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Acute Kidney Injury and Regenerative Medicine

https://libcat.nshealth.ca/en/permalink/provcat45511
Yoshio Terada, Takashi Wada, Kent Doi, editors. --Singapore: Springer , c2020.
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This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (AR…
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Other Authors
Terada, Yoshio
Wada, Takashi
Doi, Kent
Responsibility
Yoshio Terada, Takashi Wada, Kent Doi, editors
Place of Publication
Singapore
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (ix, 396 p.) : 39 illus., 33 illus. in color
ISBN
9789811511080
9789811511073 (Print ed.)
9789811511097 (Print ed.)
9789811511103 (Print ed.)
Subjects (MeSH)
Acute Kidney Injury - etiology
Acute Kidney Injury - therapy
Regenerative Medicine - methods
Specialty
Nephrology
Regenerative Medicine
Abstract
This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis. Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.
Contents
Part I. Diagnosis and Risk Factors of AKI -- 1. Acute Kidney Injury: Definition and Epidemiology -- 2. Causes of AKI (Prerenal, Intrarenal, Postrenal) -- 3. Pathophysiology of AKI -- 4. Diagnosis of AKI: Clinical Assessment, Novel Biomarkers, History, and Perspectives -- 5. Risk Factors for AKI Development in Surgery (Non-cardiac Surgery) -- 6. Risk Factors for AKI Development in Acute Decompensated Heart Failure -- 7. Contrast-Induced Acute Kidney Injury -- 8. Antibiotics- and Immunosuppressants-Related AKI -- 9. AKI in Setting of Cancer -- 10. Community- and Hospital-Acquired Acute Kidney Injury -- Part II. Complication of AKI -- 11. Complication of Homeostasis (Electrolytes and Acid-Base) -- 12. Volume Overload and Pulmonary Complications -- Part II.I Prevention and Management of AKI -- 13. Prophylaxis and Management of Acute Kidney Injury -- 14. Postrenal AKI -- 15. Acute Kidney Injury in Intensive Care Medicine -- 16. Nondialytic Supportive Management of AKI -- 17. Renal Replacement Therapy in AKI -- 18. Short-Term and Long-Term Outcomes of AKI Patients -- 19. Management of Pediatric AKI -- Part IV. Experimental Novel Findings -- 20. AKI-to-CKD Transition -- 21. Role of the Nervous System in Acute Kidney Injury -- 22. AKI and Immune System -- 23. Acute Kidney Injury and Cytokines -- Part V. AKI and Regenerative Medicine -- 24. iPS Cell and Renal Regenerative Medicine -- 25. Kidney Development and Injury: A Road to Regeneration -- 26. Xenotransplanted Embryonic Kidney.
Format
e-Book
Location
Online
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Adipose stem cells and regenerative medicine

https://libcat.nshealth.ca/en/permalink/provcat29804
--Berlin, Heidelberg: Springer-Verlag , c2011.
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Location
Online
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Other Authors
Illouz, Yves-Gérard
Sterodimas, Aris
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2011
ISBN
9783642200120
Subjects (MeSH)
Adipose Tissue - cytology
Regenerative Medicine - methods
Stem cell transplantation
Stem cells - cytology
Tissue Engineering
Subjects (LCSH)
Biomedical engineering
Transplantation of organs tissues etc
Format
e-Book
Location
Online
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Advanced Procedures for Pain Management : A Step-by-Step Atlas

https://libcat.nshealth.ca/en/permalink/provcat43113
Sudhir Diwan, Timothy R. Deer, editors. --Cham: Springer , c2018.
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Edited by Sudhir Diwan, a former Director of Pain Medicine fellowship program at Ivy League Weill Cornell Medical College, and Timothy R. Deer, an internationally renowned expert in neuromodulation and minimally invasive spinal procedures, this atlas covers advanced procedures that normal residency and fellowship programs may not cover. It consolidates information pain fellows usually amass by traveling throughout the country to various specialized weekend courses. Advanced Procedures for Inter…
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Other Authors
Diwan, Sudhir
Deer, Timothy R.
Responsibility
Sudhir Diwan, Timothy R. Deer, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xviii, 606 p.) : 267 illus., 197 illus. in color
ISBN
9783319688411
9783319688398 (print ed.)
9783319688404 (print ed.)
Subjects (MeSH)
Electric Stimulation Therapy
Orthopedic Procedures
Pain Management - methods
Regenerative Medicine - methods
Specialty
Pain Management
Abstract
Edited by Sudhir Diwan, a former Director of Pain Medicine fellowship program at Ivy League Weill Cornell Medical College, and Timothy R. Deer, an internationally renowned expert in neuromodulation and minimally invasive spinal procedures, this atlas covers advanced procedures that normal residency and fellowship programs may not cover. It consolidates information pain fellows usually amass by traveling throughout the country to various specialized weekend courses. Advanced Procedures for Interventional Pain Management: A Step-by-Step Atlas is for physicians that know the fundamentals of pain medicine and want to push their knowledge further. Through easy-to-digest bullet points, extensive diagrams, hundreds of figures, and expanded legends beneath each illustration, this compendium covers techniques such as uoroscopic guidance and radiation safety, endoscopic transforaminal discectomy, endoscopic direct-percutaneous discectomy, transforaminal myelogram, percutaneous facet fusion, percutaneous sacroplasty, vertebral augmentations, percutaneous tumor ablation, percutaneous spinal fusion, minimally invasive spinal decompression (MILD), Interspinous Spacer Placement and advanced neuroaugmentation techniques like high frequency stimulation and DRG stimulation. This book also has a dedicated section on Regenerative Medicine with chapters on platelet rich plasma, stem cell therapy, and intradiscal regenerative therapy. Each chapter has a strict chapter format that includes the indications and contraindications for each procedure, a list of equipment and drugs, a step-by-step illustration-focused how-to, a list of possible post-procedural complications, and bullet-pointed clinical pearls and pitfalls. Within each chapter the authors will also cover the variations of each procedure due to different equipment. This book is ideal for pain medicine fellows, spine surgeons, and interventional pain physicians who want access to the best minds and specialized procedures in a single package.
Contents
Section I: Advanced Spinal Interventions -- 1. Advanced Spinal Mapping: An Interventional Continuum for Axial, Radicular, and Dorsal Root Ganglion-Related Pain -- 2. MILD: Percutaneous Lumbar Decompression -- 3. Superion: An Indirect Lumbar Decompression -- 4. Minimally Invasive Discectomy: Transforaminal Approach -- 5. Minimally Invasive Percutaneous Endoscopic Discectomy: Transdiscal Approach -- 6. Minimally Invasive Facet Fusion -- 7. Vertebral Augmentation: Vertebroplasty and Kyphoplasty -- Section II: Advanced Neuromodulation -- 8. Neuromodulation: Mechanisms of Action -- 9. Anatomy of Neuromodulatory Targets: Central Nervous System and the Periphery -- 10. Neuromodulation: Optimizing Surgical Outcomes and Risk Reduction -- 11. Extracranial Peripheral Nerve and Peripheral Nerve Field Stimulation for Headache: Trialing -- 12. Extracranial Peripheral Nerve Field and Peripheral Nerve Stimulation for Headache: Permanent Implant -- 13. Intracranial Neuromodulation: Deep Brain Stimulation for Pain -- 14. Spinal Cord Stimulation, Cervical: Trialing -- 15. Spinal Cord Stimulation: Thoracic and Lumbar Trial -- 16. Spinal Cord Stimulation Hybrid Lead Array: Epidural and Peripheral Nerve Field Stimulation Trial -- 17. Hybrid Neuromodulation -- 18. Permanent Percutaneous Spinal Cord Stimulator Implantation: Cervical/Lumbar -- 19. Spinal Cord Stimulation for Chronic Abdominal Pain -- 20. Spinal Cord Stimulation: Pelvic Pain -- 21. Truncal Stimulation Trial and Implant -- 22. Peripheral Nerve Stimulation for the Painful Extremity -- 23. Advanced Neuromodulation Techniques: Dorsal Root Ganglion Stimulation -- 24. High-Frequency Stimulation -- 25. Burst Stimulation: An Innovative Waveform Strategy for Spinal Cord Stimulation -- 26. Novel Waveforms -- 27. Transcutaneous Vagus Nerve Stimulation: Novel Treatment Strategies -- 28. Sacral Stimulation for Pelvic Pain -- 29. Intrathecal Drug Delivery: Pharmacokinetics and Dynamics -- 30. Patient Selection for Drug Delivery System Implantation -- 31. Intrathecal Drug Delivery: Medication Selection -- 32. Intrathecal Drug Delivery: Trialing -- 33. Intrathecal Drug Delivery: Implantation -- 34. Intrathecal Drug Delivery Maintenance: Refill and Programming -- 35. Intrathecal Drug Delivery Maintenance: Catheter Evaluation -- 36. Intrathecal Drug Delivery: Innovation -- Section III: Advanced Regenerative Medicine -- 37. History of Regenerative Medicine -- 38. Platelet-Rich Plasma -- 39. Alpha-2-Macroglobulin: Protease Inhibitor Treatment (PRP Variant) -- 40. Bone Marrow Derived Stem Cells and their Application in Pain Medicine -- 41. Adipose-Derived Stromal Stem Cells -- 42. Intradiscal Biologic Treatments: Allogeneic Stem Cells -- 43. Intradiscal Biologic Treatments: Intra-annular Fibrin Disc Sealant -- 44. Amniotic Tissue -- 45. Platelet-Rich Plasma (PRP): Procedural Techniques for Musculoskeletal Injuries -- 46. Technical Aspects of Regenerative Injection Therapy -- 47. Platelet-Rich Plasma Therapy: An Overview.
Format
e-Book
Publication Type
Atlas
Location
Online
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Antibody Therapy : Substitution—Immunomodulation—Monoclonal Immunotherapy

https://libcat.nshealth.ca/en/permalink/provcat42891
edited by Paul Imbach. --Cham: Springer , c2018.
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This practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice). The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other dise…
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Other Authors
Imbach, Paul
Responsibility
edited by Paul Imbach
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xiv, 363 p.) : 47 illus., 32 illus. in color
ISBN
9783319680385
9783319680378 (print ed.)
9783319680392 (print ed.)
Subjects (MeSH)
Antibodies, Monoclonal - therapeutic use
Immunoglobulin G - therapeutic use
Immunologic Factors
Immunomodulation
Specialty
Regenerative Medicine
Abstract
This practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice). The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other diseases. Basic aspects of IgG concentrates, including methods of production, safety, currently available products, and mechanisms of action, are then discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally, the transition from polyclonal to monoclonal antibody (mAb) treatment is addressed in detail, covering mAb development, methods, mechanisms of action, adverse effects, and more. Particular attention is paid to theáexample of anti-CD20 (B-cell) antibody.
Format
e-Book
Location
Online
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Autologous resurfacing and fracture dowelling : a manual of tranplantantion technique

https://libcat.nshealth.ca/en/permalink/provcat25712
Draenert, Klaus. --Heidelberg, Germany: Springer , c2012.
Call Number
WE 190 A939 2012
Location
Dickson Building
Call Number
WE 190 A939 2012
Author
Draenert, Klaus
Place of Publication
Heidelberg, Germany
Publisher
Springer
Date of Publication
c2012
Physical Description
140 p.
ISBN
9783642249105
Subjects (MeSH)
Bone Substitutes - therapeutic use
Fractures, bone - surgery
Fracture Fixation, Internal - methods
Regenerative Medicine - methods
Transplantation, Autologous
Format
Book
Location
Dickson Building
Copies
1
Loan Period
3 weeks
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Autologous Resurfacing and Fracture Dowelling : A Manual of Transplantation Technique

https://libcat.nshealth.ca/en/permalink/provcat31152
Klaus Draenert ... [et al.] ; foreword by Allan E. Gross. --Berlin, Heidelberg: Springer , c2012.
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This book describes in detail a unique and very precise operative technique that uses autologous cartilage/bone grafts for the reconstruction of load-bearing joint surfaces and for dowelling of non-unions. The technique, employing diamond instruments and a wet grinding process, has been developed and refined over the past 30 years at the Center for Orthopaedic Sciences (ZOW), first in Bern and later in Munich. A step-by-step description of the method is provided for each indication, with the ai…
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Other Authors
Draenert, Klaus
Responsibility
Klaus Draenert ... [et al.] ; foreword by Allan E. Gross
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xii, 140 p. : 189 ill., 149 ill. in color)
ISBN
9783642249112
Subjects (MeSH)
Bone Substitutes - therapeutic use
Fractures, bone - surgery
Regenerative Medicine - methods
Transplantation, Autologous
Subjects (LCSH)
Orthopedic surgery
Abstract
This book describes in detail a unique and very precise operative technique that uses autologous cartilage/bone grafts for the reconstruction of load-bearing joint surfaces and for dowelling of non-unions. The technique, employing diamond instruments and a wet grinding process, has been developed and refined over the past 30 years at the Center for Orthopaedic Sciences (ZOW), first in Bern and later in Munich. A step-by-step description of the method is provided for each indication, with the aid of many high-quality illustrations. Correctly applied, the technique has been very successful in restoring high-level athletes to competition; it can be applied even in "hopeless cases" and offers excellent late results. This guide will be invaluable for orthopaedic surgeons wishing to master this proven and effective approach.
Contents
Historical Background -- Microscopical Anatomy -- Growth -- Turnover and Healing Processes -- Bone Substitutes -- Cartilage-Bone Grafting -- Clinical Practice of Autologous Resurfacing’ -- Fracture Dowelling -- Instrumentation.
Format
e-Book
Location
Online
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The Basics of Cancer Immunotherapy

https://libcat.nshealth.ca/en/permalink/provcat42870
edited by Haidong Dong, Svetomir N. Markovic. --Cham: Springer , c2018.
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This book provides patients and their physicians (especially "non-oncologist" health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient's own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitat…
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Other Authors
Dong, Haidong
Markovic, Svetomir N.
Responsibility
edited by Haidong Dong, Svetomir N. Markovic
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (x, 160 p.) : 8 illus., 4 illus. in color
ISBN
9783319706221
9783319706214 (print ed.)
9783319706238 (print ed.)
Subjects (MeSH)
Immunology
Neoplasms
Specialty
Medical Oncology
Regenerative Medicine
Abstract
This book provides patients and their physicians (especially "non-oncologist" health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient's own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are: Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today's daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer types. The authors' expertise in treating different types of cancers, including melanoma, lung, kidney, bladder, and lymphoma, provides disease-specific insights in applying immunotherapy to each disease.
Contents
The Basic Concepts in Cancer Immunology and Immunotherapy -- Therapeutic Targets of FDA-approved Immunotherapies in Oncology -- Melanoma Immunotherapy -- Significance of Immune Checkpoints in Lung Cancer -- Immunotherapy for Genitourinary Cancers -- Next-generation Immunotherapy in Lymphoma Immunotherapy -- Combined Immunothepary with Conventional Cancer Treatment -- Immunotherapy for Other Malignancies -- Management of Immune-related Adverse Events from Immune Checkpoint Inhibitor Therapy -- Resources for Patients.
Format
e-Book
Location
Online
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Best Practices in Processing and Storage for Hematopoietic Cell Transplantation

https://libcat.nshealth.ca/en/permalink/provcat43148
Joseph Schwartz, Beth H. Shaz, editors. --Cham: Springer , c2018.
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Location
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This concise book examines clinically relevant issues relating to the ways in which bone marrow, cord blood and apheresis products, are processed and stored for the purpose of Hematopoietic Cell Transplantation and Cell Therapy. The twin aims are to offer up-to-date content covering a wide spectrum of topics and controversies and to provide practitioners in the field of transplant and cell therapy with practical, immediately applicable information from the internationally experts in the field. …
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Other Authors
Schwartz, Joseph
Shaz, Beth H.
Responsibility
Joseph Schwartz, Beth H. Shaz, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (vi, 160 p.) : 19 illus., 10 illus. in color
Series Title
Advances and controversies in hematopoietic transplantation and cell therapy
ISBN
9783319589497
9783319589480 (print ed.)
9783319589503 (print ed.)
9783319865171 (print ed.)
ISSN
2569-1376
Subjects (MeSH)
Cord Blood Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation
Specimen Handling - methods
Specialty
Clinical Laboratory Techniques
Hematology
Regenerative Medicine
Abstract
This concise book examines clinically relevant issues relating to the ways in which bone marrow, cord blood and apheresis products, are processed and stored for the purpose of Hematopoietic Cell Transplantation and Cell Therapy. The twin aims are to offer up-to-date content covering a wide spectrum of topics and controversies and to provide practitioners in the field of transplant and cell therapy with practical, immediately applicable information from the internationally experts in the field. Each chapter focuses on a particular subject, and numerous working tables, algorithms, and figures are included. Whenever appropriate, the reader's attention is drawn to the availability of potentially high-impact clinical trials and expert practices. The authors are all experts who have been carefully selected for their knowledge of the topics that they address. The book will appeal to clinical and laboratory personnels, residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant products and patients. Its format ensures that it will also serve as a robust, engaging tool to aid vital activities in every hematology and oncology trainee's daily work.
Contents
Journey of Hematopoietic Cells: Procurement to Infusion -- Regulations & Accreditation of Processing Laboratories -- Part I: HPC, Apheresis and HPC, Marrow: Donor qualification -- Routine HPC Apheresis & Marrow processing -- CD34 Enrichment /T-cell depletion -- Cryopreservation: Techniques, Freezing Solutions -- Hematopoietic Cell Graft Thawing—Best Practices -- Part II: HPC, Cord Blood: CB Donor Qualification -- Cord Blood Processing -- Cord Blood Graft Assessment -- Cord Blood Graft Thawing - Best Practices -- Hematopoietic Graft Handling during Transportation.
Format
e-Book
Location
Online
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Biologic and Nanoarthroscopic Approaches in Sports Medicine

https://libcat.nshealth.ca/en/permalink/provcat46810
Chad Lavender. Springer , 2021.
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Location
Online
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Responsibility
Chad Lavender
Publisher
Springer
Date of Publication
2021
Physical Description
1 online resource (xiv, 174 pages) : illustrations
ISBN
9783030713232
Specialty
Regenerative Medicine
Sports Medicine
Format
e-Book
Location
Online
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Biologics in orthopaedic surgery

https://libcat.nshealth.ca/en/permalink/provcat42509
Augustus D. Mazzocca, Adam D. Lindsay. --St. Louis, MI: Elsevier , c2019.
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Location
Online
Designed with the practicing clinician in mind, Biologics in Orthopaedic Surgery provides a succinct, easy-to-digest overview of the integration of biologics (platelet-rich-plasma [PRP], bone marrow aspirate [BMA], and stem cells) into today’s orthopaedic practice. Covering relevant basic science as well as clinical applications, this concise reference takes a head-to-toe approach to the emerging role of orthobiologics for specific conditions and procedures, in addition to future directions fo…
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Author
Mazzocca, Augusts D.
Other Authors
Lindsay, Adam D.
Responsibility
Augustus D. Mazzocca, Adam D. Lindsay
Alternate Title
Biologics in orthopedic surgery
Orthopedic procedures
Operative techniques
Place of Publication
St. Louis, MI
Publisher
Elsevier
Date of Publication
c2019
Physical Description
1 online resource, 234 p.
Series Title
Operative techniques
ISBN
9780323551403
Subjects (MeSH)
Orthopedic Procedures
Biological Products - therapeutic use
Specialty
Orthopedic Procedures
Regenerative Medicine
Abstract
Designed with the practicing clinician in mind, Biologics in Orthopaedic Surgery provides a succinct, easy-to-digest overview of the integration of biologics (platelet-rich-plasma [PRP], bone marrow aspirate [BMA], and stem cells) into today’s orthopaedic practice. Covering relevant basic science as well as clinical applications, this concise reference takes a head-to-toe approach to the emerging role of orthobiologics for specific conditions and procedures, in addition to future directions for implementation.
Access
Registration required for PDF access.
Format
e-Book
Publication Type
Atlas
Location
Online
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Biology of blood and marrow transplantation

https://libcat.nshealth.ca/en/permalink/provcat19450
American Society for Blood and Marrow Transplantation
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Holdings
Vol 13, 2007 -
Location
Online
Available Online
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Publisher
American Society for Blood and Marrow Transplantation
Holdings
Vol 13, 2007 -
Publication Frequency
Monthly
ISSN
1083-8791
Specialty
Regenerative Medicine
Transplantation
Format
e-Journal
Location
Online
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Bio-orthopaedics : A New Approach

https://libcat.nshealth.ca/en/permalink/provcat41906
Alberto Gobbi, João Espregueira-Mendes, John G. Lane, Mustafa Karahan, editors. --Berlin, Heidelberg: Springer , 2017.
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Location
Online
This book introduces the exciting field of orthobiology, which will usher in a new array of therapeutic approaches that stimulate the body's natural resources to regenerate musculoskeletal tissues damaged by trauma or disease. The book addresses a range of key topics and discusses emerging approaches that promise to offer effective alternatives to traditional treatments for injuries to bone, cartilage, muscles, ligaments, and tendons. It explains in detail how a variety of innovative products, …
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Other Authors
Gobbi, Alberto
Espregueira-Mendes, João
Lane, John G.
Karahan, Mustafa
Other Authors
International Society of Arthroscopy Knee Surgery and Orthopaedic Sports Medicine
Responsibility
Alberto Gobbi, João Espregueira-Mendes, John G. Lane, Mustafa Karahan, editors
Alternate Title
Bio-orthopedics
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xix, 696 pages) : 167 illus., 108 illus. in color
ISBN
9783662541814
9783662541807 (print ed.)
Subjects (MeSH)
Biocompatible Materials
Biological Factors
Musculoskeletal Diseases - therapy
Orthopedics - trends
Regenerative Medicine
Tissue Engineering
Transplantation, Autologous
Abstract
This book introduces the exciting field of orthobiology, which will usher in a new array of therapeutic approaches that stimulate the body's natural resources to regenerate musculoskeletal tissues damaged by trauma or disease. The book addresses a range of key topics and discusses emerging approaches that promise to offer effective alternatives to traditional treatments for injuries to bone, cartilage, muscles, ligaments, and tendons. It explains in detail how a variety of innovative products, including biomaterials, growth factors, and autogenous cells, together provide the basis for the regeneration of these musculoskeletal structures and how recent scientific progress has created unique opportunities to address pathological situations that until recently have been treated with unsatisfactory results. The authors are experts from across the world who come together to provide a truly global overview. The book is published in collaboration with ISAKOS. It will be invaluable for all with an interest in this area of medicine, which has already attained huge popularity in Orthopaedics and Sports Medicine and has also attracted the attention of the lay public.
Contents
Overview -- Muscle -- Tendon -- Ligaments -- Menisci -- Bone -- Cartilage.
Format
e-Book
Location
Online
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Biotechnology in Surgery

https://libcat.nshealth.ca/en/permalink/provcat29926
edited by Alfonso Barbarisi. --Milan: Springer-Verlag , c2011.
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Location
Online
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Author
Barbarisi, Alfonso
Responsibility
edited by Alfonso Barbarisi
Place of Publication
Milan
Publisher
Springer-Verlag
Date of Publication
c2011
Series Title
Updates in surgery
ISBN
9788847016583
Subjects (MeSH)
Biotechnology - methods
Regenerative Medicine - methods
Surgical Procedures, Operative - methods
Subjects (LCSH)
Biotechnology
Surgery
Format
e-Book
Location
Online
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Cancer Immunology : Bench to Bedside Immunotherapy of Cancers

https://libcat.nshealth.ca/en/permalink/provcat46359
Nima Rezaei, editor. (Second edition) --Cham: Springer , c2021.
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NEW Springer 2021
Location
Online
This translational, clinically oriented book describes in detail novel approaches to cancer immunotherapy, current strategies to target tumor immunosuppression, and prognostic biomarkers for personalized cancer treatments. Since the first, very successful edition of the book was published in 2015, the original chapters have been significantly updated and entirely new chapters are included on, for example, cancer immunoprevention, aptamer-mediated cancer gene therapy, haploidentical bone marrow …
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Other Authors
Rezaei, Nima
Responsibility
Nima Rezaei, editor
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2021
Physical Description
1 online resource (xl, 658 p.) : 53 illus., 46 illus. in color
ISBN
9783030502874
9783030502867 (Print ed.)
9783030502881 (Print ed.)
9783030502898 (Print ed.)
Subjects (MeSH)
Immunotherapy - methods
Neoplasms - immunology
Neoplasms - therapy
Specialty
Allergy and Immunology
Medical Oncology
Regenerative Medicine
Abstract
This translational, clinically oriented book describes in detail novel approaches to cancer immunotherapy, current strategies to target tumor immunosuppression, and prognostic biomarkers for personalized cancer treatments. Since the first, very successful edition of the book was published in 2015, the original chapters have been significantly updated and entirely new chapters are included on, for example, cancer immunoprevention, aptamer-mediated cancer gene therapy, haploidentical bone marrow transplantation for pediatric malignancies, and nanoimmunotherapy. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and cancer immunotherapy for organ-specific tumors. Cancer Immunology: Bench to Bedside Immunotherapy of Cancers will be of special value to clinical immunologists, hematologists, and oncologists.
Contents
Frontiers in Cancer Immunotherapy -- Novel Strategy of Cancer Immunotherapy: Spiraling Up -- Novel Prognostic Biomarkers for Personalized Cancer Treatments -- Tumor Antigen and Epitope Identification for Pre-Clinical and Clinical Evaluation -- Strategies to Target Tumor Immunesuppression -- Immune Modulation of Drugs in Prevention and Treatment of Cancers -- Overcoming Immune Tolerance With Immune Checkpoint Blockade -- Gene therapy and Virus-Based Cancer Vaccines -- Cancer Stem Cells: Biology and Potential therapeutic Applications -- Hematopoietic Stem Cell Transplantation and Lymphodepletion in Treatment of Cancers -- Combination of Chemotherapy and Cytokine Therapy in Treatment of Cancers -- T Cell Immunotherapy: From Synthetic Biology to Clinical Practice -- Role of Gamma-Delta T Lymphocytes in Cancer Immunosurveillance and Immunotherapy -- Adoptive T Cell therapy: Optimizing Chemokine Receptor-Mediated Homing of T Cells in Cancer Immunotherapy -- Cellular therapy of Cancer With B Effector Cells -- Monoclonal Antibodies for Treatment of Cancers -- Pattern Recognition Receptors in Cancers and Immunotherapy by Triggering or Targeting of Toll Like Receptors Pathway -- Recent Advances in the Use of NK Cells Against Cancer -- Dendritic Cell Vaccines for Cancer Therapy: Fundamentals and Clinical Trials -- Tumor Associated Macrophages and iNOS in Cancer Immunotherapy -- Photodynamic therapy and Anti-Tumor Immune Response -- Polarization of Tumor Milieu: Therapeutic Implications -- Immunotherapies Targeting 5T4 Oncofoetal Glycoprotein -- Immune Monitoring During Clinical Development of Anti-CTLA-4 Antibody Therapy -- PD-1 Blockade in Cancer Therapy -- New Advances in Radioimmunotherapy for the Treatment of Cancers -- Psychoneuroendocrinoimmunotherapy of Cancers -- Ethical Considerations in Cancer Immunotherapy.
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NEW Springer 2021
Format
e-Book
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Online
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Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches

https://libcat.nshealth.ca/en/permalink/provcat30001
edited by Hidezo Mori, Hikaru Matsuda. --Tokyo: Springer-Verlag , c2005.
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Location
Online
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Author
Mori, Hidezo
Other Authors
Matsuda, Hikaru
Responsibility
edited by Hidezo Mori, Hikaru Matsuda
Place of Publication
Tokyo
Publisher
Springer-Verlag
Date of Publication
c2005
ISBN
9784431273783
Subjects (MeSH)
Cardiovascular Physiological Phenomena
Regeneration
Regenerative Medicine - methods
Tissue Engineering - methods
Subjects (LCSH)
Cardiology
Heart - Surgery
Vascular Surgery
Transplantation of organs tissues etc
Biomedical engineering
Format
e-Book
Location
Online
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Cardiovascular Regenerative Medicine : Tissue Engineering and Clinical Applications

https://libcat.nshealth.ca/en/permalink/provcat44479
Vahid Serpooshan, Sean M. Wu, editors. --Cham: Springer , c2019.
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Online
This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic s…
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Other Authors
Serpooshan, Vahid
Wu, Sean M.
Responsibility
Vahid Serpooshan, Sean M. Wu, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xv, 233 p.) : 39 illus., 36 illus. in color
ISBN
9783030200473
9783030200466 (Print ed.)
9783030200480 (Print ed.)
9783030200497 (Print ed.)
Subjects (MeSH)
Cardiovascular Diseases - therapy
Guided Tissue Regeneration
Regenerative Medicine - methods
Tissue Engineering
Specialty
Cardiology
Regenerative Medicine
Abstract
This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.
Contents
1. Tissue-Engineered Stem Cell Models of Cardiovascular Diseases -- 2. Phenotypic Screening of iPSC-Derived Cardiomyocytes for Cardiotoxicity Testing and Therapeutic Target Discovery -- 3. Decellularized Extracellular Matrix-Based Cardiovascular Tissue Engineering - 4. 3D Bioprinting of Cardiovascular Tissue Constructs: Cardiac Bioinks -- 5. Nanobiomaterial Advances in Cardiovascular Tissue Engineering -- 6. Bioengineering 3D Cardiac Microtissues Using Bioassembly -- 7. From Bench to Clinic: Translation of Cardiovascular Tissue Engineering Products to Clinical Applications -- 8. Cardiac Patch-Based Therapies of Ischemic Heart Injuries -- 9. Cell-Based Cardiovascular Regenerative Therapies -- 10. Injectable Hydrogels to Treat Myocardial Infarction -- 11. Regenerative Medicine for the Treatment of Congenital Heart Disease -- 12. Cardiovascular Regenerative Medicine: Challenges, Perspectives, and Future Directions.
Format
e-Book
Location
Online
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Cell Therapy Against Cerebral Stroke : Comprehensive Reviews for Translational Researches and Clinical Trials

https://libcat.nshealth.ca/en/permalink/provcat41920
Kiyohiro Houkin, Koji Abe, Satoshi Kuroda, editors. --Tokyo: Springer , 2017.
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This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating…
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Other Authors
Houkin, Kiyohiro
Abe, Koji
Kuroda, Satoshi
Responsibility
Kiyohiro Houkin, Koji Abe, Satoshi Kuroda, editors
Place of Publication
Tokyo
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (x, 156 pages) : 15 illus., 11 illus. in color
ISBN
9784431560593
9784431560579 (print ed.)
Subjects (MeSH)
Cell- and Tissue-Based Therapy
Regenerative Medicine - methods
Stroke - therapy
Abstract
This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity. Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy. The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan.
Contents
Part I. Optimal Cell Cources -- 1. Bone Marrow-Derived Mononuclear Cells -- 2. Cell Therapy for Ischemic Stroke with Bone Marrow Stromal Cells -- 3. Neural Stem Cells/Neuronal Progenitor Cells -- 4. iPS Cells and iN Cells -- Part II. Translational Researches -- 5. Cell Culture -- 6. Route, Cell Dose, and Timing -- 7. Role of Biomaterials as Scaffolding in Cell Therapy for Stroke -- 8. In Vivo Cell Tracking Techniques for Applications in Central Nervous System Disorders -- 9. Functional Bio-imaging -- Part III. Clinical Trials -- 10. Review of Previous Clinical Trials and Guidelines of Cell Therapy -- 1.1 Intravenous Autologous Bone Marrow Mononuclear Cell Transplantation for Stroke Patients -- 12. Mesenchymal Stem Cells.
Format
e-Book
Location
Online
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Cell Therapy for Perinatal Brain Injury

https://libcat.nshealth.ca/en/permalink/provcat43092
Haruo Shintaku, Akira Oka, Makoto Nabetani, editors. --Singapore: Springer , c2018.
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Online
This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The b…
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Other Authors
Shintaku, Haruo
Oka, Akira
Nabetani, Makoto
Responsibility
Haruo Shintaku, Akira Oka, Makoto Nabetani, editors
Place of Publication
Singapore
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xii, 150 p.)
ISBN
9789811014123
9789811014116 (print ed.)
9789811014130 (print ed.)
Subjects (MeSH)
Brain Injuries - therapy
Infant, Newborn
Stem Cell Transplantation
Specialty
Neurology
Perinatology
Regenerative Medicine
Abstract
This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.
Contents
1. Clinical trial of autologous cord blood cell therapy for neonatal hypoxic-ischemic encephalopathy (HIE) -- 2. New strategy of clinical studies for premature babies with ischemic brain damage -- 3. Pathophysiology and pathology of neonatal hypoxic-ischemic encephalopathy -- 4. Neural stem/progenitor cells for perinatal brain injury -- 5. Hematopoietic stem cells for perinatal brain injury -- 6. Umbilical cord-derived mesenchymal stromal cells for perinatal brain injury -- 7. Other tissues-derived mesenchymal stem cells for perinatal brain injury -- 8. CD34+ cell in cord blood and neonates -- 9. The history of hypothermia therapy for perinatal ischemic brain injury -- 10. Clinical procedure of cell therapy (cord blood collection) -- 11. Clinical procedure of cell therapy (separation and infusion) -- 12. Cell therapy for adult infarction -- 13. Clinical trials on cell therapy for perinatal brain injury: Challenges and opportunities -- 14. A new prospective cell therapy for neonatal brain injury.
Format
e-Book
Location
Online
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Cellular and Molecular Approaches to Regeneration and Repair

https://libcat.nshealth.ca/en/permalink/provcat42771
Paul A. Lapchak, John H. Zhang, editors. --Cham: Springer , c2018.
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This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery. Throughout th…
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Other Authors
Lapchak, Paul A.
Zhang, John H.
Responsibility
Paul A. Lapchak, John H. Zhang, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (vii, 541 p.) : 46 illus., 45 illus. in color
Series Title
Springer series in translational stroke research
ISBN
9783319666792
9783319666785 (print ed.)
9783319666808 (print ed.)
9783319882994 (print ed.)
ISSN
2363-958X
Subjects (MeSH)
Cell- and Tissue-Based Therapy
Regenerative Medicine
Stem Cells
Stroke - therapy
Specialty
Neurology
Regenerative Medicine
Abstract
This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery. Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to understand the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential. Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke. Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.
Format
e-Book
Location
Online
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Cellular Dedifferentiation and Regenerative Medicine

https://libcat.nshealth.ca/en/permalink/provcat43393
Xiaobing Fu, Andong Zhao, Tian Hu. --Berlin, Heidelberg: Springer , c2018.
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This book focuses on the contribution of cell dedifferentiation to the regenerative process in all body systems, as well as its underlying molecular mechanisms and applications. The book is divided into four parts, the first of which addresses the history of cell dedifferentiation and regenerative medicine. In turn, Part II compares three routes by which cells change their phenotype: dedifferentiation, transdifferentiation, and reprogramming. Part III includes an extensive review of cell dediff…
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Author
Fu, Xiaobing
Other Authors
Zhao, Andong
Hu, Tian
Responsibility
Xiaobing Fu, Andong Zhao, Tian Hu
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xii, 291 p.) : 27 illus., 21 illus. in color
ISBN
9783662561799
9783662561775 (print ed.)
9783662561782 (print ed.)
9783662572573 (print ed.)
Subjects (MeSH)
Cell Dedifferentiation
Regenerative Medicine
Specialty
Cell Biology
Regenerative Medicine
Abstract
This book focuses on the contribution of cell dedifferentiation to the regenerative process in all body systems, as well as its underlying molecular mechanisms and applications. The book is divided into four parts, the first of which addresses the history of cell dedifferentiation and regenerative medicine. In turn, Part II compares three routes by which cells change their phenotype: dedifferentiation, transdifferentiation, and reprogramming. Part III includes an extensive review of cell dedifferentiation events in all nine body systems for lower organisms and mammalians, respectively. The final part reviews the relationship between cell dedifferentiation and the development of cancer and several other diseases, while also outlining the prospects of and future research directions in cell dedifferentiation and regenerative medicine. The main purpose of the book is to underline the importance of cell dedifferentiation in stem cell and regenerative medicine by providing a systematical review of dedifferentiation in all body systems, together with the latest reliable evidence.
Contents
1. Central Nervous System and Dedifferentiation -- 2. Peripheral Nerve Regeneration and Dedifferentiation -- 3. Dedifferentiation and the Heart -- 4. Dedifferentiation and Kidney System -- 5. Dedifferentiation and Musculoskeletal Repair and Regeneration -- 6. Dedifferentiation and Skin Regeneration -- 7. Dedifferentiation and Vision System -- 8. Blood Vessel Repair, Atherosclerosis, and Dedifferentiation -- 9. Dedifferentiation and Adipose Tissue -- 10. Dedifferentiation and Organ Regeneration -- 11. Dedifferentiation and Regenerative Medicine: The Past and the Future -- 12. Authors’ Related Publications.
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e-Book
Location
Online
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