medical
- Precision Medicine
- Abstract
- Genomic and Precision Medicine: Inflammation and Metabolic Disorders, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Genomic and precision medicine : infectious and inflammatory disease
https://libcat.nshealth.ca/en/permalink/provcat50739
Ginsburg, Geoffrey S.
(3rd ed.)
--London, England:
Academic Press
, 2019.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Ginsburg, Geoffrey S.
- Other Authors
- Willard, Huntington F.
- Tsalik, Ephraim L.
- Woods, Christopher W.
- Edition
- 3rd ed.
- Place of Publication
- London, England
- Publisher
- Academic Press
- Date of Publication
- 2019
- ISBN
- 9780128014967
- Notes
- Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
- Format
- e-Book
- Location
- Online
Genomic and precision medicine : primary care
https://libcat.nshealth.ca/en/permalink/provcat41032
edited by Sean P. David.
(3rd ed.)
--London, UK:
Elsevier
, c2017.
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- Location
- Online
Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care.
- Available Online
- View e-Book
- Other Authors
- David, Sean P
- Responsibility
- edited by Sean P. David
- Edition
- 3rd ed.
- Place of Publication
- London, UK
- Publisher
- Elsevier
- Date of Publication
- c2017
- Physical Description
- 1 online resource, 370 p.
- ISBN
- 9780128006856
- Abstract
- Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Manual of Cardiovascular Proteomics
https://libcat.nshealth.ca/en/permalink/provcat40208
Giulio Agnetti, Merry L. Lindsey, D. Brian Foster, editors.
--Cham:
Springer
, c2016.
- Available Online
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- Location
- Online
This book highlights the remarkable advances that have contributed to the development of proteomics over the last two decades. While many of the concepts, methods, and technologies can be widely applied across fields of biomedical research, this book has been tailored for the cardiovascular researcher, with the many facets of cardiovascular disease reflected within the chapters. New methods and technologies are discussed in a manner that is understandable to scientists who are new to the proteo…
- Available Online
- View e-Book
- Other Authors
- Agnetti, Giulio
- Lindsey, Merry L
- Foster, D. Brian
- Responsibility
- Giulio Agnetti, Merry L. Lindsey, D. Brian Foster, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xvi, 430 p. : 65 illus., 58 illus. in color)
- ISBN
- 9783319318288
- 9783319318264 (print ed.)
- Subjects (MeSH)
- Biomarkers - analysis
- Cardiovascular Diseases - metabolism
- Cardiovascular System - metabolism
- Proteomics - methods
- Abstract
- This book highlights the remarkable advances that have contributed to the development of proteomics over the last two decades. While many of the concepts, methods, and technologies can be widely applied across fields of biomedical research, this book has been tailored for the cardiovascular researcher, with the many facets of cardiovascular disease reflected within the chapters. New methods and technologies are discussed in a manner that is understandable to scientists who are new to the proteomics arena in order to accelerate knowledge dissemination. The full measure of topics that define modern cardiovascular proteomics have been covered, including but not limited to experimental design, sample preparation and separation, mass spectrometry technologies, protein identification and quantitation, as well as statistical, pathway and network analyses of proteomics results. Manual of Cardiac Proteomics addresses many of the technical subtleties to be considered when embarking on a cardiovascular proteomic study. It as an invaluable guide for scientists entering the field, as well as clinicians and trainees in cardiology and all related disciplines.
- Contents
- 1. A Historical Perspective on Cardiovascular Proteomics -- 2. Basic Concepts in Mass Spectrometry and Protein Quantitation -- 3. How to Design a Cardiovascular Proteomics Experiment -- 4. Organelle, Protein and Peptide Fractionation in Cardiovascular Proteomics -- 5. Vascular Proteomics -- 6 Stem Cell Proteomics -- 7. Bottom-Up Proteomics -- 8. Top-Down Proteomics -- 9. Targeted Proteomics (MRM) in Cardiovascular Research -- 10. Label-Free Quantification by Data Independent Acquisition Mass Spectrometry to Map Cardiovascular Proteomes -- 11. Labeling and Label-Free Shotgun Proteomics Quantification in the Research of Cardiovascular Diseases -- 12. Analysis of Proteomic Data -- 13. Post-translational Modifications in the Cardiovascular Proteome -- 14. Proteomic Network Systems Analysis -- 15. Sensing and Remembering Cellular States Through Chromatin -- 16. Synergizing Proteomic and Metabolomic Data to Study Cardiovascular Systems -- 17. Clinical Cardiovascular Proteomics -- 18. Concluding Remarks: Proteomics AD 2025.
- Format
- e-Book
- Location
- Online
