Active Surveillance for Localized Prostate Cancer : A New Paradigm for Clinical Management
https://libcat.nshealth.ca/en/permalink/provcat31028
Laurence Klotz, editor.
--New York, NY:
Humana Press
, c2012.
- Available Online
- View e-Book
- Location
- Online
Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management will serve as a useful resource for physicians dealing with, and interested in, this complex and evolving branch of prostate cancer management. The book will also be of interest to scientifically literate patients and their families. The volume provides an introduction to the concept of active surveillance in oncology in general and prostate cancer specifically. The primary focus is to provide a comprehens…
- Available Online
- View e-Book
- Other Authors
- Klotz, Laurence
- Responsibility
- Laurence Klotz, editor
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xi, 208 p. : 33 ill., 22 ill. in color)
- Series Title
- Current clinical urology
- ISBN
- 9781617799129
- Subjects (MeSH)
- Disease Progression
- Early Diagnosis
- Prostatic Neoplasms - diagnosis
- Prostatic Neoplasms - therapy
- Watchful Waiting
- Abstract
- Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management will serve as a useful resource for physicians dealing with, and interested in, this complex and evolving branch of prostate cancer management. The book will also be of interest to scientifically literate patients and their families. The volume provides an introduction to the concept of active surveillance in oncology in general and prostate cancer specifically. The primary focus is to provide a comprehensive guide to the management of patients on surveillance. The volume covers the many complexities and nuances to this approach including, patient selection, risk assessment, how to overcome 'cancer hysteria' when counseling patients, identifying appropriate triggers for intervention, use of PSA kinetics and MR imaging information, technique and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy.
- Contents
- 1. The Problem of Cancer Overdiagnosis and Overtreatment -- 2. Patient Selection for Active Surveillance -- 3. Predicting High Risk Disease Using Tissue Biomarkers -- 4. Predicting High Risk Disease Using Serum and DNA Biomarkers -- 5. Triggers for Intervention in Men on Surveillance -- 6. The Role of MRI in Active Surveillance -- 7. Active Surveillance: The European Experience -- 8. Active Surveillance: The Canadian Experience -- 9. Psychosocial Aspects of Active Surveillance -- 10. Statistical Considerations for Patient Selection and Triggers for Intervention in Active Surveillance -- 11. Interpreting PSA Kinetics using GLMM Technique -- 12. The Potential Benefits of Diet and Physical Activity among Active Surveillance Patients with Low-Burden Prostate Cancer -- 13. The Role of 5[alpha]-Reductase Inhibitors (5-ARIs) in Expectant Management of Low Risk Prostate Cancer -- 14. Urologists' Opinion on Active Surveillance: United States vs. the Netherlands -- 15. Clinical "Pearls" in Managing Patients on Surveillance -- 16. Active Surveillance, Focal Therapy and the Future -- 17. The Economics of Active Surveillance for Prostate Cancer -- 18. The Future of Active Surveillance.
- Format
- e-Book
- Location
- Online
Active Surveillance for Localized Prostate Cancer : A New Paradigm for Clinical Management
https://libcat.nshealth.ca/en/permalink/provcat43371
Laurence Klotz, editor.
(Second edition)
--Cham:
Humana Press
, c2018.
- Available Online
- View e-Book
- Location
- Online
This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the…
- Available Online
- View e-Book
- Other Authors
- Klotz, Laurence
- Responsibility
- Laurence Klotz, editor
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xii, 250 p.) : 39 illus., 27 illus. in color
- Series Title
- Current clinical urology
- ISBN
- 9783319627106
- 9783319627090 (print ed.)
- 9783319627113 (print ed.)
- 9783319873756 (print ed.)
- ISSN
- 2197-7194
- Subjects (MeSH)
- Disease Progression
- Medical Overuse - prevention & control
- Prostatic Neoplasms - diagnosis
- Prostatic Neoplasms - therapy
- Watchful Waiting
- Specialty
- Medical Oncology
- Urology
- Abstract
- This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the role of biomarkers and MRI in patient selection and management and details the world wide results of active surveillance. Specific chapters address communication and ethical issues, QOL outcomes, economic aspects, and psycho-social aspects of surveillance. The role of focal therapy for low risk disease is summarized, and the data supporting preventive interventions during surveillance reviewed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in this common malignancy, as it provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.
- Contents
- Cancer Overdiagnosis and Overtreatment -- Can We Screen and Still Reduce Overdiagnosis? -- The Role of Fear in Overdiagnosis and Overtreatment -- Ethical and Legal Considerations in Active Surveillance for Prostate Cancer -- Gleason 6 Tumors Should Still Be Labeled As Cancer -- Risk Based Selection for Active Surveillance -- Surveillance at the Margins: Management of High Volume Gleason 6, PSA>10, or Gleason 3+4 -- How Should Patients on Active Surveillance be Followed? -- Triggers for Intervention -- MR Imaging in Prostate Tumor Volume Assessment: How Accurate? -- Can MRI Replace Biopsy in Men on Surveillance? -- Tissue Based Markers for Risk Prediction -- International AS Registry: The Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance Initiative -- Better Informed Decision Making to Optimize Patient Selection -- How Does QOL Compare Between Surveillance and Active Treatment? -- The Potential Benefits of Diet and Physical Activity among Active Surveillance Patients with Low-Burden Prostate Cancer -- Is there a Role for Pharmacologic Manipulation to Prevent Progression in Men on Active Surveillance? The Role of 5-ARIs, Statins, and Metformin -- The Update of Active Surveillance around the World: Utilization and Outcomes -- Tissue Preservation: Active Surveillance and Focal Therapy as Complimentary Strategies -- The Economics of Active Surveillance for Prostate Cancer -- Research Questions in Active Surveillance.
- Format
- e-Book
- Location
- Online
The Prostate Cancer Dilemma : Selecting Patients for Active Surveillance, Focal Ablation and Definitive Therapy
https://libcat.nshealth.ca/en/permalink/provcat39851
Nelson N. Stone, E. David Crawford, editors.
(1st ed.)
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This comprehensive text provides a complete description of the newest technologies to diagnose and manage the most common prostate cancer diagnosed today: low risk disease. The book reviews new data about genetic markers, transperineal mapping biopsy and mpMRI, how to apply each of these technologies in patients with elevated PSA, when a prior prostate biopsy performed by the standard TRUS method is negative, and, in cases where low risk disease is already diagnosed, how to differentiate those …
- Available Online
- View e-Book
- Other Authors
- Stone, Nelson N
- Crawford, E. David
- Responsibility
- Nelson N. Stone, E. David Crawford, editors
- Edition
- 1st ed.
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xiv, 206 p. : 55 illus., 49 illus. in color)
- ISBN
- 9783319214856
- 9783319214849 (print ed.)
- Subjects (MeSH)
- Early Detection of Cancer
- Neoplasm Grading
- Patient Selection
- Prostatic Neoplasms - diagnosis
- Prostatic Neoplasms - therapy
- Watchful Waiting
- Abstract
- This comprehensive text provides a complete description of the newest technologies to diagnose and manage the most common prostate cancer diagnosed today: low risk disease. The book reviews new data about genetic markers, transperineal mapping biopsy and mpMRI, how to apply each of these technologies in patients with elevated PSA, when a prior prostate biopsy performed by the standard TRUS method is negative, and, in cases where low risk disease is already diagnosed, how to differentiate those men who might harbor more aggressive disease from those who do not. Over 75% of newly diagnosed prostate cancer meets the criteria for low risk disease which has created a dilemma for both patients and clinicians because of the inaccuracy of the standard TRUS biopsy method. Active surveillance programs have been initiated and are reviewed. How the new technologies impact surveillance programs are addressed. Clinical stage designation is updated and a new intra-prostatic staging system is discussed. Prostate biopsy techniques utilizing transrectal ultrasound, transperineal mapping, elastography and mpMRI are compared. Finally, utilization of these new technologies in the application of focal therapy is reviewed. The Prostate Cancer Dilemma will serve as a valuable resource for clinicians, surgeons and researchers with an interest in early prostate cancer. Chapters are written by experts in their fields and include the most up-to-date scientific and clinical information as well as links to procedural video content.
- Contents
- Part I. Diagnosis -- History of PSA, from Detection to Over Diagnosis -- Pathology of Prostate Cancer: What has Changed in the Last 30 years?- Clinical Risk Prediction Tools for Prostate Cancer: TMN to CAPRA-Should Risk be Re-defined? -- TRUS Biopsy: Is There Still a Role? -- Transperineal Biopsy Technique -- 3D Biopsy: A New Method to Diagnose Prostate Cancer -- Elastography: Can it Improve Prostate Biopsy Results? -- Multi parametric MRI of the Prostate as a Tool for Prostate Cancer Detection -- Genomic Markers -- Part II. Treatment -- Current Status of Clinical Trials in Active Surveillance -- Focused targeted Therapy in Prostate Cancer -- Technologies and Methods in Primary Ablation with Focal Therapy -- Multi parametric MRI (mpMRI): Guided Focal Therapy -- Conclusions.
- Format
- e-Book
- Location
- Online
