topic:"Vasculitis - pathology" found 2 records - Provincial Hospitals Library Catalogue

In 1947, Lerner and Watson showed that the cold-precipitable proteins in serum were gammaglobulins. These "cryoglobulins" were responsible for the corresponding clinical condition "cryoglobulinemia." Meltzer and Franklin, in 1966, provided an accurate description of the typical clinical symptoms associated with cryoglobulinemia. Subsequent progress in this field was rather slow until the end of the 1980s, when cryoglobulinemia was definitively shown to be an extrahepatic manifestation of hepati…

Available Online: View e-Book

Other Authors: Dammacco, Franco

Responsibility: Franco Dammacco, editor

Place of Publication: Milan

Publisher: Springer

Date of Publication: c2012

Physical Description: 1 online resource (xvii, 360 p. : 64 ill., 52 ill. in color)

ISBN: 9788847017054

Subjects (MeSH): Cryoglobulinemia; Hepacivirus; Hepatitis C, Chronic; Vasculitis - pathology

Subjects (LCSH): Infectious diseases; Hematology

Abstract: In 1947, Lerner and Watson showed that the cold-precipitable proteins in serum were gammaglobulins. These "cryoglobulins" were responsible for the corresponding clinical condition "cryoglobulinemia." Meltzer and Franklin, in 1966, provided an accurate description of the typical clinical symptoms associated with cryoglobulinemia. Subsequent progress in this field was rather slow until the end of the 1980s, when cryoglobulinemia was definitively shown to be an extrahepatic manifestation of hepatitis C virus infection. The book is unique in its detailed presentation and fundamental approach. Highly qualified authors have contributed critical articles reviewing significant developments in our understanding of and therapeutic approach to HCV infection and cryoglobulinemia. The text is accompanied by striking color images and illustrations and highly informative tables. This comprehensive review of a systemic disease with a complex etiology is a valuable source of up-to-date, expert information not only for basic scientists and specialists in several disciplines but also for general practitioners as well as graduate and post-graduate students in clinical and medical research.

Contents: [Machine generated contents note] 1. Introductory Remarks / Domenico Sansonno -- Pt. I. Hepatitis C Virus Infection and the Role of the Immune System -- 2. Natural History, Pathogenesis, and Prevention of HCV Infection / Charles M. Rice -- 3. Immune Control of HCV Infection / Lynn B. Dustin -- 4. B Cell Activation: General to HCV-Specific Considerations / Claudia Brunetti -- 5. Organ-Specific Autoimmunity in HCV-Positive Patients / Fabio Presotto -- Pt. II. Cellular Compartments of HCV Infection (and Replication) -- 6. HCV and Blood Cells: How Can We Distinguish Infection from Association? / Charles M. Rice -- 7. Mechanisms of Cell Entry of Hepatitis C Virus / Vito Racanelli -- 8. HCV Infection of Hematopoietic and Immune Cell Subsets / Tomasz I. Michalak -- Pt. III. Cryoglobulinemia and the Complement System -- 9. Cryoglobulinemia and Chronic HCV Infection: An Evolving Story / Marten Trendelenburg -- 10. Complement System in Cryoglobulinemia / Marten Trendelenburg -- 11. Pivotal Role of C1qR in Mixed Cryoglobulinemia / Franco Dammacco -- Pt. IV. Structural and Genetic Features, Cytokines and Chemokines in Cryoglobulinemia -- 12. Mixed Cryoglobulinemia (MC) Cross-Reactive Idiotypes (CRI): Structural and Clinical Significance / Peter D. Gorevic -- 13. Molecular Insights into the Disease Mechanisms of Type II Mixed Cryoglobulinemia / Marica Garziera -- 14. Role of VCAM-1 in the Pathogenesis of Hepatitis-C-Associated Mixed Cryoglobulinemia Vasculitis / Gilles Kaplanski -- 15. Up-Regulation of B-Lymphocyte Stimulator (BLyS) in Patients with Mixed Cryoglobulinemia / Salvatore De Vita -- 16. Role of B-Cell-Attracting Chemokine-1 in HCV-Related Cryoglobulinemic Vasculitis / Franco Dammacco -- 17. Serum a-Chemokine CXCL10 and ß-Chemokine CCL2 Levels in HCV-Positive Cryoglobulinemia / Poupak Fallahi -- Pt. V. Clinical Manifestations of Cryoglobulinemia -- 18. Experimental Models of Mixed Cryoglobulinemia / Kelly L. Hudkins -- 19. Expanding Spectrum of Clinical Features in HCV-Related Mixed Cryoglobulinemia / Anna Linda Zignego -- 20. Classification of Cryoglobulinemic Vasculitis / Luca Quartuccio -- 21. Demographic and Survival Studies of Cryoglobulinemic Patients / Laura Castelnovo -- 22. HCV-Associated Membranoproliferative Glomerulonephritis / John Prentiss Johnson -- 23. Rheumatologic Symptoms in Patients with Mixed Cryoglobulinemia / Elisa Gremese -- 24. Endocrine Manifestations of HCV-Positive Cryoglobulinemia / Poupak Fallahi -- 25. Cutaneous Cryoglobulinemic Vasculitis / J. Andrew Carlson -- 26. Peripheral Neuropathy and Central Nervous System Involvement in Cryoglobulinemia / Sergio Ferrari -- 27. Long-Term Course of Patients with Mixed Cryoglobulinemia / Patrice P. Cacoub -- 28. HBV/HCV Co-infection and Mixed Cryoglobulinemia / Salvatore Sollima -- 29. Clinical and Immunological Features of HCV/HIV Co-infected Patients with Mixed Cryoglobulinemia / Patrice P. Cacoub -- 30. HCV-Negative Mixed Cryoglobulinemia: Facts and Fancies / Giuseppe Monti -- 31. Cryoglobulinemia in HCV-Positive Renal Transplant and Liver Transplant Patients / Nassim Kamar -- Pt. VI. HCV Infection, Cryoglobulinemia and Non-Hodgkin’s Lymphomas -- 32. Chromosome Abnormalities in HCV-Related Lymphoproliferation / Caterina Matteucci -- 33. Molecular Features of Lymphoproliferation in Mixed Cryoglobulinemia / Maria Paola Simula -- 34. Higher Prevalence of B-Cell Non-Hodgkin’s Lymphoma in HCV-Positive Patients with and Without Cryoglobulinemia / Domenico Sansonno -- 35. Incidence and Characteristics of Non-Hodgkin’s Lymphomas in HCV-Positive Patients with Mixed Cryoglobulinemia / Pietro Enrico Pioltelli -- 36. Waldenstrom’s Macroglobulinemia Associated with Cryoglobulinemia: Pathogenetic, Clinical, and Therapeutic Aspects / Efstathios Kastritis -- Pt. VII. Therapy of Cryoglobulinemia -- 37. Should HCV-Positive Asymptomatic Patients with Mixed Cryoglobulinemia Be Treated with Combined Antiviral Therapy? / Fernando Pons Renedo -- 38. Role of Rituximab in the Therapy of Mixed Cryoglobulinemia / Renato Fanin -- 39. Rituximab in Cryoglobulinemic Vasculitis: First- or Second-Line Therapy? / Paul Klenerman -- 40. PIRR Therapy in HCV-Related Mixed Cryoglobulinemia / Domenico Sansonno -- 41. Antiviral Therapy in HCV-Positive Non-Hodgkin’s Lymphoma: Pathogenetic Implications / Domenico Sansonno -- 42. Active or Indolent Cutaneous Ulcers in Cryoglobulinemia: How Should They Be Treated? / Maurizio Pietrogrande -- 43. Double Filtration Plasmapheresis: An Effective Treatment of Cryoglobulinemia / Paola Brescia -- 44. Emergency in Cryoglobulinemia: Clinical and Therapeutic Approach / Giuseppe Monti -- 45. Novel Therapeutic Approaches to Cryoglobulinemia: Imatinib, Infliximab, Bortezomib, and Beyond / Maurizio Zangari.

Format: e-Book

Location: Online