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Development of Antibody-Based Therapeutics : Translational Considerations

https://libcat.nshealth.ca/en/permalink/provcat30858
Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors. --New York, NY: Springer , c2012.
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Development of Antibody-Based Therapeutics: Translational Considerations examines important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics. Translational strategies for development of antibody-based therapeutics require an understanding of the relationship between the 'unit dose' and 'unit effect' with respect to both beneficial and deleterious biological effects from early stages of development. The flow of in…
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Other Authors
Tabrizi, Mohammad A
Bornstein, Gadi G
Klakamp, Scott L
Responsibility
Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xiv, 425 p. : 58 ill., 30 ill. in color)
ISBN
9781441959553
Subjects (MeSH)
Antibodies, Monoclonal - pharmacology
Antibodies, Monoclonal - therapeutic use
Antigens - immunology
Drug Discovery
Translational Medical Research
Subjects (LCSH)
Pharmacy
Biochemistry
Immunology
Abstract
Development of Antibody-Based Therapeutics: Translational Considerations examines important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics. Translational strategies for development of antibody-based therapeutics require an understanding of the relationship between the 'unit dose' and 'unit effect' with respect to both beneficial and deleterious biological effects from early stages of development. The flow of information across various stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Successful strategies for the development of monoclonal antibodies require integration of knowledge with regards to target antigen properties in health and disease, as well as antibody design criteria including affinity, isotype selection, pharmacokinetics/pharmacodynamics (PK/PD) properties, antibody cross-reactivity across species, and safety. Selection and evaluation of appropriate biomarkers in early preclinical development in "relevant" animal models should allow identification of potential risks and liabilities of an antibody drug candidate to humans and establishment of safe First-In-Human (FIH) dosing strategies. This volume provides a comprehensive review of the topics critical for establishing successful translational strategies for the development of antibody-based therapeutics.
Contents
1. Translational Strategies for Development of Antibody-Based Therapeutics: An Overview -- 2. Discovery Process for Antibody-Based Therapeutics -- 3. Technologies for the Generation of Human Antibodies -- 4. Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutics -- 5. Biophysical Considerations for Development of Antibody-Based Therapeutics -- 6. Considerations in Establishing Affinity Design Goals for Development of Antibody-Based Therapeutics -- 7. Bioanalytical Considerations for Development of Antibody-Based Therapeutics: Pharmacokinetics and Immunogenicity -- 8. Preclinical Considerations for Development of Antibody-Based Therapeutics in Oncology -- 9. Factors Impacting the Tumor Localization and Distribution of Antibody-Based Therapeutics in Oncology -- 10. Preclinical Safety Considerations for the Development of Antibody-Based Therapeutics -- 11. Application of Pharmacokinetic/Pharmacodynamic Modeling in the Development of Antibody-Based Therapeutics -- 12. Application of Population Pharmacokinetic-Pharmacodynamic Approaches in the Design of Translational Strategies for Development of Antibody-Based Therapeutics -- 13. Translational Biomarkers: Essential Tools in Development of Antibody-Based Therapeutics -- 14. Translational Research in Alzheimer’s Disease for Development of Antibody-Based Therapeutics -- 15. Considerations in Manufacturing Process Development for Antibody-Based Therapeutics -- 16. Strategies for Development of Next Generation Antibody-Based Therapeutics -- 17. Immune Complex Therapies for Treatment of Immune Thrombocytopenia -- 18. Application of Bioinformatics Principles for Target Evaluation -- 19. Concluding Remarks.
Format
e-Book
Location
Online
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Development of Antibody-Based Therapeutics : Translational Considerations & Challenges

https://libcat.nshealth.ca/en/permalink/provcat42727
Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors. (2nd edition) --Singapore: Adis , c2018.
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With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2…
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Other Authors
Tabrizi, Mohammad A.
Bornstein, Gadi G.
Klakamp, Scott L.
Responsibility
Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors
Edition
2nd edition
Place of Publication
Singapore
Publisher
Adis
Date of Publication
c2018
Physical Description
1 online resource (viii, 248 p.) : 106 illus., 87 illus. in color
ISBN
9789811304965
9789811304958 (print ed.)
9789811304972 (print ed.)
Subjects (MeSH)
Antibodies, Monoclonal - pharmacology
Antibodies, Monoclonal - therapeutic use
Antigens - immunology
Drug Discovery
Translational Medical Research
Specialty
Pharmacology
Regenerative Medicine
Abstract
With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students. Mohammad A. Tabrizi, Ph.D. is a leader in translational sciences as related to development of antibody-based therapeutics. His product development experience spans many therapeutic areas including oncology and inflammatory disease, and his technical expertise includes preclinical pharmacology and safety, preclinical and clinical pharmacokinetics, pharmacodynamics, GLP-compliant bioanalytics, and clinical pharmacology of therapeutic monoclonal antibodies. Gadi Bornstein, Ph.D. has over seventeen years of experience in Oncology R&D with an emphasis in preclinical antibody discovery and development. Dr. Bornstein currently leads and directs biologics discovery efforts at TESARO. He received his B.S. in biochemistry at the University of California, Davis and his doctoral degree in biochemistry at the University of Southern California Keck School of Medicine. Dr. Bornstein completed his postdoctoral training at Stanford University in the Division of Immunology and Rheumatology. Following his postdoctoral training, Dr. Bornstein joined Amgen Fremont, Inc. (formerly Abgenix, Inc.) as a Staff Scientist in the Preclinical Oncology department. Dr. Bornstein has held roles of increasing responsibility at AstraZeneca, Pfizer, and Novartis, where he was a project team leader, lead biologist, and key contributor to scientific strategies for multiple oncology programs. Dr. Bornstein has authored numerous research papers, reviews, as well as book chapters, and is a co-inventor on multiple patents. Scott L. Klakamp, Ph.D. is one of the leading scientists in utilizing Surface Plasmon Resonance (SPR) and KinExA’ to measure the binding kinetics and equilibrium dissociation constants of human monoclonal antibody/antigen complexes. He was the founder of SKD Consulting LLC and acted as Principal Consultant at that company during the development of this title. Prior to SKD Consulting LLC, he was the Vice President of Chemistry and Biochemistry at BiOptix Inc., a company that provided the 404pi biosensor. Dr. Klakamp has also held positions of increasing responsibility in the areas of analytical and biophysical characterization at Chiron, Amgen/Abgenix, AstraZeneca/MedImmune, and Takeda Pharmaceuticals. Dr. Klakamp has been an author on over 30 research and review papers, book chapters, and patents. He has also been an invited speaker at numerous international and national meetings. Dr. Klakamp received his B.A. in Chemistry from Houghton College and his PhD in Chemistry at the Pennsylvania State University. From 1990 to 1993, he completed a postdoctoral fellowship (funded by a National Research Service Award from the National Institutes of Health) at the California Institute of Technology in bioinorganic chemistry.
Contents
1. Introduction -- 2. Translational Considerations and Challenges: An Overview -- 3. Considerations for Construct and Affinity Design Goals -- 4. Epitope Characterization and Isotype Selection -- 5. Biophysical Considerations for Development of Antibody-Based Therapeutics -- 6. Novel Technologies for Generation of Bispecific Constructs -- 7. Stimulus-Response Mechanisms: An Overview -- 8. Evaluation of Tumor Growth Inhibition in Preclinical Tumor Models: A Quantitative Approach -- 9. Application of Proof-of-Mechanism Biomarkers (POM) in Design and Development of Biologics Modalities -- 10. Antibody Drug Conjugates: Translational Considerations -- 11. Application of PK-PD Modeling and Simulation Approaches for Immuno-Oncology Drugs -- 12. Translational Biomarkers: Application in the Clinical Development of Combination Therapies.
Format
e-Book
Location
Online
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Diabetic Bone Disease : Basic and Translational Research and Clinical Applications

https://libcat.nshealth.ca/en/permalink/provcat39772
Beata Lecka-Czernik, John L. Fowlkes, editors. --Cham: Springer , c2016.
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Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology to orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This…
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Other Authors
Lecka-Czernik, Beata
Fowlkes, John L
Responsibility
Beata Lecka-Czernik, John L. Fowlkes, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (x, 241 p. : 40 illus., 28 illus. in color)
ISBN
9783319164021
9783319164014 (print ed.)
Subjects (MeSH)
Bone Diseases - physiopathology
Diabetes Complications
Translational Medical Research
Abstract
Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology to orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researchers and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.
Contents
Part I. Clinical and Pre-clinical Applications and Research -- Skeletal deficits in Type 1 Diabetes Mellitus -- Skeletal Deficits in Type 2 Diabetes Mellitus -- Fracture Risk Assessment in Diabetes -- Diabetes-related Conditions and Complications in Orthopedic Surgery -- Impact of Diabetes on Periodontal Disease -- Biomarkers of Diabetic Bone Disease -- Safety of Anti-diabetic Therapies on Bone -- Bone Marrow Stem Cells and Bone Turnover in Diabetic Disease -- Part II: Biomechanics and Bone Quality -- Material Properties of Diabetic Bone -- Bone Quality in Type 2 Diabetes Mellitus -- Imaging of Diabetic Bone Structure.
Format
e-Book
Location
Online
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Hepatocellular Carcinoma : Translational Precision Medicine Approaches

https://libcat.nshealth.ca/en/permalink/provcat44371
Yujin Hoshida, editor. --Cham: Humana Press , c2019.
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This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment opti…
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Other Authors
Hoshida, Yujin
Responsibility
Yujin Hoshida, editor
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2019
Physical Description
1 online resource (xv, 364 p.) : 56 illus., 37 illus. in color
Series Title
Molecular and translational medicine
ISBN
9783030215408
9783030215392 (Print ed.)
9783030215415 (Print ed.)
9783030215422 (Print ed.)
ISSN
2197-7852
Subjects (MeSH)
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - therapy
Precision Medicine
Translational Medical Research
Specialty
Gastroenterology
Medical Oncology
Precision Medicine
Abstract
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
Contents
Part I: Clinical Demographics and Management -- 1. Risk Factors of Hepatocellular Carcinoma for Precision Personalized Care -- 2. Hepatocellular Carcinoma Surveillance and Staging -- 3. Changing Epidemiology of Hepatocellular Carcinoma and Role of Surveillance -- Part II: Diagnosis and Prognostication -- 4. Radiological Diagnosis and Characterization of HCC -- 5. Analysis of Hepatocellular Carcinoma Tissue for Biomarker and Therapeutic Target Discovery -- 6. Molecular Subtypes and Genomic Signatures of Hepatocellular Carcinoma for Prognostication and Therapeutic Decision Making -- 7. Liquid Biopsy in Hepatocellular Carcinoma -- Part III: Treatment -- 8. Surgical Therapies in Hepatocellular Carcinoma -- 9. Interventional Radiologic Therapies for Hepatocellular Carcinoma: From Where We Began To Where We Are Going -- 10. Precision Locoregional Therapies for Hepatocellular Carcinoma: Percutaneous Ablation and Radiotherapy -- 11. Molecular-targeted Therapies in Hepatocellular Carcinoma -- 12. Immune Therapies -- 13. Prevention Strategies for Hepatocellular Carcinoma -- Part IV: Molecular Pathogenesis and Therapeutic Discovery -- 14. Molecular Alterations and Heterogeneity in Hepatocellular Carcinoma -- 15. Stromal and Immune Drivers of Hepatocarcinogenesis -- 16. Experimental Models for Preclinical Research in Hepatocellular Carcinoma.
Format
e-Book
Location
Online
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Innovative Medicine : Basic Research and Development

https://libcat.nshealth.ca/en/permalink/provcat43980
Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto, editors. --Tokyo: SpringerOpen , c2015.
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Open access
Location
Online
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, …
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Other Authors
Nakao, Kazuwa
Minato, Nagahiro
Uemoto, Shinji
Other Authors
Uehara Memorial Foundation Symposium (2014 : Tokyo Japan)
Responsibility
Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto, editors
Place of Publication
Tokyo
Publisher
SpringerOpen
Date of Publication
c2015
Physical Description
1 online resource (ix, 339 p.)
ISBN
9784431556510
9784431556527 (Print ed.)
9784431556503 (Print ed.)
9784431562467 (Print ed.)
Subjects (MeSH)
Biomedical Research
Biomedical Technology
Translational Medical Research
Specialty
Biomedical Technology
Research
Abstract
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Contents
Part I. Basic Research for Innovative Medicine -- 1. Diverting Glycolysis to Combat Oxidative Stress -- 2. Metabolic Regulation by Nuclear Receptors -- 3. Fighting Fire with Fire in Cancer -- 4. Linear Polyubiquitination: a Crucial Regulator of NF-kB Activation -- 5. VCP, a major ATPase in the cells, as a novel drug target for currently incurable disorders -- 6. Roles of E-cadherin in hepatocarcinogenesis -- 7. The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors -- 8. Inhibitory immunoreceptors on mast cells in allergy and inflammation -- 9. Doxycycline-inducible Autoimmune Blistering Skin Disease Model -- 10. T-cell Senescence and Autoimmunity -- Part II. Translational Research for Innovative Medicine -- 11. IL-6: A new era for the treatment of autoimmune inflammatory diseases -- 12. Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies -- 13. Multifaceted translational approach of major mental illness -- 14. Translational research of leptin in lipodystrophy and its related diseases -- 15. Translational research of the activation of the C-type natriuretic peptide (CNP)-guanylyl cyclase-B pathway for skeletal dysplasia -- 16. Clarity and Challenges in Tissue Fibrosis -- 17. TRP Channels: Their Function and Potentiality as Drug Targets -- 18. Autophagic Cell Death and Cancer Chemotherapeutics -- 19. Adrenomedullin as a Potential Therapeutic Agent for Refractory Ulcerative Colitis -- 20. RNA activation -- Part III. New Technology for Innovative Medicine -- 21. Cardiac Reprogramming for Heart Repair -- 22. Development of a new in vivo optical probe for biological diagnosis and therapy -- 23. Introduction of mesenchymal stem cells for liver surgery (hepatectomy and transplantation) -- 24. Synaptic and axonal plasticity induction in the human cerebral cortex -- 25. TIM-3 is a novel therapeutic target for eradicating acute myelogenous leukemia stem cells -- 26. TGF-beta LAP degradation products, a novel biomarker and promising therapeutic target for liver fibrogenesis -- 27. Cell-based regenerative therapy for liver disease.
Access
Open access
Format
e-Book
Publication Type
Congress
Location
Online
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Knowledge translation in health care : moving from evidence to practice

https://libcat.nshealth.ca/en/permalink/provcat24534
Straus, Sharon E. --Chichester, England: Wiley-Blackwell , 2009.
Call Number
W 20.55 .T7 K73 2009
Location
Dickson Building
Call Number
W 20.55 .T7 K73 2009
Author
Straus, Sharon E
Other Authors
Tetroe, Jacqueline
Graham, Ian D
Place of Publication
Chichester, England
Publisher
Wiley-Blackwell
Date of Publication
2009
Physical Description
318 p.
Series Title
BMJ books
ISBN
9781405181068
Subjects (MeSH)
Evidence-Based Medicine
Health Services Research
Translational Medical Research
Format
Book
Location
Dickson Building
Loan Period
3 weeks
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Molecular and Translational Vascular Medicine

https://libcat.nshealth.ca/en/permalink/provcat31027
Jonathon W. Homeister, Monte S. Willis, editors. --New York, NY: Humana Press , c2012.
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Molecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine. The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis. Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascula…
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Other Authors
Homeister, Jonathon W
Willis, Monte S
Responsibility
Jonathon W. Homeister, Monte S. Willis, editors
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2012
Physical Description
1 online resource (xiv, 335 p. : 42 ill., 36 ill. in color)
Series Title
Molecular and translational medicine
ISBN
9781617799068
Subjects (MeSH)
Translational Medical Research - methods
Vascular Diseases - physiopathology
Subjects (LCSH)
Cardiology
Pathology
Abstract
Molecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine. The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis. Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascular disease, endothelial progenitor cells for disease treatment, and the genetic basis of thoracic aortic aneurysms. Lastly, this volume includes sections on the newly emerging field of therapeutic angiogenesis, and the developing technology of nanoparticle-based imaging and therapeutic treatment of the diseased vasculature. All chapters are written by established experts in their fields, including pathologists, cardiovascular surgeons, and internists as well as translational biomedical researchers in a wide range of disciplines. While comprehensive, the material is presented in a manner that simplifies the complex pathophysiologic mechanisms that underlie common vascular diseases. Molecular and Translational Vascular Medicine will be of great value to a broad audience including internists, cardiovascular and vascular surgeons, pathologists, residents and fellows, as well as translational biomedical researchers.
Contents
The Molecular Biology and Genetics of Aneurysms -- The Molecular Biology and Treatment of Systemic Vasculitis in Children -- Recent Insights into the Molecular and Cellular Contributions to Venous Thrombosis -- The Ubiquitin Proteasome System in Endothelial Cell Dysfunction and Vascular Disease -- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis -- Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions -- Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges -- Modulating the Proliferative Response to Treat Restenosis after Vascular Injury -- Cardiovascular Nanomedicine: Challenges and Opportunities -- Endothelial Progenitor Cells in the Treatment of Vascular Disease.
Format
e-Book
Location
Online
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Pediatric Neoplasia : Advances in Molecular Pathology and Translational Medicine

https://libcat.nshealth.ca/en/permalink/provcat31030
Alexander Craig Mackinnon, Jr., editor. --New York, NY: Humana Press , c2012.
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Location
Online
Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts …
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Other Authors
Mackinnon, Alexander Craig
Responsibility
Alexander Craig Mackinnon, Jr., editor
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2012
Physical Description
1 online resource (ix, 267 p. : 76 ill., 73 ill. in color)
Series Title
Molecular and translational medicine
ISBN
9781627031165
Subjects (MeSH)
Neoplasms - pathology
Pathology, Molecular - methods
Pediatrics
Translational Medical Research - methods
Subjects (LCSH)
Oncology
Pathology
Pediatrics
Abstract
Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts in their field with subspecialty training and extensive clinical experience. Each chapter describes a variable number of tumors and includes an overview of the classification system and clinicopathological characteristics of each tumor. This is followed by a discussion of the molecular pathology relevant to a specific tumor, including specific molecular markers of the tumors, methods used for diagnosis or clinical management, clinical significance of the markers, and if appropriate, a description or discussion of current activities in translational research or issues that need to be addressed in the future. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine will be of great value to pathologists, oncologists, hematologists, internal medicine and pediatric specialists, as well as pharmaceutical professionals and translational and clinical researchers.
Contents
1. Towards Personalized Medicine in Pediatric Cancer: Genome-Wide Strategies to Investigate Cancer Risk and Response to Therapy -- 2. Acute Leukemia -- 3. Molecular Techniques Used in Evaluation of Pediatric Acute Leukemia -- 4. Myelodysplasia and Myeloid Proliferations -- 5. Childhood Lymphoma -- 6. Children are Not Small Adults: Importance of Molecular Analysis for Diagnosis, Prognosis, and Treatment of Pediatric CNS Tumors -- 7. Pediatric Bone Tumors -- 8. Soft Tissue "Small Round Blue Cell Tumors" of Childhood -- 9. Fibroblastic and Myofibroblastic Pediatric Soft Tissue Tumors -- 10. Molecular Analysis in Pediatric Renal Tumors -- 11. Hepatoblastoma: New Insights into the Biology of Embryonal Tumors of the Liver.
Format
e-Book
Location
Online
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Practical Biostatistics in Translational Healthcare

https://libcat.nshealth.ca/en/permalink/provcat43127
Allen M. Khakshooy, Francesco Chiappelli. --Berlin, Heidelberg: Springer , c2018.
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Online
There is an ever-increasing emphasis on evidence-based medicine that is distinguished by systematic crafting of the patient-centered research question, detailed literature searches, and careful appraisal of the resulting evidence. The consensus that ultimately emerges must then be applied in specific clinical settings, and it is to this process that translational effectiveness analysis refers. This portable and easy-to-use handbook is intended as a practical teaching guide on translational effe…
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Author
Khakshooy, Allen M.
Other Authors
Chiappelli, Francesco
Responsibility
Allen M. Khakshooy, Francesco Chiappelli
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xviii, 227 p.) : 127 illus., 62 illus. in color
ISBN
9783662574379
9783662574355 (print ed.)
9783662574362 (print ed.)
Subjects (MeSH)
Biostatistics
Comparative Effectiveness Research
Data Interpretation, Statistical - methods
Research Design
Translational Medical Research
Specialty
Data Science
Research
Abstract
There is an ever-increasing emphasis on evidence-based medicine that is distinguished by systematic crafting of the patient-centered research question, detailed literature searches, and careful appraisal of the resulting evidence. The consensus that ultimately emerges must then be applied in specific clinical settings, and it is to this process that translational effectiveness analysis refers. This portable and easy-to-use handbook is intended as a practical teaching guide on translational effectiveness for students and clinicians. Specifically, it will serve as a primer on patient-centered outcomes research methodology in the health sciences and explain how to acquire and understand the fundamental data that determine which reports are valued as the "best available" evidence. It presents an accessible and readily intelligible set of principles which doctors, dentists, nurses, and insurance carriers will be able to use in the process of health care-related decision-making.
Contents
Part I. Fundamental Biostatistics for Translational Research -- 1. Introduction to Biostatistics -- 2. Study Design -- 3. Methodology -- 4. Descriptive Statistics -- 5. Inferential Statistics I -- 6. Inferential Statistics II -- 7. Nonparametric Statistics -- Part II. Biostatistics for Translational Effectiveness -- 8. Individual Patient Data -- 9. Evaluation -- 10. New Frontiers in Comparative Effectiveness Research -- Appendices -- Answers to Chapter Practice Problems.
Format
e-Book
Location
Online
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A practical guide to drug development in academia : the SPARK approach

https://libcat.nshealth.ca/en/permalink/provcat33397
Daria Mochly-Rosen, Kevin Grimes, editors. --Cham, Switzerland: Springer , c2014.
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Online
Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to help their discoveries become the novel drugs of the future. Often many potentially transformative basic science discoveries are not pursued because they are deemed "too early" to attract industry interest. There are simple, relativel…
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Other Authors
Mochly-Rosen, Daria
Grimes, Kevin D
Responsibility
Daria Mochly-Rosen, Kevin Grimes, editors
Place of Publication
Cham, Switzerland
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xii, 176 pages)
Series Title
SpringerBriefs in pharmaceutical science & drug development
ISBN
9783319022017 (electronic bk.)
9783319022000
Subjects (MeSH)
Drug Discovery - methods
Drug Evaluation - methods
Drug Industry
Translational Medical Research - organization & administration
Subjects (LCSH)
Drug development - Handbooks, manuals, etc
Drugs - Design - Handbooks, manuals, etc
Drug Discovery - Handbooks
Drug Design - Handbooks
Abstract
Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to help their discoveries become the novel drugs of the future. Often many potentially transformative basic science discoveries are not pursued because they are deemed "too early" to attract industry interest. There are simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest.
Contents
Getting started -- Discovery and preclinical work -- Preparing for the clinic -- Transferring technology -- Commercialization and entrepreneurship -- Concluding thoughts.
Format
e-Book
Location
Online
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Research for the public good : applying methods of translational research to improve human health and well-being

https://libcat.nshealth.ca/en/permalink/provcat25479
Wethington, Elaine. --Washington, DC: American Psychological Association , 2012.
Call Number
WA 20.5 W539r 2012
Location
Nova Scotia Hospital
Call Number
WA 20.5 W539r 2012
Author
Wethington, Elaine
Other Authors
Dinifon, Rachel E
Place of Publication
Washington, DC
Publisher
American Psychological Association
Date of Publication
2012
Physical Description
212 p.
ISBN
9781433811685
Subjects (MeSH)
Translational Medical Research
Format
Book
Location
Nova Scotia Hospital
Loan Period
3 weeks
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Resuscitation : translational research, clinical evidence, education, guidelines

https://libcat.nshealth.ca/en/permalink/provcat33312
Antonino Gullo, Giuseppe Ristagno, editors ; foreword by Massimo Antonelli. --Milan: Springer , c2014.
Available Online
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Location
Online
Resuscitation is a two-stage process comprising the achievement/maintenance of spontaneous circulation and post-resuscitation management. The approach is complex and multifaceted and entails the integration of new physiological insights, pharmacological options, and technological advances. The purpose of this volume, written by top experts in the field, is to promote, share, and disseminate new advances in resuscitation and post-resuscitation care. The issues addressed are wide ranging and of g…
Available Online
View e-Book
Other Authors
Gullo, A
Ristagno, Giuseppe
Antonelli, Massimo
Responsibility
Antonino Gullo, Giuseppe Ristagno, editors ; foreword by Massimo Antonelli
Place of Publication
Milan
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xi, 254 pages)
ISBN
9788847055070 (electronic bk.)
9788847055063
Subjects (MeSH)
Cardiopulmonary Resuscitation
Electric Countershock
Heart Arrest - therapy
Translational Medical Research
Subjects (LCSH)
Resuscitation
Emergency medicine
Emergency Services
Anesthesiology
Abstract
Resuscitation is a two-stage process comprising the achievement/maintenance of spontaneous circulation and post-resuscitation management. The approach is complex and multifaceted and entails the integration of new physiological insights, pharmacological options, and technological advances. The purpose of this volume, written by top experts in the field, is to promote, share, and disseminate new advances in resuscitation and post-resuscitation care. The issues addressed are wide ranging and of great topical interest or controversy. They include priorities of intervention, quality of resuscitation, use of mechanical supports, new defibrillation strategies, prevention of organ damage, strategies in cases of sudden cardiac death, new pharmacological treatments, and post-resuscitation care, including temperature management and prediction and improvement of outcome after cardiac arrest. Particular attention is devoted to up-to-date evidence from the most recent experimental and clinical trials on resuscitation science and to gold standard evidence-based resuscitation and post-resuscitation treatments and interventions. In addition, organizational models and integrated care systems for trauma are considered, and critical care education and the process of guideline development are reviewed.
Contents
Part I. State of the Art in Resuscitation -- 1 Resuscitation Science: From the Beginning to the Present Day -- 2. From Experimental and Clinical Evidence to Guidelines -- 3. Trauma Systems and Trauma Care -- Part II. Advances in Cardiopulmonary Resuscitation (CPR) and Defibrillation -- 4. Compression-Only CPR Versus CPR with Ventilations -- 5. Ventricular Fibrillation and Defibrillation: State of Our Knowledge and Uncertainities -- 6. Amplitude Spectrum Area to Predict the Success of Defibrillation -- 7. The Importance of Automated External Defibrillation Implementation Programs -- Part III. Optimization of Cardiopulmonary and Cerebral Resuscitation on Sudden Cardiac Death -- 8. Mechanical Versus Manual CPR -- 9. Improving Survival from Out-of-Hospital Cardiac Arrest with Bystander Chest Compression-Only CPR: The First Component of Cardiocerebral Resuscitation -- 10. Reperfusion Strategies in Sudden Cardiac Arrest -- 11. Extracorporeal Membrane Oxygenation Strategy in Cardiac Arrest -- Part IV. Pharmacological Approach During CPR -- 12. Vasopressors During CPR -- 13. Targeting Mitochondria During CPR -- 14. The Potential Contribution of Corticosteroids to Positive Cardiac Arrest Outcomes -- 15. Pharmacological Induction of Hypothermia -- Part V. Post-Resuscitation Care -- 16. Effectiveness of Hypothermia in Human Cardiac Arrest and Update on the Target Temperature Management-Trial -- 17. New Strategies to Improve Outcome After Cardiac Arrest -- 18. New Methods to Induce Localized Brain and General Hypothermia -- 19. Predicting Outcome After Cardiac Arrest -- Part VI. Combining Physiology, Clinical Outcome, and Ethics -- 20. Circulating Cardiac Biomarkers and Outcome -- 21. Circulatory Shock: Definition, Assessment, and Management -- 22. Resuscitation and Ethics: How to Deal with the ‘‘Do not Resuscitate Order’’? -- 23. Translational Research: An Ongoing Challenge in Cardiac Arrest.
Format
e-Book
Location
Online
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Success in academic surgery : basic science

https://libcat.nshealth.ca/en/permalink/provcat33983
Melina R. Kibbe, Scott A. LeMaire, editors. --London: Springer , c2014.
Available Online
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Location
Online
Academic surgeons play an essential role in advancing the field and improving the care of patients with surgical disease. As the Association for Academic Surgery (AAS) Fall Courses (www.aasurg.org) and international courses continue to evolve to address the rapidly expanding scope and complexity of academic surgery, there is a greater need for an accompanying textbook to supplement the material presented in the courses. Success in Academic Surgery: Basic Science is a unique and portable handboo…
Available Online
View e-Book
Other Authors
Kibbe, Melina R.
LeMaire, Scott A.
Responsibility
Melina R. Kibbe, Scott A. LeMaire, editors
Place of Publication
London
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (x, 242 pages)
Series Title
Success in academic surgery
ISBN
9781447147367 (electronic bk.)
9781447147350
Subjects (MeSH)
Biomedical Research
Translational Medical Research
Subjects (LCSH)
Surgery - Research
Surgery
Medical Education
Abstract
Academic surgeons play an essential role in advancing the field and improving the care of patients with surgical disease. As the Association for Academic Surgery (AAS) Fall Courses (www.aasurg.org) and international courses continue to evolve to address the rapidly expanding scope and complexity of academic surgery, there is a greater need for an accompanying textbook to supplement the material presented in the courses. Success in Academic Surgery: Basic Science is a unique and portable handbook that focuses on the basic and translational research. It includes new educational materials that are necessary to address not only the rapid evolution and rise of novel research methodologies in basic science and translational research, but also the changing environment for academic surgeons.
Contents
How to set up, staff and fund your basic science or translational research laboratory -- Choosing a good basic science or translational research mentor -- Effective time management strategies for conducting laboratory research -- How to read the literature, develop a hypothesis, and design an experiment for basic science and translational research -- Tips on maintaining an effective lab notebook for bench research -- How to conduct cell culture -- Modern techniques for protein assessment -- Modern techniques for DNA and RNA assessments -- Utilizing flow cytometry effectively -- Considerations for immunohistochemistry -- Stem cells: are they pertinent to my research? -- Use of genetically engineered mice for research -- Getting you IACUC proposal approved -- How to protect your intellectual property: invention disclosures and patents -- Statistics for bench research -- Ethics in laboratory research.
Format
e-Book
Location
Online
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Systemic Sclerosis : Basic and Translational Research

https://libcat.nshealth.ca/en/permalink/provcat40403
Kazuhiko Takehara, Manabu Fujimoto, Masataka Kuwana, editors. (1st ed.) --Tokyo: Springer Japan , c2016.
Available Online
View e-Book
Location
Online
This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines an…
Available Online
View e-Book
Other Authors
Takehara, Kazuhiko
Fujimoto, Manabu
Kuwana, Masataka
Responsibility
Kazuhiko Takehara, Manabu Fujimoto, Masataka Kuwana, editors
Edition
1st ed.
Place of Publication
Tokyo
Publisher
Springer Japan
Date of Publication
c2016
Physical Description
1 online resource (viii, 247 p. : 28 illus., 7 illus. in color)
ISBN
9784431557081
9784431557074 (print ed.)
Subjects (MeSH)
Scleroderma, Systemic
Translational Medical Research
Abstract
This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.
Contents
1. Fibrosis: Overview -- 2. Autoimmunity in Systemic Sclerosis: Overview -- 3. Endothelial Progenitor Cells -- 4. Animal Models of Systemic Sclerosis -- 5. Genetics of Systemic Sclerosis -- 6. Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis -- 7. Interleukin-6 in the Pathogenesis of Systemic Sclerosis -- 8. Epigenetics -- 9. Transforming Growth Factor-ß and Connective Tissue Growth Factor -- 10. Endothelin -- 11. The Role of B Cells in Systemic Sclerosis -- 12. Fli1 -- 13. Biomarker -- 14. Autoantibodies in Systemic Sclerosis.
Format
e-Book
Location
Online
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Temporomandibular Disorders : A Translational Approach From Basic Science to Clinical Applicability

https://libcat.nshealth.ca/en/permalink/provcat42974
edited by Henry A. Gremillion, Gary D. Klasser. --Cham, Switzerland: Springer , c2018.
Available Online
View e-Book
Location
Online
This book acquaints the reader with the basic science principles needed in order to understand temporomandibular disorders (TMDs) with a view to helping practitioners manage individuals with TMDs in accordance with the tenets of evidence-based dental medicine. The opening chapters provide essential information on the embryology, anatomy, and physiology of the masticatory system, which includes both myogenous and arthrogenous anatomic structures. Using this knowledge as a foundation, the reader …
Available Online
View e-Book
Other Authors
Gremillion, Henry A.
Klasser, Gary D.
Responsibility
edited by Henry A. Gremillion, Gary D. Klasser
Place of Publication
Cham, Switzerland
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xi, 217 p.) : 68 illus., 42 illus. in color
ISBN
9783319572475
9783319572451 (print ed.)
9783319572468 (print ed.)
9783319861128 (print ed.)
Subjects (MeSH)
Temporomandibular Joint Disorders - diagnosis
Temporomandibular Joint Disorders - therapy
Translational Medical Research
Specialty
Anatomy
Orthognathic Surgery
Abstract
This book acquaints the reader with the basic science principles needed in order to understand temporomandibular disorders (TMDs) with a view to helping practitioners manage individuals with TMDs in accordance with the tenets of evidence-based dental medicine. The opening chapters provide essential information on the embryology, anatomy, and physiology of the masticatory system, which includes both myogenous and arthrogenous anatomic structures. Using this knowledge as a foundation, the reader will be better prepared to grasp the function and, ultimately, the dysfunction of masticatory muscles and the temporomandibular joint, both of which are addressed in detail. The book's final section is exclusively devoted to management principles and includes a chapter on psychosocial considerations. By following a translational approach to evidence-based practice measures, as outlined in this book, the clinician will be excellently positioned to choose appropriate interventions on a case-specific basis.
Contents
Fundaments and Principles: Embryology of the Masticatory System -- Anatomy of the Masticatory System -- Physiology of the Masticatory System. Normal Function of the Masticatory System: Muscles -- TM Joints. Dysfunction of the Masticatory System: Muscles -- TM Joints. Management Principles: Muscles -- TM Joints -- Psychosocial Considerations.
Format
e-Book
Location
Online
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Translational Acupuncture Research

https://libcat.nshealth.ca/en/permalink/provcat44442
Ying Xia, editor. --Cham: Springer , c2019.
Available Online
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Location
Online
Written by many scientists and clinicians from China, USA, Canada and other countries, this monograph discusses translational research on acupuncture. Besides general topics on acupuncture practice (e.g., different styles and techniques of acupuncture), topics include some refractory diseases such as chronic fatigue syndrome, Parkinson’s disease, cardiovascular dysfunction, chronic pain, post-concussion syndrome and post-traumatic stress disorder and cancer-related symptoms. The factors influen…
Available Online
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Other Authors
Xia, Ying
Responsibility
Ying Xia, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xiii, 487 p.) : 114 illus., 79 illus. in color
ISBN
9783030160890
9783030160876 (Print ed.)
9783030160883 (Print ed.)
Subjects (MeSH)
Acupuncture
Translational Medical Research
Specialty
Complementary Therapies
Abstract
Written by many scientists and clinicians from China, USA, Canada and other countries, this monograph discusses translational research on acupuncture. Besides general topics on acupuncture practice (e.g., different styles and techniques of acupuncture), topics include some refractory diseases such as chronic fatigue syndrome, Parkinson’s disease, cardiovascular dysfunction, chronic pain, post-concussion syndrome and post-traumatic stress disorder and cancer-related symptoms. The factors influencing acupuncture research are comprehensively addressed in the final chapter. This unique book provides a translational perspective on modern acupuncture for not only acupuncturists, but also neuroscientists, neurologists, and other clinicians. For medical students and undergraduate and graduate students majoring in biology, this book is an advanced course for learning the progress in alternative and complementary Medicine.
Contents
Acupuncture: A Therapeutic Modality, but not a Placebo -- Acupuncture Styles in Current Practice -- Acupuncture Treatment for Chronic Fatigue Syndrome -- Acupuncture Cardiovascular Regulation: Translational, Clinical Studies and Underlying Mechanisms -- Electroacupuncture Inhibition of Hypertension is Slow Onset and Long-Lasting -- Acupuncture Treatment for Pain: Clinical and Laboratory Research -- Effect of Acupuncture on Parkinson’s disease -- Aung Vital Energetic Alignment: The Answer to Post-Concussion Syndrome and Post-Traumatic Stress Disorder -- Acupuncture in Oncology -- Electrotherapy: An Old Technique for A New Use -- Factors Influencing Acupuncture Research.
Format
e-Book
Location
Online
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Translational Anatomy and Cell Biology of Autism Spectrum Disorder

https://libcat.nshealth.ca/en/permalink/provcat41695
Michael J. Schmeisser, Tobias M. Boeckers, editors. --Cham: Springer , 2017.
Available Online
View e-Book
Location
Online
Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational a…
Available Online
View e-Book
Other Authors
Schmeisser, Michael J
Boeckers, Tobias M
Responsibility
Michael J. Schmeisser, Tobias M. Boeckers, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (viii, 211 pages) : 17 illus. in color
Series Vol.
224
Series Title
Advances in anatomy, embryology and cell biology
ISBN
9783319524986
9783319524962 (print ed.)
ISSN
0301-5556
Subjects (MeSH)
Autism Spectrum Disorder - physiopathology
Models, Neurological
Translational Medical Research
Abstract
Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational anatomy and cell biology of ASD. International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals. Primary objective is to clarify how anatomical and cell biological phenotypes of ASD will help to translate basic mechanisms to clinical practice and to efficiently treat affected individuals in the near future.
Contents
1. Anatomy and cell biology of autism spectrum disorder: Lessons from human genetics -- 2. Neuroanatomy and neuropathology of autism spectrum disorder in humans -- 3. Modelling autistic neurons with induced pluripotent stem cells -- 4. Modelling autistic features in mice using quantitative genetic approaches -- 5. Behavioural phenotypes and neural circuit dysfunctions in mouse models of autism spectrum disorder -- 6. Cerebellar and striatal pathologies in mouse models of autism spectrum disorder -- 7. The role of neurotrophic factors in mouse models of autism spectrum disorder: focus on Bdnf and Igf-1 -- 8. The role of the oxytocin/arginine vasopressin system in animal models of autism spectrum disorder -- 9. Extracerebral dysfunction in animal models of autism spectrum disorder -- 10. Genetic and pharmacological reversibility of phenotypes in mouse models of autism spectrum disorder.
Format
e-Book
Location
Online
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Translational Cardiology : Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques

https://libcat.nshealth.ca/en/permalink/provcat31023
Cam Patterson, Monte S. Willis, editors. --New York, NY: Humana Press , c2012.
Available Online
View e-Book
Location
Online
Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not c…
Available Online
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Other Authors
Patterson, Cam
Willis, Monte S
Responsibility
Cam Patterson, Monte S. Willis, editors
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2012
Physical Description
1 online resource (xv, 543 p. : 67 ill., 52 ill. in color)
Series Title
Molecular and translational medicine
ISBN
9781617798917
Subjects (MeSH)
Heart Diseases - therapy
Molecular Targeted Therapy
Myocardium - metabolism
Translational Medical Research
Subjects (LCSH)
Cardiology
Pathology
Abstract
Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.
Contents
Relationship Between Myocardial Ischemia/Reperfusion and Time-of-Day -- Phosphotransfer Reactions in the Failing Heart -- Mitochondria in Cardiac Disease -- PPAR/PGC-1 Regulation of Metabolism in Cardiac Disease -- AMPK and Metabolic Remodeling in Cardiac Disease -- Mechanotransduction in Cardiac Hypertrophy and Ischemia -- Cardiac Plasticity in Health and Disease -- Ubiquitylation-Dependent Signaling in Heart Disease -- Mechanisms of Cardiac Dysfunction Associated with Cancer Therapeutics -- Molecular Basis of Cardiac Development and Congenital Heart Disease -- Cellular Therapy for the Infarcted Myocardium -- Novel Approaches to Deliver Molecular Therapeutics in Cardiac Disease Using Adeno-Associated Virus Vectors -- Novel Delivery of Molecular Therapeutics to the Heart Using Non-Biologic Constructs (PPMO/Morpholino) in Muscular Dystrophy -- Molecular Imaging of Cardiovascular Disease.
Format
e-Book
Location
Online
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Translational neuroscience : applications in psychiatry, neurology and neurodevelopmental disorders

https://libcat.nshealth.ca/en/permalink/provcat25799
--Cambridge, England: Cambridge University Press , 2012.
Call Number
WL 140 T772 2012
Location
Halifax Infirmary
Call Number
WL 140 T772 2012
Other Authors
Barrett, James E
Coyle, Joseph T
Williams, Michael
Place of Publication
Cambridge, England
Publisher
Cambridge University Press
Date of Publication
2012
Physical Description
366 p.
ISBN
9780521519762
Subjects (MeSH)
Nervous System Diseases
Mental Disorders
Drug Discovery
Translational Medical Research - methods
Contents
The discovery and development of drugs to treat psychiatric disorders : historical perspective / Michael Williams and James E. Barrett -- Translational approaches to the treatment of anxiety disorders / Charles F. Gillespie, Tamara Weiss, and Kerry J. Ressler -- Mood disorders / Jorge A. Quiroz ... [et al.] -- Schizophrenia / Donald C. Goff and Darrick T. Balu -- Addictive disorders / Charles P. O'Brien -- Section summary and perspectives : translational medicine in psychiatry / Joseph T. Coyle -- Historical perspectives on the discovery and development of drugs to treat neurological disorders / Michael Williams and Joseph T. Coyle -- Alzheimer's disease / Donald L. Price ... [et al.] -- Pain therapeutics / Anthony W. Bannon -- Multiple sclerosis / Alfred W. Sandrock Jr. and Richard A. Rudick -- Parkinson's disease / Jiang-Fan Chen -- Amyotrophic lateral sclerosis / Nicholas J. Maragakis -- Epilepsy / Maciej Gasior and Frank Wiegand -- Section summary and perspectives : translational medicine in neurology / James E. Barrett and Joseph T. Coyle -- Historical perspectives on the use of therapeutic agents to treat neurodevelopmental disorders / Kimberly A. Stigler ... [et al.] -- Autism spectrum disorders / Timothy P.L. Roberts ... [et al.] -- Attention deficit hyperactivity disorder / Craig W. Berridge, David M. Devilbiss, and Amy F.T. Arnsten -- Epigenetic mechanisms in central nervous system disorders / Swati Gupta , Ryley Parrish, and Farah D. Lubin -- Section summary and perspectives : neurodevelopmental disorders and regulation of epigenetic changes / James E. Barrett and Joseph T. Coyle -- Promises and challenges of translational research in neuropsychiatry / David L. Braff.
Format
Book
Location
Halifax Infirmary
Copies
1
Loan Period
3 weeks
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Translational Oral Health Research

https://libcat.nshealth.ca/en/permalink/provcat43099
Jukka H. Meurman, editor. --Cham: Springer , c2018.
Available Online
View e-Book
Location
Online
This book is the first to be devoted to translational research--which aims to expedite the transfer of knowledge gained in the lab to clinical practice—within the field of oral health. It is examined how basic sciences and basic research are providing new methods and materials that will enable clinicians to treat patients more effectively. Readers will gain a translational perspective on a variety of oral conditions and related systemic diseases. Individual chapters are devoted to such topics a…
Available Online
View e-Book
Other Authors
Meurman, Jukka H.
Responsibility
Jukka H. Meurman, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 173 p.) : 56 illus., 49 illus. in color
ISBN
9783319782058
9783319782041 (print ed.)
9783319782065 (print ed.)
Subjects (MeSH)
Dental Research
Oral Health
Translational Medical Research
Specialty
Oral Health
Abstract
This book is the first to be devoted to translational research--which aims to expedite the transfer of knowledge gained in the lab to clinical practice—within the field of oral health. It is examined how basic sciences and basic research are providing new methods and materials that will enable clinicians to treat patients more effectively. Readers will gain a translational perspective on a variety of oral conditions and related systemic diseases. Individual chapters are devoted to such topics as dental biomaterials, implants, and tissue engineering. The importance of evidence-based research and the roles and comparative value of preclinical and clinical trials are also highlighted. Knowledge of translational and clinical research is essential in understanding how new inventions and developments are being accomplished, and what regulations and guidelines need to be taken into account when planning studies, and not forgetting the ethical aspects of any research. Translational Oral Health Research is the first book to be devoted entirely to the subject, and it will be of interest to both researchers and practitioners.
Contents
1. Translational Research in the Oral Health Sciences -- 2. How Cross-Disciplinary Research Has Increased Our Understanding of Oral Mucosal Diseases -- 3. Epigenetics and Periodontitis: A Source of Connection to Systemic Diseases -- 4. Topic: aMMP-8 Oral Fluid PoC Test -- 5. Composite Biomaterials: From Lab to Clinics -- 6. Translational Oral Health Research Implants and Bone Regeneration -- 7. A Critical Reason for Conducting Clinical Trials Is that Results with Humans Are Not Necessarily Predictable from Preclinical Studies -- 8. Evidence-Based Approach in Translational Dental Research -- 9. Tissue Engineering in Oral and Maxillofacial Surgery: From Lab to Clinics -- 10. Translational Research in Sjögren’s Syndrome -- 11. The Secrets of Jönköping: Why Do Most 80-Year-Olds Have More Than 20 Remaining Teeth, and Why Are There Very Few Edentulous -- 12. Developing Remedies for Oral Mucosal Diseases -- 13. Ethics in Biomedical Research.
Format
e-Book
Location
Online
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