5-minute toxicology consult
https://libcat.nshealth.ca/en/permalink/provcat27397
Dart, Richard C.
--Philadelphia, PA:
Lippincott Williams & Wilkins
, 2000.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Dart, Richard C.
- Place of Publication
- Philadelphia, PA
- Publisher
- Lippincott Williams & Wilkins
- Date of Publication
- 2000
- Series Title
- 5-minute consult
- ISBN
- 068330207
- Subjects (MeSH)
- Poisoning - Handbooks
- Antidotes - Handbooks
- Hazardous Substances - adverse effects
- Toxicology - Handbooks
- Format
- e-Book
- Location
- Online
Acute and critical care formulas and laboratory values
https://libcat.nshealth.ca/en/permalink/provcat33286
Joseph Varon, Robert E. Fromm, Jr.
--New York:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
This pocket guide is a single-volume source of the most common and important formulas and laboratory values used in the daily practice of acute care and critical care medicine. Information is presented in outline format and as tables, graphics, and algorithms to facilitate quick look up. Acute and Critical Care Formulas and Laboratory Values is designed to help clinicians interpret clinical data, apply formulas, understand laboratory values, and integrate this information with their knowledge o…
- Available Online
- View e-Book
- Author
- Varon, Joseph
- Other Authors
- Fromm, Robert E
- Responsibility
- Joseph Varon, Robert E. Fromm, Jr.
- Place of Publication
- New York
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xi, 194 pages)
- ISBN
- 9781461475101 (electronic bk.)
- 9781461475095
- Subjects (MeSH)
- Clinical Laboratory Techniques - Handbooks
- Critical Care - Handbooks
- Reference Values - Handbooks
- Subjects (LCSH)
- Critical care medicine - Laboratory manuals
- Critical Care - Handbooks
- Abstract
- This pocket guide is a single-volume source of the most common and important formulas and laboratory values used in the daily practice of acute care and critical care medicine. Information is presented in outline format and as tables, graphics, and algorithms to facilitate quick look up. Acute and Critical Care Formulas and Laboratory Values is designed to help clinicians interpret clinical data, apply formulas, understand laboratory values, and integrate this information with their knowledge of pathophysiology to promote the delivery of evidence-based care. Essential formulas and laboratory values. Multiple ways to derive a value, where appropriate. Non-clinical formulas useful for understanding physiologic concepts or that underlie diagnostic tests or clinical measurement.
- Contents
- Cardiovascular Formulas and Facts -- Endocrinology and Metabolism Formulas -- Environmental Facts and Formulas -- Gastrointestinal Facts and Formulas -- Hematological Facts and Formulas -- Infectious Diseases Formulas and Facts -- Neurological Formulas and Facts -- Nutrition Formulas and Facts -- Obstetrics & Gynecology Formulas and Facts -- Oncology Formulas -- Pediatric Formulas and Laboratory Values -- Pulmonary Formulas and Facts -- Renal, Fluid & Electrolyte Formulas and Facts -- Statistics and Epidemiology -- Toxicology Formulas and Facts -- Trauma Facts and Formulas -- Common Laboratory Values -- Key Telephone Numbers -- Notes -- Abbreviations -- Index.
- Format
- e-Book
- Location
- Online
Advances in molecular toxicology. Vol. 1
https://libcat.nshealth.ca/en/permalink/provcat27194
edited by James C. Fishbein.
--Amsterdam, Netherlands:
Elsevier
, 2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Fishbein, James C
- Responsibility
- edited by James C. Fishbein.
- Place of Publication
- Amsterdam, Netherlands
- Publisher
- Elsevier
- Date of Publication
- 2006
- ISBN
- 9786610707997
- Subjects (MeSH)
- Toxicology
- Molecular Biology
- Contents
- Cover -- Contents -- Contributors -- Editor's Preface -- Bioactivation of Estrogens to Toxic Quinones -- Introduction -- Mechanisms of Estrogen Carcinogenesis -- Oxidation of Catechol Estrogens to O-Quinones -- DNA Damage Induced by Catechol Estrogens -- Protein Damage Induced by Catechol Estrogens -- Role of the Estrogen Receptor in Estrogen Carcinogenesis -- Substitution of the 4-Hydroxy group on Catechol Estrogens with Fluorine Abolishes Quinoid Formation while Maintaining Estrogenic Activity -- Summary -- Acknowledgment -- References -- Diverse Mechanisms of Endogenous Nucleobase Deamination in DNA and RNA -- Introduction -- Simple Hydrolytic Mechanisms -- Nitrosative Deamination and Inflammation -- Enzymatic Deamination of Nucleobases -- Purine Metabolism as a Source of Nucleobase Deamination in DNA and RNA -- Repair and Mutagenesis of Nucleobase Deamination Products -- Summary -- Acknowledgments -- References -- Site-Specific Modification of the Electrophile Sensor Protein Keap1 and Activation of Nrf2-Dependent Gene Expression -- Introduction -- Patterns of Keap1 Modification by Electrophiles -- Relationship of Keap1 Modification Sites and Functionally Significant Cysteine Residues -- Electrophile-Induced Ubiquitination of Keap1 -- Unresolved Questions about Electrophile-Induced Activation of NRF2 -- Acknowledgments -- References -- Genotoxicity of Chlorophenols and Ochratoxin A -- Introduction -- Chlorophenols -- Ochratoxin A -- Acknowledgments -- References -- Idiosyncratic Drug Reactions: Clinical Evidence for Mechanistic Hypotheses -- Background -- Postulated Mechanisms -- Summary and Conclusions -- Acknowledgments -- References -- Subject Index -- Last Page
- Format
- e-Book
- Location
- Online
Albert and Jakobiec's Principles and practice of ophthalmology
https://libcat.nshealth.ca/en/permalink/provcat24179
Albert, Daniel M.
(3rd ed.)
--Philadelphia, PA:
Saunders Elsevier
, 2008.
- Call Number
- WW 100 A333 2008 REF
- Location
- Dickson Building
- Sub-Location
- REFERENCE
- Call Number
- WW 100 A333 2008 REF
- Author
- Albert, Daniel M
- Other Authors
- Miller, Joan W
- Edition
- 3rd ed.
- Place of Publication
- Philadelphia, PA
- Publisher
- Saunders Elsevier
- Date of Publication
- 2008
- Physical Description
- 4 v. (5461 p.)
- ISBN
- 9781416000167
- Subjects (MeSH)
- Ophthalmology - methods
- Eye Diseases
- Ocular Physiological Phenomena
- Contents
- v. 1. Genetics -- Immunology -- Microbiology -- Pharmacology and toxicology -- Principles of epidemiology -- Cornea and conjunctiva -- Refractive surgery -- Uveitis -- v. 2. Lens -- Retina and vitreous -- Glaucoma -- v. 3. Oculoplastics -- Ophthalmic pathology -- Neuro-ophthalmology -- v. 4. Pediatric ophthalmology -- The eye and systemic disease -- Ocular oncology -- Trauma -- Optics -- Low vision -- Ethics and professionalism.
- Format
- Book
- Location
- Dickson Building
- Sub-Location
- REFERENCE
- Loan Period
- In library use
Alternatives to Animal Testing : Proceedings of Asian Congress 2016
https://libcat.nshealth.ca/en/permalink/provcat43939
Hajime Kojima, Troy Seidle, Horst Spielmann, editors.
--Singapore:
SpringerOpen
, c2019.
- Available Online
- View e-Book
- Access
- Open access
- Location
- Online
The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0. ; This book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collective…
- Available Online
- View e-Book
- Other Authors
- Kojima, Hajime
- Seidle, Troy
- Spielmann, Horst
- Responsibility
- Hajime Kojima, Troy Seidle, Horst Spielmann, editors
- Place of Publication
- Singapore
- Publisher
- SpringerOpen
- Date of Publication
- c2019
- Physical Description
- 1 online resource (vi, 130 p. 46 illus., 39 illus. in color.)
- ISBN
- 9789811324475
- 9789811324468 (Print ed.)
- 9789811324482 (Print ed.)
- Specialty
- Laboratory Animal Science
- Abstract
- The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
- This book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare.
- Contents
- 1. Zebrafish, Danio rerio as a replacement alternative model useful in CKDu experiments -- 2. Testing method development and validation for in vitro skin irritation testing (SIT) by using reconstructed human epidermis (RhE) skin equivalent: EPiTR -- 3. Development the technique for the preparation and characterization of reconstructed human epidermis (RHE) -- 4. Alternative research (3Rs) in the world, Asia and Japan -- 5. Approaches to reducing animal use for acute toxicity testing: Retrospective analyses of pesticide data -- 6. Progress in deleting the 1-year dog study for the safety assessment of pesticides -- 7. Cosmetic regulation and alternatives to animal experimentation in India -- 8. Guidance on the use of alternative test methods for the safety assessment of cosmetics and quasi-drugs -- 9. Alternatives and refinement for animal experimentation in cancer research -- 10. 3Rs in quality control of human vaccines: opportunities and barriers -- 11. The use of adverse outcome pathways (AOPs) to support chemical safety decisions within the context of integrated approaches to testing and assessment (IATA) -- 12. Mechanism-based evaluation system for hepato- and nephrotoxicity or carcinogenicity using omics technology -- 13. Alternative methods for developmental toxicity testing using mouse ESCs -- 14. Futuristic approach to alternative model organisms: hydra stakes its claim -- 15. The Lush Prize and Young Researcher Asia Awards 2016.
- Access
- Open access
- Format
- e-Book
- Publication Type
- Congress
- Location
- Online
Application of peptide-based prodrug chemistry in drug development
https://libcat.nshealth.ca/en/permalink/provcat32406
Arnab De, author ; with special thanks to Richard DiMarchi and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University ; with foreword by Jean Martinez.
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- De, Arnab
- Responsibility
- Arnab De, author ; with special thanks to Richard DiMarchi and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University ; with foreword by Jean Martinez
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- ISBN
- 9781461448754
- Subjects (MeSH)
- Drug Design
- Peptides - pharmacology
- Prodrugs
- Subjects (LCSH)
- Toxicology
- Pharmaceutical technology
- Diabetes
- Contents
- Introduction -- Application of prodrug chemistry to GLP-1 -- Experimental procedures -- Characterization of prodrugs -- Conclusion -- Appendix I: Schematic Synthesis of Longer Acting Prodrugs -- Appendix II: Structure of Peptides in Table A.1 -- Appendix III: Structure of Peptides in Table A.2 -- Appendix IV: Structure of Peptides in Table A.3 -- Appendix V: Structure of Peptides in Table A.4 -- Appendix VI: Structure of Peptides in Table A.5 -- Appendix VII: Structure of Peptides in Table A.6 -- Appendix VIII: Acylation of HO-His7, GLP(8–37) -- Appendix IX: A Note on Nomenclature.
- Format
- e-Book
- Location
- Online
Atlas of Adult Autopsy : A Guide to Modern Practice
https://libcat.nshealth.ca/en/permalink/provcat40026
S. Kim Suvarna, editor.
(1st ed.)
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This atlas leads the reader through the adult autopsy process, and its common variations, with a large number of high-quality macroscopic photographs and concise accompanying text. It provides a manual of current practice and is an easy-to-use resource for case examination for consent, medico-legal and radiological autopsies. External realities and checks are discussed at the beginning of the book, which goes on to cover specific body cavities and organ systems in detail. The book ends with cha…
- Available Online
- View e-Book
- Other Authors
- Suvarna, S. Kim
- Responsibility
- S. Kim Suvarna, editor
- Edition
- 1st ed.
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xi, 399 p. : 1100 illus., 1066 illus. in color)
- ISBN
- 9783319270227
- 9783319270203 (print ed.)
- Subjects (MeSH)
- Adult
- Autopsy - methods
- Abstract
- This atlas leads the reader through the adult autopsy process, and its common variations, with a large number of high-quality macroscopic photographs and concise accompanying text. It provides a manual of current practice and is an easy-to-use resource for case examination for consent, medico-legal and radiological autopsies. External realities and checks are discussed at the beginning of the book, which goes on to cover specific body cavities and organ systems in detail. The book ends with chapters on topics including forensic autopsies, specialist sampling, toxicology analyses and the radiological autopsy. Atlas of Adult Autopsy is aimed at practicing pathologists, particularly those in training grades. It may also be of interest to anatomical technicians in autopsy suites, as well as parties with a legal interest in autopsy practice.
- Contents
- General Considerations and Safety -- External Examination -- Evisceration -- Thorax: Heart, Lungs, Mediastinum, and Pleura -- Gastrointestinal and Hepatobiliary System -- Genitourinary and Breast Tissues, Including Pregnancy -- Lymphoreticular Tissues: Lymph Node, Spleen and Thymus, Bone and Marrow -- Endocrine Glands: Thyroid, Parathyroid, Adrenal, and Pituitary -- The Central Nervous System, with Eye and Ear -- Standard and Special Tests -- Devices: Foreign Items Encountered During the Autopsy -- The Forensic Autopsy -- The Radiological Autopsy -- Toxicology -- Appendix.
- Format
- e-Book
- Publication Type
- Atlas
- Location
- Online
Atlas of human poisoning and envenoming
https://libcat.nshealth.ca/en/permalink/provcat26458
James H. Diaz.
(2nd ed.)
--Boca Raton, FL:
Taylor and Francis
, c2015.
- Call Number
- QV 17 H542 2015
- Location
- Halifax Infirmary
Clinicians undergoing competency testing, certification, and periodic recertification are frequently faced with computer-based exams designed to evaluate clinical acumen and judgment. Test questions often include an image or radiograph followed by a vignette of the clinical encounter and a series of questions. Designed to better prepare practitioners for image-intense, computer-based examinations in their respective fields, Atlas of Human Poisoning and Envenoming is a visual and written remind…
- Call Number
- QV 17 H542 2015
- Author
- Diaz, James H
- Responsibility
- James H. Diaz
- Edition
- 2nd ed.
- Former Title
- Color atlas of human poisoning and envenoming
- Place of Publication
- Boca Raton, FL
- Publisher
- Taylor and Francis
- Date of Publication
- c2015
- Physical Description
- 890 p.
- ISBN
- 9781466505407
- Subjects (MeSH)
- Antidotes - Atlases
- Poisoning - Atlases
- Poisons - Atlases
- Toxicology - Atlases
- Toxins, Biological - Atlases
- Venoms - Atlases
- Notes
- Preceded by: Color atlas of human poisoning and envenoming / by James Diaz. 1st ed. 2006.
- Abstract
- Clinicians undergoing competency testing, certification, and periodic recertification are frequently faced with computer-based exams designed to evaluate clinical acumen and judgment. Test questions often include an image or radiograph followed by a vignette of the clinical encounter and a series of questions. Designed to better prepare practitioners for image-intense, computer-based examinations in their respective fields, Atlas of Human Poisoning and Envenoming is a visual and written reminder of the ubiquitous sources of toxins and toxoids in the environment and the outcomes of accidental or intentional toxic exposures in humans. The 2nd ed. has been restructured with bulleted text, tables, and figures resembling the vignettes that accompany national examinations. Combining the four specialties of toxicology analytical, medical, environmental, and industrial into one comprehensive atlas, the book presents photographs and diagrams of toxic plants and animals, their mechanisms of poisoning or envenoming, and the human responses caused by toxic exposure. Highlights include: Prescription and illicit drug abuse epidemics; Environmental and occupational nephrotoxicology and neurotoxicology; Tick paralysis; Petrochemical toxicants; Biological, chemical, and radiological warfare agents; Workplace substance abuse screening and monitoring; Epidemiological design and statistical analysis of toxicological investigations. The book is conveniently divided into four sections covering general medical toxicology, environmental toxicology, industrial and occupational toxicology, and epidemiology and statistics for toxicology. Supplemented with a 16-page color insert, the second edition includes new images and tables. The atlas will be a useful study guide for a range of practitioners preparing for a lifetime of image-intense national examinations.
- Format
- Book
- Location
- Halifax Infirmary
- Copies
- 1
- Loan Period
- 3 weeks
Atlas of toxicological pathology
https://libcat.nshealth.ca/en/permalink/provcat33845
Chirukandath Gopinath, Vasanthi Mowat.
--New York:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Gopinath, Chirukandath
- Other Authors
- Mowat, Vasanthi
- Responsibility
- Chirukandath Gopinath, Vasanthi Mowat
- Former Title
- Atlas of experimental toxicological pathology
- Place of Publication
- New York
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xi, 285 pages)
- ISBN
- 9781627039987 (electronic bk.)
- 9781627039970
- Subjects (MeSH)
- Pathologic Processes - Atlases
- Toxicology - Atlases
- Subjects (LCSH)
- Toxicology, Experimental - Atlases
- Histology, Pathological - Atlases
- Laboratory animals - Histopathology - Atlases
- Diseases - Animal models - Atlases
- Notes
- Preceded by: Atlas of experimental toxicological pathology / by C. Gopinath, D.E. Prentice, D.J. Lewis.
- Contents
- The Cardiovascular System -- The Respiratory System -- The Liver -- The Alimentary System and Pancreas -- The Urinary System -- The Male Reproductive System -- The Female Reproductive System -- The Endocrine System -- The Lymphoid System -- The Nervous System -- The Musculoskeletal System and Skin -- The Eye and Ear.
- Format
- e-Book
- Location
- Online
Basic & clinical pharmacology
https://libcat.nshealth.ca/en/permalink/provcat13200
edited by Bertram G. Katzung ; associate editors, Susan B. Masters, Anthony J. Trevor.
(11th ed.)
--New York, NY:
McGraw-Hill Medical
, 2009.
- Call Number
- QV 4 B3115 2009
- Location
- Cape Breton Regional
- Call Number
- QV 4 B3115 2009
- Other Authors
- Katzung, Bertram G.
- Trevor, Anthony J.
- Masters, Susan B.
- Responsibility
- edited by Bertram G. Katzung ; associate editors, Susan B. Masters, Anthony J. Trevor
- Edition
- 11th ed.
- Alternate Title
- Basic and clinical pharmacology
- Place of Publication
- New York, NY
- Publisher
- McGraw-Hill Medical
- Date of Publication
- 2009
- Physical Description
- xiii, 1218 p. : ill.
- ISBN
- 9780071604055
- 0071604057
- Subjects (MeSH)
- Drug Therapy
- Pharmacology, Clinical
- Contents
- Basic principles -- Autonomic drugs -- Cardiovascular-renal drugs -- Drugs with important actions on smooth muscle -- Drugs that act in the central nervous system -- Drugs used to treat diseases of the blood, inflammation, & gout -- Endocrine drugs -- Chemotherapeutic drugs -- Toxicology -- Special topics.
- Format
- Book
- Location
- Cape Breton Regional
Basic Principles of Forensic Chemistry
https://libcat.nshealth.ca/en/permalink/provcat30987
JaVed I. Khan, Thomas J. Kennedy, Donnell R. Christian Jr.
--New York, NY:
Humana Press
, c2012.
- Available Online
- View e-Book
- Location
- Online
Basic Principles of Forensic Chemistry is designed to provide a clear and concise understanding of forensic chemistry. The text begins with an introduction to the basic principles of chemistry and expands through organic chemistry into forensic investigation. The detailed chapters focus on both the theoretical and practical aspects of forensic chemistry with emphasis on controlled substance testing and identification. Leading experts in the field contribute general examination techniques follow…
- Available Online
- View e-Book
- Author
- Khan, JaVed I
- Other Authors
- Kennedy, Thomas J
- Christian Jr., Donnell R
- Responsibility
- JaVed I. Khan, Thomas J. Kennedy, Donnell R. Christian Jr
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xxii, 353 p. : 370 ill., 25 ill. in color)
- ISBN
- 9781597454377
- Subjects (MeSH)
- Chemical Phenomena
- Chemistry Techniques, Analytical - methods
- Forensic Sciences - methods
- Subjects (LCSH)
- Toxicology
- Analytical biochemistry
- Forensic Medicine
- Abstract
- Basic Principles of Forensic Chemistry is designed to provide a clear and concise understanding of forensic chemistry. The text begins with an introduction to the basic principles of chemistry and expands through organic chemistry into forensic investigation. The detailed chapters focus on both the theoretical and practical aspects of forensic chemistry with emphasis on controlled substance testing and identification. Leading experts in the field contribute general examination techniques followed by applications to more specific models. In addition, the text contains a comprehensive collection of information and data on controlled substances commonly encountered in forensic investigation including; detailed structural analysis, physical and physiological effects, functional group reactivity, and results of analytical examination. Also illustrated is arguably the greatest challenge to the forensic chemist: the investigation and processing of clandestine laboratory operations. The Forensic Chemistry Laboratory Manual is included on a CD-ROM and contains a collection of practical exercises designed to support theoretical principles covered in the text. This provides the student with valuable hands-on experience while adding clarity and continuity to the topics of discussion. Essential and comprehensive, Basic Principles of Forensic Chemistry provides the fundamental knowledge required for a rewarding journey into the field of forensic chemistry.
- Contents
- I. Introduction to forensic chemistry -- Introduction -- Atomic structure -- Molecules -- Organic chemistry -- II. Tools of forensic chemistry -- Forensic language -- Forensic documentation -- Chemical screening -- Microcrystal techniques -- Chemical extractions and sample properties -- Chromatography and mass spectrometry -- Infrared spectroscopy -- III. Examination of drugs/narcotics -- Cannabis -- Phenethylamines -- Tertiary amines -- Tryptamines -- Anabolic steroids -- Miscellaneous controlled substances -- IV. Clandestine laboratory operations -- Clandestine operations: synthetic methods, hazards, and safety -- Evidence identification and collection -- Examination of clandestine evidence.
- Format
- e-Book
- Location
- Online
Botulinum Toxin Treatment of Pain Disorders
https://libcat.nshealth.ca/en/permalink/provcat39020
Bahman Jabbari.
--New York, NY:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 14 pain categories with an evidence based literature review on each pain disorder, illustrative figures along with brief video clips showing the techniques and patient interviews. Introductory chapters cover basic information about the mechanism, function and the analgesic effects of the BoNTs based on the data derived from animal studies. Clinical chapters define pain in conditions such as post-herp…
- Available Online
- View e-Book
- Author
- Jabbari, Bahman
- Responsibility
- Bahman Jabbari
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xiv, 246 p. : 44 illus., 19 illus. in color)
- ISBN
- 9781493925018
- 9781493925001 (print ed.)
- Subjects (MeSH)
- Analgesics
- Botulinum Toxins - administration & dosage
- Botulinum Toxins - therapeutic use
- Neuromuscular Agents
- Pain - drug therapy
- Abstract
- This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 14 pain categories with an evidence based literature review on each pain disorder, illustrative figures along with brief video clips showing the techniques and patient interviews. Introductory chapters cover basic information about the mechanism, function and the analgesic effects of the BoNTs based on the data derived from animal studies. Clinical chapters define pain in conditions such as post-herpetic and post-traumatic neuralgias, plantar fasciitis, low back pain, post-surgical pain syndromes and migraine in detail, provide discussion of current modes of treatment and updated information on BoNT therapy. Each chapter also includes illustrative case histories. Botulinum Toxin Treatment of Pain Disorders will prove an invaluable resource for clinicians and researchers involved in the treatment of pain disorders including neurologists, pain medicine specialists, anesthesiologists, internists, those conducting research in pharmacology and toxicology as well as students in these areas.
- Contents
- Molecular Structure, Mode of Action and Immunology of Botulinum Neurotoxins -- Analgesic effects of botulinum neurotoxins: Data from animal studies -- Neuropathic Pain (NP) -- Migraine and Other Primary Headaches -- Botulinum Neurotoxins and Chronic Low Back Pain -- Botulinum Toxin Treatment of Plantar Fasciitis (Plantar Fasciopathy) -- Botulinum Toxin Treatment of Piriformis Syndrome -- Botulinum Toxin Treatment of Myofascial Pain Syndrome and Fibromyalgia -- Pelvic and Urogenital Pain -- Botulinum Toxin Treatment of Chronic Facial Pain: Trigeminal Neuralgia, Temporo-Mandibular Disorders and Dental-Related Pain -- Botulinum Neurotoxins for Relief of Pain Associated with Spasticity -- Treatment of Dystonic Pain with Botulinum Neurotoxins -- Botulinum Toxin Therapy for Prevention of Post-surgical Pain -- Botulinum Toxins for Treatment of Pain in Orthopedic Disorders -- Botulinum Toxins for Treatment of Cancer-related, Post-radiation, Post-surgical and End of Life Pain -- Botulinum Neurotoxin Treatment of Unusual and Rare Painful Disorders -- Future Prospects of Pain Treatment with Botulinum Neurotoxins.
- Format
- e-Book
- Location
- Online
Burkitt's lymphoma
https://libcat.nshealth.ca/en/permalink/provcat32384
Erle S. Robertson, editor.
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
This volume aims to bring together efforts with a patient-oriented focus from physicians to diagnostics and clinical implications of the disease as mostly seen in the equatorial African setting. However, the chapters cover the breadth of studies on Burkitt's lymphoma with some clues for the potential future of Burkitt's lymphoma research that can have therapeutic benefits for patients. This text explore a range of topics associated with Burkitt's lymphoma, including molecular biology, diagnosi…
- Available Online
- View e-Book
- Other Authors
- Robertson, Erle S
- Responsibility
- Erle S. Robertson, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (viii, 332 p. : 60 ill., 48 ill. in color)
- Series Title
- Current cancer research
- ISBN
- 9781461443131
- Subjects (MeSH)
- Africa South of the Sahara
- Burkitt Lymphoma
- Subjects (LCSH)
- Oncology
- Toxicology
- Abstract
- This volume aims to bring together efforts with a patient-oriented focus from physicians to diagnostics and clinical implications of the disease as mostly seen in the equatorial African setting. However, the chapters cover the breadth of studies on Burkitt's lymphoma with some clues for the potential future of Burkitt's lymphoma research that can have therapeutic benefits for patients. This text explore a range of topics associated with Burkitt's lymphoma, including molecular biology, diagnosis, its association with AIDS and Malaria, immune responses, therapeutic approaches and a unique view from the bedside. This volume is comprehensive and unique and represents the most up-to-date clinical and research activities on Burkitt's lymphoma.
- Contents
- Preface -- Introduction -- Diagnosis of Burkitt's Lymphoma -- Burkitt's Lymphoma : A View from the Bedside -- Clinical Implications of Burkitt's Lymphoma -- Definition of Burkitt's Lymphoma -- Classical and Endemic Burkitt's Lymphoma -- Sporadic Burkitt's Lymphoma -- AIDS-Associated Burkitt's Lymphoma -- Diffuse Large B-Cell Lymphoma and High Grade Diffuse Large B-Cell Lymphoma -- EBV Associated Burkitt's Lymphoma -- Molecular Biology of Burkitt's Lymphoma -- Burkitt's Lymphoma and the Immune Response -- The Many Roles of Malaria in the Etiology of Endemic Burkitt Lymphoma -- Therapeutic Approaches to Burkitt’s Lymphoma -- Animal Models of Burkitt’s Lymphoma -- Summary and Conclusion: Thinking About Latent BL -- Index.
- Format
- e-Book
- Location
- Online
Cadmium Toxicity : New Aspects in Human Disease, Rice Contamination, and Cytotoxicity
https://libcat.nshealth.ca/en/permalink/provcat44135
Seiichiro Himeno, Keiko Aoshima, editors.
--Singapore:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pa…
- Available Online
- View e-Book
- Other Authors
- Himeno, Seiichiro
- Aoshima, Keiko
- Responsibility
- Seiichiro Himeno, Keiko Aoshima, editors
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (viii, 190 p.) : 68 illus., 51 illus. in color
- Series
- Current Topics in Environmental Health and Preventive Medicine
- ISBN
- 9789811336300
- 9789811336294 (Print ed.)
- 9789811336317 (Print ed.)
- ISSN
- 2364-8333
- Subjects (MeSH)
- Cadmium - toxicity
- Cadmium Poisoning
- Environmental Exposure
- Food Contamination - prevention & control
- Specialty
- Toxicology
- Abstract
- This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pathophysiology of itai-itai disease, a serious condition caused by Cd pollution. Cadmium: New Aspects in Human Disease, Rice Contamination, and Cytotoxicity is a valuable resource for scientists involved in heavy metal toxicology, botanical sciences, and regulatory sciences. Addressing the features of Cd pollution in the past and in the present, as well as future perspectives, this is a must-have book for students, researchers and practitioners interested in global and local metal pollution.
- Contents
- Part I. Overview -- 1. Historical Lessons on Cadmium Environmental Pollution Problems in Japan and Current Cadmium Exposure Situation -- Part II. Health Effects of Cadmium in Human Populations and its Relation to Cadmium Exposure Levels -- 2. Recent Clinical and Epidemiological Studies of Itai-Itai Disease (Cadmium-Induced Renal Tubular Osteomalacia) and Cadmium Nephropathy in the Jinzu River Basin in Toyama Prefecture, Japan -- 3. Novel Pathological Study of Cadmium Nephropathy of Itai-itai Disease -- 4. Long-Term Follow-Up Study of Residents Exposed to Cadmium in Kakehashi River Basin, Ishikawa, Japan -- 5. Effects of Cadmium Exposure on Life Prognosis -- 6. Cadmium Exposure and Its Effects on the Health Status of Rice Farmers in Akita Prefecture 7. Dietary Cadmium Intake Among General Populations in Japan and East Asia -- Part III. Rice Contamination by Cadmium and its Remediation -- 8. Regulations for Cadmium in Rice and Soil in Japan and Countermeasures to Reduce the Concentrations -- 9. Molecular Mechanism of Cadmium Accumulation in Rice - 10. Mitigation Strategies for Cadmium and Arsenic in Rice -- 11. Development of Low-Cadmium-Accumulating Rice -- Part IV. New Aspects in the Mechanisms of Cadmium Toxicity -- 12. Novel Mechanisms of Cadmium-Induced Toxicity in Renal Cells - 13. Roles of Metal Transporters in Cellular Cadmium Transport in Mammals -- 14. Disturbance in Phosphorus Metabolism by Cadmium Exposure.
- Format
- e-Book
- Location
- Online
Cancer immunotherapy : immune suppression and tumor growth
https://libcat.nshealth.ca/en/permalink/provcat27591
Pendergast, George C.
--Amsterdam, Netherlands:
Elsevier Academic Press
, 2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Pendergast, George C
- Other Authors
- Jaffee, Elizabeth M
- Place of Publication
- Amsterdam, Netherlands
- Publisher
- Elsevier Academic Press
- Date of Publication
- 2007
- Physical Description
- 409 p.
- ISBN
- 9780080521855
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Immunotherapy
- Neoplasms - therapy
- Contents
- Cancer immunoediting: from immune surveillance to immune escape / Ryungsa Kim -- Immunosurveillance: innate and adaptive antitumor immunity / Masahisa Jinushi and Glenn Dranoff -- Cytokine regulation of immune tolerance to tumors / Ming O. Li and Richard A. Flavell -- Immunological sculpting: natural killer cell receptors and ligands / David A. Sallman and Julie Y. Djeu -- Immune escape: immunosuppressive networks / Shuang Wei, Alfred Chang, and Weiping Zou -- Cytotoxic chemotherapy in clinical treatment of cancer / Rajesh Thirumaran, George C. Prendergast, and Paul B. Gilman -- Targeted therapeutics in cancer treatment / Colin D. Weekes and Manuel Hidalgo -- Concepts in pharmacology and toxicology / Richard A. Westhouse and Bruce D. Car -- Cancer immunotherapy: challenges and opportunities / Andrew J. Lepisto, John R. McKolanis, and Olivera J. Finn -- Cancer vaccines / Freda K. Stevenson ... [et al.] -- Immunotherapy and cancer therapeutics: why partner? / Leisha A. Emens and Elizabeth M. Jaffee -- Immune stimulatory features of classical chemotherapy / Robbert G. van der Most, Anna K. Nowak, and Richard A. Lake -- Dendritic cells and coregulatory signals: immune checkpoint blockade to stimulate immunotherapy / Drew Pardoll -- Regulatory T cells in tumor immunity: role of toll-like receptors / Rong-Fu Wang -- Tumor-associated macrophages in cancer growth and progression / Alberto Mantovani, Paola Allavena and Antonio Sica -- Tumor-associated myeloid-derived suppressor cells / Stephanie K. Bunt ... [et al.] -- Programmed death ligand-1 and galectin-1: pieces in the puzzle of tumor-immune escape / Gabriel A. Rabinovich and Thomas F. Gajewski -- Indoleamine 2,3-dioxygenase in immune escape: regulation and therapeutic inhibition / Alexander J. Muller and George C. Prendergast -- Arginase, nitric oxide synthase, and novel inhibitors of L-arginine metabolism in immune modulation / Susanna Mandruzzato, Simone Mocellin, and Vincenzo Bronte.
- Format
- e-Book
- Location
- Online
Cancer immunotherapy meets oncology : in honor of Christoph Huber
https://libcat.nshealth.ca/en/permalink/provcat33730
Cedrik Michael Britten, Sebastian Kreiter, Mustafa Diken, Hans-Georg Rammensee, editors.
--Heidelberg:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical developmen…
- Available Online
- View e-Book
- Other Authors
- Britten, Cedrik Michael
- Huber, Christoph
- Responsibility
- Cedrik Michael Britten, Sebastian Kreiter, Mustafa Diken, Hans-Georg Rammensee, editors
- Place of Publication
- Heidelberg
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (ix, 248 pages)
- ISBN
- 9783319051048 (electronic bk.)
- 9783319051031
- Subjects (LCSH)
- Cancer - Immunotherapy
- Oncology
- Cancer Research
- Pharmacology/Toxicology
- Immunology
- Abstract
- This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
- Contents
- Part I. Immunological and Regulatory Framework for Immuno-oncology -- From Basic Immunology to New Therapies for Cancer Patients -- How T Cells Single Out Tumor Cells: "And That Has Made All the Difference" -- Effects of Regulatory T Cell-Dendritic Cell Interactions on Adaptive Immune Responses -- Evolution of the Regulatory Landscape for Immunomodulatory Compounds and Personalized Therapeutic Cancer Vaccines -- Immunoguiding, the Final Frontier in the Immunotherapy of Cancer -- Developing Cancer Immunotherapies as Drugs: Setting the Stage Through Methodological Progress -- Part II. Immunotherapies -- Reflections on Cancer Vaccines -- Dendritic Cell-Based Cancer Vaccines -- mRNA Vaccination and Personalized Cancer Therapy -- Antibody Therapy in Oncology -- Bispecific Antibodies for the Treatment of Cancer: The Challenges of Translation -- The ABCs of T Cell Receptor Gene Therapy -- The Express Drivers: Chimeric Antigen Receptor-Redirected T Cells Make It to the Clinic -- Part III. Cancer Entities -- Immunotherapy of Malignant Melanoma -- Prostate Cancer Vaccines Generated with the Disruptive RNActive® Technology Follow the Path Paved by Sipuleucel-T and Prostvac-VF -- Recent Developments in the Active Immunotherapy of Renal Cell Cancer -- Current Status of Immunotherapy in Gastroesophageal Cancer -- Non-small Cell Lung Cancer, NSCLC -- Towards More Specificity and Effectivity in the Antileukemia Immune Response -- Part IV. Biomarkers -- Molecular and Metabolic Cues of the Key-Lock Paradigm Dictating Immunogenic Cell Death -- Pathogenesis of Minimal Residual Disease: CTCs as Novel Biomarkers in Cancer Disease -- Genomics Meets Cancer Immunotherapy -- Part V. Featured Chapters -- Oncolytic Viruses -- Part VI. Final Remarks -- Final Words.
- Format
- e-Book
- Location
- Online
Cannabis in Medicine : An Evidence-Based Approach
https://libcat.nshealth.ca/en/permalink/provcat45327
Kenneth Finn, editor.
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
Legalization of marijuana is becoming increasingly prominent in the United States and around the world. While there is some discussion of the relationship between marijuana and overall health, a comprehensive resource that outlines the medical literature for several organ systems, as well as non-medical societal effects, has yet to be seen. While all physicians strive to practice evidence-based medicine, many clinicians aren't aware of the facts surrounding cannabis and are guided by public opi…
- Available Online
- View e-Book
- Other Authors
- Finn, Kenneth
- Responsibility
- Kenneth Finn, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (xxxi, 554 p.) : 39 illus., 32 illus. in color
- ISBN
- 9783030459680
- 9783030459673 (Print ed.)
- 9783030459697 (Print ed.)
- Subjects (MeSH)
- Cannabinoids - pharmacology
- Cannabinoids - therapeutic use
- Medical Marijuana - therapeutic use
- Specialty
- Pharmacology
- Abstract
- Legalization of marijuana is becoming increasingly prominent in the United States and around the world. While there is some discussion of the relationship between marijuana and overall health, a comprehensive resource that outlines the medical literature for several organ systems, as well as non-medical societal effects, has yet to be seen. While all physicians strive to practice evidence-based medicine, many clinicians aren't aware of the facts surrounding cannabis and are guided by public opinion. This first of its kind book is a comprehensive compilation of multiple facets of cannabis recommendation, use and effects from a variety of different perspectives. Comprised of chapters dedicated to separate fields of medicine, this evidence-based guide outlines the current data, or lack thereof, as well as the need for further study. The book begins with a general overview of the neurobiology and pharmacology of THC and hemp. It then delves into various medical concerns that plague specific disciplines of medicine such as psychiatry, cardiology, gastrointestinal and neurology, among others. The end of the book focuses on non-medical concerns such as public health and safety, driving impairment and legal implications. Comprised of case studies and meta-analyses, Cannabis in Medicine: An Evidence-Based Approach provides clinicians with with a concise, evidence-based guide to various health concerns related to the use of marijuana. By addressing non-medical concerns, this book is also a useful resource for professionals working in the public health and legal fields.
- Contents
- Forward: Losing Ground: The Rise of Cannabis Culture -- Part I. Basic Science -- 1. The Properties and Use of Cannabis Sativa Herb and Extracts -- 2. Cannabinoid and Marijuana Neurobiology -- 3. The Pharmacodynamics, Pharmacokinetics, and Potential Drug Interactions of Cannabinoids -- Part II. Clinical Evidence -- 4. Cannabis and Neuropsychiatric Effects -- 5. Cannabis and the Impact on the Pediatric and Adolescent Population -- 6. Acute Emergency Department Presentations Related to Cannabis -- 7. Evidence of Cannabinoids in Pain -- 8. Cannabis in Pulmonary Medicine -- 9. Clinical Cardiovascular Effects of Cannabis Use -- 10. Cannabinoids in Neurologic Conditions -- 11. Ocular Conditions and the Endocannabinoid System -- 12. Cannabis in Oncology and Symptom Management -- 13. Cannabis in Palliative Medicine -- 14. Cannabis in Older Persons -- 15. Cannabinoids in Dermatology -- 16. Fetal and Neonatal Marijuana Exposure -- 17. Cannabinoids in Gastrointestinal Disorders -- 18. Looking at Marijuana Through the Lens of Public Health -- 19. Cannabis-Impaired Driving: Evidence and the Role of Toxicology Testing -- 20. The Legal Aspects of Marijuana as Medicine -- Epilogue: Epilogue: The Medical Cannabis Landscape.
- Format
- e-Book
- Location
- Online
Cardiovascular toxicology
https://libcat.nshealth.ca/en/permalink/provcat19037
- Available Online
- View e-Journal
- Publisher
- Springer
- Holdings
- Vol 1, 2001 -
- Publication Frequency
- Quarterly
- ISSN
- 1559-0259
- Specialty
- Cardiology
- Toxicology
- Format
- e-Journal
- Location
- Online
Casarett and Doull's essentials of toxicology
https://libcat.nshealth.ca/en/permalink/provcat25509
editors, Curtis D. Klassen, John B. Watkins.
(2nd ed.)
--New York, NY:
McGraw-Hill
, c2010.
- Call Number
- QV 600 C335 2010
- Location
- Halifax Infirmary
- Dickson Building
- Call Number
- QV 600 C335 2010
- Other Authors
- Klassen, Curtis D
- Watkins, John B
- Responsibility
- editors, Curtis D. Klassen, John B. Watkins
- Edition
- 2nd ed.
- Place of Publication
- New York, NY
- Publisher
- McGraw-Hill
- Date of Publication
- c2010
- Physical Description
- 459 p.
- ISBN
- 9780071622400
- Subjects (MeSH)
- Poisons - toxicity
- Toxicology
- Format
- Book
- Location
- Halifax Infirmary
- Dickson Building
- Copies
- 2
- Loan Period
- 3 weeks
Casarett and Doull's essentials of toxicology
https://libcat.nshealth.ca/en/permalink/provcat26041
editors, Curtis D. Klassen, John B. Watkins.
(2nd ed.)
--New York, NY:
McGraw-Hill
, c2010.
- Call Number
- QV 600 C335 2010 REF
- Location
- Halifax Infirmary
- Dickson Building
- Sub-Location
- REFERENCE
- Call Number
- QV 600 C335 2010 REF
- Other Authors
- Klassen, Curtis D
- Watkins, John B
- Responsibility
- editors, Curtis D. Klassen, John B. Watkins
- Edition
- 2nd ed.
- Place of Publication
- New York, NY
- Publisher
- McGraw-Hill
- Date of Publication
- c2010
- Physical Description
- 459 p.
- ISBN
- 9780071622400
- Subjects (MeSH)
- Poisons - toxicity
- Toxicology
- Format
- Book
- Location
- Halifax Infirmary
- Dickson Building
- Sub-Location
- REFERENCE
- Copies
- 2
- Loan Period
- In library use
