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The ACL Handbook : Knee Biology, Mechanics, and Treatment

https://libcat.nshealth.ca/en/permalink/provcat40712
Martha M. Murray, Patrick Vavken, Braden C. Fleming, editors. --New York, NY: Springer , c2013.
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ACL injuries affect the lives of hundreds of thousands of people each year. Treatment is far from perfect, and physicians and patients face challenges such as high failure rates in adolescent athletes and the inability to slow the accelerated progression of arthritis after an ACL rupture, for example. The ACL Handbook takes a complete view of ACL injuries and treatments, discussing: Normal ACL and knee mechanics; The body's response to ACL injury; Development of new treatment methods. Ideal for…
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Other Authors
Murray, Martha M
Vavken, Patrick
Fleming, Braden C
Responsibility
Martha M. Murray, Patrick Vavken, Braden C. Fleming, editors
Alternate Title
Anterior cruciate ligament handbook
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xi, 317 p. : ill.)
ISBN
9781461407607
9781461407591 (print ed.)
Subjects (MeSH)
Anterior Cruciate Ligament - injuries
Anterior Cruciate Ligament Reconstruction - methods
Models, Biological
Tissue Engineering
Wound Healing - physiology
Abstract
ACL injuries affect the lives of hundreds of thousands of people each year. Treatment is far from perfect, and physicians and patients face challenges such as high failure rates in adolescent athletes and the inability to slow the accelerated progression of arthritis after an ACL rupture, for example. The ACL Handbook takes a complete view of ACL injuries and treatments, discussing: Normal ACL and knee mechanics; The body's response to ACL injury; Development of new treatment methods. Ideal for orthopedists, sports medicine physicians, and physical therapists, The ACL Handbook is a unique resource for information on the basic and applied science of ACL injury, repair, and the future of treatment.
Contents
Part I. ACL Injury: The Clinical Problem -- ACL Injury Epidemiology -- History of ACL Treatment and Current Gold Standard of Care -- ACL Clinical Outcomes -- ACL Treatment in the Skeletally Immature Patient -- Part II. ACL Injury: The Biologic Problem -- The Biology of the Normal ACL -- The Role of Inflammation and Blood Cells in Wound Healing -- The ACL Response to Injury -- The Biology of Impaired Healing of Joint Issues -- Part III. Translational Medicine: In Vitro and In Vivo Models -- Translational Medicine -- In Vitro Models of ACL Injury -- In Vivo Models of ACL Injury (Central Defect, Porcine, Ovine, Canine) -- Tissue Engineering of Ligaments and Tendons -- Outcome Assessment for ACL Tissue Engineering -- Part IV. Stimulating Healing of the ACL Using Tissue Engineering -- Scaffolds and Biologic Additives for ACL Surgery -- Use of Biologics to Treat Partial ACL Tears -- Can We Get a Complete ACL Tear to Heal? -- The Effects of Platelets and Their Concentration on ACL Healing -- The Effects of WBCs and RBCs on Ligament Healing -- Safety of the Bioenhanced Repair -- Re-Innervation and Revascularization in Engineered ACL Healing -- Bio-enhancement of ACL Graft Healing -- The Effects of Age and Skeletal Maturity on Healing of the Anterior Cruciate Ligament.
Format
e-Book
Location
Online
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Adipose stem cells and regenerative medicine

https://libcat.nshealth.ca/en/permalink/provcat29804
--Berlin, Heidelberg: Springer-Verlag , c2011.
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Location
Online
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Other Authors
Illouz, Yves-Gérard
Sterodimas, Aris
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2011
ISBN
9783642200120
Subjects (MeSH)
Adipose Tissue - cytology
Regenerative Medicine - methods
Stem cell transplantation
Stem cells - cytology
Tissue Engineering
Subjects (LCSH)
Biomedical engineering
Transplantation of organs tissues etc
Format
e-Book
Location
Online
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Bio-orthopaedics : A New Approach

https://libcat.nshealth.ca/en/permalink/provcat41906
Alberto Gobbi, João Espregueira-Mendes, John G. Lane, Mustafa Karahan, editors. --Berlin, Heidelberg: Springer , 2017.
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This book introduces the exciting field of orthobiology, which will usher in a new array of therapeutic approaches that stimulate the body's natural resources to regenerate musculoskeletal tissues damaged by trauma or disease. The book addresses a range of key topics and discusses emerging approaches that promise to offer effective alternatives to traditional treatments for injuries to bone, cartilage, muscles, ligaments, and tendons. It explains in detail how a variety of innovative products, …
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Other Authors
Gobbi, Alberto
Espregueira-Mendes, João
Lane, John G.
Karahan, Mustafa
Other Authors
International Society of Arthroscopy Knee Surgery and Orthopaedic Sports Medicine
Responsibility
Alberto Gobbi, João Espregueira-Mendes, John G. Lane, Mustafa Karahan, editors
Alternate Title
Bio-orthopedics
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xix, 696 pages) : 167 illus., 108 illus. in color
ISBN
9783662541814
9783662541807 (print ed.)
Subjects (MeSH)
Biocompatible Materials
Biological Factors
Musculoskeletal Diseases - therapy
Orthopedics - trends
Regenerative Medicine
Tissue Engineering
Transplantation, Autologous
Abstract
This book introduces the exciting field of orthobiology, which will usher in a new array of therapeutic approaches that stimulate the body's natural resources to regenerate musculoskeletal tissues damaged by trauma or disease. The book addresses a range of key topics and discusses emerging approaches that promise to offer effective alternatives to traditional treatments for injuries to bone, cartilage, muscles, ligaments, and tendons. It explains in detail how a variety of innovative products, including biomaterials, growth factors, and autogenous cells, together provide the basis for the regeneration of these musculoskeletal structures and how recent scientific progress has created unique opportunities to address pathological situations that until recently have been treated with unsatisfactory results. The authors are experts from across the world who come together to provide a truly global overview. The book is published in collaboration with ISAKOS. It will be invaluable for all with an interest in this area of medicine, which has already attained huge popularity in Orthopaedics and Sports Medicine and has also attracted the attention of the lay public.
Contents
Overview -- Muscle -- Tendon -- Ligaments -- Menisci -- Bone -- Cartilage.
Format
e-Book
Location
Online
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Bone and cartilage engineering

https://libcat.nshealth.ca/en/permalink/provcat22772
Meyer, Ulrich. --Berlin, Germany: Springer , 2006.
Call Number
QT 37 M613b 2006
Location
Halifax Infirmary
Call Number
QT 37 M613b 2006
Author
Meyer, Ulrich
Other Authors
Wiesmann, Hans Peter
Place of Publication
Berlin, Germany
Publisher
Springer
Date of Publication
2006
Physical Description
264 p.
ISBN
3540253475
9783540253471
Subjects (MeSH)
Tissue Engineering
Biocompatible Materials
Bone and Bones - surgery
Cartilage - surgery
Bone Regeneration
Format
Book
Location
Halifax Infirmary
Loan Period
3 weeks
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Bone and Cartilage Engineering

https://libcat.nshealth.ca/en/permalink/provcat28058
by Ulrich Meyer, Hans Peter Wiesmann. --Berlin, Heidelberg: Springer-Verlag , c2006.
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Online
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Author
Meyer, Ulrich
Other Authors
Wiesmann, Hans Peter
Responsibility
by Ulrich Meyer, Hans Peter Wiesmann
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2006
ISBN
9783540336068
Subjects (MeSH)
Biocompatible Materials
Bone Regeneration
Bone and Bones - surgery
Cartilage - surgery
Tissue Engineering
Subjects (LCSH)
Orthopedics
Biomaterials
Biomedical engineering
Format
e-Book
Location
Online
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Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches

https://libcat.nshealth.ca/en/permalink/provcat30001
edited by Hidezo Mori, Hikaru Matsuda. --Tokyo: Springer-Verlag , c2005.
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Location
Online
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Author
Mori, Hidezo
Other Authors
Matsuda, Hikaru
Responsibility
edited by Hidezo Mori, Hikaru Matsuda
Place of Publication
Tokyo
Publisher
Springer-Verlag
Date of Publication
c2005
ISBN
9784431273783
Subjects (MeSH)
Cardiovascular Physiological Phenomena
Regeneration
Regenerative Medicine - methods
Tissue Engineering - methods
Subjects (LCSH)
Cardiology
Heart - Surgery
Vascular Surgery
Transplantation of organs tissues etc
Biomedical engineering
Format
e-Book
Location
Online
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Cardiovascular Regenerative Medicine : Tissue Engineering and Clinical Applications

https://libcat.nshealth.ca/en/permalink/provcat44479
Vahid Serpooshan, Sean M. Wu, editors. --Cham: Springer , c2019.
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This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic s…
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Other Authors
Serpooshan, Vahid
Wu, Sean M.
Responsibility
Vahid Serpooshan, Sean M. Wu, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xv, 233 p.) : 39 illus., 36 illus. in color
ISBN
9783030200473
9783030200466 (Print ed.)
9783030200480 (Print ed.)
9783030200497 (Print ed.)
Subjects (MeSH)
Cardiovascular Diseases - therapy
Guided Tissue Regeneration
Regenerative Medicine - methods
Tissue Engineering
Specialty
Cardiology
Regenerative Medicine
Abstract
This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.
Contents
1. Tissue-Engineered Stem Cell Models of Cardiovascular Diseases -- 2. Phenotypic Screening of iPSC-Derived Cardiomyocytes for Cardiotoxicity Testing and Therapeutic Target Discovery -- 3. Decellularized Extracellular Matrix-Based Cardiovascular Tissue Engineering - 4. 3D Bioprinting of Cardiovascular Tissue Constructs: Cardiac Bioinks -- 5. Nanobiomaterial Advances in Cardiovascular Tissue Engineering -- 6. Bioengineering 3D Cardiac Microtissues Using Bioassembly -- 7. From Bench to Clinic: Translation of Cardiovascular Tissue Engineering Products to Clinical Applications -- 8. Cardiac Patch-Based Therapies of Ischemic Heart Injuries -- 9. Cell-Based Cardiovascular Regenerative Therapies -- 10. Injectable Hydrogels to Treat Myocardial Infarction -- 11. Regenerative Medicine for the Treatment of Congenital Heart Disease -- 12. Cardiovascular Regenerative Medicine: Challenges, Perspectives, and Future Directions.
Format
e-Book
Location
Online
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Dermal Replacements in General, Burn, and Plastic Surgery : Tissue Engineering in Clinical Practice

https://libcat.nshealth.ca/en/permalink/provcat40817
edited by Lars-Peter Kamolz, David Benjamin Lumenta. --Vienna: Springer , c2013.
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The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. The most common cause of significant skin loss is thermal injury, followed by trauma and chronic ulcerations. Over the past decades extraordinary advances have been made in the understanding of cellular and molecular processes of wound healing and the pathobiology of chronic wounds. This knowledge has led to woun…
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Other Authors
Kamolz, Lars-Peter
Lumenta, David Benjamin
Responsibility
edited by Lars-Peter Kamolz, David Benjamin Lumenta
Place of Publication
Vienna
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (vi, 227 p. : ill.)
ISBN
9783709115862
9783709115855 (print ed.)
Subjects (MeSH)
Burns - surgery
Skin Transplantation - methods
Skin, Artificial
Tissue Engineering - methods
Wounds, Penetrating - surgery
Abstract
The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. The most common cause of significant skin loss is thermal injury, followed by trauma and chronic ulcerations. Over the past decades extraordinary advances have been made in the understanding of cellular and molecular processes of wound healing and the pathobiology of chronic wounds. This knowledge has led to wound care innovations that facilitate more rapid closure of wounds with better functional and aesthetic outcome. A sensible and resource-saving utilization of these innovative technologies requires a broad knowledge of these processes and innovations. This book intends to give an overview about today's wound care developments in tissue engineering and skin replacement. It presents a variety of indications and diversities of clinical applications to help the surgeon select a specific procedure for each clinical situation.
Contents
Skin: Architecture and Function -- Skin Tissue Engineering -- Use of Novel Biomaterial Design and Stem Cell Therapy in Cutaneous Wound Healing -- In vivo Visualisation of Skin Graft Revascularisation -- The Role of Elastin in Wound Healing and Dermal Substitute Design -- Surface Modification by Cold Gasplasma: A Method to Optimize the Vascularization of Biomaterials -- Collagen Matrices with Enhanced Angiogenic and Regenerative Capabilities -- 3D Visualisation of Skin Substitutes -- Wound Coverage Technologies in Burn Care: Established and Novel Approaches.-Collagen Implants in Hernia Repair and Abdominal Wall Surgery -- The Use of Dermal Substitutes in Dermatosurgery -- The Use of Dermal Substitutes in Breast Reconstruction: An Overview -- Reconstruction of the Skin in Post-traumatic Wounds -- Subdermal Tissue Regeneration -- Bioengineering and Analysis of Oral Mucosa Models -- The Use of Dermal Substitutes in Burn Surgery: Acute Phase -- Burn Reconstruction.
Format
e-Book
Location
Online
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Developing Insights in Cartilage Repair

https://libcat.nshealth.ca/en/permalink/provcat39569
Pieter J. Emans, Lars Peterson, editors. --London: Springer , c2014.
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This book reviews the current basic and clinical research into the mechanisms of cartilage injury and its management. It illustrates the considerable progress made in the search for solutions to cartilage related problems. Developing Insights in Cartilage Repair describes fundamental research and the use of biomaterials, bioreactors, and imaging as part of existing cartilage repair strategies, while revealing the on-going trends for emerging techniques. The aim of the Editors and their team of …
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Other Authors
Emans, Pieter J
Peterson, Lars
Other Authors
International Cartilage Repair Society
Responsibility
Pieter J. Emans, Lars Peterson, editors
Place of Publication
London
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xiv, 329 p. : 74 illus., 65 illus. in color)
ISBN
9781447153856
9781447153849 (print ed.)
Subjects (MeSH)
Cartilage Diseases - surgery
Cartilage, Articular - injuries
Cartilage, Articular - surgery
Regenerative Medicine - methods
Tissue Engineering
Abstract
This book reviews the current basic and clinical research into the mechanisms of cartilage injury and its management. It illustrates the considerable progress made in the search for solutions to cartilage related problems. Developing Insights in Cartilage Repair describes fundamental research and the use of biomaterials, bioreactors, and imaging as part of existing cartilage repair strategies, while revealing the on-going trends for emerging techniques. The aim of the Editors and their team of authorities in cartilage medicine has been to provide a link between laboratory work and the daily treatment of patients in a clinical setting. This book reveals the highly multidisciplinary nature of the topic and it will thus not only be of considerable interest to a large proportion of the orthopaedic community, but also any discipline in which cartilaginous tissue is involved, including otorhinolaryngology and plastic surgery. Provides an insight of cartilage and its repair to physicians and scientists with an active interest in cartilage repair and new transplantation techniques. Describes different strategies to repair cartilage defects as well as fundamental research concerning cartilage biology and imaging. Up-to-date research enables fast clinical implementation of novel findings to optimize cartilage repair.
Contents
Part I. Introduction -- Introduction -- Part II. Fundamental Research, Biomaterials and Bioreactor Involved in Cartilage Repair -- Gene Therapy in articular cartilage repair -- Targeting inflammatory processes for optimization of cartilage homeostasis and repair techniques -- Osteoarthritis: molecular mechanisms and treatments -- Bioreactor Tissue Engineering for Cartilage Repair -- Biomaterials for osteochondral reconstruction -- Part III. Imaging of Cartilage -- Advanced magnetic resonance imaging of cartilage repair -- Part IV. Cartilage Repair Techniques -- Osteochondral Allograft Transplantation: The Rationale and Basic Science -- Osteochondral Allograft Transplantation: Surgical Technique and Results -- The Genesis of Autologous Chondrocyte Transplantation/Implantation: From a Hypothesis via an Animal Model to a Clinical Reality -- Characterized Chondrocyte Implantation challenges current paradigms for the treatment of symptomatic joint surface lesions -- Part V. Other Aspects of Cartilage Repair -- Autologous Chondrocyte Implantation after Previous Treatment With Marrow Stimulation Techniques -- Arthroscopic approaches for cartilage repair in the knee joint -- Cartilage repair of the knee in athletes -- Meniscus Substitution: Scaffolds, allografts and prosthetic implants -- Part VI. Clinical Studies/Overview Ankle -- Cartilage Repair, Replacement, and Regenerative Strategies for Osteochondral Lesions of the Talus -- How to treat cartilage injuries in the ankle joint by BMDC's transplantation -- Part VII. Emerging Techniques -- Pure cartilage-based repair modalities of focal cartilage lesions.
Format
e-Book
Location
Online
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Engineering of Functional Skeletal Tissues

https://libcat.nshealth.ca/en/permalink/provcat28106
edited by Felix Bronner, Mary C. Farach-Carson, Antonios G. Mikos. --London: Springer-Verlag , c2007.
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Location
Online
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Author
Bronner, Felix
Other Authors
Farach-Carson, Mary C
Mikos, Antonios G
Responsibility
edited by Felix Bronner, Mary C. Farach-Carson, Antonios G. Mikos
Place of Publication
London
Publisher
Springer-Verlag
Date of Publication
c2007
Series Vol.
3
Series Title
Topics in bone biology
ISBN
9781846283666
Subjects (MeSH)
Tissue Engineering
Bone Regeneration
Prostheses and Implants
Graft Rejection - prevention & control
Transplantation, Homologous - adverse effects
Subjects (LCSH)
Orthopedics
Biomedical engineering
Format
e-Book
Location
Online
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Fundamentals of Tissue Engineering and Regenerative Medicine

https://libcat.nshealth.ca/en/permalink/provcat29303
edited by Ulrich Meyer, Jörg Handschel, Hans Peter Wiesmann, Thomas Meyer. --Berlin, Heidelberg: Springer , c2009.
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Location
Online
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Author
Meyer, Ulrich
Other Authors
Handschel, Jörg
Wiesmann, Hans Peter
Meyer, Thomas
Responsibility
edited by Ulrich Meyer, Jörg Handschel, Hans Peter Wiesmann, Thomas Meyer
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2009
ISBN
9783540777557
Subjects (MeSH)
Bioartificial Organs
Biocompatible Materials
Regenerative Medicine - methods
Stem cell transplantation
Tissue Culture Techniques
Tissue Engineering
Subjects (LCSH)
Biomedical engineering
Biotechnology
Transplantation of organs tissues etc
Format
e-Book
Location
Online
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Innovations and Advances in Wound Healing

https://libcat.nshealth.ca/en/permalink/provcat40346
Seung-Kyu Han. (Second edition) --Berlin, Heidelberg: Springer , c2016.
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This book presents state of the art knowledge on new techniques and materials that can improve functional and aesthetic results in wound healing while reducing invasiveness, based on the author's extensive personal experience. The aim is to equip the practitioner with all the information required in order to select a strategy that will accelerate wound healing and minimize both the risk of complications and scar formation after the wound has fully healed. The opening chapters set the stage by p…
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Author
Han, Seung-Kyu
Responsibility
Seung-Kyu Han
Edition
Second edition
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xi, 287 p. : 267 illus., 259 illus. in color)
ISBN
9783662465875
9783662465868 (print ed.)
Subjects (MeSH)
Skin Transplantation
Tissue Engineering
Wound Healing
Abstract
This book presents state of the art knowledge on new techniques and materials that can improve functional and aesthetic results in wound healing while reducing invasiveness, based on the author's extensive personal experience. The aim is to equip the practitioner with all the information required in order to select a strategy that will accelerate wound healing and minimize both the risk of complications and scar formation after the wound has fully healed. The opening chapters set the stage by providing an overview of wound healing, including brief descriptions of the anatomy of the skin, the wound healing process, and advanced wound dressings. A full description follows of the various methodologies employed in repairing acute wounds with the goal of achieving optimal functional and cosmetic outcomes while utilizing the safest and least invasive method. Treatment protocols that have proven successful in closing nonhealing and/or delayed healing chronic wounds are then presented. The closing chapter addresses aesthetic procedures using advanced technology in wound healing. The text is supported by 1170 full color photos.
Contents
[publisher supplied] 1. Basics of Wound Healing -- 1) Clinical Anatomy of the Skin -- 2) Wound Overview -- 3) Wound Healing Process -- 4) Conventional Wound Healing Methods -- 2. Interactive Wound Dressings -- 1) Overview -- 2) Classification -- 3) Antimicrobial Dressing -- 4) Dressing Selection -- 3. Autogenous/Artificial Dermis Graft -- 1) Autogenous Dermis Graft -- 2) Artificial Dermis Graft -- 4. Tissue-engineered Dermis Graft -- 1) Fibroblasts-Hyaluronic Acid Complex -- 2) Adipose-Derived Stromal Vascular Fraction Cells-Collagen Complex -- 5. Atypical Island Flaps -- 1) Arterial Island Flap -- 2) Venous Island Flap -- 6. Management of Chronic Wounds - With Focus on Diabetic Ulcers -- 1) Why is Diabetic Ulcer Focused on? -- 2) Management of Ischemia -- 3) Management of Infection -- 4) Debridements -- 5) Pressure Off-Loading -- 6) Restoration of Cell Function -- 7. Negative Pressure Wound Therapy (NPWT) -- 1) Benefits -- 2) Applying Method -- 3) Precaution -- 4) NPWT for Diabetic Foot Ulcers -- 8. Growth Factors -- 1) Overview -- 2) Platelet-derived Growth Factor -- 3) Epidermal Growth Factor -- 4) Basic Fibroblast Growth Factor -- 9. Cell Therapy -- 1) Overview -- 2) Fresh Fibroblast Allograft -- 3) Fresh Fibroblast Autograft -- 4) Keratinocyte Allograft -- 5) Autograft of Adipose-Derived Stromal Vascular Fraction Cells -- 6) Allograft of Blood Bank Platelet Concentrate -- 7) Potential of Using Stem Cells -- 10. Injectable Tissue-engineered Soft Tissue -- 1) Biologic Implants for Soft Tissue Augmentation -- 2) Injectable Soft Tissue Using Fibroblasts -- 3) Injectable Soft Tissue Using Adipose-Derived Cells.
Format
e-Book
Location
Online
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The intervertebral disc : molecular and structural studies of the disc in health and disease

https://libcat.nshealth.ca/en/permalink/provcat33985
Irving M. Shapiro, Makarand V. Risbud, editors. --Wien: Springer , c2014.
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The intervertebral disc is composed of a complex tissue that separates neighboring vertebrae, permits a wide range of motion, and cushions the high biomechanical forces on the spine. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scientists and clinicians, this is the only book in the past fifty years devoted entirely to the study of the intervertebral disc. The first part of the book provides a review of the basic biology of the…
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Other Authors
Shapiro, Irving M.
Risbud, Makarand V.
Responsibility
Irving M. Shapiro, Makarand V. Risbud, editors
Place of Publication
Wien
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (x, 446 pages)
ISBN
9783709115350 (electronic bk.)
9783709115343
Subjects (MeSH)
Arthroplasty, Replacement
Intervertebral Disc Degeneration - pathology
Intervertebral Disc Degeneration - surgery
Intervertebral Disc - pathology
Intervertebral Disc - physiology
Tissue Engineering
Subjects (LCSH)
Intervertebral disk - Diseases
Surgical Orthopedics
Neurosurgery
Orthopedics
Abstract
The intervertebral disc is composed of a complex tissue that separates neighboring vertebrae, permits a wide range of motion, and cushions the high biomechanical forces on the spine. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scientists and clinicians, this is the only book in the past fifty years devoted entirely to the study of the intervertebral disc. The first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies for mitigating the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is dedicated to approaches that model normal development, and the elucidation of the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques.
Contents
Part I. Biomechanical and Molecular Studies of the Intervertebral Disc -- Introduction to the Structure, Function and Comparative Anatomy of the Vertebrae and the Intervertebral Disc -- The Intervertebral Disc: Overview of Disc Mechanics -- Development of the Intervertebral Disc -- Proteoglycans of the Intervertebral Disc -- Collagen and Other Proteins of the Nucleus Pulposus, Annulus Fibrosus and Cartilage Endplates -- Microenvironmental Regulation of Cell Function and Extracellular Matrix Synthesis by Disc Cells -- The Effects of Mechanical Forces on Nucleus and Annulus Cells -- The Role of the ADAMTS Proteins in the Intervertebral Disc -- Part II. Intervertebral Disc Disease: Pathogenesis and Current Treatment Modalities -- Epidemiology of Lumbar Disc Degeneration -- Genetic Basis of Intervertebral Disc Degeneration -- Pathogenesis of Intervertebral Disc Degeneration -- Imaging Modalities for Studying Disc Pathology -- Surgical Indications for Lumbar Degenerative Disease -- Spinal Motion Restoration Devices for the Degenerate Disc -- The Non-Surgical Treatment of Back Pain -- Back Pain and Disc Degeneration: Are They Linked? -- Clinical Features and Pathobiology of Chordoma -- Part III. Models of Disc Disease and Biological Regeneration -- Large Animal Models of Disc Degeneration -- Intervertebral Disc Herniation: Pathophysiology and Emerging Therapies -- The Sand Rat (Psammomys obesus obesus) Model of Spontaneous, Age-Related Intervertebral Disc Generation -- Use of Knockout and Transgenic Mouse Models in Disc Research -- Intervertebral Disc Culture Models and Their Applications to Study Pathogenesis and Repair -- Use of Stem Cells for Regeneration of the Intervertebral Disc -- Gene Therapy Approaches for Disc Regeneration -- Enhancing Disc Repair by Growth Factors and Other Modalities -- Tissue Engineering of the Disc.
Format
e-Book
Location
Online
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Musculoskeletal Tissue Regeneration : Biological Materials and Methods

https://libcat.nshealth.ca/en/permalink/provcat30175
edited by William S. Pietrzak. --Totowa, NJ: Humana Press , c2008.
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Location
Online
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Author
Pietrzak, William S
Responsibility
edited by William S. Pietrzak
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2008
Series Title
Orthopedic biology and medicine
ISBN
9781597452397
Subjects (MeSH)
Biocompatible Materials
Bone Transplantation - methods
Cartilage - transplantation
Guided Tissue Regeneration
Tissue Engineering - methods
Subjects (LCSH)
Orthopedics
Biomaterials
Format
e-Book
Location
Online
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Neuroprotection and neuroregeneration for retinal diseases

https://libcat.nshealth.ca/en/permalink/provcat33877
Toru Nakazawa, Yasushi Kitaoka, Takayuki Harada, editors. --Tokyo: Springer , c2014.
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This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa. Glaucoma is one of the main causes of blindness throughout the world, and other diseases such as AMD and retinitis pigmentosa also lead to loss of vision. All these conditions are characterized by degeneration of specific retinal cell types, making it e…
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Other Authors
Nakazawa, Toru
Kitaoka, Yasushi
Harada, Takayuki
Responsibility
Toru Nakazawa, Yasushi Kitaoka, Takayuki Harada, editors
Place of Publication
Tokyo
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (x, 356 pages)
ISBN
9784431549659 (electronic bk.)
9784431549642
Subjects (MeSH)
Nerve Growth Factors
Neuroprotective Agents
Retinal Diseases
Subjects (LCSH)
Retina - Diseases
Nervous system - Regeneration
Ophthalmology
Neurology
Regenerative Medicine/Tissue Engineering
Abstract
This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa. Glaucoma is one of the main causes of blindness throughout the world, and other diseases such as AMD and retinitis pigmentosa also lead to loss of vision. All these conditions are characterized by degeneration of specific retinal cell types, making it essential to establish treatments to protect retinal neurons and the optic nerve. With that aim in mind, this book explains the mechanisms underlying aforementioned diseases and their experimental models. The novel strategy proposals for the treatment of retinal diseases based on the concept of neuroprotection are also discussed in the main body of the text, while the section on regenerative research discusses optic nerve regeneration, endothelial progenitor cells, and iPS cells.
Contents
Part I. Neuroprotection for Glaucoma -- 1. Molecular Architecture of Glutamate Signaling Pathway in Glaucomatous Optic Neuropathy -- 2. Calcium and Calpain Activation -- 3. Classical Signaling Pathways -- 4. Antioxidative Treatment for Neuroprotection in Glaucoma -- 5. ER stress -- 6. Nitric Oxide Contributes to Retinal Ganglion Cell Survival Through Protein S-Nitrosylation after Optic Nerve Injury -- 7. Neurotrophic factors -- 8. RIP Kinase-Mediated Programmed Necrosis -- 9. Axonal Degeneration -- 10. Axonal Transport -- 11. Interaction Between RGC Bodies and Glia -- 12. Aquaporin in optic neuropathies -- 13. Microglia -- Part II. Neuroprotection for Age-Related Macular Degeneration (AMD), Retinal Pigmentary Degeneration -- 14. Neuroprotection for Photoreceptors -- 15. Retinal Photooxidative Stress and Its Modifiers -- 16. Roles of the Retinal Pigment Epithelium in Neuroprotection -- 17. Oxidative Stress in the RPE and Its Contribution to AMD Pathogenesis; Implication of Light Exposure -- 18. Interaction Between Photoreceptors and RPEs -- Part III. Neuroprotection for Other Retinal Diseases -- 19. Neuroprotection for Retinal Detachment -- 20. Neuroinflammation -- 21. Optic Neuritis -- 22. Neuroprotection by Endothelial Progenitor Cells for Retinal Degeneration -- 23. Optic Nerve Regeneration.
Format
e-Book
Location
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Platelet Rich Plasma in Orthopaedics and Sports Medicine

https://libcat.nshealth.ca/en/permalink/provcat42881
edited by Eduardo Anitua, Ramon Cugat, Mikel Sanchez. --Cham, Switzerland: Springer , c2018.
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This book provides a comprehensive, state-of-the art review of platelet rich plasmas (PRPs) in the field of regenerative medicine. The book begins with an overview of the basic science behind PRP, describing the role of platelets and growth factors followed by the most important biological effects expected from the use of PRPs. Platelet Rich Plasma in Orthopaedics, Sports Medicine and Maxillofacial surgery includes numerous contributions detailing the rapidly growing field of PRPs in clinical p…
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Other Authors
Anitua, Eduardo
Cugat, Ramon
Sanchez, Mikel
Responsibility
edited by Eduardo Anitua, Ramon Cugat, Mikel Sanchez
Place of Publication
Cham, Switzerland
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xi, 276 p
ISBN
9783319637303
9783319637297 (print ed.)
9783319637310 (print ed.)
9783030097028 (print ed.)
Subjects (MeSH)
Athletic Injuries - surgery
Oral Surgical Procedures
Orthopedic Procedures
Platelet-Derived Growth Factor
Platelet-Rich Plasma - physiology
Tissue Engineering
Specialty
Orthopedic Procedures
Regenerative Medicine
Sports Medicine
Abstract
This book provides a comprehensive, state-of-the art review of platelet rich plasmas (PRPs) in the field of regenerative medicine. The book begins with an overview of the basic science behind PRP, describing the role of platelets and growth factors followed by the most important biological effects expected from the use of PRPs. Platelet Rich Plasma in Orthopaedics, Sports Medicine and Maxillofacial surgery includes numerous contributions detailing the rapidly growing field of PRPs in clinical practice. From the origins in oral and maxillofacial surgery, to the latest advances in orthopaedics and sports medicine including the use of Platelet Rich Growth Factors (PRGF) in muscle, bone, tendon, ligament and nerve injuries among others. The volume concludes with contributions from experts in biology, orthopaedics, oral and maxillofacial surgery, where the convergence of expertise is leading to unprecedented insights into how to minutely control the in vivo fate and function of PRGF. This book will provide a useful resource for physicians and researchers interested in the rapidly changing field of biomedicine and learning more about this growing area of treatment.
Contents
Part 1. Basic science -- Platelets: at the interface between inflammation and repair process -- Characterization of plasma rich in growth factor: content and formulation -- Effects of PRGF on cells and tissues of musculoskeletal system: from muscle to articular cartilage -- Regeneration: connecting the dots among hemostasis and clotting, immune system, and fibrogenesis -- PRGF molecular intervention to enhance muscle perfusion and tissue remodeling -- Part 2. Oral and Maxillofacial surgery -- The use of plasma rich in growth factor in the treatment of post-extraction defects -- Efficacy and safety of PRGF versus platelet rich fibrin in post-extraction defects -- An autologous treatment to a challenging pathology medication-related osteonecrosis of the jaw. Part 3. Orthopaedics & Sports Medicine -- A biological approach to apply plasma rich in growth factors on joint tissues -- Scientific evidence of the effects of PRGF on musculoskeletal tissues in animal model -- A new approach to treat joint and cartilage injuries: intraosseous infiltrations of PRGF -- Knee Osteoarthritis: one versus two cycles of PRGF infiltrations treatment -- Application of PRGF on Sports-related injuries -- Why to use Plasma rich in growth factors on the repair of damaged tendons -- Infiltrations of PRGF to treat ligament injuries -- Treatment of injured peripheral nerves with PRGF: from bench to patient -- Treatment of tendinopathies with Plasma rich in growth factors -- Intradiscal and intra-articular facet infiltrations with plasma rich in growth factors to treat chronic low back pain.
Format
e-Book
Location
Online
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Principles of regenerative medicine

https://libcat.nshealth.ca/en/permalink/provcat42375
edited by Anthony Atala, Robert Lanza ... [et al]. (3rd ed.) --Philadelphia, PA: Elsevier / Academic Press , c2019.
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Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as …
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Other Authors
Atala, Anthony
Responsibility
edited by Anthony Atala, Robert Lanza ... [et al]
Edition
3rd ed.
Alternate Title
Regenerative medicine
Place of Publication
Philadelphia, PA
Publisher
Elsevier / Academic Press
Date of Publication
c2019
Physical Description
1 online resource, 1454 p.
ISBN
9780128098806
Subjects (MeSH)
Biocompatible Materials
Regenerative Medicine
Stem Cells
Tissue Engineering
Tissue Transplantation
Specialty
Regenerative Medicine
Abstract
Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies.
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Format
e-Book
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Principles of regenerative medicine

https://libcat.nshealth.ca/en/permalink/provcat51181
Atala, Anthony. (3rd ed.) --London, England: Academic Press , 2019.
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Author
Atala, Anthony
Other Authors
Lanza, Robert
Mikos, Antonios G.
Edition
3rd ed.
Place of Publication
London, England
Publisher
Academic Press
Date of Publication
2019
ISBN
9780128098806
Subjects (MeSH)
Biocompatible Materials
Regenerative Medicine
Stem Cells
Tissue Engineering
Tissue Transplantation
Notes
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
Format
e-Book
Location
Online
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Regenerative and Cell Therapy : Clinical Advances

https://libcat.nshealth.ca/en/permalink/provcat30040
edited by A. Keating, K. Dicke, N. Gorin, R. Weber, H. Graf. --Berlin, Heidelberg: Springer-Verlag , c2005.
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Location
Online
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Author
Keating, A
Other Authors
Dicke, K
Gorin, N
Weber, R
Graf, H
Responsibility
edited by A. Keating, K. Dicke, N. Gorin, R. Weber, H. Graf
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2005
Series Vol.
Supplement 11
Series Title
Ernst Schering Research Foundation workshop
ISBN
9783540268437
Subjects (MeSH)
Hematopoietic Stem Cell Transplantation - methods
Immunotherapy, Adoptive - methods
Regeneration
Regenerative Medicine - trends
Stem cell transplantation - methods
Tissue Engineering - methods
Subjects (LCSH)
Gene therapy
Format
e-Book
Location
Online
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Regenerative medicine for the inner ear

https://libcat.nshealth.ca/en/permalink/provcat34047
Juichi Ito, editor. --Tokyo: Springer , c2014.
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The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are exp…
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Other Authors
Ito, Juichi
Responsibility
Juichi Ito, editor
Place of Publication
Tokyo
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xi, 321 pages)
ISBN
9784431548621 (electronic bk.)
9784431548614
Subjects (MeSH)
Ear, Inner - surgery
Labyrinth Diseases - physiopathology
Labyrinth Diseases - surgery
Regenerative Medicine - methods
Subjects (LCSH)
Labyrinth (Ear) - Diseases - Treatment
Regenerative medicine
Otorhinolaryngology
Regenerative Medicine/Tissue Engineering
Gene Therapy
Neurosciences
Abstract
The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness-vertigo, and Ménière's disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems.
Contents
Part I. Targets of Regenerative Medicine for the Inner Ear -- 1. Anatomy of the Inner Ear -- 2. Therapeutic Targets and Possible Strategies for Regenerative Medicine for the Inner Ear -- 3. Hair cell -- 4. Stereocilia -- 5. Cochlear Lateral Wall -- 6. Spiral Ganglion Cell and Auditory Neuron -- 7. Synaptic Contacts between Hair Cells and Primary Neurons -- 8. Otolith -- 9. Tectorial membrane -- Part II. Development of the Inner Ear -- 10. Development and Regeneration -- 11. Otic Induction -- 12. Cochlear Development -- 13. Vestibular Development -- Part III. Cochlear Implants -- 14. Cochlear Implant: Past, Present and Future -- 15. Recent Progress in Cochlear Implant -- 16. Regenerative Medicine in Cochlear Implantation -- 17. Artificial Cochlear Epithelium -- 18. Auditory Brainstem Implant -- Part IV. Hair Cell Regeneration -- 19. Hair Cell Regeneration in the Avian -- 20. Self Repair -- 21. Transdifferentiation -- 22. Dedifferentiation-Mediated Regeneration -- 23. Gene Therapy -- 24. Cell Therapy -- Part V. Spiral Ganglion Neuron Regeneration -- 25. Clinical Background -- 26. SGN Development -- 27. Gene Therapy for Regeneration and Preservation of Spinal Ganglion Neurons -- 28. Cell Therapy -- 29. Afferent Dendrite and Axon -- Part VI. Stem Cells -- 30. Inner Ear Stem Cells -- 31. Pluripotent Stem Cells -- 32. Somatic Stem Cells -- Part VII. Future Perspective -- 33. Regenerative Medicine for the Inner Ear.
Format
e-Book
Location
Online
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