Autoimmune Thrombocytopenia
https://libcat.nshealth.ca/en/permalink/provcat41988
Yoji Ishida, Yoshiaki Tomiyama, editors.
--Singapore:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book provides a concise yet comprehensive summary of the current state of knowledge concerning the pathophysiology, differential diagnosis and treatment options that support day-to-day patient management. It reviews a variety of treatments including TOP-R antagonists, along with Syk inhibitor, which has recently proven to be effective, enabling readers to update and broaden their knowledge of the disease. Covering topics ranging from basic science to clinical practice, Autoimmune Thrombocy…
- Available Online
- View e-Book
- Other Authors
- Ishida, Yoji
- Tomiyama, Yoshiaki
- Responsibility
- Yoji Ishida, Yoshiaki Tomiyama, editors
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (x, 229 pages) : 26 illus., 7 illus. in color
- ISBN
- 9789811041426
- 9789811041419 (print ed.)
- Subjects (MeSH)
- Purpura, Thrombocytopenic, Idiopathic
- Abstract
- This book provides a concise yet comprehensive summary of the current state of knowledge concerning the pathophysiology, differential diagnosis and treatment options that support day-to-day patient management. It reviews a variety of treatments including TOP-R antagonists, along with Syk inhibitor, which has recently proven to be effective, enabling readers to update and broaden their knowledge of the disease. Covering topics ranging from basic science to clinical practice, Autoimmune Thrombocytopenia will appeal to a wide readership, from medical interns and residents to clinicians and hematologists, offering them a thought-provoking, instructive and informative collection of cutting-edge works. Accordingly, readers will gain an overview of the autoimmune and other causes of the disease, and the book will serve as a foundation for new research directions that further our understanding of the pathophysiology and development of diagnosis and treatment options.
- Contents
- Part I: Introduction -- History of Immune Thrombocytopenia -- Part II: Basic Aspects of Platelet Biology -- Megakaryopoiesis and Thrombopoiesis -- Platelet Membrane Glycoproteins -- Part III: Epidemiology -- Epidemiology -- Part IV: Pathophysiology -- Autoantigens in ITP -- T-Cell Abnormalities -- Part V: Adult ITP -- ITP in Adults -- Part VI: Diagnosis -- Diagnosis in General -- Differential Diagnosis: Secondary ITP -- Differential Diagnosis: Hypoplastic Thrombocytopenia -- Differential Diagnosis: Congenital Macrothrombocytopenia -- Part VII: Treatment of Adult ITP -- Helicobacter pylori (H. pylori) Eradication -- Steroids -- High-Dose Immunoglobulin -- Splenectomy -- Rituximab -- Thrombopoietin Receptor Agonists -- Others (Syk Inhibitor and Other Medications) -- Transfusion -- Therapy in Pregnancy -- Part VIII: Child ITP -- Clinical Manifestations of ITP in Children -- Management and Treatment of Primary Immune Thrombocytopenia in Children.
- Format
- e-Book
- Location
- Online
Behçet’s Disease : From Genetics to Therapies
https://libcat.nshealth.ca/en/permalink/provcat39479
Yoshiaki Ishigatsubo, editor.
--Tokyo:
Springer Japan
, c2015.
- Available Online
- View e-Book
- Location
- Online
This book, besides reviewing basic and clinical aspects of Beh©et's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Beh©et's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis…
- Available Online
- View e-Book
- Other Authors
- Ishigatsubo, Yoshiaki
- Responsibility
- Yoshiaki Ishigatsubo, editor
- Place of Publication
- Tokyo
- Publisher
- Springer Japan
- Date of Publication
- c2015
- Physical Description
- 1 online resource (ix, 176 p. : 38 illus., 31 illus. in color)
- ISBN
- 9784431544876
- 9784431544869 (print ed.)
- Subjects (MeSH)
- Behcet Syndrome
- Abstract
- This book, besides reviewing basic and clinical aspects of Beh©et's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Beh©et's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behçet’s disease. Behçet’s Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behçet’s disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.
- Contents
- 1. Overview -- 2. The Immunopathology of Behçet’s Disease -- 3. Genetics -- 4. Ocular Involvement -- 5. Vascular Involvement of Behçet’s Disease -- 6. Neurological Involvement -- 7. Gastrointestinal Involvement -- 8. Mucocutaneous Manifestations -- 9. Perspective.
- Format
- e-Book
- Location
- Online
Make Life Visible
https://libcat.nshealth.ca/en/permalink/provcat44715
Yoshiaki Toyama, Atsushi Miyawaki, Masaya Nakamura, Masahiro Jinzaki, editors.
--Singapore:
SpringerOpen
, c2020.
- Available Online
- View e-Book
- Access
- Open access
- Location
- Online
This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completely impossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology in …
- Available Online
- View e-Book
- Other Authors
- Toyama, Yoshiaki
- Miyawaki, Atsushi
- Nakamura, Masaya
- Jinzaki, Masahiro
- Responsibility
- Yoshiaki Toyama, Atsushi Miyawaki, Masaya Nakamura, Masahiro Jinzaki, editors
- Place of Publication
- Singapore
- Publisher
- SpringerOpen
- Date of Publication
- c2020
- Physical Description
- 1 online resource (ix, 292 p.) : 137 illus., 106 illus. in color
- ISBN
- 9789811379086
- 9789811379079 (Print ed.)
- 9789811379093 (Print ed.)
- 9789811379109 (Print ed.)
- Subjects (MeSH)
- Biomedical Technology
- Clinical Laboratory Techniques
- Diagnostic Imaging - methods
- Image Processing, Computer-Assisted - methods
- Subjects (LCSH)
- Neurosciences
- Immunology
- Cell biology
- Specialty
- Diagnostic Imaging
- Abstract
- This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completely impossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology in the broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. The book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.
- Contents
- Part 1: Visualizing and Controlling Molecules for Life -- 1. Photoacoustic Tomography: Deep Tissue Imaging by Ultrasonically Beating Optical Diffusion -- 2. Regulatory Mechanism of Neural Stem Cells Revealed by Optical Manipulation of Gene Expressions -- 3. Eavesdropping on Biological Processes with Multi-Dimensional Molecular Imaging -- 4. Apical microtubules define the function of epithelial cell sheets consisting of non-ciliated or multi-ciliated cells -- 5. Illuminating the brain -- 6. Optogenetic assemblies of cortical force-generating complexes during mitosis -- 7. In vivo Imaging Probes with Tunable Chemical Switches -- 8. Circuit-dependent striatal PKA and ERK signaling underlying action selection -- 9. Electrophysiology, Unplugged: New Chemical Tools to Image Voltage -- 10. Molecular dynamics revealed by single-molecule FRET measurement -- 11. Comprehensive approaches using luminescence to studies of cellular functions -- Part II: Imaging Disease Mechanisms -- 12. Make Chronic Pain Visible -- 13. Cortical plasticity after spinal cord injury using resting-state functional magnetic resonance imaging -- 14. Multimodal Label-free imaging to assess compositional and morphological changes in cells during immune activation -- 15. Investigating in vivo myocardial and coronary molecular pathophysiology in mice with X-ray radiation imaging approaches -- 16. Visualizing the Immune Response to Infections -- 17. Imaging Sleep and Wakefulness -- 18. Abnormal local translation in dendrites impairs cognitive functions in neuropsychiatric disorders -- 19. Imaging synapse formation and remodeling in vitro and in vivo -- Part III: Imaging-based Diagnosis and Therapy -- 20. How MRI makes the Brain Visible -- 21. Intravital multiphoton imaging revealing cellular dynamics in vivo -- 22. Theranostic Near Infrared Photoimmunotherapy for Cancer -- 23. Novel and integrated imaging on Chronic Fatigue -- 24. Novel fluorescent probes for rapid tumor imaging and fast glutathione dynamics -- 25. Coronary Heart Disease Diagnosis: Engineering Triumphs, Economic Barriers -- 26. Live imaging of the skin immune responses -- 27. Development of a horizontal CT and its application to musculoskeletal disease -- 28. The Future of Precision Health & Integrated Diagnostics -- 29. Imaging and therapy against hypoxic tumors with 64Cu-ATSM.
- Access
- Open access
- Format
- e-Book
- Location
- Online
Neuroprotection and regeneration of the spinal cord
https://libcat.nshealth.ca/en/permalink/provcat33728
Kenzo Uchida, Masaya Nakamura, Hiroshi Ozawa, Shinsuke Katoh, editors ; Yoshiaki Toyama, honorary editor.
--Tokyo:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
Neuroprotection and Regeneration of the Spinal Cord comprehensively covers the most recent research in the field of spinal cord injury. The first part of this book focuses on the latest animal models and clinically oriented work, providing extensive information on morphological factors and, biomechanical analysis, in addition to the mechanism of functional recovery. The book goes on to provide information on clinical relevance introducing analysis of spinal cord injuries using MRI and PET. Edit…
- Available Online
- View e-Book
- Responsibility
- Kenzo Uchida, Masaya Nakamura, Hiroshi Ozawa, Shinsuke Katoh, editors ; Yoshiaki Toyama, honorary editor
- Place of Publication
- Tokyo
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (x, 419 pages)
- ISBN
- 9784431545026 (electronic bk.)
- 9784431545019
- Subjects (MeSH)
- Neuroprotective Agents
- Spinal Cord Injuries
- Spinal Cord Regeneration
- Subjects (LCSH)
- Spinal cord - Regeneration
- Neuroprotective agents
- Abstract
- Neuroprotection and Regeneration of the Spinal Cord comprehensively covers the most recent research in the field of spinal cord injury. The first part of this book focuses on the latest animal models and clinically oriented work, providing extensive information on morphological factors and, biomechanical analysis, in addition to the mechanism of functional recovery. The book goes on to provide information on clinical relevance introducing analysis of spinal cord injuries using MRI and PET. Edited by renowned experts in the field, this book will provide clinical physicians, basic researchers, and postgraduate students with valuable insight into the cutting-edge research and progress in the field of spinal cord injury, treatment, and repair.
- Contents
- Part I. Pathologies of Spinal Cord Injury -- The Mechanism Behind Functional Recovery After the Incomplete Spinal Cord Injury -- Microenvironment Within the Injured Spinal Cord Focusing on IL-6 -- Autophagy in Spinal Cord Injury: Pathogenic Roles and Therapeutic Implications -- The Role of the Endoplasmic Reticulum Stress Response in Neural Apoptosis of the Injured Spinal Cord -- Roles of Microglia in Spinal Cord Injury -- Part II. Pathologies of Chronic Compressive Spinal Cord -- Biomechanics of the Spinal Cord and the Pia Mater -- Biomechanical Analysis of Compressive Myelopathy: The Influence of Morthometry of the Spinal Cord -- Morphologic Change and Glial Response to Unilateral Spinal Cord Compression -- Morphological Changes in Anterior Horn Cells, Immunoreactivity to Neurotrophic Factors, and Neuronal Cell Death of Spinal Cord Lesions in the Spinal Hyperostotic Mouse (twy/twy) with Chronic Mechanical Cord Compression -- In Vivo Tracing of Neural Tracts in Tiptoe-Walking Yoshimura Mice by Diffusion Tensor Tractography -- Microarray Analysis of Expression of Cell Death-Associated Genes in Spinal Cord Cells with Cyclic Tensile Strain -- Spinal Kyphosis Causes Demyelination and Neuronal Loss in the Spinal Cord -- Part III. Neuroprotection -- Granulocyte Colony-Stimulating Factor-Mediated Neuroprotective Therapy for Spinal Cord Injury -- Recombinant Human Hepatocyte Growth Factor Promotes Functional Recovery After Spinal Cord Injury -- The Proteoglycan-Degrading Enzymes Promote Functional Recovery After Spinal Cord Injury: Keratan Sulfate and Chondroitin Sulfate -- Targeted Retrograde Gene Delivery into the Injured Spinal Cord Using Recombinant Adenovirus Vector Carrying Neurotrophic Factor Gene -- Blockade of Interleukin-6 Effects on Cytokine Profiles and Macrophage Activation After Spinal Cord Injury in Mice -- Oxidative Stress as Secondary Injury Mechanism After Mechanical Trauma in the Spinal Cord -- Part IV. Transplantation -- Regenerative Medicine for Spinal Cord Injury Utilizing iPS Cells -- Transplantation of Neural Stem Cells with Valproate for Spinal Cord Injury -- The Effects of Mesenchymal Stem Cell-Transduced Multineurotrophin to Improve Function Following Spinal Cord Injury -- Axonal Regeneration Across an Artificial Scaffold Combined with Cell Transplantation Applied to the Transected Spinal Cord -- Transplantation of Mesenchymal Stem Cells Derived from Bone Marrow in the Injured Spinal Cord -- Vascular Regeneration Therapies for Spinal Cord Injury -- Part V. Clinical Relevance -- Stress Distribution of the Spinal Cord and Clinical Relevance in Cervical Spondylotic Myelopathy -- Applications and Limitations of pNF-H, a Novel Biomarker for Spinal Cord Injury: Strategy for the Evaluation of Therapeutic Outcomes -- Neuroprotective Therapy Using Granulocyte Colony-Stimulating Factor for Acute Spinal Cord Injury: A Multicenter Prospective Controlled Clinical Trial -- Assessment of Injured Spinal Cord Using Diffusion Tensor Tractography -- Clinical Significance of 3D-MRI/18F-FDG PET Fusion Imaging of Patients with Cervical Compressive Myelopathy -- Visualization of Electrophysiological Activity in the Spinal Cord Using Magnetospinography -- Spinal Synaptic Plasticity in Chronic Pain -- Evaluation of Pain with Functional Neuroimaging.
- Format
- e-Book
- Location
- Online
OPLL : Ossification of the Posterior Longitudinal Ligament
https://libcat.nshealth.ca/en/permalink/provcat29862
edited by Kazuo Yonenobu, Kozo Nakamura, Yoshiaki Toyama.
(2nd ed.)
--Tokyo:
Springer
, c2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Yonenobu, Kazuo
- Other Authors
- Nakamura, Kozo
- Toyama, Yoshiaki
- Responsibility
- edited by Kazuo Yonenobu, Kozo Nakamura, Yoshiaki Toyama
- Edition
- 2nd ed.
- Place of Publication
- Tokyo
- Publisher
- Springer
- Date of Publication
- c2006
- ISBN
- 9784431325635
- Subjects (MeSH)
- Ossification of Posterior Longitudinal Ligament
- Spinal Cord Compression - etiology
- Spinal Osteophytosis
- Subjects (LCSH)
- Orthopedics
- Format
- e-Book
- Location
- Online
