99mTc-sestamibi is a single-photon emission computed tomography (SPECT) radiotracer that was introduced into clinical routine for myocardial perfusion imaging more than two decades ago. Although today the main application of 99mTc-sestamibi SPECT remains the imaging of myocardial perfusion, it is also an accepted and well-proven imaging technique for a variety of oncologic and non-oncologic applications, including brain, breast, and thyroid cancer and thyroid and parathyroid adenoma. Its effica…
This book explains in detail the potential value of the hybrid modalities, SPECT-CT and PET-CT, in the imaging of cardiac innervation in a wide range of conditions and diseases, including ischemic heart disease, diabetes mellitus, heart failure, amyloidosis, heart transplantation, and ventricular arrhythmias. Imaging of the brain-heart axis in neurodegenerative disease and stress and of cardiotoxicity is also discussed. The roles of the various available tracers are fully considered, and indivi…
This book describes newly developed methods of assessing the autonomic nervous system. Up-to-date information on microneurographic analysis of human cardiovascular and thermoregulatory function in humans, heart rate variability, and 131I-metaiodobenzylguanidine (MIBG) scintigraphy are provided. Microneurography, which was originally developed as a technique to analyze the afferent muscle spindle, came to be used to analyze sympathetic nerve activity in the mid-1980s. In the twenty-first century…
This book, now in a revised and updated second edition, offers a comprehensive overview of the state of the art in orthopedic nuclear medicine, including the impressive recent advances in the field and the diagnosis of under-recognized conditions on the basis of their imaging patterns. The opening chapters acquaint the reader briefly with anatomic, physiologic, pathologic, and technical concepts crucial to a sound understanding of orthopedic nuclear medicine and its utilization in clinical prac…
This book provides a comprehensive overview of the use of PET and SPECT in the classic psychiatric disorders such as depression, bipolar disorder, anxiety disorders, and schizophrenia. In addition, it discusses the application of these functional neuroimaging techniques in a variety of other conditions, including sleep disorders, eating disorders, autism, and chronic fatigue syndrome. The new edition has been extensively revised and updated to reflect the latest advances and results in nuclear …
This book covers both the science of PET/CT imaging in tuberculosis and the impact that this technique can have on disease management through the provision of high-quality evidence regarding function and structure. The scientific principles of PET/CT, the radiopharmaceuticals used in the context of tuberculosis (FDG and non-FDG tracers), patient preparation, and imaging protocols are fully explained. Imaging findings obtained in different settings, including pulmonary and extrapulmonary tubercu…