topic:"Toxicology" found 66 records - Provincial Hospitals Library Catalogue

5-minute toxicology consult

https://libcat.nshealth.ca/en/permalink/provcat27397

Dart, Richard C. --Philadelphia, PA: Lippincott Williams & Wilkins , 2000.

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Location: Online

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Author: Dart, Richard C.

Place of Publication: Philadelphia, PA

Publisher: Lippincott Williams & Wilkins

Date of Publication: 2000

Series Title: 5-minute consult

ISBN: 068330207

Subjects (MeSH): Poisoning - Handbooks; Antidotes - Handbooks; Hazardous Substances - adverse effects; Toxicology - Handbooks

Format: e-Book

Location: Online

Advances in molecular toxicology. Vol. 1

https://libcat.nshealth.ca/en/permalink/provcat27194

edited by James C. Fishbein. --Amsterdam, Netherlands: Elsevier , 2006.

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Location: Online

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Author: Fishbein, James C

Responsibility: edited by James C. Fishbein.

Place of Publication: Amsterdam, Netherlands

Publisher: Elsevier

Date of Publication: 2006

ISBN: 9786610707997

Subjects (MeSH): Toxicology; Molecular Biology

Contents: Cover -- Contents -- Contributors -- Editor's Preface -- Bioactivation of Estrogens to Toxic Quinones -- Introduction -- Mechanisms of Estrogen Carcinogenesis -- Oxidation of Catechol Estrogens to O-Quinones -- DNA Damage Induced by Catechol Estrogens -- Protein Damage Induced by Catechol Estrogens -- Role of the Estrogen Receptor in Estrogen Carcinogenesis -- Substitution of the 4-Hydroxy group on Catechol Estrogens with Fluorine Abolishes Quinoid Formation while Maintaining Estrogenic Activity -- Summary -- Acknowledgment -- References -- Diverse Mechanisms of Endogenous Nucleobase Deamination in DNA and RNA -- Introduction -- Simple Hydrolytic Mechanisms -- Nitrosative Deamination and Inflammation -- Enzymatic Deamination of Nucleobases -- Purine Metabolism as a Source of Nucleobase Deamination in DNA and RNA -- Repair and Mutagenesis of Nucleobase Deamination Products -- Summary -- Acknowledgments -- References -- Site-Specific Modification of the Electrophile Sensor Protein Keap1 and Activation of Nrf2-Dependent Gene Expression -- Introduction -- Patterns of Keap1 Modification by Electrophiles -- Relationship of Keap1 Modification Sites and Functionally Significant Cysteine Residues -- Electrophile-Induced Ubiquitination of Keap1 -- Unresolved Questions about Electrophile-Induced Activation of NRF2 -- Acknowledgments -- References -- Genotoxicity of Chlorophenols and Ochratoxin A -- Introduction -- Chlorophenols -- Ochratoxin A -- Acknowledgments -- References -- Idiosyncratic Drug Reactions: Clinical Evidence for Mechanistic Hypotheses -- Background -- Postulated Mechanisms -- Summary and Conclusions -- Acknowledgments -- References -- Subject Index -- Last Page

Format: e-Book

Location: Online

Alternatives to Animal Testing : Proceedings of Asian Congress 2016

https://libcat.nshealth.ca/en/permalink/provcat43939

Hajime Kojima, Troy Seidle, Horst Spielmann, editors. --Singapore: SpringerOpen , c2019.

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Access: Open access

Location: Online

The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0. ; This book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collective…

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Other Authors: Kojima, Hajime; Seidle, Troy; Spielmann, Horst

Responsibility: Hajime Kojima, Troy Seidle, Horst Spielmann, editors

Place of Publication: Singapore

Publisher: SpringerOpen

Date of Publication: c2019

Physical Description: 1 online resource (vi, 130 p. 46 illus., 39 illus. in color.)

ISBN: 9789811324475; 9789811324468 (Print ed.); 9789811324482 (Print ed.)

Subjects (MeSH): Animal Testing Alternatives - trends; Animals, Laboratory; Toxicology - methods

Specialty: Laboratory Animal Science

Abstract: The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.; This book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare.

Contents: 1. Zebrafish, Danio rerio as a replacement alternative model useful in CKDu experiments -- 2. Testing method development and validation for in vitro skin irritation testing (SIT) by using reconstructed human epidermis (RhE) skin equivalent: EPiTR -- 3. Development the technique for the preparation and characterization of reconstructed human epidermis (RHE) -- 4. Alternative research (3Rs) in the world, Asia and Japan -- 5. Approaches to reducing animal use for acute toxicity testing: Retrospective analyses of pesticide data -- 6. Progress in deleting the 1-year dog study for the safety assessment of pesticides -- 7. Cosmetic regulation and alternatives to animal experimentation in India -- 8. Guidance on the use of alternative test methods for the safety assessment of cosmetics and quasi-drugs -- 9. Alternatives and refinement for animal experimentation in cancer research -- 10. 3Rs in quality control of human vaccines: opportunities and barriers -- 11. The use of adverse outcome pathways (AOPs) to support chemical safety decisions within the context of integrated approaches to testing and assessment (IATA) -- 12. Mechanism-based evaluation system for hepato- and nephrotoxicity or carcinogenicity using omics technology -- 13. Alternative methods for developmental toxicity testing using mouse ESCs -- 14. Futuristic approach to alternative model organisms: hydra stakes its claim -- 15. The Lush Prize and Young Researcher Asia Awards 2016.

Access: Open access

Format: e-Book

Publication Type: Congress

Location: Online

Application of peptide-based prodrug chemistry in drug development

https://libcat.nshealth.ca/en/permalink/provcat32406

Arnab De, author ; with special thanks to Richard DiMarchi and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University ; with foreword by Jean Martinez. --New York, NY: Springer , c2013.

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Location: Online

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Author: De, Arnab

Responsibility: Arnab De, author ; with special thanks to Richard DiMarchi and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University ; with foreword by Jean Martinez

Place of Publication: New York, NY

Publisher: Springer

Date of Publication: c2013

Series Title: SpringerBriefs in pharmaceutical science & drug development

ISBN: 9781461448754

Subjects (MeSH): Drug Design; Peptides - pharmacology; Prodrugs

Subjects (LCSH): Toxicology; Pharmaceutical technology; Diabetes

Contents: Introduction -- Application of prodrug chemistry to GLP-1 -- Experimental procedures -- Characterization of prodrugs -- Conclusion -- Appendix I: Schematic Synthesis of Longer Acting Prodrugs -- Appendix II: Structure of Peptides in Table A.1 -- Appendix III: Structure of Peptides in Table A.2 -- Appendix IV: Structure of Peptides in Table A.3 -- Appendix V: Structure of Peptides in Table A.4 -- Appendix VI: Structure of Peptides in Table A.5 -- Appendix VII: Structure of Peptides in Table A.6 -- Appendix VIII: Acylation of HO-His7, GLP(8–37) -- Appendix IX: A Note on Nomenclature.

Format: e-Book

Location: Online

Atlas of human poisoning and envenoming

https://libcat.nshealth.ca/en/permalink/provcat26458

James H. Diaz. (2nd ed.) --Boca Raton, FL: Taylor and Francis , c2015.

Call Number: QV 17 H542 2015

Location: Halifax Infirmary

Clinicians undergoing competency testing, certification, and periodic recertification are frequently faced with computer-based exams designed to evaluate clinical acumen and judgment. Test questions often include an image or radiograph followed by a vignette of the clinical encounter and a series of questions. Designed to better prepare practitioners for image-intense, computer-based examinations in their respective fields, Atlas of Human Poisoning and Envenoming is a visual and written remind…

Call Number: QV 17 H542 2015

Author: Diaz, James H

Responsibility: James H. Diaz

Edition: 2nd ed.

Former Title: Color atlas of human poisoning and envenoming

Place of Publication: Boca Raton, FL

Publisher: Taylor and Francis

Date of Publication: c2015

Physical Description: 890 p.

ISBN: 9781466505407

Subjects (MeSH): Antidotes - Atlases; Poisoning - Atlases; Poisons - Atlases; Toxicology - Atlases; Toxins, Biological - Atlases; Venoms - Atlases

Notes: Preceded by: Color atlas of human poisoning and envenoming / by James Diaz. 1st ed. 2006.

Abstract: Clinicians undergoing competency testing, certification, and periodic recertification are frequently faced with computer-based exams designed to evaluate clinical acumen and judgment. Test questions often include an image or radiograph followed by a vignette of the clinical encounter and a series of questions. Designed to better prepare practitioners for image-intense, computer-based examinations in their respective fields, Atlas of Human Poisoning and Envenoming is a visual and written reminder of the ubiquitous sources of toxins and toxoids in the environment and the outcomes of accidental or intentional toxic exposures in humans. The 2nd ed. has been restructured with bulleted text, tables, and figures resembling the vignettes that accompany national examinations. Combining the four specialties of toxicology analytical, medical, environmental, and industrial into one comprehensive atlas, the book presents photographs and diagrams of toxic plants and animals, their mechanisms of poisoning or envenoming, and the human responses caused by toxic exposure. Highlights include: Prescription and illicit drug abuse epidemics; Environmental and occupational nephrotoxicology and neurotoxicology; Tick paralysis; Petrochemical toxicants; Biological, chemical, and radiological warfare agents; Workplace substance abuse screening and monitoring; Epidemiological design and statistical analysis of toxicological investigations. The book is conveniently divided into four sections covering general medical toxicology, environmental toxicology, industrial and occupational toxicology, and epidemiology and statistics for toxicology. Supplemented with a 16-page color insert, the second edition includes new images and tables. The atlas will be a useful study guide for a range of practitioners preparing for a lifetime of image-intense national examinations.

Format: Book

Location: Halifax Infirmary

Copies: 1

Loan Period: 3 weeks

Atlas of toxicological pathology

https://libcat.nshealth.ca/en/permalink/provcat33845

Chirukandath Gopinath, Vasanthi Mowat. --New York: Springer , c2014.

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Location: Online

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Author: Gopinath, Chirukandath

Other Authors: Mowat, Vasanthi

Responsibility: Chirukandath Gopinath, Vasanthi Mowat

Former Title: Atlas of experimental toxicological pathology

Place of Publication: New York

Publisher: Springer

Date of Publication: c2014

Physical Description: 1 online resource (xi, 285 pages)

ISBN: 9781627039987 (electronic bk.); 9781627039970

Subjects (MeSH): Pathologic Processes - Atlases; Toxicology - Atlases

Subjects (LCSH): Toxicology, Experimental - Atlases; Histology, Pathological - Atlases; Laboratory animals - Histopathology - Atlases; Diseases - Animal models - Atlases

Notes: Preceded by: Atlas of experimental toxicological pathology / by C. Gopinath, D.E. Prentice, D.J. Lewis.

Contents: The Cardiovascular System -- The Respiratory System -- The Liver -- The Alimentary System and Pancreas -- The Urinary System -- The Male Reproductive System -- The Female Reproductive System -- The Endocrine System -- The Lymphoid System -- The Nervous System -- The Musculoskeletal System and Skin -- The Eye and Ear.

Format: e-Book

Location: Online

Basic Principles of Forensic Chemistry

https://libcat.nshealth.ca/en/permalink/provcat30987

JaVed I. Khan, Thomas J. Kennedy, Donnell R. Christian Jr. --New York, NY: Humana Press , c2012.

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Location: Online

Basic Principles of Forensic Chemistry is designed to provide a clear and concise understanding of forensic chemistry. The text begins with an introduction to the basic principles of chemistry and expands through organic chemistry into forensic investigation. The detailed chapters focus on both the theoretical and practical aspects of forensic chemistry with emphasis on controlled substance testing and identification. Leading experts in the field contribute general examination techniques follow…

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Author: Khan, JaVed I

Other Authors: Kennedy, Thomas J; Christian Jr., Donnell R

Responsibility: JaVed I. Khan, Thomas J. Kennedy, Donnell R. Christian Jr

Place of Publication: New York, NY

Publisher: Humana Press

Date of Publication: c2012

Physical Description: 1 online resource (xxii, 353 p. : 370 ill., 25 ill. in color)

ISBN: 9781597454377

Subjects (MeSH): Chemical Phenomena; Chemistry Techniques, Analytical - methods; Forensic Sciences - methods

Subjects (LCSH): Toxicology; Analytical biochemistry; Forensic Medicine

Abstract: Basic Principles of Forensic Chemistry is designed to provide a clear and concise understanding of forensic chemistry. The text begins with an introduction to the basic principles of chemistry and expands through organic chemistry into forensic investigation. The detailed chapters focus on both the theoretical and practical aspects of forensic chemistry with emphasis on controlled substance testing and identification. Leading experts in the field contribute general examination techniques followed by applications to more specific models. In addition, the text contains a comprehensive collection of information and data on controlled substances commonly encountered in forensic investigation including; detailed structural analysis, physical and physiological effects, functional group reactivity, and results of analytical examination. Also illustrated is arguably the greatest challenge to the forensic chemist: the investigation and processing of clandestine laboratory operations. The Forensic Chemistry Laboratory Manual is included on a CD-ROM and contains a collection of practical exercises designed to support theoretical principles covered in the text. This provides the student with valuable hands-on experience while adding clarity and continuity to the topics of discussion. Essential and comprehensive, Basic Principles of Forensic Chemistry provides the fundamental knowledge required for a rewarding journey into the field of forensic chemistry.

Contents: I. Introduction to forensic chemistry -- Introduction -- Atomic structure -- Molecules -- Organic chemistry -- II. Tools of forensic chemistry -- Forensic language -- Forensic documentation -- Chemical screening -- Microcrystal techniques -- Chemical extractions and sample properties -- Chromatography and mass spectrometry -- Infrared spectroscopy -- III. Examination of drugs/narcotics -- Cannabis -- Phenethylamines -- Tertiary amines -- Tryptamines -- Anabolic steroids -- Miscellaneous controlled substances -- IV. Clandestine laboratory operations -- Clandestine operations: synthetic methods, hazards, and safety -- Evidence identification and collection -- Examination of clandestine evidence.

Format: e-Book

Location: Online

Burkitt's lymphoma

https://libcat.nshealth.ca/en/permalink/provcat32384

Erle S. Robertson, editor. --New York, NY: Springer , c2013.

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Location: Online

This volume aims to bring together efforts with a patient-oriented focus from physicians to diagnostics and clinical implications of the disease as mostly seen in the equatorial African setting. However, the chapters cover the breadth of studies on Burkitt's lymphoma with some clues for the potential future of Burkitt's lymphoma research that can have therapeutic benefits for patients. This text explore a range of topics associated with Burkitt's lymphoma, including molecular biology, diagnosi…

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Other Authors: Robertson, Erle S

Responsibility: Erle S. Robertson, editor

Place of Publication: New York, NY

Publisher: Springer

Date of Publication: c2013

Physical Description: 1 online resource (viii, 332 p. : 60 ill., 48 ill. in color)

Series Title: Current cancer research

ISBN: 9781461443131

Subjects (MeSH): Africa South of the Sahara; Burkitt Lymphoma

Subjects (LCSH): Oncology; Toxicology

Abstract: This volume aims to bring together efforts with a patient-oriented focus from physicians to diagnostics and clinical implications of the disease as mostly seen in the equatorial African setting. However, the chapters cover the breadth of studies on Burkitt's lymphoma with some clues for the potential future of Burkitt's lymphoma research that can have therapeutic benefits for patients. This text explore a range of topics associated with Burkitt's lymphoma, including molecular biology, diagnosis, its association with AIDS and Malaria, immune responses, therapeutic approaches and a unique view from the bedside. This volume is comprehensive and unique and represents the most up-to-date clinical and research activities on Burkitt's lymphoma.

Contents: Preface -- Introduction -- Diagnosis of Burkitt's Lymphoma -- Burkitt's Lymphoma : A View from the Bedside -- Clinical Implications of Burkitt's Lymphoma -- Definition of Burkitt's Lymphoma -- Classical and Endemic Burkitt's Lymphoma -- Sporadic Burkitt's Lymphoma -- AIDS-Associated Burkitt's Lymphoma -- Diffuse Large B-Cell Lymphoma and High Grade Diffuse Large B-Cell Lymphoma -- EBV Associated Burkitt's Lymphoma -- Molecular Biology of Burkitt's Lymphoma -- Burkitt's Lymphoma and the Immune Response -- The Many Roles of Malaria in the Etiology of Endemic Burkitt Lymphoma -- Therapeutic Approaches to Burkitt’s Lymphoma -- Animal Models of Burkitt’s Lymphoma -- Summary and Conclusion: Thinking About Latent BL -- Index.

Format: e-Book

Location: Online

Cadmium Toxicity : New Aspects in Human Disease, Rice Contamination, and Cytotoxicity

https://libcat.nshealth.ca/en/permalink/provcat44135

Seiichiro Himeno, Keiko Aoshima, editors. --Singapore: Springer , 2019.

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Location: Online

This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pa…

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Other Authors: Himeno, Seiichiro; Aoshima, Keiko

Responsibility: Seiichiro Himeno, Keiko Aoshima, editors

Place of Publication: Singapore

Publisher: Springer

Date of Publication: 2019

Physical Description: 1 online resource (viii, 190 p.) : 68 illus., 51 illus. in color

Series: Current Topics in Environmental Health and Preventive Medicine

Series Title: Current Topics in Environmental Health and Preventive Medicine

ISBN: 9789811336300; 9789811336294 (Print ed.); 9789811336317 (Print ed.)

ISSN: 2364-8333

Subjects (MeSH): Cadmium - toxicity; Cadmium Poisoning; Environmental Exposure; Food Contamination - prevention & control

Specialty: Toxicology

Abstract: This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pathophysiology of itai-itai disease, a serious condition caused by Cd pollution. Cadmium: New Aspects in Human Disease, Rice Contamination, and Cytotoxicity is a valuable resource for scientists involved in heavy metal toxicology, botanical sciences, and regulatory sciences. Addressing the features of Cd pollution in the past and in the present, as well as future perspectives, this is a must-have book for students, researchers and practitioners interested in global and local metal pollution.

Contents: Part I. Overview -- 1. Historical Lessons on Cadmium Environmental Pollution Problems in Japan and Current Cadmium Exposure Situation -- Part II. Health Effects of Cadmium in Human Populations and its Relation to Cadmium Exposure Levels -- 2. Recent Clinical and Epidemiological Studies of Itai-Itai Disease (Cadmium-Induced Renal Tubular Osteomalacia) and Cadmium Nephropathy in the Jinzu River Basin in Toyama Prefecture, Japan -- 3. Novel Pathological Study of Cadmium Nephropathy of Itai-itai Disease -- 4. Long-Term Follow-Up Study of Residents Exposed to Cadmium in Kakehashi River Basin, Ishikawa, Japan -- 5. Effects of Cadmium Exposure on Life Prognosis -- 6. Cadmium Exposure and Its Effects on the Health Status of Rice Farmers in Akita Prefecture 7. Dietary Cadmium Intake Among General Populations in Japan and East Asia -- Part III. Rice Contamination by Cadmium and its Remediation -- 8. Regulations for Cadmium in Rice and Soil in Japan and Countermeasures to Reduce the Concentrations -- 9. Molecular Mechanism of Cadmium Accumulation in Rice - 10. Mitigation Strategies for Cadmium and Arsenic in Rice -- 11. Development of Low-Cadmium-Accumulating Rice -- Part IV. New Aspects in the Mechanisms of Cadmium Toxicity -- 12. Novel Mechanisms of Cadmium-Induced Toxicity in Renal Cells - 13. Roles of Metal Transporters in Cellular Cadmium Transport in Mammals -- 14. Disturbance in Phosphorus Metabolism by Cadmium Exposure.

Format: e-Book

Location: Online

Cancer immunotherapy meets oncology : in honor of Christoph Huber

https://libcat.nshealth.ca/en/permalink/provcat33730

Cedrik Michael Britten, Sebastian Kreiter, Mustafa Diken, Hans-Georg Rammensee, editors. --Heidelberg: Springer , c2014.

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Location: Online

This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical developmen…

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Other Authors: Britten, Cedrik Michael; Huber, Christoph

Responsibility: Cedrik Michael Britten, Sebastian Kreiter, Mustafa Diken, Hans-Georg Rammensee, editors

Place of Publication: Heidelberg

Publisher: Springer

Date of Publication: c2014

Physical Description: 1 online resource (ix, 248 pages)

ISBN: 9783319051048 (electronic bk.); 9783319051031

Subjects (MeSH): Immunotherapy; Neoplasms - immunology; Neoplasms - therapy; Tumor Markers, Biological

Subjects (LCSH): Cancer - Immunotherapy; Oncology; Cancer Research; Pharmacology/Toxicology; Immunology

Abstract: This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.

Contents: Part I. Immunological and Regulatory Framework for Immuno-oncology -- From Basic Immunology to New Therapies for Cancer Patients -- How T Cells Single Out Tumor Cells: "And That Has Made All the Difference" -- Effects of Regulatory T Cell-Dendritic Cell Interactions on Adaptive Immune Responses -- Evolution of the Regulatory Landscape for Immunomodulatory Compounds and Personalized Therapeutic Cancer Vaccines -- Immunoguiding, the Final Frontier in the Immunotherapy of Cancer -- Developing Cancer Immunotherapies as Drugs: Setting the Stage Through Methodological Progress -- Part II. Immunotherapies -- Reflections on Cancer Vaccines -- Dendritic Cell-Based Cancer Vaccines -- mRNA Vaccination and Personalized Cancer Therapy -- Antibody Therapy in Oncology -- Bispecific Antibodies for the Treatment of Cancer: The Challenges of Translation -- The ABCs of T Cell Receptor Gene Therapy -- The Express Drivers: Chimeric Antigen Receptor-Redirected T Cells Make It to the Clinic -- Part III. Cancer Entities -- Immunotherapy of Malignant Melanoma -- Prostate Cancer Vaccines Generated with the Disruptive RNActive® Technology Follow the Path Paved by Sipuleucel-T and Prostvac-VF -- Recent Developments in the Active Immunotherapy of Renal Cell Cancer -- Current Status of Immunotherapy in Gastroesophageal Cancer -- Non-small Cell Lung Cancer, NSCLC -- Towards More Specificity and Effectivity in the Antileukemia Immune Response -- Part IV. Biomarkers -- Molecular and Metabolic Cues of the Key-Lock Paradigm Dictating Immunogenic Cell Death -- Pathogenesis of Minimal Residual Disease: CTCs as Novel Biomarkers in Cancer Disease -- Genomics Meets Cancer Immunotherapy -- Part V. Featured Chapters -- Oncolytic Viruses -- Part VI. Final Remarks -- Final Words.

Format: e-Book

Location: Online

Cardiovascular toxicology

https://libcat.nshealth.ca/en/permalink/provcat19037

Springer

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Holdings: Vol 1, 2001 -

Location: Online

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Publisher: Springer

Holdings: Vol 1, 2001 -

Publication Frequency: Quarterly

ISSN: 1559-0259

Specialty: Cardiology; Toxicology

Format: e-Journal

Location: Online

Casarett and Doull's essentials of toxicology

https://libcat.nshealth.ca/en/permalink/provcat25509

editors, Curtis D. Klassen, John B. Watkins. (2nd ed.) --New York, NY: McGraw-Hill , c2010.

Call Number: QV 600 C335 2010

Location: Halifax Infirmary; Dickson Building

Call Number: QV 600 C335 2010

Other Authors: Klassen, Curtis D; Watkins, John B

Responsibility: editors, Curtis D. Klassen, John B. Watkins

Edition: 2nd ed.

Place of Publication: New York, NY

Publisher: McGraw-Hill

Date of Publication: c2010

Physical Description: 459 p.

ISBN: 9780071622400

Subjects (MeSH): Poisons - toxicity; Toxicology

Format: Book

Location: Halifax Infirmary; Dickson Building

Copies: 2

Loan Period: 3 weeks

Casarett and Doull's essentials of toxicology

https://libcat.nshealth.ca/en/permalink/provcat26041

editors, Curtis D. Klassen, John B. Watkins. (2nd ed.) --New York, NY: McGraw-Hill , c2010.

Call Number: QV 600 C335 2010 REF

Location: Halifax Infirmary; Dickson Building

Sub-Location: REFERENCE

Call Number: QV 600 C335 2010 REF

Other Authors: Klassen, Curtis D; Watkins, John B

Responsibility: editors, Curtis D. Klassen, John B. Watkins

Edition: 2nd ed.

Place of Publication: New York, NY

Publisher: McGraw-Hill

Date of Publication: c2010

Physical Description: 459 p.

ISBN: 9780071622400

Subjects (MeSH): Poisons - toxicity; Toxicology

Format: Book

Location: Halifax Infirmary; Dickson Building

Sub-Location: REFERENCE

Copies: 2

Loan Period: In library use

Cellular and molecular pathobiology of cardiovascular disease

https://libcat.nshealth.ca/en/permalink/provcat33110

edited by Monte S. Willis, Jonathon W. Homeister, James R. Stone. --London, UK: Elsevier / AP , c2014.

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Access: Registration required for PDF access.

Location: Online

Focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine.

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Other Authors: Willis, Monte S; Homeister, Jonathon W; Stone, James R

Responsibility: edited by Monte S. Willis, Jonathon W. Homeister, James R. Stone

Place of Publication: London, UK

Publisher: Elsevier / AP

Date of Publication: c2014

Physical Description: 1 online resource (xvii, 320 pages)

ISBN: 9780124055254 (e-Book)

Subjects (MeSH): Cardiovascular Diseases - genetics; Cardiovascular Diseases - physiopathology

Subjects (LCSH): Cardiovascular system - Diseases - Molecular aspects; Cardiovascular toxicology; Cardiovascular Diseases - genetics; Cardiovascular Diseases - physiopathology; Cardiovascular diseases - Chemically induced

Abstract: Focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine.

Access: Registration required for PDF access.

Format: e-Book

Location: Online

Chemical Carcinogenesis

https://libcat.nshealth.ca/en/permalink/provcat29650

edited by Trevor M. Penning. --Totowa, NJ: Springer Science+Business Media , c2011.

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Location: Online

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Author: Penning, Trevor M

Responsibility: edited by Trevor M. Penning

Place of Publication: Totowa, NJ

Publisher: Springer Science+Business Media

Date of Publication: c2011

Series Title: Current cancer research

ISBN: 9781617379956

Subjects (MeSH): Carcinogens - toxicity; DNA Damage

Subjects (LCSH): Oncology; Toxicology

Format: e-Book

Location: Online

Clinical Guide to Bioweapons and Chemical Agents

https://libcat.nshealth.ca/en/permalink/provcat28260

by Vincent E. Friedewald. --London: Springer , c2008.

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Location: Online

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Author: Friedewald, Vincent E

Responsibility: by Vincent E. Friedewald

Place of Publication: London

Publisher: Springer

Date of Publication: c2008

ISBN: 9781846287879

Subjects (MeSH): Biological Warfare Agents; Chemical Warfare Agents; Bioterrorism; Chemical Terrorism; Communicable Diseases - diagnosis; Poisons; Emergency Medicine

Subjects (LCSH): Emergency medicine; Toxicology

Format: e-Book

Location: Online

Clinical Nephrotoxins : Renal Injury from Drugs and Chemicals

https://libcat.nshealth.ca/en/permalink/provcat28992

edited by Marc E. Broe, George A. Porter, William M. Bennett, Gilbert Deray. (3rd ed.) --Boston, MA: Springer-Verlag US , c2008.

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Location: Online

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Author: Broe, Marc E

Other Authors: Porter, George A; Bennett, William M; Deray, Gilbert

Responsibility: edited by Marc E. Broe, George A. Porter, William M. Bennett, Gilbert Deray

Edition: 3rd ed.

Place of Publication: Boston, MA

Publisher: Springer-Verlag US

Date of Publication: c2008

ISBN: 9780387848433

Subjects (MeSH): Kidney Diseases - chemically induced; Kidney - drug effects

Subjects (LCSH): Nephrology; Pharmacy; Toxicology

Format: e-Book

Location: Online

Contrast media : safety issues and ESUR guidelines

https://libcat.nshealth.ca/en/permalink/provcat33251

Henrik S. Thomsen, Judith A. W. Webb, editors. (Third edition) --Heidelberg: Springer , c2014.

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Location: Online

In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned ESUR members, reviewed the literature, proposed guidelines, and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006, which was followed by an equally successful second edition in 2009. Thi…

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Other Authors: Thomsen, Henrik S; Webb, Judith A. W

Responsibility: Henrik S. Thomsen, Judith A. W. Webb, editors

Edition: Third edition

Place of Publication: Heidelberg

Publisher: Springer

Date of Publication: c2014

Physical Description: 1 online resource (xvi, 280 pages)

Series: Medical radiology. Diagnostic imaging

Series Title: Medical radiology (Series)

ISBN: 9783642367243 (electronic bk.); 9783642367236

Subjects (MeSH): Contrast Media - adverse effects; Extravasation of Diagnostic and Therapeutic Materials; Safety Management - standards - Europe

Subjects (LCSH): Radiographic contrast media - Safety measures; Radiographic contrast media - Toxicology; Genitourinary organs - Imaging - Safety measures - Standards - Europe

Notes: Previous edition: 2009

Abstract: In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned ESUR members, reviewed the literature, proposed guidelines, and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006, which was followed by an equally successful second edition in 2009. This third edition not only fully updates the previous edition, but also includes new chapters on complex topics such as use of contrast media in children and practical aspects of off-label contrast media use. The authorship includes members, past members, and non-members of the Contrast Media Safety Committee. Comprehensive consideration is given to the many different safety issues relating to iodine-based contrast media, gadolinium-based contrast media, microbubbles for ultrasound, and barium sulfate. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All of the questions frequently raised in radiological practice are addressed. This book, presented in a handy, easy-to-use format, provides an invaluable, unique, and unparalleled source of information.

Contents: General Issues: Classification and Terminology -- Requests for Imaging using contrast agents: What information must be provided -- Off-label use of medicines: legal aspects -- Off-label use of contrast media: practical aspects -- Pharmacovigilance: When to report adverse reactions to contrast media -- What is required to get the authorities to approve a new contrast medium? -- A critical review of meta-analysis of adverse events after contrast media -- Iodine- and Gadolinium-Based Contrast Media: General Adverse Reactions: Acute adverse reactions to contrast media: Mechanisms and prevention -- Iodine-based contrast medium temperature and adverse reactions -- Management of acute adverse reactions to contrast media -- Renal Adverse reactions:Chronic kidney disease, serum creatinine and estimated glomerular filtration rate (eGFR) -- Contrast medium-induced nephropathy -- Dialysis and contrast media -- Other adverse effects: Pregnancy and lactation: intravascular use of contrast media -- Pheochromocytoma and contrast media -- Contrast media and interactions with other drugs and clinical tests -- Contrast media extravasation injury -- Iodine-based contrast media: Late adverse reactions to iodine-based contrast media -- Effects of iodine-based contrast media on blood and endothelium -- Effects of iodine-based contrast media on thyroid function -- Pulmonary effects of iodine-based contrast media -- MR contrast media: Gadolinium chelates and stability -- Diagnostic efficacy of gadolinium-based contrast media -- Radiography with gadolinium-based contrast media -- Acute adverse reactions to gadolinium-based contrast media -- Nephrogenic systemic fibrosis and gadolinium- based contrast media -- Organ specific gadolinium-based contrast media -- Ultrasonographic Contrast media -- Barium Preparations: Barium preparations: safety issues -- Pediatric use of Contrast Media: Contrast media use in pediatrics: Safety issues -- Appendix: ESUR Guidelines on Contrast Media Version 8.1 -- Official publications from the Contrast Media Safety Committee of the European Society of Urogenital Radiology.