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Chromosomal Instability in Cancer Cells

https://libcat.nshealth.ca/en/permalink/provcat39360
B. Michael Ghadimi, Thomas Ried, editors. (1st ed.) --Cham: Springer , c2015.
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This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which chan…
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Other Authors
Ghadimi, B. Michael
Ried, Thomas
Responsibility
B. Michael Ghadimi, Thomas Ried, editors
Edition
1st ed.
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (vii, 224 p. : 39 illus. in color)
Series Vol.
200
Series Title
Recent results in cancer research
ISBN
9783319202914
9783319202907 (print ed.)
ISSN
0080-0015
Subjects (MeSH)
Aneuploidy
Chromosomal Instability - genetics
Gene Expression Regulation, Neoplastic - genetics
Neoplasms - genetics
Translocation, Genetic
Abstract
This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
Contents
DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The Diverse Effects of Complex Chromosome Rearrangements and Chromothripsis in Cancer Development. -- Consequences of Aneuploidy in Cancer: Transcriptome and Beyond.
Format
e-Book
Location
Online
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Encyclopedia of AIDS

https://libcat.nshealth.ca/en/permalink/provcat43085
Thomas J. Hope, Douglas D. Richman, Mario Stevenson, editors-in-chief. --New York, NY: Springer , c2018.
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For the first time, the world's experts in HIV-AIDS have come together to publish the Encyclopedia of AIDS. The work features over 4,000 A-Z entries including medical, cultural, social, and pharmacological essays. The Pathology entries cover the various types of HIV-related illnesses, including those that are and are not AIDS-defining. Many of the conditions that are AIDS-defining illnesses have their own entries or are cross-referenced to a generic entry in which several related conditions are…
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Other Authors
Hope, Thomas J.
Richman, Douglas D.
Stevenson, Mario
Responsibility
Thomas J. Hope, Douglas D. Richman, Mario Stevenson, editors-in-chief
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (ix, 2192 p.) : 341 illus., 305 illus. in color
Series Title
Springer reference
ISBN
9781493971015
9781493971008 (print ed.)
Subjects (MeSH)
Acquired Immunodeficiency Syndrome
Specialty
Infectious Disease Medicine
Notes
"eReference"--Publisher.
Abstract
For the first time, the world's experts in HIV-AIDS have come together to publish the Encyclopedia of AIDS. The work features over 4,000 A-Z entries including medical, cultural, social, and pharmacological essays. The Pathology entries cover the various types of HIV-related illnesses, including those that are and are not AIDS-defining. Many of the conditions that are AIDS-defining illnesses have their own entries or are cross-referenced to a generic entry in which several related conditions are discussed (such as enteric diseases and fungal infections). Typically, the treatment of any given form of pathology is briefly discussed in the entry that covers that illness. The reference is a must-read for Infectious Disease specialists, Immunologists, Public Health researchers, Virologists, Microbiologists, Pharmacologists, and Physicians.
Contents
Abstinence, Be Faithful, Condoms (ABC), Prevention of HIV -- Acetylation -- Actin -- AIDS-related -- Primary Central Nervous System Lymphoma -- Anal Cancer -- Anatomic Compartments as a Barrier to HIV Cure -- Antiretroviral Drug Penetration into Lymphoid Tissue -- Antiretroviral Drug Penetration into the CNS Compartment -- Antiretroviral Medications, Adult Care and Treatment -- Antiretroviral therapy (ART), Prevention of HIV -- Anti-Retroviral Therapy and Drug Resistance in HIV-2 Infection -- Antiretroviral Therapy for HIV-Infected Infants, Children, and Adolescents in Resource-Rich Settings -- Antiretroviral Therapy: When to Start -- Antiretroviral Treatment in Resource-Limited Settings -- APOBEC3F/G and Vif: Action and Counteractions -- Apoptosis Dysregulation during HIV Disease -- Arp2/3 -- Attachment/Binding -- Autophagy and HIV Infection -- Bacterial Respiratory and Invasive Pneumococcal Infections and HIV -- BAF (BANF1) -- Behavioral Aspects of HIV Mother-to-Child Transmission -- Behavioral Aspects of HIV Treatment as Prevention -- Behavioral Interventions for Adherence -- Behavioral Science highlights of evidence and research -- Blood and blood product donors and recipients in China, Epidemiology of HIV/AIDS -- Budding -- Burkitt and Burkitt-like Lymphoma -- Cardiovascular Complications -- cART and Supportive Care for HIV-Associated Malignancies -- Case Management for Linkage -- Cell Intrinsic Immunity -- Cellular and Soluble Immune Activation Markers in HIV-Infected Subjects -- Cellular Cofactors for HIV-1 Transcription -- Cellular Cofactors of HIV as Drug Targets -- Central Memory CD4 T cells -- Cervical Cancer and HIV -- Chagas Disease and HIV -- Children, Care and Treatment -- Children, Epidemiology of HIV/AIDS -- Chronic Immune Activation in HIV -- Circumcision and AIDS -- Clinical Ethics in HIV/AIDS Prevention, Care, and Research -- Cofilin, Trafficking -- Collagen Deposition and Fibrosis in the Lymphatic Tissues of HIV-1 Infected Individuals -- Combination Approaches to HIV Prevention -- Community Viral Load -- Co-morbidity: Opiods -- Comorbidity: Progressive Multifocal Leukoencephalopathy -- Conjunctival Carcinoma -- Counteraction of SAMHD1 by Vpx -- Chromosome Region Maintenance 1 (CRM1) -- Cryptococcosis and HIV -- Cryptosporidiosis -- Epidemic Kaposi Sarcoma, Pathogenesis and Presentation of -- CXCR4, Coreceptors -- Cyclophilin A and HIV-1 Replication -- Cystoisosporiasis -- Cytomegalovirus Infection and HIV -- DDX3, Cofactors, and RNA Export -- Delayed Sexual Debut -- Dendritic Cell Interactions with HIV-1 Envelope Glycoprotein, Implications for Preventing Transmission -- Differential Diagnosis of HIV-Associated Neurocognitive Disorders -- Diffuse Large B-Cell Lymphoma -- Eastern Europe and Central Asia, specific characteristics of HIV/AIDS epidemic -- Elderly: Epidemiology of HIV/AIDS -- Entry Inhibitors -- Epidemiology of AIDS-Defining Malignancies -- Epidemiology of HIV-2 Infection in West Africa -- Epidemiology of Non-AIDS-Defining Malignancies -- Epstein Barr Virus (EBV) -- Faith Based Interventions -- Family Interventions -- Female Condoms -- Female, Male and Transgender Sex Workers, Epidemiology of HIV/AIDS -- Fusion -- Gamma delta T cells -- Global NeuroAIDS -- HAND Adjunctive Therapies: Reversing Neuronal Injury -- Harm Reduction for Injection Drug Users -- Health care workers, Epidemiology of HIV/AIDS -- Health care workers, Shortage and task shifting of -- Hepatitis B Virus infection and HIV -- Hepatitis C Virus Infection and HIV -- Hepatocellular Carcinoma in HIV-Positive Patients -- History of the AIDS epidemic -- HIV "auxiliary" proteins, essential role of -- HIV & SIV, CD4 T cell responses to -- HIV and Opportunistic Infections, an Overview -- HIV and Sexual Violence -- HIV and SIV, B-Cell Responses to -- HIV and SIV, CD8 T Cell Responses to -- HIV Antigen Processing and Presentation -- HIV Associated Immune Exhaustion -- HIV Cancers in Resource-Limited Regions -- HIV Compartments and Viral Rebound During Treatment Interruption -- HIV Coreceptor Tropism in Different Reservoirs -- HIV Counseling and Testing, Prevention of HIV -- HIV Funding agencies and major programs -- HIV Infection, Immune-based Interventions for -- HIV Life Cycle: Overview -- HIV Neurocognitive Diagnosis, Natural History and Treatment -- HIV Prevention and African Americans -- HIV Prevention and Asians and Pacific Islanders -- HIV Prevention and Hispanics -- HIV Prevention and Labor Migration -- HIV Prevention and Women -- HIV Prevention Efforts Within Substance Use Disorder Treatment Settings -- HIV Prevention for MSM -- HIV Prevention for Serodiscordant Couples -- HIV Prevention for Stimulant Using Men Who have Sex with Men -- HIV Prevention in Persons 50 and Older -- HIV Prevention in the Correctional System -- HIV Prevention in Transgender Persons -- HIV Prevention in Youth -- HIV Reservoirs in Lymph Nodes and Spleen -- HIV Reservoirs in the Central Nervous System -- HIV Reservoirs Within the Lungs -- HIV Testing and Counseling -- HIV Transmission in Female Commercial Sex Workers and Host Protective Factors -- HIV-1 Assembly Cofactors -- HIV-1 Maturation -- HIV-1 Mutational Escape from Host Immunity -- HIV-1 Pathogenesis in the Gut -- HIV-1 Pre-Exposure Prophylaxis -- HIV-1 Prevention Using Live-attenuated Vaccines -- HIV-1 Rev Expression and Functions -- HIV-1 Transmission Blocking Microbicides -- HIV-1 Transmission; Influence of Bodily Secretions -- HIV-1 Virion Structure -- HIV-2 Diagnosis and Viral Load Measurements -- HIV-2 Envelope: Structure, Diversity and Evolution -- HIV-2 Infection in Europe, Epidemiology of -- HIV-2 Infection: The Role of Immune Activation in Pathogenesis -- HIV-2 Neurological Manifestations -- HIV-2 Transmission -- HIV-2: Lessons from the Dakar Cohort -- HIV-Associated Cancers -- Hodgkin Lymphoma in Patients with HIV Infection -- Host Genetics and Genomics -- Housing as HIV Prevention -- Human Papillomavirus (HPV) -- Identification and Validation of HIV Cofactors -- Identifying Opportunities to Block HIV-1 Transmission in the Female Genital Tract -- Immune Activation and HIV Transmission -- Immunogenetics of HIV-2 Infection -- Immunological Responses to Antiretroviral Therapy -- Immunology of Latent HIV Infection -- Immunopathogenesis of HIV Co-infections -- Inflammasome and HIV -- Inflammatory Cytokines -- Inhibition of HIV-1 Spread: Cell-Free Versus Cell-Cell -- Initial Antiretroviral Regimens -- Integrase Inhibitors -- Integration -- Integrin Alpha4beta7 -- Interactions Between HIV-2 and Host Restriction Factors -- Kaposi's Sarcoma-associated Herpesvirus (KSHV) or Human Herpesvirus 8 (HHV-8) -- KIR Locus Variation -- Latin America and the Caribbean, specific characteristics of HIV/AIDS epidemic -- Leishmaniasis and HIV -- Long-Acting Nanoformulated Antiretroviral Therapy -- Long-Term Nonprogressors and Elite Controllers -- Lung Cancer -- M. avium Complex and Other Nontuberculous Mycobacteria and HIV -- Macrophages in HIV Immunopathogenesis -- Macrophage-Specific Aspects of HIV-1 Infection -- Male Condoms -- Malignancies in Children with HIV Infection -- Management of AIDS-related Kaposi's Sarcoma -- Mass Media and HIV Prevention -- Maturation Inhibitor -- Medical male circumcision, infant circumcision, Prevention of HIV -- Men who have sex with men (MSM), Epidemiology of HIV/AIDS -- Merkel Cell Carcinoma and Other HIV-Associated Skin Cancers -- Merkel Cell Polyomavirus (MCV) -- MHC Locus Variation -- Microbial Translocation -- Microfinance/Microenterprise Approaches to HIV Prevention -- Microsporidiosis -- Molecular Biology of HIV-2 -- Mother-to-Child Transmission of HIV-1: Role of Receptor Usage and Target Cells -- MTCT HIV-1 Transmission Update: Transmission Routes & Mechanisms -- Mucosal Immunity to HIV-1 -- Mucosal Pathogenesis in SIV Infection -- Multicentric Castleman Disease -- Multilevel Interventions/Structural Approaches to HIV Prevention -- MX2 and HIV-1 Restriction -- Natural History and Clinical Features of HIV-2 Infection -- Natural Killer Cells and Innate Immunity in HIV-2 Infection -- Natural Killer Cells and their Role in Preventing HIV-1 Transmission -- Nef/Env/Vpu/Tetherin -- Network Interventions -- NeuroAIDS in Resource-Poor Settings, Assessment, and Treatment of -- Neuro-AIDS, Immunopathogenesis of -- Neurocognitive Functioning in HIV Substance Users -- Neurocognitive Outcomes in HIV-Infected Children and Adolescents -- Neuroinflammation and HAND: Therapeutic Targeting -- Neuropsychological testing in HIV infected individuals -- Neurotoxic Consequences of Antiretroviral Therapies -- NKT Cells: Bridging Innate and Adaptive Immunity -- Nonhuman Primate Models of HIV Transmission -- Non-injecting drug users, Epidemiology of HIV/AIDS -- Non-Neutralizing Antibody Responses and Protection Against HIV-1 -- Non-Nucleoside Reverse Transcriptase Inhibitors for Treatment of HIV Infection -- Non-Pathogenic SIV Infection of Sooty Mangabeys -- Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTIs) -- Nuclear Import: HIV-1 Goes NUPs -- Nurse-Delivered Interventions for Adherence -- Origin and Distribution of HIV-1 Subtypes -- Other HPV-Associated Cancers (Oropharyngeal and Penile) -- Overcoming the Transcriptional Block: The HIV-1 Tat Auxiliary Protein -- Overview of HIV CNS Infection -- Overview: Immunopathogenesis -- Programmed Death-1 -- Peer-Based Intervention Approaches -- Phylogeographic Insights into the Origins and Epidemic History of the Human Immunodeficiency Virus Type 2 -- PIMT/TGS1 -- PKR and HIV Replication -- Plasmablastic Lymphoma -- Pneumocystis Jirovecii Infection and HIV -- Positive Health, Dignity, and Prevention (PHDP) -- Post-treatment Controllers -- Preexposure Prophylaxis (PrEP) -- Pregnant Women: Care and Treatment -- Presentation and Pathogenesis of B-Cell Lymphoid Cancers Associated with HIV Infection -- Preventing HIV-1 Transmission Through Vaccine-Induced Immune Responses -- Preventing Mother-to-Child Transmissi.
Format
e-Book
Publication Type
Encyclopedia
Location
Online
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Guide for Genetic Consultation

https://libcat.nshealth.ca/en/permalink/provcat44186
Birgit Zirn, Karl Mehnert, eds. --Cham: Springer , 2019.
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Supported by figures, tables and photos, this book illustrates the basics of genetic diagnostics, prenatal and reproductive medicine, syndromology and familial cancers. It also includes numerous illustrated examples of the most frequent genetic diseases, making it a valuable resource in genetic counselling. This book is an essential tool for genetic counsellors, paediatricians, gynaecologists and all healthcare professionals who explain genetic issues to their patients. Useful also for teaching…
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Other Authors
Zirn, Birgit
Mehnert, Karl
Responsibility
Birgit Zirn, Karl Mehnert, eds.
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (v, 187 p.) : 97 illus., 87 illus. in color
ISBN
9783030043452
9783030043445 (Print ed.)
9783030043469 (Print ed.)
Subjects (MeSH)
Genetic Counseling
Genetic Diseases, Inborn
Specialty
Genetics, Medical
Reproductive Medicine
Abstract
Supported by figures, tables and photos, this book illustrates the basics of genetic diagnostics, prenatal and reproductive medicine, syndromology and familial cancers. It also includes numerous illustrated examples of the most frequent genetic diseases, making it a valuable resource in genetic counselling. This book is an essential tool for genetic counsellors, paediatricians, gynaecologists and all healthcare professionals who explain genetic issues to their patients. Useful also for teaching students.
Contents
A. Basic Principles -- 1. Chromosomes, genes and proteins -- 2. Chromosome analysis -- 3. FISH -- 4. Array CGH -- 5. Gene analysis --- 6. Sequencing: Sanger and NGS -- B. Cytogenetics -- 7. Female karyotype (46,XX) -- 8. Male karyotype (46,XY) -- 9. Gamete formation and nondisjunction -- 10. Trisomy 21 (Down syndrome) -- 11. Trisomy 13/18 -- 12. Klinefelter syndrome -- 13. Turner syndrome -- 14. Triple X syndrome -- 15. Triploidy -- 16. Reciprocal translocation -- 17. Robertsonian translocation -- C. Prenatal Diagnostics -- 18. Background risk -- 19. Maternal age risk -- 20. Chorionic villus sampling (CVS) -- 21. Amniocentesis (AC) -- 22. Noninvasive prenatal testing (NIPT) -- 23. Chromosome abnormalities: pregnancy and birth (iceberg) -- D. Inheritance Patterns -- 24. Autosomal dominant inheritance -- 25. Autosomal recessive inheritance -- 26. X-linked inheritance -- 27. Mitochondrial inheritance -- 28. Germline mosaicism -- E. Reproduction -- 29. Recurrent pregnancy loss -- 30. Pregnancy: ovulation to implantation -- 31. IVF and ICSI -- 32. Polar body diagnosis and preimplantation diagnosis -- 33. Consanguineous marriage -- F. Cancer -- 34. How does cancer develop? -- 35. Bowel cancer -- 36. Breast and ovarian cancer -- G. Common Disorders -- 37. Developmental disorders -- 38. Fragile X syndrome -- 39. Prader-Willi syndrome -- 40. Angelman syndrome -- 41. Noonan syndrome -- 42. Microdeletion syndrome 22q11 -- 43. Neurofibromatosis -- 44. Marfan syndrome -- 45. Cystic fibrosis -- 46. Metabolic disorders -- 47. Myotonic dystrophy type 1 -- 48. Huntington disease -- 49. Haemophilia -- 50. Thrombophilia.
Format
e-Book
Publication Type
Handbook
Location
Online
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The Kidney : A Comprehensive Guide to Pathologic Diagnosis and Management

https://libcat.nshealth.ca/en/permalink/provcat39713
Donna E. Hansel, Christopher J. Kane, Gladell P. Paner, Sam S. Chang, editors. (1st ed.) --New York, NY: Springer , c2016.
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This volume provides a practical, comprehensive overview on benign and malignant disease of the adult kidney. The text addresses the topic of assessment and management of patients with surgical renal disease. Within this scope, it includes hereditary and spontaneous renal neoplasms, as well as non-neoplastic disease that manifests as a clinically relevant mass. The book is organized into chapters focusing on discrete disease entities and incorporating pathology, surgical management, oncologic t…
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Other Authors
Hansel, Donna E
Kane, Christopher J
Paner, Gladell P
Chang, Sam S
Responsibility
Donna E. Hansel, Christopher J. Kane, Gladell P. Paner, Sam S. Chang, editors
Edition
1st ed.
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (ix, 215 p. : 153 illus., 143 illus. in color)
ISBN
9781493932863
9781493932856 (print ed.)
Subjects (MeSH)
Kidney Diseases - diagnosis
Kidney Diseases - therapy
Kidney Neoplasms - diagnosis
Kidney Neoplasms - therapy
Kidney - pathology
Abstract
This volume provides a practical, comprehensive overview on benign and malignant disease of the adult kidney. The text addresses the topic of assessment and management of patients with surgical renal disease. Within this scope, it includes hereditary and spontaneous renal neoplasms, as well as non-neoplastic disease that manifests as a clinically relevant mass. The book is organized into chapters focusing on discrete disease entities and incorporating pathology, surgical management, oncologic therapy, radiologic findings, and molecular alterations. This text is designed to address relevant areas of clinical management of renal neoplastic and non-neoplastic disease across multiple specialties and levels of training. Written by experts in the field, The Kidney: A Comprehensive Guide to Pathologic Diagnosis and Management is a valuable resource on the diagnosis and management of patients with not only renal cell carcinoma, but also other renal processes that require surgical intervention.
Contents
Embryology, Anatomy and Histology of the Kidney -- Polycystic Kidney Disease -- Non-Neoplastic Disease Presenting as a Renal Lesion -- Overview and Staging of Renal Neoplasms -- Conventional Forms of Renal Neoplasia -- Familial Forms of Renal Cell Carcinoma and Associated Syndromes -- Translocation-Associated Carcinoma -- Collecting Duct Carcinoma and Renal Medullary Carcinoma -- Emerging and Recently Described Subtypes of Renal Carcinoma -- Non-Epithelial Renal Neoplasms of the Adult Kidney -- Pediatric Renal Neoplasms -- Glomerular Disease -- Non-Neoplastic Kidney Diseases in the Setting of a Renal Mass.
Format
e-Book
Location
Online
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L-Arginine in Clinical Nutrition

https://libcat.nshealth.ca/en/permalink/provcat41276
Vinood B. Patel, Victor R. Preedy, Rajkumar Rajendram, editors. --Cham: Humana Press , 2017.
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This text presents the application of current nutritional knowledge by physicians and incorporates emerging fields of science and important discoveries. Written by authors of international and national standing, leaders in the field and trendsetters, Arginine in Clinical Nutrition is essential reading for nutritionists and dietitians, public health scientists, doctors, epidemiologists, health care professionals of various disciplines, policy makers and marketing and economic strategists.
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Other Authors
Patel, Vinood B
Preedy, Victor R
Rajendram, Rajkumar
Responsibility
Vinood B. Patel, Victor R. Preedy, Rajkumar Rajendram, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
2017
Physical Description
1 online resource (xxx, 645 pages) : 215 illus., 112 illus. in color
Series
Nutrition and Health
Series Title
Nutrition and health (Totowa, N.J.)
ISBN
9783319260099
9783319260075 (print ed.)
Subjects (MeSH)
Arginine - therapeutic use
Abstract
This text presents the application of current nutritional knowledge by physicians and incorporates emerging fields of science and important discoveries. Written by authors of international and national standing, leaders in the field and trendsetters, Arginine in Clinical Nutrition is essential reading for nutritionists and dietitians, public health scientists, doctors, epidemiologists, health care professionals of various disciplines, policy makers and marketing and economic strategists.
Contents
Part I. Basic Processes at the Cellular Levels -- Arginine uptake by cells -- L-arginine and the expression of HSP70 and p-53 proteins -- AMP-activated protein kinase and L-arginine -- Amidine-based compounds affecting arginine metabolism -- Oxy- and sulfoanalogues of L-arginine -- Regulation of expression and activity of L-arginine transporters by nutrients and hormones: A focus in transcriptional mechanisms regulated by glucose and insulin -- Arginine, pancreatic beta cell function and diabetes: mechanisms of stimulated insulin release and pathways of metabolism -- Erythrocytes by-products of arginine catabolism -- Part II.: Arginine Metabolism and Functions -- Arginine synthesis from enteral proline -- Arginine and macrophages: role in classical and alternative activation -- Arginine and TNF alpha production in macrophages: a focus on metabolism, ageing, metabolic syndrome and type 2 diabetes -- Arginine metabolism impairment during sepsis and diseases: causes and consequences -- Use of arginine with Growth Hormone Releasing Hormone (GHRH) and the endocrine response -- Serum arginase in healthy subjects and nitric oxide -- Part III. Arginine Status in Cells Related to Organ Damage and Disease -- Protein Arginine Methylation of RNA-binding Proteins and Their Impact on Human Diseases -- DNA-arginine adducts and implications in disease -- Homoarginine and L-arginine: Glycine amidinotransferase in stroke -- The L-arginine/asymmetric dimethylarginine (ADMA) ratio in health and disease: an overview -- Arginine and its transporters in colorectal cancer -- Arginine Uptake and Its Role in the Survival of Breast Cancer Cells -- Part IV: Arginine Status and Use in Healthy Individuals -- Arginine production during pregnancy -- L-arginine in the uterus and placenta and during gestation in mammals -- Oral L-arginine supplementation in young males: endocrinology, metabolic, and physiological responses at rest and during exercise -- Metabolic precursors of L-Arginine supplementation in sport: a focus on L-Citrulline and L-Ornithine -- Part V. Arginine and Diseases of the Gastrointestinal Tract -- Arginine and its use in ameliorating Cryptosporidium parvum infection in undernourished children -- Arginine and Inflammatory Bowel Disease (IBD) -- Dietary L-arginine and intestinal recovery -- Enteral and parenteral arginine supplementation in intestinal ischemia and reperfusion injury -- Mucosal Protection by Arginine in the Upper Gastrointestinal Tract -- Enteral L-arginine and necrotizing enterocolitis -- Part VI. Therapeutic uses of Arginine: Diabetes, Obesity and Cardiovascular Diseases -- L-arginine usage in Type I diabetes: From the autoimmune event to human dietary supplementation -- Oral l-arginine supplementation and glucose metabolism and vascular function -- Arginine enriched apples and diabetic control -- Beneficial impact of cod protein, arginine and other amino acids on insulin sensitivity -- Obese subjects and supplemental L-arginine -- Mitochondrial cardiomyopathy and usage of L-arginine -- Arginine Measurement and Concentrations in Hypertension and other Cardiovascular Disease -- L-Arginine and cardiovascular disease -- Arginine therapy in sickle cell disease -- Part VII. Therapeutic Uses of Arginine: Cancer, Wound Healing and Infectious Disease -- Role of arginine in surgical patients with head and neck cancer -- Arginine-Incorporated Albumin Mesospheres: A Drug Delivery System for Cancer Therapy -- Use of L-arginine and glycine supplementation to reduce radiotherapy damage -- Arginine in Cancer Therapy -- Mechanisms of Arginine-Auxotrophic Response and Their Cancer Therapeutic Implications -- The role of arginine in wound healing -- L-arginine and bacterial translocation: implications for health -- L-arginine in Pulmonary Tuberculosis -- Arginine in Health and Disease: Recommended Resources and Further Reading.
Format
e-Book
Location
Online
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Management of macular hemorrhage

https://libcat.nshealth.ca/en/permalink/provcat42902
edited by Lars-Olof Hattenbach. --Cham: Springer , c2018.
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Sub- or preretinal hemorrhage involving the macula is a typical complication in a variety of ocular diseases, including age-related macular degeneration, arterial macroaneurysm, Valsalva retinopathy, and trauma. However, there is currently no consensus regarding the ideal treatment for macular hemorrhage. The purpose of this book on macular hemorrhage is twofold: it aims both to impart valuable information on pathophysiology, risk factors, diagnostic aspects, and prognostic criteria under diff…
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Other Authors
Hattenbach, Lars-Olof
Responsibility
edited by Lars-Olof Hattenbach
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (ix, 96 p.) : 81 illus., 75 illus. in color
ISBN
9783319658773
9783319658759 (print ed.)
9783319658766 (print ed.)
Subjects (MeSH)
Retinal Hemorrhage - therapy
Specialty
Ophthalmology
Abstract
Sub- or preretinal hemorrhage involving the macula is a typical complication in a variety of ocular diseases, including age-related macular degeneration, arterial macroaneurysm, Valsalva retinopathy, and trauma. However, there is currently no consensus regarding the ideal treatment for macular hemorrhage. The purpose of this book on macular hemorrhage is twofold: it aims both to impart valuable information on pathophysiology, risk factors, diagnostic aspects, and prognostic criteria under different conditions and to provide a systematic overview of therapeutic approaches that cover the most important situations a vitreoretinal surgeon might encounter when treating patients with this disorder.
Contents
Types of Macular Hemorrhages and Clinical Appearance -- Macular Hemorrhage: Natural Course and Risk Factors -- Classification of Subretinal Hemorrhage -- The Pathophysiology of Subretinal Hemorrhage -- Anti-VEGF and Fibrinolytic Agents for the Management of Subretinal Hemorrhage -- Minimally Invasive Surgical Approaches to the Management of Macular Hemorrhages -- Surgical Treatment of Massive Subretinal Hemorrhage -- Macular Translocation in Submacular Hemorrhage Secondary to Age-Related Macular Degeneration -- Retinal Pigment Epithelium and Choroid Translocation in Massive Submacular Hemorrhage -- Surgical and Nonsurgical Treatment of Pre-Retinal Hemorrhages -- Management of Trauma Associated Macular Hemorrhages.
Format
e-Book
Location
Online
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Practical Handbook for Small-Gauge Vitrectomy : A Step-By-Step Introduction to Surgical Techniques

https://libcat.nshealth.ca/en/permalink/provcat42667
Ulrich Spandau, Heinrich Heimann. (Second edition) --Cham: Springer , c2018.
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Since publication of the first edition of this book in 2012 vitreoretinal surgery has marched with huge steps forward. In 2012 23G was standard, today 25G and 27G are the most commonly used gauge sizes for vitrectomy. In 2012 the cutting rate was 5.000 cuts/min and today with the development of a novel vitreous cutter the cutting rate has increased to 16.000 cuts/min. The advent of 25G/27G made the instruments smaller and surgery less traumatic. Practical Handbook for Small-Gauge Vitrectomy: A …
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Author
Spandau, Ulrich
Other Authors
Heimann, Heinrich
Responsibility
Ulrich Spandau, Heinrich Heimann
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xxvii, 387 p.) : 384 illus., 363 illus. in color
ISBN
9783319896779
9783319896762 (print ed.)
9783319896786 (print ed.)
9783030078294 (print ed.)
Subjects (MeSH)
Eye Injuries - surgery
Retinal Diseases - surgery
Suture Techniques
Vitrectomy - methods
Vitreous Body - surgery
Specialty
Ophthalmology
Surgical Procedures, Operative
Abstract
Since publication of the first edition of this book in 2012 vitreoretinal surgery has marched with huge steps forward. In 2012 23G was standard, today 25G and 27G are the most commonly used gauge sizes for vitrectomy. In 2012 the cutting rate was 5.000 cuts/min and today with the development of a novel vitreous cutter the cutting rate has increased to 16.000 cuts/min. The advent of 25G/27G made the instruments smaller and surgery less traumatic. Practical Handbook for Small-Gauge Vitrectomy: A Step-By-Step Introduction to Surgical Techniques, 2nd Edition focuses on these new developments and features new chapters on PVR detachment, intraocular tumour, macular translocation, sub macular hemorrhages and ocular trauma. The surgeries are demonstrated step-by-step and the material is shown in detail and videos visualize the surgery.This book will serve as an immensely useful guide for all surgeons who are intending to make use of this exciting and increasingly used technique.
Contents
Part I. Introduction to Small-Gauge Vitrectomy -- 1. Introduction to Small-Gauge Vitrectomy -- Part II. Equipment -- 2. Equipment -- Part III. Fundamentals of Pars Plana Vitrectomy -- 3. Fundamentals to Pars Plana Vitrectomy -- 4. Pars Plana Vitrectomy for Beginners -- Part IV. Silicone Oil Injection and Removal -- 5. Silicone Oil Tamponade -- 6. Silicone Oil, Densiron 68®, and Oxane Hd® Removal -- Part V. Macular Peeling -- 7. Vitrectomy for Macular Peeling -- Part VI. Secondary IOL Implantation 8. Dislocated IOL Extraction and Secondary IOL Implantation -- Part VII. Dropped Nucleus -- 9. Dropped Nucleus (Posterior Dislocated Nucleus) -- Part VIII. Retinal Detachment -- 10. Usage of a Chandelier Light -- 11. Episcleral Buckling for Detachment Surgery with BIOM -- 12. Vitrectomy for Easy Retinal Detachment -- 13. Vitrectomy for Difficult Retinal Detachment (PVR) -- Part IX. Diabetic Retinopathy -- 14. Easy Proliferative Diabetic Retinopathy -- 15. Difficult Proliferative Diabetic Retinopathy -- Part X. Submacular Hemorrhage -- 16. Submacular Hemorrhage Secondary to CNV -- 17. Submacular Hemorrhage Secondary to Arterial Macroaneurysm -- Part XI. Endophthalmitis and Intraocular Tumor Biopsy -- 18. Endophthalmitis -- 19. Intraocular Tumor Biopsies -- Part XII. Macular Translocation and Choroidal Detachment -- 20. Macular Translocation -- 21. Choroidal Detachment: Surgical Management of a Serous Choroidal Detachment -- Part XIII. Trauma -- 22. Open Globe Injury -- 23. Surgical Management of a Suprachoroidal Hemorrhage (SCH) -- 24. Penetrating Eye Injury by Metal Intraocular Foreign Bodies (IOFB): Delayed and Stepwise Surgery -- 25. FAQ.
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e-Book
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Precision Molecular Pathology of Lung Cancer

https://libcat.nshealth.ca/en/permalink/provcat43227
Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier, Eric H. Bernicker, editors. (Second edition) --Cham: Springer , c2018.
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This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, …
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Other Authors
Cagle, Philip T.
Responsibility
Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier, Eric H. Bernicker, editors
Edition
Second edition
Former Title
Molecular pathology of lung cancer
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 296 p.) : 57 illus., 55 illus. in color
Series Vol.
13
Series Title
Molecular pathology library
ISBN
9783319629414
9783319629407 (print ed.)
9783319629421 (print ed.)
9783319874340 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Lung Neoplasms - pathology
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Pathology, Molecular - methods
Precision Medicine - methods
Specialty
Medical Oncology
Molecular Medicine
Pathology
Pulmonary Medicine
Precision Medicine
Notes
Preceded by: Molecular pathology of lung cancer / Philip T. Cagle ... [et al.], editors. c2012.
Abstract
This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and precursor and preinvasive lesions. Authored by experts in the field, Precision Molecular Pathology of Lung Cancer, Second Edition remains one of the few books that comprehensively covers the new molecular pathology of lung cancer and is a valuable resource for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, and thoracic radiologists.
Contents
Part I. Background -- 1. Precision Medicine of Lung Cancer: Introduction -- 2. Lung Cancer Epidemiology and Demographics -- 3. Genetic Susceptibility to Lung Cancer -- 4. Lung Cancer Stem Cells -- 5. The 2015 World Health Organization Classification of Lung Cancer: Overview -- Part II. Testing Methods -- 6. Preanalytic Considerations -- 7. Mutation Testing of Lung Cancer Biomarkers -- 8. Translocation Testing of Lung Cancer Biomarkers -- 9. Immunohistochemistry of Lung Cancer Biomarkers -- 10. Next Generation and Third Generation Sequencing of lung cancer biomarkers -- Part III. Molecular Pathology of Specific Cell Types -- 11. Mutations as Predictive Biomarkers for Adenocarcinoma -- 12. Translocations as Predictive Biomarkers for Adenocarcinoma -- 13. Predictive Biomarkers for Squamous Cell Carcinoma -- 14. Molecular Pathology of Small Cell Carcinoma -- 15. Molecular Pathology of Uncommon Carcinomas -- 16. Molecular Pathology of Lung Cancer Metastases -- 17. Molecular Pathology of Precursor and Preinvasive Lesions -- Part IV. General and Emerging Fields in Molecular Pathology of Lung Cancer -- 18. Prognostic Biomarkers in Lung Cancer -- 19. Biomarkers and Differing Therapy Modalities -- 20. Immuno-oncology of Lung Cancer -- 21. Liquid Biopsy.
Format
e-Book
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Online
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Prenatal Diagnosis of Orofacial Malformations

https://libcat.nshealth.ca/en/permalink/provcat41318
Gabriele Tonni, Waldo Sepulveda, Amy E. Wong, editors. --Cham: Springer , 2017.
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This book describes how different diagnostic techniques may facilitate the prenatal identification of orofacial malformations. The role of standard two-dimensional ultrasound is documented and explained, but detailed attention is also paid to the use of three-dimensional (3D) ultrasound, including the novel 3D reslicing technique, and to the value of complementary magnetic resonance imaging. The malformations considered include cleft lip, cleft lip and palate, ocular malformations, abnormalitie…
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Other Authors
Tonni, Gabriele
Sepulveda, Waldo
Wong, Amy E
Responsibility
Gabriele Tonni, Waldo Sepulveda, Amy E. Wong, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xvii, 219 pages) : 193 illus., 154 illus. in color
ISBN
9783319325163
9783319325149 (print ed.)
Subjects (MeSH)
Fetus - abnormalities
Maxillofacial Abnormalities - diagnosis
Prenatal Diagnosis - methods
Abstract
This book describes how different diagnostic techniques may facilitate the prenatal identification of orofacial malformations. The role of standard two-dimensional ultrasound is documented and explained, but detailed attention is also paid to the use of three-dimensional (3D) ultrasound, including the novel 3D reslicing technique, and to the value of complementary magnetic resonance imaging. The malformations considered include cleft lip, cleft lip and palate, ocular malformations, abnormalities associated with fetal aneuploidy, and tumors. These conditions are depicted in numerous high-quality images accompanied by thorough and informative descriptions of imaging findings. The excellence of the illustrative material and the caliber of the authors, who are leading international experts in the field, ensure that Prenatal Diagnosis of Orofacial Malformations will be an invaluable tool for obstetricians and gynecologists.
Contents
Part I: Prenatal Diagnosis of Orofacial Malformations -- 1. Orofacial Clefts in the Fetus: What We Know and What We Should Know -- 2. The Genetics of Facial Cleft -- 3. Evaluation of the Fetal Face in the First Trimester -- 4. The Role of 2D/3D/4D Ultrasound in the Prenatal Assessment of Cleft Lip and Palate -- 5. 2D/3D/4D Ultrasound of the Fetal Face in Genetic Syndromes -- 6. Prenatal Diagnosis of Orofacial and Neck Tumors -- 7. Micrognathia -- 8. Magnetic Resonance Imaging (MRI) in the Evaluation of the Fetal Face -- 9. The Fetal Brain in Fetuses with Orofacial Abnormalities -- 10. Development and Autopsy Assessment of the Fetal Head and Face -- 11. Postnatal Management of Cleft Lip and Palate -- Part II: Interesting Cases and Rare Syndromes -- 12. Binder Syndrome: Prenatal Diagnosis, Management, and Prognosis -- 13. Atypical Facial Cleft Detected by Prenatal Scan and Confirmed by Postmortem Reconstructive Computed Tomography (CT REC) -- 14. Congenital Subcutaneous Mixed Venous-Lymphatic Orofacial Malformation Associated with Macroglossia: Prenatal Diagnosis with Ultrasound and Fetal MRI -- 15. Acromelic Frontonasal Dysplasia (Median Cleft Face Syndrome) -- 16. Prenatal Diagnosis of Severe Midfacial Hypoplasia Using 3D Ultrasound -- 17. 3D Virtual Model Reconstruction by 3D Ultrasound Volume Data Sets in a Case of Prenatally Diagnosed Agnathia/Otocephaly Complex Associated with Multiple Congenital Anomalies -- 18. Unilateral Agenesis of the Mandible (Agnathia) in a Fetus with 4p-/10q Duplication Associated with Balanced Paternal Cryptic 4p/10q Translocation: Multidisciplinary Management of a Complex Case -- 19. Prenatal Diagnosis of Beckwith-Wiedemann Syndrome Using 3D Ultrasound and Fetal MRI
Format
e-Book
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Online
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Rare Genitourinary Tumors

https://libcat.nshealth.ca/en/permalink/provcat40151
Lance Pagliaro, editor. --Cham: Springer , c2016.
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Rare Genitourinary Tumors offers the reader an up-to-date discussion of the less common neoplasms affecting the urinary tract and reproductive organs. Each authoritative chapter provides and in-depth discussion that is frequently not found in other urologic oncology textbooks. A valuable reference for urologists, oncologists, and those in specialty training, this volume provides ready access to information on etiology, incidence, risk factors, diagnosis, prognosis, insights from molecular patho…
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Other Authors
Pagliaro, Lance
Responsibility
Lance Pagliaro, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xii, 367 p. : 63 illus., 11 illus. in color)
ISBN
9783319300467
9783319300443 (print ed.)
Subjects (MeSH)
Rare Diseases
Urogenital Neoplasms
Abstract
Rare Genitourinary Tumors offers the reader an up-to-date discussion of the less common neoplasms affecting the urinary tract and reproductive organs. Each authoritative chapter provides and in-depth discussion that is frequently not found in other urologic oncology textbooks. A valuable reference for urologists, oncologists, and those in specialty training, this volume provides ready access to information on etiology, incidence, risk factors, diagnosis, prognosis, insights from molecular pathology and, where applicable, data from clinical trials. The practical treatment guidelines included for each tumor type are written by experts and fully referenced.
Contents
Papillary Renal Carcinoma -- Renal Medullary Carcinoma -- Translocation Renal Cell Carcinomas -- Primitive Neuroectodermal Tumors and Other Sarcomas of the Kidney -- Adult Wilms' Tumor -- Urothelial Carcinoma with Variant Histology: Sarcomatoid, Plasmacytoid, and Micropapillary -- Primary Sarcomas and Other Sarcomatoid Tumors of the Bladder -- Neuroendocrine and Small Cell Carcinomas of the Urinary Tract -- Urachal and Non-urachal Adenocarcinoma of the Bladder -- Primary Urethral Carcinomas -- Adenocarcinoma of the Urethra -- Primary Urethral Melanoma -- Neuroendocrine and Small Cell Carcinomas of the Prostate: Sentinels of Lethal Evolution -- Mucinous, Signet Ring, Ductal, and Sarcomatoid Variants of Prostate Cancer -- Prostate Sarcomas and Squamous Cell Carcinomas -- Sex Cord-Stromal Tumors of the Testis -- Granulosa Cell Tumors of the Testis -- Paratesticular Tumours -- Squamous Cell Carcinoma of the Penis and Scrotum -- Basal Cell Carcinoma of the Male External Genitalia -- Extra-mammary Paget's Disease -- Kaposi's Sarcoma of the Penis and Scrotum -- Rare Tumors of the Vulva.
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e-Book
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Online
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Spectral Domain Optical Coherence Tomography in Macular Diseases

https://libcat.nshealth.ca/en/permalink/provcat41929
Carsten H. Meyer, Sandeep Saxena, SriniVas R Sadda, editors. --New Delhi: Springer , 2017.
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This book aims to build concepts and create a solid foundation in the field of optical coherence tomography (OCT) for the general ophthalmologists as well as for the resident trainees and fellows. The chapters are written by leading international authorities in a style comprehensible to a broad audience. Numerous clinical pictures and SD-OCT scans help elucidate various clinical entities.OCT is the optical analog of ultrasound imaging and has emerged as a powerful imaging technique that enables…
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Other Authors
Meyer, Carsten H
Saxena, Sandeep
Sadda, SriniVas R
Responsibility
Carsten H. Meyer, Sandeep Saxena, SriniVas R Sadda, editors
Place of Publication
New Delhi
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xvii, 443 pages) : 345 illus., 237 illus. in color
ISBN
9788132236108
9788132236085 (print ed.)
Subjects (MeSH)
Retina - diagnostic imaging
Retinal Degeneration - diagnostic imaging
Retinal Diseases - diagnostic imaging
Tomography, Optical Coherence - methods
Abstract
This book aims to build concepts and create a solid foundation in the field of optical coherence tomography (OCT) for the general ophthalmologists as well as for the resident trainees and fellows. The chapters are written by leading international authorities in a style comprehensible to a broad audience. Numerous clinical pictures and SD-OCT scans help elucidate various clinical entities.OCT is the optical analog of ultrasound imaging and has emerged as a powerful imaging technique that enables non-invasive, in-vivo, high-resolution, cross-sectional imaging in retinal tissue. A new generation spectral domain optical coherence tomography (SD-OCT) technology has now been developed, representing a quantum leap in resolution and speed, achieving in vivo optical biopsy. i.e. the visualization of tissue architectural morphology in situ and in real time. This book encompasses the role of SD-OCT in both medical and surgical macular disorders. The book is meant coherent and comprehensive for both vitreoretinal specialists as well as general ophthalmologists.
Contents
Part I: Essentials of Optical Coherence Tomography -- Optical coherence tomography: Basic principles of image analysis -- Normal Macula: Focus on IS-OS junction, external limiting membrane and choroidal thickness -- Part II: Medical Retina -- Diabetic Macular Edema -- Retinal Vein Occlusion -- Retinal Artery Occlusion -- Dry Age-related Macular Degeneration -- Wet Age-related Macular Degeneration -- Polypoidal Disease -- Optical Coherence Tomography in Age-related Macular Degeneration Pharmacotherapy -- Juxtafoveal Telangiectasia -- Central Serous Chorioretinopathy -- Idiopathic Epiretinal membranes -- Part III: Surgical Retina -- Vitreomacular Traction Syndrome -- Idiopathic Macular Hole -- Surgery for Choroidal Neovascular Membrane and Macular Translocation -- Macula after Retinal Detachment Surgery -- Myopic Foveoschisis -- Part IV: Miscellaneous -- Retinal Degenerations and Dystrophies -- Retinal and Choroidal Inflammation -- Optic Disc Pit Maculopathy -- Retinopathy of Prematurity -- Posterior Segment Trauma -- Ocular Oncology -- Miscellaneous Retinal Disorders -- Three Dimensional Imaging in Spectral Domain Optical Coherence Tomography -- Part V: Intraoperative Optical Coherence Tomography -- Intraoperative OCT -- Ultra High Resolution OCT .
Format
e-Book
Location
Online
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Surgery of Conotruncal Anomalies

https://libcat.nshealth.ca/en/permalink/provcat39901
Francois Lacour-Gayet, Edward L. Bove, Viktor Hraška, Victor O. Morell, Thomas L. Spray, editors. --Cham: Springer , c2016.
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This book addresses the most technically demanding cardiac surgical techniques, many of which are often performed on small infants. Conotruncal heart defects are a group of congenital anomalies of the cardiovascular system that are a leading cause of symptomatic cyanotic cardiac disease diagnosed in utero. Surgery of Conotruncal Anomalies provides a wealth of practical information and has been written by a collection of world renowned experts. They discuss the most challenging but life-changing…
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Other Authors
Lacour-Gayet, Francois
Bove, Edward L
Hraška, Viktor
Morell, Victor O
Spray, Thomas L
Responsibility
Francois Lacour-Gayet, Edward L. Bove, Viktor Hraška, Victor O. Morell, Thomas L. Spray, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xvii, 627 p. : 290 illus., 186 illus. in color)
ISBN
9783319230573
9783319230566 (print ed.)
Subjects (MeSH)
Cardiovascular Surgical Procedures
Heart Defects, Congenital - surgery
Abstract
This book addresses the most technically demanding cardiac surgical techniques, many of which are often performed on small infants. Conotruncal heart defects are a group of congenital anomalies of the cardiovascular system that are a leading cause of symptomatic cyanotic cardiac disease diagnosed in utero. Surgery of Conotruncal Anomalies provides a wealth of practical information and has been written by a collection of world renowned experts. They discuss the most challenging but life-changing surgeries which, if performed perfectly, allow the child to lead a normal adult life in the majority of cases. This book and the large number of truly stunning explanatory illustrations contained within is an essential resource for junior surgeons as well as trainees and practicing cardiac surgeons, pediatric cardiologists and surgeons, and cardiac imagers, to be used as a critical reference when performing these complex cases.
Contents
1. Definition of Conotruncal Anomalies -- 2. Development and Maldevelopment of the Ventricular Outflow Tracts -- 3. Anatomy of Conotruncal Anomalies -- 4. Outcomes Data of Surgery for Conotruncal Anomalies from the Congenital EACTS and STS Databases -- 5. Tetralogy of Fallot: Transventricular Repair, Including Pulmonary Atresia Without MAPCAs -- 6. Transatrial Repair of Tetralogy of Fallot -- 7. Tetralogy of Fallot: Management of the Pulmonary Valve -- 8. Pulmonary Atresia, Ventricular Septal Defect and Major Aorto-Pulmonary Collateral Arteries -- 9. Tetralogy of Fallot with Complete Atrioventricular Canal -- 10. Tetralogy of Fallot with Absent Pulmonary Valve Syndrome -- 11. Fallot: Palliation with BT Shunt -- 12. Redo Fallot: Surgery for Pulmonary Valve Implantation -- 13. Transcatheter Pulmonary Valvulation -- 14. Arterial Switch in TGA-IVS: Coronary Transfer -- 15. Arterial Switch for TGA or DORV and VSD, with and Without Aortic Arch Obstruction -- 16. TGA-IVS and TGA-VSD Seen Late -- 17. TGA-VSD and LVOTO: Rastelli Procedure -- 18. TGA-VSD-LVOT Obstruction : REV (Réparation à l’Etage Ventriculaire) Procedure -- 19. Transposition of the Great Arteries with VSD and LVOTO. The Autograft Procedure for RVOT (the “DREAM”) -- 20. The Aortic Translocation (Nikaidoh) Procedure -- 21. Double Root Translocation Operation for Complete Transposition of Great Arteries with Ventricular Septal Defect and Pulmonary Stenosis & Double-Outlet Right Ventricle with Non-committed Ventricular Septal Defect and Pulmonary -- 22. Transposition of the Great Arteries with Ventricular Septal Defect and Left Ventricle Outflow Tract Obstruction: Pulmonary Valve Translocation -- 23. Bi-ventricular Repair of Double Outlet Right Ventricle -- 24. Biventricular Repair of Double Outlet Right Ventricle with Complete Atrioventricular Septal Defect -- 25. Double Outlet Left Ventricle -- 26. Corrected TGA-VSD: The Double Switch Procedure -- 27. Anatomic Correction of Corrected Transposition of the Great Arteries with Ventricular Septal Defect and Obstruction of the Left Ventricular Outflow Tract -- 28. Corrected TGA-VSD-LVOTO: Rastelli + Atrial Switch + Damus-Kaye-Stansel Operation -- 29. Physiologic Repair of Congenitally Corrected Transposition of the Great Arteries -- 30. Anatomically Corrected Malposition of the Great Arteries -- 31. Truncus Arteriosus -- 32. Common Arterial Trunk with Interrupted Aortic Arch -- 33. Interrupted Aortic Arch -- 34. The Dilated Aortic Root in Adult Patients with Conotruncal Anomalies -- 35. Single Ventricle Repair for Conotruncal Anomalies -- 36. Genetics of Conotruncal Anomalies.
Format
e-Book
Location
Online
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Vitreo-retinal Surgery

https://libcat.nshealth.ca/en/permalink/provcat29748
editors, Bernd Kirchhof, David Wong. ([2nd ed.]) --Berlin, Heidelberg: Springer-Verlag , c2007.
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Location
Online
Available Online
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Other Authors
Kirchhof, Bernd
Wong, David
Responsibility
editors, Bernd Kirchhof, David Wong
Edition
[2nd ed.]
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2007
Physical Description
1 online resource (xvi, 156 p.)
Series
Essentials in ophthalmology. Second cycle
Series Title
Essentials in ophthalmology
ISBN
9783540336709
9783540336693 (print)
ISSN
1612-3212
Subjects (MeSH)
Retinal Diseases - surgery
Vitrectomy - methods
Vitreous Body - surgery
Subjects (LCSH)
Ophthalmology
Surgery
Contents
1. Macular Holes -- 2. Heavy Silicone Oil for Persistent Macular Holes -- 3. The Role of Combined Adjunctive 5-Fluorouracil and Low Molecular Weight Heparin in Proliferative Vitreoretinopathy Prevention -- 4. Slippage of the Retina: What Causes It and How Can It Be Prevented? -- 5. Complete and Early Vitrectomy for Endophthalmitis (CEVE) as Today’s Alternative to the Endophthalmitis Vitrectomy Study -- 6. Treatment of Acute Bacterial Endophthalmitis After Cataract Surgery Without Vitrectomy -- 7. New Instruments in Vitrectomy -- 8. 25-Gauge Biopsy of Uveal Tumors -- 9. Vitrectomy Against Floaters -- 10. Treatment of Retinal Detachment from Inferior Breaks with Pars Plana Vitrectomy -- 11. Subclinical Retinal Detachment -- 12. Autologous Translocation of the Choroid and RPE in Patients with Geographic Atrophy.
Format
e-Book
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Online
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Vitreo-retinal Surgery

https://libcat.nshealth.ca/en/permalink/provcat28758
editors, Bernd Kirchhof, David Wong. --Berlin, Heidelberg: Springer-Verlag , c2005.
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Online
Available Online
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Other Authors
Kirchhof, Bernd
Wong, David
Responsibility
editors, Bernd Kirchhof, David Wong
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2005
Physical Description
1 online resource (xiv, 177 p.)
Series Title
Essentials in ophthalmology
ISBN
9783540271529
9783540200444 (print)
ISSN
1612-3212
Subjects (MeSH)
Retinal Diseases - surgery
Vitrectomy - methods
Vitreous Body - surgery
Subjects (LCSH)
Ophthalmology
Surgery
Contents
1. Retinal Implants -- 2. Therapeutic Approaches to Macular Oedema -- 3. Is There Room for Improvement in Pucker Surgery? -- 4. Is There Sufficient Evidence to Support Transpupillary Thermotherapy for Age-Related Macular Degeneration? -- 5. Retinal Pigment Epithelium and Choroid Translocation in Patients with Exudative Age-Related Macular Degeneration -- 6. Giant Retinal Tear -- 7. Retinal Pigment Epithelium Differentiation and Dedifferentiation -- 8. Risk Factors in Proliferative Vitreoretinopathy -- 9. Prevention of Proliferative Vitreoretinopathy -- 10. The Tamponade Effect -- 11. Vitreous Surgery in Uveitis and Allied Disorders.
Format
e-Book
Location
Online
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