Hematologic Cancers : From Molecular Pathobiology to Targeted Therapeutics
https://libcat.nshealth.ca/en/permalink/provcat31285
Jianguo Tao, Eduardo Sotomayor, editors.
--Dordrecht:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
In the last decade, there has been a remarkable explosion of knowledge in hematologic cancer from basic molecular biology and pathology to clinical therapy. This has led to many new advance and insights in the understanding of pathobiology of malignant hematology. New knowledge of disease molecular pathology, cytogenetic, epigenetic and genomic alterations have provided new strategies to attack and eradicate tumor cells at molecular level and significantly impacted our current therapeutics for …
- Available Online
- View e-Book
- Other Authors
- Tao, Jianguo
- Sotomayor, Eduardo
- Responsibility
- Jianguo Tao, Eduardo Sotomayor, editors
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (vi, 426 p. : 26 ill., 20 ill. in color)
- Series Vol.
- v. 14
- Series Title
- Cancer growth and progression
- ISBN
- 9789400750289
- Subjects (MeSH)
- Hematologic Neoplasms
- Subjects (LCSH)
- Oncology
- Medical laboratories
- Hematology
- Abstract
- In the last decade, there has been a remarkable explosion of knowledge in hematologic cancer from basic molecular biology and pathology to clinical therapy. This has led to many new advance and insights in the understanding of pathobiology of malignant hematology. New knowledge of disease molecular pathology, cytogenetic, epigenetic and genomic alterations have provided new strategies to attack and eradicate tumor cells at molecular level and significantly impacted our current therapeutics for hematological malignancies. The recent and ongoing rapid expansion of knowledge in this area has become extensive, dynamic and diffuse over the literature and research publications. This has led to the need to capture and compile the new and current information about hematologic cancer with special emphasis on translation from molecular pathobiology to targeted therapeutics. In this book experts from around the world share their thoughts and knowledge about the pathobiology of hematologic cancer, as well as their view on current treatment approaches and future development in these malignant hematologic diseases. This book is well suited for hematology residents, fellows and hematology-oncology physicians, hematopathologist as well as basic research scientist in the area of hematologic malignancies.
- Contents
- [Machine generated contents note] B Cell Growth, Differentiation and Malignancies / Chih-Chi Andrew Hu -- Follicular Lymphoma: Recent Advances / Wing C. Chan -- Chronic Lymphocytic Leukemia: From Pathobiology to Targeted Therapy / Chih-Chi Andrew Hu -- Genetic and Environmental Determinants in Multiple Myeloma: Implications for Therapy / William S. Dalton -- EBV-Positive Diffuse Large B-Cell Lymphoma of the Elderly / Jorge J. Castillo -- HIV and Lymphoma / Brady E. Betran -- Molecular Biology of Mantle Cell Lymphoma / Eduardo M. Sotomayor -- Pathogenesis of Non-Hodgkin Lymphoma Derived from Inflammatory, Autoimmune or Immunologic Disorders / Jianguo Tao -- Pathogenesis of Non-Hodgkin Lymphoma Derived from Infection Diseases / Roger Klein -- Hodgkin Lymphoma: From Molecular Pathogenesis to Targeted Therapy / Anas Younes -- Myelodysplastic Syndromes / Adam Bagg -- Chronic Myeloproliferative Disorders: From Molecular Pathogenesis to Targeted Therapy / Josef Prchal -- Chronic Myeloid Leukemia / Warren Fiskus -- Novel Targeted Therapeutics for Acute Myeloid Leukemia / Jeffrey Lancet -- Novel Targeted Therapeutics for Peripheral T-Cell Lymphoma / Jasmine Zain -- Large Granular Lymphocyte Leukemia – From Molecular Pathogenesis to Targeted Therapy / Thomas P. Loughran Jr. -- Epigenetic Regulation and Therapy in Lymphoid Malignancies / Haifeng Zhao.
- Format
- e-Book
- Location
- Online
Management of Lymphomas : A Case-Based Approach
https://libcat.nshealth.ca/en/permalink/provcat41282
Jasmine Zain, Larry W. Kwak, editors.
--Cham:
Adis
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book will provide an overview of how to manage patients with lymphoma in the format of a series of engaging case studies. Lymphomas are cancers that originate in the lymphatic system. There are two main types of lymphoma: Hodgkin lymphoma and non-Hodgkin lymphoma. These lymphomas comprise various subtypes with prognosis and treatment depending on the stage and type of the cancer. Lymphoma is a major global health problem; non-Hodgkin lymphoma in particular is the tenth most common type of …
- Available Online
- View e-Book
- Other Authors
- Zain, Jasmine
- Kwak, Larry W
- Responsibility
- Jasmine Zain, Larry W. Kwak, editors
- Place of Publication
- Cham
- Publisher
- Adis
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xxii, 204 pages) : 36 illus., 26 illus. in color
- ISBN
- 9783319268279
- 9783319268255 (print ed.)
- Subjects (MeSH)
- Lymphoma
- Hodgkin Disease
- Abstract
- This book will provide an overview of how to manage patients with lymphoma in the format of a series of engaging case studies. Lymphomas are cancers that originate in the lymphatic system. There are two main types of lymphoma: Hodgkin lymphoma and non-Hodgkin lymphoma. These lymphomas comprise various subtypes with prognosis and treatment depending on the stage and type of the cancer. Lymphoma is a major global health problem; non-Hodgkin lymphoma in particular is the tenth most common type of cancer worldwide. In response to this there have been a number of significant advances in the available treatment options for lymphoma with new breakthrough drugs being approved or registered for approval. In light of this, this case study book will be an extremely timely guide for all hematologists, oncologists, and healthcare professionals wishing to keep up-to-date with these recent developments. The format of this book is also particularly appealing as it offer readers a practical approach to the clinical management of patients with these conditions as suggested by leading physicians from the City of Hope National Medical Center in California, USA in an era of vast therapeutic development.
- Contents
- 1. Overview of lymphoma -- 2. Pathogenesis of lymphomas -- 3. Classification of Hodgkin and non-Hodgkin lymphoma -- Case Study Section One: Indolent B-Cell Lymphomas -- 4. Small B-cell lymphocytic lymphoma and chronic lymphocytic leukemia -- 5. Follicular lymphoma -- 6. Lymphoplasmacytic lymphoma in the era of next generation sequencing -- Case Study Section Two: Aggressive B-Cell Lymphomas -- 7. Mantle cell lymphoma -- 8. Burkitt lymphoma -- 9. Diffuse large B-cell lymphoma -- Case Study Section Three: T-Cell Lymphomas -- 10. Cutaneous T-cell lymphoma -- 11. Systemic T-cell lymphoma -- 12. Case Study Section Four: Hodgkin Lymphoma -- Hodgkin lymphoma -- Case Study Section Five: Lymphomas in Special Clinical Situations -- 13. Acquired immunodeficiency syndrome-related lymphoma -- 14. Central nervous system lymphoma -- 15. Conclusion.
- Format
- e-Book
- Location
- Online
T-Cell and NK-Cell Lymphomas : From Biology to Novel Therapies
https://libcat.nshealth.ca/en/permalink/provcat44039
Christiane Querfeld, Jasmine Zain, Steven T. Rosen, editors.
--Cham:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
In this book, a group of internationally distinguished lymphoma experts provide a comprehensive review of the most important advances in the biology, diagnosis, and therapy of T cell and NK cell malignancies. In particular, it demonstrates in detail how advances in our understanding of the tumor microenvironment and molecular biology have helped to elucidate the pathogenesis of these lymphomas, improve diagnostic and prognostic accuracy, and develop novel therapies that promise improved patient…
- Available Online
- View e-Book
- Other Authors
- Querfeld, Christiane
- Zain, Jasmine
- Rosen, Steven T.
- Responsibility
- Christiane Querfeld, Jasmine Zain, Steven T. Rosen, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (viii, 287 p.) : 40 illus., 37 illus. in color
- Series
- Cancer Treatment and Research
- Series Vol.
- 176
- Series Title
- Cancer treatment and research
- ISBN
- 9783319997162
- 9783319997155 (Print ed.)
- 9783319997179 (Print ed.)
- ISSN
- 0927-3042
- Subjects (MeSH)
- Killer Cells, Natural - pathology
- Lymphoma - physiopathology
- Lymphoma - therapy
- T-Lymphocytes - pathology
- Specialty
- Medical Oncology
- Abstract
- In this book, a group of internationally distinguished lymphoma experts provide a comprehensive review of the most important advances in the biology, diagnosis, and therapy of T cell and NK cell malignancies. In particular, it demonstrates in detail how advances in our understanding of the tumor microenvironment and molecular biology have helped to elucidate the pathogenesis of these lymphomas, improve diagnostic and prognostic accuracy, and develop novel therapies that promise improved patient outcomes. Individual chapters are devoted to particular tumor types and subtypes, and all aspects of transplantation for patients with T cell and NK cell lymphomas are discussed. As such, the book offers a valuable resource for hematologists, oncologists, hematopathologists, and all those seeking an up-to-date overview of how new, targeted therapies are delivering better disease control and improved quality of life.
- Contents
- 1. Epidemiology and pathology of T- and NK-cell lymphomas -- 2. Molecular and genomic landscape of peripheral T-cell lymphoma -- 3. Tumor microenvironment in T-cell lymphomas -- 4. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) -- 5. Angioimmunoblastic T-cell lymphoma -- 6. Anaplastic large cell lymphoma: contemporary concepts and optimal management -- 7. Adult T-cell leukemia-lymphoma -- 8. NK-cell lymphomas -- 9. Hepatosplenic T-cell lymphomas -- 10. Rare T-cell subtypes -- 11. Primary cutaneous T-cell lymphomas: mycosis fungoides and Sezary syndrome -- 12. CD30-positive lymphoproliferative disorders -- 13. Transplantation.
- Format
- e-Book
- Location
- Online
